Abstract: A device for manufacturing a product from strip tape includes a roll that draws off and separates a web of material. The web of material is severed into individual strips in cooperation with a multiple circular knife roll. A vacuum conveyor channel is associated with each strip. The vacuum conveyor channel is designed such that each strip is turned on its way to the channel or through the channel by about 90°. The end of the vacuum conveyor channel brings the strips together at one site to form a unit and at that site there are provided a guide and a transport device for the further transport to conversion equipment.

Abstract: A single-dose package for transdermal therapeutic systems or film-shaped administration forms, in the form of a tear-open sealed-edge pouch with a completely surrounding and continuous non-peelable sealing surface. The single-dose packages comprise two packaging material elements, which are arranged one lying an top of the other and form the upper side and underside of a pouch that contains the product. At least one packaging material element is a tear-resistant film laminate with an at least three-layer structure, wherein at least one layer of the packaging material elements is a metal layer. The single-dose package also has a linear weakening, which lies in the sealing area, does not touch the edge of the package and extends in the direction of the weaker tear resistance of the upper side and underside and the linear form of the anisotropically tear-resistant plastic.

Abstract: The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material.

Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.

Abstract: The invention relates to a dispenser for a volatile substance (4), which contains a reservoir (1) and two control elements. The first control element (6) exerts a control function that is dependent on the substance characteristics of the volatile substance (4) and the material characteristics of the constituents of said first control element (6). However, the second control element (7) exerts a control function that is independent of the substance characteristics of the volatile substance (4) and the material characteristics of the constituents of said first control element (6). The first control element (6) is located between the reservoir (1) and the second control element (7) and is permeable to at least one volatile substance (4). The second control element (7) consists of a material that is impermeable to the volatile substance and contains defined material cavities (8).

Abstract: A disposable injector (4) having a two-chamber system (99), wherein at least one first chamber (105) is part of a piston-cylinder unit (100) that can be accommodated in the disposable injector (4), and wherein the second chamber (255) is part of a chamber (250) which is at least temporarily closed by means of a stopper (257) and inserted into a container adapter (200) detachably mounted on the disposable injector (4), or part of a piston-cylinder unit (254), and wherein the container adapter (200) comprises a connecting tube (242) initially closed by means of a cap (290). To this end, on the side oriented toward the second chamber, the stopper has a recess (271), into which at least one stopper channel (275) connecting the lateral surface (277) of the stopper to the recess (271) opens.

Abstract: A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position.

Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-locked piston-actuating ram (60) being supported on the housing via support rods, draw hooks or elastic flexural beams. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part supports the pretensioned spring energy reservoir and the cylinder/piston unit. The piston (111) of the cylinder/piston unit can be manually displaced by means of a pump rod (140). The single-use injector is compact and has few components, is easy to handle and allows secure storage and functioning. The cylinder/piston unit can be filled when mounted.

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract: The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material.

Abstract: A disposable injector having a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least one cylinder-piston unit (100) that can be filled at least in part with an active substance, at least one piston actuation plunger (60) and at least one trigger unit (80). The spring energy accumulator plunger (60) has at least one tension bar (61) with at least one support surface (63) at the upper end thereof. Locking elements (16) supported on the housing lie on the support surface(s) and are secured in the locking position by a triggering element (82) placed in a locking position (8). The triggering element has a release position (9) that causes the locking element (16) to be unlocked for release of the active substance.

Abstract: The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach the agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase.

Abstract: A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.

Abstract: The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach an agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase.

Abstract: The invention relates to a single-use injector and to a two-chamber system, wherein at least one first chamber is part of a cylinder-piston unit that can be received in the single-use injector, and wherein the second chamber is part of a container having at least one opening, and closed at least intermittently by means of a stopper and place in a container adapter releasably supported on the single-use injector. To this end, the stopper and the container adapter can be permanently latched to each other. When the container is inserted, the container adapter closes off the opening and displaces the stopper. When the container is inserted into the container adapter, the adapter connects the interior of the cylinder-piston unit to the interior of the container. By means of the present invention, a single-use injector and a two-chamber system having a reduced number of components is developed.

Abstract: A non-reclosable package for products which are prejudicial to health, such as pharmaceutical products. The package comprises a first packaging material element and a second packaging material element. The two packaging material elements are arranged on top of each other. The package has at least one first surface section, at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one cavity, which is enclosed on all sides and receives the product to be packaged, is formed between the two packaging material elements. The package has at least one second surface section lying outside or adjoining the first surface section, and at the margin or margins of which the two packaging material elements are releasably connected with each other. At least one of the two packaging material elements has at least one structure extending within the second surface section and enables the packaging material element(s) to be torn.

Abstract: A unidirectional injector having at least one cylinder-piston unit, the piston thereof being displaceable between two stroke end positions relative to the cylinder, wherein the cylinder-piston unit comprises at least one sealing system sealing a compensating space from the surroundings. To this end the piston is provided at its front surface with an axial annular groove for accommodating a seal ring or a permanently elastic seal material, that the cylinder is provided with a first seal element and a second seal element which are spaced by at least a piston stroke, or that the piston is provided with the first seal element and the second seal element which are spaced by at least a piston stroke, or the cylinder carries the first seal element and the piston carries the second seal element which is displaced with respect to the first by the piston stroke.

Abstract: A disposable injector with a housing (10) in which a mechanical spring energy reservoir, a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit are arranged, wherein the spring energy reservoir comprises at least one pretensioned spring element, wherein at least part of the piston-actuating ram is positioned between the spring energy reservoir and the piston of the cylinder/piston unit, and wherein the piston (111) of the cylinder/piston unit is separately moveable via pump rod (140). The pump rod can be coupled releasably to the piston or to a piston rod of the piston. The cylinder of the cylinder/piston unit has a rear sealing element (105) that permits sterile closure of the cylinder interior located between the piston and the cylinder.

Abstract: The subject matter of the present invention is a hydrogel which includes a combination of at least four polysaccharides. These polysaccharides are those which are in the natural state and which are not produced, altered or modified by chemical reactions. The combination of konjac mannan, xanthan gum, pullulan and carrageenan and optionally sclerotium gum produces, within certain concentration ranges, a stable, slightly sticky, neutral smelling, flexible and transparent hydrogel which can be used as a cosmetic product for skin care.

Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-loaded piston-actuating ram being supported on the housing via support rods (240) or draw hooks (250) and each contact zone between an individual support rod or draw hook and the piston-actuating ram representing a wedge gear pairing that forces the respective support rod or draw hook radially outwards. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part has at least two limbs (220, 250) arranged parallel to each other. The sheet metal part has at least two pressure bars or at least two draw hooks the free ends of which are bent in an angular fashion to define a supporting section for the piston-actuating ram.