Abstract: A pharmaceutical product containing an active pharmaceutical ingredient and having a controllable release of the active pharmaceutical ingredient. The pharmaceutical product comprises yeast that is capable of fermentation. The carbon dioxide production of the fermentation releases the active pharmaceutical ingredient from the pharmaceutical product.

Abstract: A housing of the injector is made from a thin-walled sheet-metal part. The sheet-metal part has at least two branches or legs. Each branch has, at the free end thereof, an angled retaining element or a recess as a means of receiving the cylinder of a cylinder/piston unit. The branches are elastic flexural beams which, in the middle area, are each bent in a Z-shape or S-shape to form a supporting portion for the piston-actuating ram. The contact zone situated between an individual supporting portion and the piston-actuating ram represents a wedge gear pairing that forces the respective branch outwards. The trigger unit comprises at least a trigger element which is slidably supported on the metal sheet, wherein the support section or, respectively the contact sections extend outwardly into longitudinal grooves. The branches may be provided with a locking tongue to engage corresponding openings in the trigger element to lock the housing in position as desired.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least cylinder/piston unit (100) filled with an injection solution, at least one piston-actuating ram, and at least one trigger unit. The spring-loaded piston-actuating ram is supported on the housing via at least one support rod (21), wherein the contact zone located between an individual support rod and the piston-actuating ram represents a wedge gear pairing that forces the respective support rod radially outwards. The support rod or support rods bear on at least one activation element (82) that is mounted on the housing and positioned in a locking position. The activation element can be brought by displacement into a triggering position that releases the piston-actuating ram.

Abstract: The invention relates to a therapeutic system, designed as a laminate and comprising at least one adhesive laminate layer, and to a therapeutic device having such a therapeutic system. For this purpose, at least one laminate layer or one intermediate layer and/or one intermediate layer arranged between two laminate layers contains superparamagnetic nanoparticles. The therapeutic device having said therapeutic system comprises at least one electrically controllable system which is detachably connected to the therapeutic system. The electrically controllable system has a frequency-dependent electric resistance. During operation of the therapeutic device, the electrically controllable system generates an electric or magnetic field, which can be varied in orientation and intensity over time and penetrates the superparamagnetic nanoparticles.

Abstract: The invention relates to a transdermal therapeutic system (TTS), preferably in the form of a transdermal plaster, that contains an active substance and an agent which can destroy the active substance. The TTS further includes a means of bringing the active substance, e.g. buprenorphine, and the agent, e.g. potassium permanganate, into contact when the TTS is removed from the skin of the patient, thereby causing the active substance to be destroyed.

Abstract: A disposable injector with a housing that has at least one compression hook, which has at least one support surface respectively in the region of its free end. A piston-actuating plunger rests on the support surface. The locking position of the compression hook is secured by an actuating element positioned in a locked position. The actuating element has a locked position, in which it rests securely on a sealing cap. The actuating element has a triggering position, which effects lateral retreat of the compression hook when the piston-actuating plunger is released.

Abstract: A disposable injector with a housing (10) in which at least one mechanical spring energy accumulator (50), at least one cylinder-piston unit (100), at least one piston-actuating ram and at least one release unit are arranged. The housing has at least one draw hook (21) which has at least one supporting surface in the region of its free end. The piston-actuating ram bears against the supporting surface. The blocking position of the draw hook is ensured by a release element positioned in a blocking position. The release (82) has a release position which brings about an inevitable lateral retraction of the draw hook—with the piston-actuating ram being released.

Abstract: A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles.

Abstract: A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water-soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix.

Abstract: A package for flat, pliable objects, such as for wafer-shaped or film-shaped drug forms. The package has a carrier layer, a cover layer which is detachably connected to the carrier layer, and a first surface region wherein the carrier layer is not connected to the cover layer and is completely surrounded by a margin area. A cavity, enclosed on all sides, is formed for accommodating an object. The package has a second surface region wherein the carrier layer is not connected to the cover layer. At least one perforation line extends at least partially within the second surface region, and is provided both in the carrier layer and in the cover layer. Severing the perforation line forms a free edge of the cover layer which serves as a gripping aid and enables manual removal of the cover layer from the carrier layer. The disclosure further covers a process for packaging flat, pliable objects by forming the above-described package.

