Patents Assigned to Massachusetts Institute of Technology
  • Publication number: 20240085809
    Abstract: A reticle transport system having a magnetically levitated transportation stage is disclosed. Such a system may be suitable for use in vacuum environments, for example, ultra-clean vacuum environments.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicants: Massachusetts Institute of Technology, ASML Netherlands B.V.
    Inventors: Lei ZHOU, David L. TRUMPER, Ruvinda GUNAWARDANA
  • Publication number: 20240084286
    Abstract: This disclosure provides a method for substantially increasing the concentration of cfDNA in a patient. By injecting a patient with lipid and/or polymer nanoparticles, agents that bind cfDNA, or inhibit deoxyribonucleases prior to collection of a sample of cfDNA, e.g., by way of a liquid biopsy, major pathways for the degradation of cfDNA are temporarily blocked, permitting transient accumulation of cfDNA. This strategy has the potential to dramatically enhance the quality of detection achieved by downstream cfDNA e analytical applications, such as sequencing applications.
    Type: Application
    Filed: January 25, 2022
    Publication date: March 14, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Viktor A. Adalsteinsson, Shervin Tabrizi, Sangeeta N. Bhatia, J. Christopher Love, Maria Carmen Martin Alonso, Kan Xiong
  • Publication number: 20240088773
    Abstract: A wind turbine generator includes a stator having a plurality of high-temperature superconducting coils. A current is driven through the high-temperature superconducting coils to produce a magnetic field. A rotor comprising one or more phase coils is physically coupled to a wind turbine. As the wind turbine turns the rotor, current is induced in the one or more phase coils to produce electrical power. The phase coils may include conductive material, superconducting material, and/or high-temperature superconducting material.
    Type: Application
    Filed: February 8, 2022
    Publication date: March 14, 2024
    Applicants: Massachusetts Institute of Technology, Commonwealth Fusion Systems LLC
    Inventors: Alexey RADOVINSKY, Michael SEGAL
  • Publication number: 20240087136
    Abstract: A computer that includes a processor and a memory can determine a final trajectory for a vehicle by determining a candidate trajectory of a first object based on a detected second object. The candidate trajectory can be input to a reachable polyhedral marching processor to determine dynamic occupancy polyhedrals based on a shape of the candidate trajectory. A reachable tube can be determined based on combining the dynamic occupancy polyhedrals and the final trajectory can be determined based on the reachable tube avoiding the detected second object.
    Type: Application
    Filed: September 14, 2022
    Publication date: March 14, 2024
    Applicants: Ford Global Technologies, LLC, Massachusetts Institute of Technology, MIT Technology Licensing Office
    Inventors: Md Tawhid Bin Waez, Yue Meng, Zeng Qiu, Chuchu Fan
  • Publication number: 20240082781
    Abstract: The present disclosure is related to porous media with adjustable fluid permeabilities and related systems and methods. In certain cases, the fluid permeability of a porous medium can be adjusted by applying an electrical potential to the porous medium. In some such cases, the application of the electrical potential to the porous medium results in the deposition of material over or the removal of material from the porous medium. Also disclosed herein are systems and methods for capturing species (e.g., acid gases) in which porous media with adjustable fluid permeabilities are used, for example, to control the flow of fluid into and out of a medium used to capture the species.
    Type: Application
    Filed: November 17, 2023
    Publication date: March 14, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Yayuan Liu, Trevor Alan Hatton
  • Publication number: 20240082312
    Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.
    Type: Application
    Filed: June 6, 2023
    Publication date: March 14, 2024
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Guoping Feng, Boaz Barak, Zhigang He
  • Publication number: 20240082858
    Abstract: Polymeric electro spray emitters and related methods are generally described. In some embodiments, an emitter may be made from an ionic electro active polymer. The composition of the electro spray emitters described herein may enable the transport of ions and/or liquid ion sources, such as an ionic liquid or room temperature molten salt, through the bulk of the polymeric emitter. In some embodiments, the described emitters may be fabricated using a mixture of an ionic electroactive polymer, a solvent, and a liquid ion source to at least partially mitigate swelling effects of the polymer emitter that may otherwise occur when the one or more emitters are exposed to the liquid ion source during operation.
    Type: Application
    Filed: November 19, 2021
    Publication date: March 14, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Paulo C. Lozano, Brian L. Wardle, Michael D. Canonica, David Krejci, Yue Zhou, Andrew Adams
  • Publication number: 20240082534
    Abstract: Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model.
    Type: Application
    Filed: October 6, 2023
    Publication date: March 14, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: James DICARLO, Pouya BASHIVAN, Kohitij KAR
  • Publication number: 20240084364
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
    Type: Application
    Filed: August 17, 2023
    Publication date: March 14, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng ZHANG, Bernd ZETSCHE, Jonathan S. GOOTENBERG, Omar O. ABUDAYYEH, Ian SLAYMAKER
  • Patent number: 11926849
    Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: March 12, 2024
    Assignees: The General Hospital Corporation, Massachusetts Institute Of Technology
    Inventors: Alessio Fasano, Timothy K. Lu, Stefania Senger, Maria Eugenia Inda
  • Publication number: 20240076062
    Abstract: Bi-modal propulsion systems and related methods are generally described. In some embodiments, a bi-modal propulsion system may employ a single propellant for both chemical thruster(s), operating at elevated pressures, and electrical thruster(s) (e.g., electro spray thruster), operating at reduced pressures. The propellant pressure may be reduced to a desired operational range of the electrical thruster(s) using any appropriate construction including, for example, capillaries configured to reduce the pressure of the propellant to an operational range of the electrical thruster(s). In some embodiments, the reduced pressure of the propellant may be lower than a vapor pressure of at least one volatile component of the propellant, leading to the formation of “bubbles” within the propellant line. The presence of alternating gas and liquid phases along a flow path between a propellant tank and the electrical thruster(s) may help to electrically insulate the electrical thruster from the rest of the system.
