Patents Assigned to Massachusetts Institute of Technology
  • Publication number: 20190113512
    Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Hadley Sikes Johnson, Eric Alexander Miller, Ki-Joo Sung
  • Publication number: 20190112600
    Abstract: Disclosed herein are protein translation switches and conditional gene expression systems that are compatible with retroviral and lentiviral gene delivery. The linking of a protein translation switch to a 3? gene of interest suppresses translation of the gene of interest, and the alteration of the protein translation switch by DNA recombinase-mediated DNA recombination relieves the suppressed translation of the 3? gene of interest. Also disclosed herein are methods of mimicking clinical pharmacology in a pre-clinical setting.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 18, 2019
    Applicant: Massachusetts Institute of Technology
    Inventor: Patrick J. Stern
  • Publication number: 20190111393
    Abstract: A spiral-wound electrodialysis module includes an inner electrode positioned about a central axis and an outer electrode surrounding the inner electrode. Ion exchange membranes are arranged in a stack, and each membrane extends in a spiral outward from an inner position proximate the inner electrode to an outer position proximate the outer electrode. The spirals expand outward at a greater-than-linear rate as a function of angle along a length of the spiral from the inner positions to the outer positions.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Amos G. Winter, Natasha Catherine Wright
  • Patent number: 10261297
    Abstract: A remote imaging apparatus, and corresponding method, includes a hyperbolic primary mirror that receives light from a remote object to be imaged. The primary mirror has a continuous surface that reflects, at least twice, the light from the remote object. The apparatus also includes a hyperbolic secondary mirror having a continuous surface that reflects, at least twice, the light from the remote object. The secondary mirror delivers the light to a field corrector via a port of the hyperbolic primary mirror, and the field corrector is configured to correct for an optical aberration of one or both of the hyperbolic primary and secondary mirrors. Embodiments can provide low distortion, small aspect ratios, and small form factors and moments of inertia for fleets satellite-based and other imaging systems.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventor: Gregory G. Cappiello
  • Patent number: 10260866
    Abstract: A 3D imaging system uses a depth sensor to produce a coarse depth map, and then uses the coarse depth map as a constraint in order to correct ambiguous surface normals computed from polarization cues. The imaging system outputs an enhanced depth map that has a greater depth resolution than the coarse depth map. The enhanced depth map is also much more accurate than could be obtained from the depth sensor alone. In many cases, the imaging system extracts the polarization cues from three polarized images. Thus, in many implementations, the system takes only three extra images—in addition to data used to generate the coarse depth map—in order to dramatically enhance the coarse depth map.
    Type: Grant
    Filed: December 27, 2015
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Achuta Kadambi, Vage Taamazyan, Boxin Shi, Ramesh Raskar
  • Patent number: 10262428
    Abstract: A scanner system is configured for acquiring three dimensional image information of an object. The scanner includes a projector, a camera, a graphics processing device, and a processor. The projector projects one of several pre-defined patterns upon the object. The camera captures an image from the object, which is received by the processor. The processor approximates mutual information from the object and the pattern using the graphics processing device, and selects a second pattern for projecting on the object.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Guy Rosman, Daniela Rus, John W. Fisher, III
  • Patent number: 10261389
    Abstract: An integrated optical beam steering device includes a planar dielectric lens that collimates beams from different inputs in different directions within the lens plane. It also includes an output coupler, such as a grating or photonic crystal, that guides the collimated beams in different directions out of the lens plane. A switch matrix controls which input port is illuminated and hence the in-plane propagation direction of the collimated beam. And a tunable light source changes the wavelength to control the angle at which the collimated beam leaves the plane of the substrate. The device is very efficient, in part because the input port (and thus in-plane propagation direction) can be changed by actuating only log2 N of the N switches in the switch matrix. It can also be much simpler, smaller, and cheaper because it needs fewer control lines than a conventional optical phased array with the same resolution.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott Skirlo, Cheryl Marie Sorace-Agaskar, Marin Soljacic, Simon Verghese, Jeffrey S. Herd, Paul William Juodawlkis, Yi Yang, Dirk Robert Englund, Mihika Prabhu
  • Patent number: 10258926
    Abstract: A carrier gas and a combined feed liquid are directed through a humidifier, where water vaporizes from the combined feed liquid into the carrier gas, and through a dehumidifier, where the combined feed liquid cools the carrier gas to condense water from the carrier gas. At least a portion of the concentrated brine stream from the humidifier is directed through a pressure-retarded osmosis unit, while an initial feed solution is directed, in counter-flow, through the osmosis unit. Water from the initial feed solution flows through a membrane in the osmosis chamber into the concentrated brine stream to dilute and increase the volumetric flow rate of the brine stream. The diluted brine stream is extracted from the osmosis chamber and depressurized to produce power, while the concentrated initial feed solution is combined with the depressurized, diluted brine stream to form the combined feed liquid.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Parker Thiel, Leonardo David Banchik, John H. Lienhard
  • Patent number: 10260039
    Abstract: The present invention features microgels and microtissues for use in tissue engineering. Featured is a microencapsulation device for making microgels and/or microtissues via an emulsion technology. Also featured are methods of making higher ordered structures that mimic in vivo tissue structures. Methods of us are also featured.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: April 16, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Cheri Y. Li
  • Publication number: 20190106710
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to enable genome engineering in an organism to recapitulate the genetic complexity of disease or a condition and further interrogate gene function.
    Type: Application
    Filed: June 7, 2018
    Publication date: April 11, 2019
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Feng Zhang, Benjamin Levine Ebert, Dirk Heckl
  • Publication number: 20190106683
    Abstract: Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.