Abstract: A preparation having at least one unsaturated fatty acid and the use of at least one unsaturated fatty acid having a chain length of 18 or 20 carbon atoms and of plant drugs containing the unsaturated fatty acid as a free fatty acid or a fatty acid radical of a triglyceride. The fatty acid has a chain length of 18 carbon atoms which are provided with 1 to 3 double bonds and the fatty acid has a chain length of 20 carbon atoms which are provided with 1 to 4 double bonds. The double bond or one of the double bonds are located in position 9 or 11 of the carbon chain. The unsaturated fatty acid is supplied in the all-cis configuration. The at least one unsaturated fatty acid prevents and/or treats or is used for producing a preparation for preventing and/or treating thrombosis and thromboembolic diseases.

Abstract: A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles.

Abstract: The invention relates to a nasally applied, film-shaped, bioadhesive pharmaceutical form of administration containing at least one agent-containing layer that is based on crosslinked hydrophilic polymers comprising up to 60 percent by weight of Lidocaine, the percentage being in relation to the total quantity of crosslinked hydrophilic polymers. Also disclosed is the use thereof for controlling primary headaches, preferably migraine.

Abstract: The invention relates to a biopsy needle for obtaining material for histological examination of body tissue, in particular, of bone marrow, or for the isolation, culture and modification of body cells, comprising a cannula with a cutting edge and a manual turning handle and a stylet running in the cannula. At the end of the cannula is an internal thread and preferably an outer thread. An easily visible marking is preferably provided on the manual turning handle. On withdrawing the biopsy needle the biopsy sample is thus held in position in the cannula and the advancing is precisely controllable.

Abstract: A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water-soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix.

Abstract: The invention relates to a gastric juice-resistant device for releasing active substance excipients having delayed intestinal passage from a gastric juice-resistant enclosure, and which serves to increase the active substance concentration in the intestines. The inventive device is characterized in that the active substance excipient containing at least one active substance is provided in the form of a multiparticulate preparation whose individual particles have mucoadhesive properties. The invention also relates to a method for producing said device.

Abstract: Unit dose packages for transdermal therapeutic systems or film- or sheet-type dosage forms in the form of a peel-open side-sealed bag. The side-sealed bags comprise two packaging material elements arranged one upon the other. At least one consists of a tear-resistant packaging material having a low tear propagation resistance. The two packaging material elements, which are joined together by a continuous sealed seam extending around the packaged good have a tab at one end of said side-sealed bag which projects beyond the sealed margin. The tabs are half as wide as the side-sealed bag and, at the end thereof which faces away from the sealed margin, have a sealed region in which they are joined to each other. At least one of the packaging material elements has a structure for partial tearing of the packaging material in the region of the tab in which the tabs are not sealed to each other. The structure for partial tearing of the packaging material is without contact to the edge of the package.

Abstract: The invention relates to a disposable injector with a housing, an injector-side, first cylinder-piston unit—at least intermittently fillable—arranged thereon and an upstream detachable container adapter, wherein the container adapter bears a likewise at least intermittently fillable second cylinder-piston unit. A solvent is stored in the first cylinder-piston unit. In the second cylinder-piston unit there is a freeze-dried active pharmaceutical ingredient. Immediately before use of the disposable injector the solvent is conveyed to the second cylinder-piston unit to the active pharmaceutical ingredient, where a solution forms. This solution is transfer-pumped into the first cylinder-piston unit to then be administered. The present invention develops a disposable injector which stores a liquid and an active ingredient in each case separately and sterilely and provides a space in which the active ingredient is dissolved for application in the liquid or mixed with the liquid.

Abstract: A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided.

Abstract: A pressure sensitive adhesive for medicinal application purposes, based on ethylene-vinyl acetate copolymers is characterized in that it contains as polymer component (A) an ethylene-vinyl acetate copolymer or a combination of at least two ethylene-vinyl acetate copolymers, and as component (B) an adhesive resin or a combination of adhesive resins at a portion of up to 55%-wt, relative to the sum of components (A) and (B) without active substances or other auxiliary substances.