Abstract: Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which are administered, e.g., orally, transdermally, or otherwise parenterally, in a continuous and controlled manner.

Abstract: The present invention relates to a process for the production of collagen foams in the form of continuous tapes, characterized in thata) solved or dispersed collagen is cast into disk molds,b) the collagen solution or dispersion is frozen in the disk mold and subsequently is freeze-driedc) continuous tapes are produced from the freeze-dried disks by mechanical processes. Furthermore, the present invention relates to the use of said tapes so obtained in medicine, cosmetic and hygiene.

Abstract: Formulation to increase the transdermal permeation of pharmaceutical substances or other biologically active substances, characterized by a content of a penetration enhancing portion of lanoline derivatives on their own or in a mixture with esters of isopropyl alcohol with long-chain fatty acids and/or polyethyleneglycol ethers of fatty alcohols with longer chains, as penetration enhancing substances, as well as a process for their production.

Abstract: The present invention relates to a therapeutic system for the retarded and controlled transdermal or transmucous administration of active substances via an impermeable backing layer, an auxiliary agents containing reservoir, an active substance containing reservoir, and a removable protective layer, characterized in thata. the active substance reservoir comprises the active substance in a non-bioavailable form,b. the auxiliary agent of the auxiliary agent reservoir renders the active substance bioavailable andc. auxiliary agent reservoir and active substance reservoir are brought into contact just immediately prior to application or at any time after application, this being done in such a way that the auxiliary agent reaches the active substance reservoir.

Abstract: The invention relates to a patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature which comprises a multi-element system comprising(a) a matrix having distributed therein as the drug said volatile active ingredient or a physiologically acceptable salt thereof, the matrix comprising a pressure-sensitive adhesive,(b) an element of a pressure-sensitive adhesive composition which--where (a) contains a salt--contains basic groups to liberate the free base from its salt,(c) a backing layer impermeable to the diffusable ingredients of (a) and (b), and(d) a release liner impermeable to the diffusable ingredients of (a) and (b),matrix (a) or at least a part of (b), whichever is in contact with release liner (d), having a tack sufficient for affixing the patch to the skin, any part of (b) positioned between matrix (a) and release liner (d) being permeable for the deprenyl or the salt thereof or both.

Abstract: A transdermal system employing a basic active component-permeable, pressure sensitive adhesive polymer material, particularly for use with basic active components for use in transdermal administration of systemically or topically acting medicaments constituted by such active components. The adhesive polymer is a homopolymer or copolymer produced using basic monomers preferably on an acrylate base. A process for production of the polymer material comprises mixing monomers suitable for the production of an adhesive by polymerization with basic monomers which can be polymerized and copolymerizing the mixture. The adhesive composition is in particular useful with basic active components in salt form and in which the therapeutically active agent is a Lewis base.

Abstract: A flexible, hydrophilic, water-swellable but insoluble gel film which consists of(a) 0.5 to 30%-wt of at least one water-soluble polymer being anion-active at neutral pH(b) 0.5 to 50%-wt of at least one water-soluble polymer being cation-active at neutral pH(c) 0.1 to 20%-wt of at least one moisturizer(d) 0.1 to 70%-wt of water(e) 0 to 75%-wt of water-soluble or water-dispersible auxiliaries(f) 0 to 50%-wt of active substancea process for its production and the use of this film for the production of a device creating interactions between the gel film and a solid, liquid, or gaseous substrate.

Abstract: The invention relates to a self-adhesive laminate, shapeable to toe and fingernails, containinga) a film-forming polymer layer containing at least one plasticizer,b) a pressure-sensitive adhesive layer located thereon, andc) a carrier film which covers the pressure-sensitive adhesive layer and can be removed again, wherein the film-forming layer a) is also covered on the other side, at least over the entire surface, withd) a protective layer, which is likewise removable and is resistant to the other constituents of the laminate and the materials used in the preparation of the laminate.The invention also relates to a process for the preparation of such a laminate and to its use for application to toenails or fingernails as synthetic nails.

Abstract: The invention relates to a primary pack for surface-stabilized bandaging materials having a carrier layer and a skin-side contact surface having pressure sensitive adhesive areas and which prior to the use of the bandaging material is protected by a removable covering layer, and an at least one-layer supporting film detachably applied to the skin-remote surface of the carrier layer and which can be removed from the applied bandaging material, the supporting film forming part of the pack protecting the bandaging material.

Abstract: The invention relates to an apparatus for the controlled delivery of nicotine with a contact adhesive nicotine reservoir with uniform or irregular distribution of the nicotine, characterized in that the reservoir is produced using a hot melt contact adhesive with a processing temperature of 40.degree. to 80.degree., preferably 40.degree. to 60.degree. and in particularly preferred manner 40.degree. to 55.degree. C., a process for the production thereof and the use of the apparatus in human or veterinary medicine, particularly for stopping people smoking, or as a respiratory, contact or stomach poison in pest control.

