Abstract: The invention relates to a pharmaceutic product as well as to a process for its production for a transdermal application in the prophylaxis and treatment of vasodilations, said pharmaceutic product comprising at least one skin-compatible auxiliary agent and portions of an active substance, characterized in that said pharmaceutic product contains as active substance pentetrazole.
Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
Type:
Grant
Filed:
August 1, 1997
Date of Patent:
September 7, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Horst Georg Zerbe, Jian-Hwa Guo, Anthony Serino
Abstract: A transdermal therapeutic system for the prophylaxis and pretreatment of a poisoning caused by highly toxic organophosphorus neurotoxins is characterized in that it has a pharmaceutical formulation with an active substance combination consisting of at least one parasympathomimetically active substance and at least one parasympatholytically active substance.
Type:
Grant
Filed:
July 30, 1996
Date of Patent:
August 17, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Thomas Hille, Walter Muller, Bodo Asmussen
Abstract: Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which are administered, e.g., orally, transdermally, or otherwise parenterally, in a continuous and controlled manner.
Type:
Grant
Filed:
September 29, 1992
Date of Patent:
August 3, 1999
Assignees:
LTS Lohmann Therapie-Systeme GmbH & Co., KG and Hefa-Frenon Arzneimittel GmbH & Co. KG.
Abstract: A transdermal therapeutic system (TTS) comprising an active substance which is sensitive to hydrolysis, and having a layer-like structure comprising a backing layer impermeable to moisture and active substance, a matrix comprising the active substance, and optionally a protective layer covering the matrix is characterized in that the matrix contains a water-binding component.
Abstract: Implantable, partially biodegradable, polymer-containing molded articles for the administration of active substances to plants are characterized by the fact that they comprise at least one hydrophobic polymer.
Type:
Grant
Filed:
June 11, 1997
Date of Patent:
June 22, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Hans-Rainer Hoffmann, Malgorzata Kloczko, Michael Roreger
Abstract: The invention concerns a transdermal therapeutic system comprising the active substance 17-.beta.-estradiol and optionally further active substances, with a laminated structure comprising a backing layer which is substantially impermeable to moisture and impermeable to active substance, one or more matrix layers and, where non-adhesive matrix layers are present, an adhesive layer, characterized in that the concentration of the dissolved estradiol in all matrix layers and, where an adhesive layer is present, in the adhesive layer lies between its saturation concentration in dry condition und its saturation concentration in moist condition, whereby the term "dry condition" is understood to mean that the base material is in equilibrium with a gas phase with less than 10% relative humidity and the term "moist condition" is understood to mean that the base material is in equilibrium with a gas phase with more than 90% relative humidity.
Type:
Grant
Filed:
June 16, 1997
Date of Patent:
June 15, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Michael Horstmann, Sylvia Hahn, Reinhold Meconi, Robert-Pieter Klein
Abstract: A transdermal therapeutic system comprising the active substance estradiol and having a layered structure of a backing layer which is impermeable to active substances and moisture, and active substance-containing matrix, and, if necessary, a removable protective layer covering the matrix, is characterized by the fact that the matrix comprises glycerol either comprising a maximum of 1%-wt. of water or being substantially free from water.
Abstract: An active substance-containing adhesive patch with a pressure sensitive fixing device, containing at least one readily volatile ingredient, consisting of a substantially active substance-impermeable backing layer, at least two active substance-containing matrix layers and a removable protective layer, whereby the matrix layer containing the readily volatile active substance is laminated on a separately produced composite of one or more further matrix layers which are active substance-free, is characterized in that the first active substance-containing matrix layer consists of a spreadable molecularly disperse solution of the matrix base material in the readily volatile ingredient as the exclusive solvent, the composite which is obtained after laminating forming an active substance matrix that is as a whole shear-resistant after migration of the readily volatile ingredient into the composite.
