Abstract: The invention relates to a transdermal therapeutic system which comprises a back layer that is impermeable to the active substance, and a peelable protective layer that is impermeable to the active substance and at least one matrix layer consisting of polysiloxanes and/or polysiloxane derivatives and containing micro-reservoirs. Said micro-reservoirs contain at least one ion pair from a pharmacologically active substance and an additive and either the active substance is nucleophilic and the additive is electrophilic or the active substance is electrophilic and the additive is nucleophilic.

Abstract: A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.

Abstract: A consumable spice-containing film for covering or encasing foods. The film comprises a consumable carrier film having a polymer matrix which, as a polymeric base material, contains a polymer which is water-soluble or is soluble in an ethanol-water mixture, or a mixture of at least two such polymers. The carrier film has a smooth bottom side and a top side opposite the bottom side. The top side is provided with a coating of spice particles. The predominant fraction of the spice particles adheres to the surface of the carrier film and penetrates into this only partially, but is not completely enclosed within the carrier film.

Abstract: The invention relates to edible film-shaped cola-flavoured preparations which disintegrate quickly and without leaving a residue when coming in contact with moisture.

Abstract: Disclosed is a monitoring system for collecting and/or transdermally rediffusing air containing environmental contaminants. The inventive monitoring system generally includes at least one diffusion collector and/or an equilibrium diffuser. The diffusion collector is provided with at least three layers, i.e. an adhesive layer that is in direct contact with the skin of a living being, a barrier layer, and a collecting layer on the exterior face of the monitoring system. The equilibrium diffuser includes an adhesive layer and a collecting layer. The collecting layers and the adhesive layers of the two components of the monitoring system are preferably made of the same material and have the same dimensions.

Abstract: Active agent-loaded nanoparticles that are based on a hydrophilic protein or a combination of hydrophilic proteins, and methods for producing the nanoparticles and the use thereof. Functional proteins or peptide fragments are bound to the nanoparticles via polyethylene glycol-?-maleimide-?-NHS esters.

Abstract: The invention relates to thin film-shaped or wafer-shaped pharmaceutical preparations for oral administration of active substances. The preparations contain at least one matrix-forming polymer which has at least one active substance and at least one carbon dioxide-forming substance dissolved or dispersed therein.

Abstract: Rapidly disintegrating oral dosage forms for the application of active agent combinations for diabetes therapy. The dosage forms contain at least two active agents suitable for treating type-2 diabetes. The antidiabetic active agents are selected from the group comprising sulfonylureas, glitazones, glinides, biguanides, and absorption-delaying agents. The use of the active agent combination to produce an oral dosage form for the treatment of diabetes, a method for the therapeutic treatment of diabetes, and a method for the production of a sheet-like dosage form are also disclosed.

Abstract: A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles.

Abstract: Disclosed is a foil pocket (10) comprising at least one carrier foil (11) and at least one lidding foil (12). A foil-type or sheet-type product (1) is enclosed in a gas-tight and moisture-proof manner between the carrier foil (11) and the lidding foil (12), i.e. the joined parts, and is surrounded by a joining zone (30). At least one joining zone section (33, 34, 43, 44) which is not disposed perpendicular to the tear-off peeling direction (9) and is located laterally next to the product (1) widens and/or narrows in the joining zone (30) transversal to the tear-off peeling direction (9). At least the first quarter of the joining zone section (13, 43) that is not disposed perpendicular to the tear-off peeling direction (9) is provided with no widened area (35-41) and/or no narrow area (55-58). The invention make it possible to create a primary packaging which dispenses with the use of auxiliary means such as gloves, tweezers, or similar for applying systems containing active substances.

Abstract: A sheet-like pharmaceutical preparation (dosage form) that quickly disintegrates on contact with moisture, based on hydrophilic polymers for the release of at least one active agent. The dosage form contains an active agent combination for treating depression, and at least one active agent selected from the antidepressant group of drugs. In addition, the use of such a combination of active agents for the production of an orally administrable pharmaceutical product for the treatment of depression, and the therapeutic treatment of depression by oral administration of one of the named pharmaceutical preparations, is provided.

Abstract: A transdermal therapeutic system consisting of a backing layer, at least one active substance-containing matrix layer, which may at the same time possess pressure-sensitive adhesive properties, as well as a removable protective layer is characterized by a content of a neuroleptic, a content of at least one permeation enhancer as well as by a layer which is pressure-sensitive adhesive on the skin-facing side and based on polymers which are pure hydrocarbons.

Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.

Abstract: The invention relates to a method for packaging piece-items in a disposable packaging, and to a disposable packaging. A labelled support card comprising at least one gas-impermeable layer is provided with at least one piece-item. The projected bearing surface of the piece-item and a joint surface of the labelled support card surrounding said bearing surface are smaller than the largest gas-impermeable layer. Openings are made around said joint surface along a closed three-dimensional curve, piercing at least all the gas-impermeable layers. The fitted support card is covered by a gas-impermeable extensible film. The space defined by the extensible film and the support card is evacuated by means of the openings. At least one joint surface of the extensible film enters into adhesive contact with at least one joint surface of the labelled support card, forming a sealed joint.

Abstract: Sheet-like dosage forms dissolving or disintegrating in an aqueous medium for releasing at least one active substance in a body orifice or body cavity. The sheet-like dosage forms comprise a polymer matrix in the form of a solidified foam containing spaces or cavities, as well as at least one pharmaceutical or cosmetic active substance. The polymer of the polymer matrix is a polyvinyl alcohol-polyethylene glycol graft copolymer. Methods for producing such dosage forms are also provided.

Abstract: A hydrophile gel system for cosmetic and/or skin care applications. The gel system comprises a detachable carrier film and a hydrogel which contains at least 15 percent by weight of karaya gum and whose water content is less than 5 percent by weight.

Abstract: The invention relates to a device for storing and providing stacked film pockets (10) filled with film-type or laminar materials (1). Said materials, e.g. lamellae (1), are individually packed in thin film pockets (10) which are embodied in the form of primary packaging. Said film pockets (10) are stacked in a form of so-called secondary packaging (30) in a gauged manner, the secondary packaging (30) being a lamella dispenser. Said dispenser is provided with a mechanism (61) by which means the individual film pockets (10) are directly released. During said process, the film pockets (10) are automatically opened and the individual lamellae (1) are administered for consumption. The present invention enables a device to be created for storing and providing stacked film-type or laminar materials (1), said device storing said stacked materials (1) from the first to the last withdrawal without any significant change in the aromatic properties of the materials.

Abstract: Monolayered or multilayered, film-shaped, pressure-sensitive adhesive preparations for application in the oral region and a process for manufacturing such preparations. The preparations contain at least one polymethyl vinyl ether-maleic acid anhydride copolymer, polyvinyl acetate and/or at least one copolymer of the polyvinyl acetate with vinyl alcohol esters of fatty acids, as well as at least one cosmetic and/or pharmaceutical active substance.

Abstract: The invention relates to a film-shaped form of administration for topically administering at least one agent and/or nutrient to a living being. Said form of administration comprises at least one agent-containing and/or nutrient-containing layer that is based on crosslinked hydrophilic polymers which are crosslinked with at least one polyacrylic acid derivative.

Abstract: The invention relates to transdermal therapeutic systems with fentanyl or an analogous fentanyl derivative as active ingredient. In order to prevent inadvertent overdosage by uncontrolled release of active ingredient as a result of damage, the active ingredient is contained in fluid-filled micro-reservoirs in the layer containing the active ingredient. The layer containing the active ingredient can optionally be provided with a membrane.