Abstract: The present invention relates to active substance plasters for the controlled release of active substances to the skin consisting of a backing layer, an adhesive film connected therewith which film is water-soluble and consists of pressure-sensitive adhesive which comprises water-swellable polymers and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, in which plasters the pressure-sensitive adhesive is based on homo and/or copolymers with at least one derivative of the acrylic or methacrylic acid, and which comprise as active substances, partially or completely dissolved in the adhesive, at a concentration of 0.5 to 10.0%-wt estrogens and their pharmaceutically acceptable derivatives alone or in combination with gestagens.

Abstract: The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active substances, an active substance deposit comprising at least one auxiliary agent with supporting and distributing function in the form of a textile fabric material, a matrix surrounding said deposit from all sides, and optionally a removable protective layer, the matrix of which comprises 10-90%-wt polymeric material selected from the group consisting of polymers on the basis of acrylate and/or methacrylate and esters of hydrogenated colophonium, 0-30%-wt softener on the basis of hydrocarbons and/or esters, and that the active substance deposit immediately after its production comprises 15-85%-wt of a 0.1-70%-wt physostigmine solution.

Abstract: The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterized in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterized in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterised in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.

Abstract: The invention relates to an apparatus for the controlled delivery or release of nitroglycerin to the human or animal skin, preferably in plaster form with a nitroglycerin-impermeable backing layer, a one or multiple-part reservoir containing a pressure sensitive adhesive nitroglycerin in uniform or irregular distribution and optionally a removable protective layer impermeable for nitroglycerin, the reservoir being produced using hot melt pressure sensitive adhesives with a processing temperature of 40.degree. to 80.degree. C., preferably 40.degree. to 60.degree. C. and in particularly preferred manner 40.degree. to 45.degree. C., a process for the production thereof and the use of the apparatus for therapeutic purposes in human and veterinary medicine.

Abstract: The present invention relates to a device for the topical and systemic administration of active substances to or through the skin consisting of a backing layer, at least one self-adhesive layer, and a removable protective layer, wherein the self-adhesive layer consists of(a) 100 parts by weight of a polyacrylate adhesive,(b) 5 to 150, preferably 10 to 100, and in particular 15 to 50 parts by weight of a film former compatible with polyacrylates,(c) 0 to 250 parts by weight of a non-softening active substance and/or adjuvant, and(d) 10 to 250 parts by weight of a softening active substance and/or adjuvant.

Abstract: The invention relates to an apparatus for the release or delivery of substances from hot melt contact adhesives with uniform or irregular distribution of the substances, the hot melt contact adhesive having a processing temperature between 40.degree. and 80.degree. C., preferably between 40.degree. and 60.degree. C. and in particularly preferred manner between 40.degree. and 55.degree. C.; a process for the production of this apparatus; as well as the use of this apparatus in human and veterinary medicine, diagnosis or cosmetics.

Abstract: The invention relates to a process for producing an administration and/or dosage form for medicament active substances using a printing process, in which the printing process used is a pad printing process.

Abstract: The present invention relates to a transdermal therapeutic system with tulobuterol or one of the pharmaceutically acceptable salts thereof as active substance, comprising a backing layer which is substantially impermeable to active substances and at least one matrix layer which contains the active substance, which matrix layer comprises at least one styrene-1,3-diene-styrene block copolymer. The present invention is further directed to a process for the production of said transdermal therapeutic system.

Abstract: An application aid for one or several articles, such as therapeutic systems, plasters, labels, or the like, adhering to and positioned in a mechanically releasable manner on a carrier or covering layer, respectively, which extends in sheet-like form and particularly is flexible, in the form of cuts or predetermined breaking lines formed within the carrier or covering layer is characterized in that each article (2) is assigned a portion (4, 4a) of the carrier or cover layer (1), which portion laterally projects said article and is removable from the rest of the carrier or cover layer (1) by means of non-linear cuts or predetermined breaking lines, whereby the cuts or predetermined breaking lines connect two points at the edge of the carrier or cover layer and at least partially run below the contact surface of the articles, at least one of these points lies on that portion of the carrier or covering layer projecting the articles at the side, and the imaginary straight connecting line between these two points,

Abstract: The controlled release of buprenorphine or the pharmaceutically acceptable salts thereof to the skin over a period of time of at least 24 hours is ensured by a transdermal therapeutic system consisting of a backing layer which is impermeable to the active substance, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer. Said reservoir layer of said system comprises 20 to 90%-wt polymeric material, 0.1 to 30%-wt softener, 0.1 to 20%-wt buprenorphine base or one of the pharmaceutically acceptable salts thereof, and 0.1 to 30%-wt solvent for the active substance base.