Abstract: An oral administration form with a carrier for acid active substances wherein the active substance has at least one free carboxyl group ionically bound to a polymer having tertiary amino groups is characterized by the fact that the polymer is colestipol or colestipol hydrochloride.

Abstract: A device for the controlled release of active substances in liquid media from an active substance-containing matrix exhibiting active substance releasing-surfaces has, the active substance releasing surfaces of the matrix covered, at least partially, by an erodible mass of solids; the thickness of the erodible mass across its extent on the active substance releasing-areas is determined by gradients.

Abstract: A transdermal therapeutic system containing the active substance 17-.beta.-estradiol and optionally further active substances has a laminated structure positioned on a backing layer which is essentially impermeable to active substance and moisture, at least one matrix layer and optionally an adhesive layer. The at least one matrix layer or the adhesive layer contains anhydrous 17-.beta.-estradiol in crystalline form.

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: The invention relates to transdermal therapeutic system for the systemic administration of active substances which is characterized by the fact that at least one of the active substances is a serotonin agonist of the group comprising the indole derivatives, e.g., Sumatriptan.

Abstract: An active substance-containing patch for the controlled release of active substances, comprising a backing layer, an adjoining active substance-containing reservoir layer softening at body temperature, a membrane controlling the active substance release, a pressure-sensitive adhesive device permitting fixation of the patch to the skin, and a removable protective layer, is characterized by the fact that the reservoir layer which softens at body temperature is spaced away from the controlling membrane by means of a device made of a material impermeable to the active substance which extends all over the mutually facing surfaces of the reservoir and the membrane and which has at least one passage for the reservoir layer which softens at body temperature.

Abstract: Transdermal therapeutic system comprising the active substance acetylsalicylic acid, having a layered structure consisting of a backing layer which is substantially impermeable to active substances and moisture and one or several active substance-containing matrix layers, which is characterized in that at least one of said matrix layers comprises acetylsalicylic acid in mainly crystalline form.

Abstract: A scopolamine-containing transdermal therapeutic system in the form of a patch is described whose active substance-containing layers comprise as base polymer copolymers of acrylic acid or methacrylic acid derivatives and scopolamine base in a concentration corresponding to 50-100% of the saturation solubility, preferably 60-100% of the saturation solubility, in the total vehicle formulation.

Abstract: A pharmaceutical composition for systemic transdermal administration containing morphine-6-glucuronide or a pharmaceutically acceptable acid addition salt thereof as the active agent.

Abstract: A transdermal therapeutic system exhibiting layered structure consists of a backing layer which is impermeable to active substances, a matrix having water-insoluble basic material and islands (inclusions) divided therein, and a layer controlling the access of cutaneous liquid by means of which the matrix is activatable. Process for the production are described.

Abstract: A transdermal therapeutic system for the administration of physostigmine to the skin, consisting of a backing layer impermeable to active substance, a pressure-sensitive reservoir layer containing 40 to 90%-wt. polymeric material and 0.1 to 20%-wt. physostigmine base or one of the pharmaceutically acceptable salts thereof, and of a detachable protective layer covering the reservoir layer, comprises in its reservoir layer acrylate- and/or methacrylate-based polymeric material and 0.1 to 40%-wt. of a softener containing the hydroxyl group with an HLB value between 1.1 and 12.0.

Abstract: A therapeutic system for topically administering active substances for the treatment of skin diseases involving severe cell proliferation is characterized in that the active substance is a pharmaceutically acceptable derivate of vitamin D.sub.3, with the exception of such derivates as serve to regulate the calcium metabolism.

Abstract: An active substance patch releasing estradiol to the skin is characterized by the fact that it consists essentially of a backing layer and an attached active substance reservoir which comprises pressure sensitive adhesive and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, the active substance reservoir being a polymer matrix which--in order to improve the bioavailability of the estradiol--comprises an added penetration enhancer of the general formula: ##STR1## wherein R=--CH.sub.2 OH or --CH.sub.2 --O--CH.sub.2 --CHOH--CH.sub.2 OH.

Abstract: The invention provides a process for the production of transdermal therapeutic systems. A layer containing active substance is initially present as a tape or web in the form of a laminate, with a carrier layer and, possibly, further auxiliary layers and/or protective layers or the like. The active substance is then transferred from this layer, either by itself or in combination with at least one further layer, in sections, to the center of a second, wider web.

Abstract: Self-adhesive plaster for the transdermal application of systemically active steroid hormones, comprising an active substance-impermeable backing layer, an active substance-containing pressure-sensitive adhesive layer and a detachable protective layer which, prior to application to the skin, covers said pressure-sensitive adhesive layer, characterized in that the active substance-containing pressure-sensitive adhesive layer comprises a pressure-sensitive hot melt adhesive having a processing temperature of between 60.degree. an 100.degree. C., and dexpanthenol in a concentration of 15 to 25%-wt.

Abstract: A presentation which, in the form of a film, permits the individual dosage of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The presentation is characterized by the fact that it comprises a mass of 20 to 60%-wt. of at least a film former, 2 to 40%-wt. of at least a gel former, 0.1 to 35%-wt. of at least an active substance, and up to 40%-wt. of an inert filling agent, being applied on a carrier, or by consisting of a mass having the aforementioned composition but is unsupported. In the production thereof, an intimate mixture of said components is prepared, optionally with the addition of up to 30%-wt. of a polar solvent, and processed to form a homogeneous, spreadable or extrudable mass.

Abstract: The invention relates to a floatable, oral, therapeutic system, in which a lengthening of the gastrointestinal residence time of medicaments and a controlled delivery thereof are achieved by systems, which are specifically lighter than the gastric fluid, float on the latter and can only with difficulty reach the lower-lying pylorus, said system using at least one structural element with cavities or voids, such as foams or hollow bodies.

Abstract: A process is provided for the production of a flat administration form with a dosable portion of drugs or of a flat-shaped device for the dosable release of volatile substances, such as aromatic substances, to the ambient air by using high-volatile or thermolabile dosing media in liquid or semisolid state as the ingredients of the administration form or of the device by means of printing processes. A free-flowing preparation of the ingredients is knife-coated in a measured amount into at least one volumetrically defined cavity of a flat printing block. A substrate to be charged with the ingredients or dosing media, respectively, is gradually led as web-shaped material under web tension over the cavity of the printing block and pressed into the filled cavity by means of a mechanical pressure device whereby the substrate takes up the ingredient from the printing block in a dosed amount.

Abstract: The invention relates to an active substance-containing plaster for the controlled administration of active substances to the skin, which has a back and a skin side, with a back layer, an active substance reservoir divided substantially perpendicularly to the skin contact surface of the plaster and having one or more active substances, a contact adhesive device on the skin side and optionally a cover layer detachable prior to the application of the plaster, whereas at least one active substance reservoir part (12) is detachable from the skin, while leaving behind one or more active substance reservoir parts (13) on the skin. For this object there is provided that the part of the active substance reservoir remaining on the skin is having a better adhesion to the skin than to the back layer (11).

Abstract: The invention relates to a self-adhesive, plasticizer-containing laminate consisting ofa) a film-forming polymeric layer containing dyestuffs and/or pigments,b) a pressure-sensitive adhesive layer, andc) a removable, preferably siliconized protective film covering the pressure-sensitive adhesive layer,the film-forming polymeric layer a) of which is at least entirely covered by a layer being resistant towards the other components of the laminate and towards the materials used in the production of the laminate. The invention further relates to the use of said laminate as artificial nails applicable to toenails or fingernails.