Abstract: In a process for the production of a transdermal therapeutic system for the administration of active substances to the skin in the form of a plane multichamber or multichamber-channel system an active substance-containing layer is introduced between top layer and bottom layer; subsequently top and bottom layer are squeezed at individual and/or coherent sites under displacement of the intermediary sites of the active substance-containing layer and formation of active substance-containing chambers or channels, and at the same time or after that top layer and bottom layer are bonded permanently at the squeezed places.
Abstract: A drug for the release of active substances to the skin, which has an increased deuterium portion as compared to the natural isotope distribution.
Type:
Grant
Filed:
August 15, 1996
Date of Patent:
April 20, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Hans-Rainer Hoffmann, Thomas Hille, Andreas Koch, Rudolf Matusch
Abstract: A device for the transfer of sections (10) that are self-adhesive on one side from a moving first web (20) onto a moving second web (21), portions (11) to be discarded remaining undetached on the first web (20), comprising a dispenser edge (1) that is associated to and extends across the direction of the first web (20) and around which the web (20) is led with reversal of its direction to release the sections (10) is characterized by the fact that the dispenser edge (1) has a shape in the region of portions (11) that are not to be detached which is different from that in the region of portions (10) that are to be released.
Type:
Grant
Filed:
November 15, 1996
Date of Patent:
April 6, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Lothar Deurer, Ludwig Grader, Thomas Hille, Peter Steinborn
Abstract: A dispenser for a cleaning and dental-care formulation which is present in solid form as a sheet (1) and is provided in conjunction with a toothbrush (10) for oral and dental hygiene is characterized in that the dispenser and the toothbrush (10) together are designed as a functional unit (20).
Abstract: An active substance-containing patch for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens, comprising a backing layer, an active substance-containing reservoir which is bonded thereto and produced by using pressure-sensitive adhesives, and a removable protective layer, is characterized by the fact that the pressure-sensitive adhesive comprises ethylcellulose, esters of non-hydrogenated and/or hydrogenated colophony, and lauric acid.
Abstract: A transdermal therapeutic system (TTS) comprises compounds releasing carbon monoxide in organisms to increase the CO-concentration in the organism.
Abstract: The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
Type:
Grant
Filed:
January 12, 1998
Date of Patent:
March 2, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Thomas Hille, Hans-Rainer Hoffmann, Mirko Kreh, Rudolf Matusch
Abstract: In an implantable device for the release of active substances to plants, wherein said device is a ceramic molded article that is interspersed with pores and in which the active substance is distributed in open pores, the pore volume at the time of implantation is dimensioned such that it comprises the total active substance amount to be released, with the kind of the total porosity, its volume, size and scattering as well as the distribution of the pores being determinable within given limits.
Type:
Grant
Filed:
May 12, 1997
Date of Patent:
February 23, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Hans-Rainer Hoffmann, Malgorzata Kloczko, Michael Roreger
Abstract: In a process for reprocessing devices for the transdermal application of active substances or their process waste, active substance-containing components are brought into solution and the active substances are recovered therefrom.
Type:
Grant
Filed:
January 2, 1998
Date of Patent:
February 9, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Bodo Asmussen, Hans-Rainer Hoffmann, Walter Muller
Abstract: A transdermal therapeutic system for the controlled active substance release to the skin having a backing layer and a pressure sensitive adhesive reservoir layer, wherein the reservoir layer comprises a polymeric material, a plasticizer, and pilocarpine base or one of the pharmaceutically acceptable salts thereof. Furthermore, the use of a capsule made of a semipermeable membrane for the controlled release of pilocarpine, the capsule comprising the pilocarpine in encapsulated form and having an aperture in the capsular material, for the treatment of glaucoma.
Type:
Grant
Filed:
March 26, 1996
Date of Patent:
February 9, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH
Inventors:
Lothar Deurer, Karlheinz Otto, Thomas Hille
Abstract: A transdermal therapeutic system for antithrombotic therapy is disclosed. The system comprises a hydrophobic polymer matrix, acetic anhydride, and acetylsalicylic acid as the only active ingredient.
Type:
Grant
Filed:
March 22, 1994
Date of Patent:
January 19, 1999
Assignee:
LTS Lohmann Therapie-Systeme GmbH & Co. KG