    Type: Application
    Filed: October 22, 2018
    Publication date: April 11, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Hiroki Ando, Sebastien Lemire
  • Patent number: 10252239
    Abstract: According to some aspects, described herein is an automated droplet-based reactor that utilizes oscillatory motion of a droplet in a tubular reactor under inert atmosphere. In some cases, such a reactor may address current shortcomings of continuous multi-phase flow platforms.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Milad Abolhasani, Connor Wilson Coley, Klavs F. Jensen
  • Patent number: 10256596
    Abstract: The disclosure relates to method and apparatus for micro-contact printing of micro-electromechanical systems (“MEMS”) in a solvent-free environment. The disclosed embodiments enable forming a composite membrane over a parylene layer and transferring the composite structure to a receiving structure to form one or more microcavities covered by the composite membrane. The parylene film may have a thickness in the range of about 100 nm-2 microns; 100 nm-1 micron, 200-300 nm, 300-500 nm, 500 nm to 1 micron and 1-30 microns. Next, one or more secondary layers are formed over the parylene to create a composite membrane. The composite membrane may have a thickness of about 100 nm to 700 nm to several microns. The composite membrane's deflection in response to external forces can be measured to provide a contact-less detector. Conversely, the composite membrane may be actuated using an external bias to cause deflection commensurate with the applied bias.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: April 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Vladimir Bulovic, Jeffrey Hastings Lang, Apoorva Murarka, Annie I-Jen Wang, Wendi Chang
  • Patent number: 10252231
    Abstract: The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: April 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
  • Patent number: 10252466
    Abstract: The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration parameters and/or an object formed by the device or in the process of being formed by the device. According to some aspects, a method is provided for calibrating an additive fabrication device. According to some aspects, a method is provided for assessing at least a portion of an object formed using an additive fabrication device. According to some aspects, a method is provided for fabricating a second object in contact with a first object using an additive fabrication device. According to some aspects, an additive fabrication device configured to perform one or more of the above methods may be provided.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: April 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Javier E. Ramos, Pitchaya Sitthi-Amorn, Wojciech Matusik, Yuwang Wang
  • Patent number: 10255070
    Abstract: Global synchrony changes the way computers can be programmed. A new class of ISA level instructions (the globally-synchronous load-store) of the present invention is presented. In the context of multiple load-store machines, the globally synchronous load-store architecture allows the programmer to think about a collection of independent load-store machines as a single load-store machine. These ISA instructions may be applied to a distributed matrix transpose or other data that exhibit a high degree of data non-locality and difficulty in efficiently parallelizing on modern computer system architectures. Included in the new ISA instructions are a setup instruction and a synchronous coalescing access instruction (“sca”). The setup instruction configures a head processor to set up a global map that corresponds processor data contiguously to the memory. The “sca” instruction configures processors to block processor threads until respective times on a global clock, derived from the global map, to access the memory.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: April 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: David Joseph Whelihan, Paul Stanton Keltcher
  • Patent number: 10254770
    Abstract: Self-regulating valve. The valve includes a static pressure chamber with an elastically collapsible tube supported within the static pressure chamber. A flow restrictor is in fluid communication with an inlet into the static pressure chamber for flow through the collapsible tube. Piping connects a source of pressurized liquid, both to the flow restrictor and to an opening into the static pressure chamber, whereby flow rate through the valve remains substantially constant with variations in pressure of the pressurized liquid. In a preferred embodiment, the flow restrictor is a needle valve.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: April 9, 2019
    Assignees: Massachusetts Institute of Technology, Jain Irrigation Systems Ltd.
    Inventors: Ruo-Qian Wang, Amos G Winter, Abhijit Bhaskar Joshi, Pawel Jerzy Zimoch
  • Patent number: 10252924
    Abstract: A water stream is passed between two juxtaposed similar ion exchange membranes (AEMs or CEMs), forming an ion depletion and ion enrichment zones when an electric field is applied. As cations are selectively transferred through the CEMs, for example, anions are relocated in order to achieve electro-neutrality, resulting in the concentration drop (increase) in ion depletion (enrichment) zone. Trifurcation of the output channel allows collection of concentrated, dilute and intermediate streams, with the intermediate stream serving as input to the next stage of a serialized implementation.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: April 9, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Bumjoo Kim, Jongyoon Han, Rhokyun Kwak, Bader Shafaqa Al-Anzi
  • Patent number: 10256516
    Abstract: Provided are electrochemical cells that include a compound having the general formula wherein R1 is moiety associated with a lithium ion, X1 and X3 are unsubstituted methylene moieties, X2 and X4 are each independently selected from a substituted or unsubstituted methylene moiety, X is a substituted or unsubstituted C1-C10 alkylene moiety, arylene moiety or heteroarylene moiety, R2 is selected from Li, H, an alkyl moiety, or a heteroalkyl moiety, 0<m?1, 0?n?1, and m+n=1.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: April 9, 2019
    Assignees: SAMSUNG ELECTRONICS CO., LTD., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Sang Bok Ma, Mariya Khiterer, Young-Gyoon Ryu, Paula T. Hammond, Yang Shao-Horn, Chibueze Vincent Amanchukwu
  • Patent number: 10256262
    Abstract: Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: April 9, 2019
    Assignees: Massachusetts Institute of Technology, Hamamatsu Photonics K.K.
    Inventors: Gabriel Popescu, Ramachandra Dasari, Michael Feld, Takahiro Ikeda