    Type: Application
    Filed: October 20, 2021
    Publication date: March 7, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Paulo C. Lozano, Amelia Bruno
  • Publication number: 20240080630
    Abstract: An active acoustic system includes a thin-film sheet having an array of piezoelectric microstructures embossed in the film. Each piezoelectric microstructure may act as a speaker and/or a microphone. A control circuit is configured to individually address the piezoelectric microstructures to provide a separate voltage signal to, or receive a separate voltage signal from, each piezoelectric microstructure.
    Type: Application
    Filed: November 1, 2023
    Publication date: March 7, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Jinchi HAN, Jeffrey H. LANG, Vladimir BULOVIC
  • Publication number: 20240078462
    Abstract: Quantum information processing involves entangling large numbers of qubits, which can be realized as defect centers in a solid-state host. The qubits can be implemented as individual unit cells, each with its own control electronics, that are arrayed in a cryostat. Free-space control and pump beams address the qubit unit cells through a cryostat window. The qubit unit cells emit light in response to these control and pump beams and microwave pulses applied by the control electronics. The emitted light propagates through free space to a mode mixer, which interferes the optical modes from adjacent qubit unit cells for heralded Bell measurements. The qubit unit cells are small (e.g., 10 ?m square), so they can be tiled in arrays of up to millions, addressed by free-space optics with micron-scale spot sizes. The processing overhead for this architecture remains relatively constant, even with large numbers of qubits, enabling scalable large-scale quantum information processing.
    Type: Application
    Filed: October 24, 2023
    Publication date: March 7, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Hyeongrak CHOI, Dirk Robert ENGLUND
  • Publication number: 20240079106
    Abstract: A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.
    Type: Application
    Filed: November 9, 2023
    Publication date: March 7, 2024
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, LAHEY CLINIC FOUNDATION, INC.
    Inventors: Randall Davis, Dana L. Penney
  • Patent number: 11918658
    Abstract: Embodiments described herein relate to hydrogels, and in particular, hydrogels for crystal formation, and related compositions and methods.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: March 5, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Paul Douglas Godfrin, Patrick S. Doyle
  • Patent number: 11920150
    Abstract: Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: March 5, 2024
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Pardis Sabeti, Mohammadsharif Tabebordbar, Simon Ye
  • Patent number: 11919077
    Abstract: Systems and methods for manufacturing sintered materials are disclosed. Metal nano- and microparticles can be sintered to form thin films. The metals are sintered in the presence of a binder such as a tar, e.g., steam cracker tar (SCT), which has strong absorbing and antioxidant properties that allow the metal particles to retain heat. Retention of heat by the binder can allow the sintering to occur at ambient temperatures. In some embodiments, the mixture and/or the resulting films can be used in additive manufacturing processes to build various components from the layers of thin film manufactured from the presently disclosed methods.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: March 5, 2024
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Jeffrey Grossman, Xining Zang, Nicola Ferralis, Cuiying Jian, Kiera Y. Tai
  • Publication number: 20240066443
    Abstract: Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
    Type: Application
    Filed: September 1, 2023
    Publication date: February 29, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: David Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp, Naomi Elizabeth Barbara Briggs
  • Publication number: 20240067957
    Abstract: Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. The present disclosure relates to engineered programmable single-transcript RNA sensors in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert trigger hybridization into a translational output. This system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. Amplification is mediated by the expression of a hyperactive, minimal ADAR variant and its recruitment to the edit site via an orthogonal RNA targeting mechanism. This topology confers high dynamic range, low background, minimal off-target effects, and a small genetic footprint. The circuits and systems disclosed herein leverage an ability to detect single nucleotide polymorphisms and modulate translation in response to endogenous transcript levels in mammalian cells.
    Type: Application
    Filed: June 22, 2023
    Publication date: February 29, 2024
    Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: James J. Collins, Raphael Gayet, Katherine IIia, Shiva Razavi, Nathaniel Tippens, Kehan Zhang, Jack Chen, Jonathan Chen, Makoto Lalwani
  • Publication number: 20240069259
    Abstract: The present invention describes photoluminescent apparatuses or colour filters (100a,100b,100c,100d) and methods (1000a,1000b) for manufacturing. A photoluminescent (PL) or quantum dot (QD) material (100) fills a pattern of trenches (40,42) formed on a surface or on opposite surfaces of an optically transparent substrate (20), being cured and sealed by an optically transparent cover (22); in another embodiment, the PL or QD material (100) are cured and sealed when two patterned optically substrates (20) are bonded together. Sealing of the PL or QD material in the trenches (40,42) preserves the optical and performance stability of these colour filters. These colour filters (100a, . . . 100d) are suitable for use in next generation UHD display screens or lighting applications.
    Type: Application
    Filed: January 13, 2022
    Publication date: February 29, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Saurabh SRIVASTAVA, Li ZHANG, Kenneth Eng Kian LEE, Silvija GRADECAK-GARAJ