Patents Assigned to Massachusetts Institute of Technology
  • Patent number: 10024860
    Abstract: Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyzes of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: July 17, 2018
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation, The Broad Institute, Inc.
    Inventors: Richard O. Hynes, Alexandra Naba, Karl Clauser, Steven A. Carr, Kenneth Tanabe
  • Patent number: 10027399
    Abstract: A method, apparatus and computer program product for -based, delay-efficient data transmission for broadcasting a single file is presented. A file (f) comprised of K packets to be broadcast to a plurality of receivers is determined. A plurality of packets (Pk) of the file are selected for transmission during a timeslot (t). Next, a linear combination of the selected packets (P[t]) are produced, the linear combination of packets are selected at random within the file. The linear combination of selected packets is then transmitted to a plurality of receivers over unreliable channels.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: July 17, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Muriel Medard, Atilla Eryilmaz, Asuman Ozdaglar
  • Patent number: 10023536
    Abstract: The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: July 17, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Niels Holten-Andersen, Scott Charles Grindy, Ken Kawamoto, Aleksandr V. Zhukhovitskiy
  • Patent number: 10028369
    Abstract: Ions are released over time from an ion source into a beam area proximate a central axis. A radiofrequency (RF) system with a variable frequency and variable voltage accelerates the ions in orbiting trajectories expanding outward from the central axis. The ions are accelerated to different extraction energy levels within a given design range at a shared extraction radius from the central axis. An RF-frequency versus ion-time-of-flight scenario is set such that the frequency versus time scenario is the same for any ion extraction energy from the given design range, and a constant-or-variable-RF-voltage versus ion-time-of-flight scenario is adjusted to provide ion acceleration from injection to extraction for ions with different respective extraction energy levels within the given design range; and the ions are extracted at the different energy levels at the shared extraction radius.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: July 17, 2018
    Assignee: Massachusetts Institute of Technology
    Inventor: Alexey Radovinsky
  • Patent number: 10022542
    Abstract: In one aspect, the disclosure features systems for providing auditory signals to a subject. The systems include a sensor front-end circuit configured to be connected to an acoustic sensor and to convert analog signals received from the acoustic sensor to digital electric signals. The systems further include a sound processor circuit configured to be connected to the sensor front-end circuit and receive the electric signals provided by the sensor front end circuit. The sound processor includes multiple filters that spectrally decompose the received electrical signals into multiple spectral channels during operation of the system. The multiple spectral channels include at least a low frequency channel and a high frequency channel and the sound processor circuit is configured to operate the low frequency channel at a sample rate lower than a sample rate of the high frequency channel.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: July 17, 2018
    Assignees: Massachusetts Eye & Ear Infirmary, Massachusetts Institute of Technology
    Inventors: Marcus Yip, Anantha Chandrakasan, Konstantina Stankovic
  • Patent number: 10022709
    Abstract: Transition metal carbide, nitride, phosphide, sulfide, or boride nanoparticles can be made by transforming metal oxide materials coated in a ceramic material in a controlled environment. The coating prevents sintering while allowing the diffusion of reactive gases through the inorganic matrix that can then alter the metal nanoparticle oxidation state, remove oxygen, or intercalate into the lattice to form a carbide, nitride, phosphide, sulfide, or boride.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: July 17, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Yuriy Roman-Leshkov, Sean Hunt
  • Patent number: 10024723
    Abstract: An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. The substrate can be a dielectric or semiconductor material. Each of the one or more resonator structures has at least one dimension that is less than the wavelength of target electromagnetic radiation within the target frequency range, and each of the resonator structures includes at least two conductive structures separated by a spacing. Charge carriers are induced in the substrate near the spacing when the resonator structures are exposed to the target electromagnetic radiation. A measure of the change in conductivity of the substrate due to the induced charge carriers provides an indication of the presence of the target electromagnetic radiation.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: July 17, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Harold Y. Hwang, Mengkun Liu, Richard D. Averitt, Keith A. Nelson, Aaron Sternbach, Kebin Fan
  • Patent number: 10024978
    Abstract: Systems and methods for collecting travel data include a mobile application capable of being executed on a mobile computing device and configured to monitor and log travel data related to travel of the mobile computing device, and to communicate the travel data over a network. A networked data processing device may be coupled to receive the travel-related data from the network and analyze the travel-related data to identify a mode of travel of the mobile computing device. A graphical user interface allows a user of the mobile computing device to verify accuracy of the identified means of travel.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: July 17, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Moshe E. Ben-Akiva, Francisco C. Pereira, Pericles C. Zegras, Fang Zhao
  • Publication number: 20180192974
    Abstract: An x-ray imaging device can include an x-ray detector and an optical-blocking filter. The x-ray detector has an entrance-window surface for receiving x-rays, at least one side surface, and a back surface facing in an opposite direction from the entrance-window surface. The optical-blocking filter is deposited on and fully covers at least the entrance-window surface and the side surface of the x-ray detector, wherein the optical-blocking filter blocks visible, ultraviolet, and near-infrared light.
    Type: Application
    Filed: January 8, 2018
    Publication date: July 12, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Kevin K. Ryu, Peter W. O'Brien, Marshall W. Bautz, Vyshnavi Suntharalingam
  • Publication number: 20180197999
    Abstract: A transistor includes a first gate-controlled region having a first threshold voltage and a second gate-controlled region in parallel with the first gate-controlled region. The second gate-controlled region has a second threshold voltage different form the first threshold voltage.
    Type: Application
    Filed: December 20, 2017
    Publication date: July 12, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Tomas Apostol Palacios, Sameer Jayanta-Joglekar, Ujwal Radhakrishna
  • Publication number: 20180194066
    Abstract: The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration parameters and/or an object formed by the device or in the process of being formed by the device. According to some aspects, a method is provided for calibrating an additive fabrication device. According to some aspects, a method is provided for assessing at least a portion of an object formed using an additive fabrication device. According to some aspects, a method is provided for fabricating a second object in contact with a first object using an additive fabrication device. According to some aspects, an additive fabrication device configured to perform one or more of the above methods may be provided.
    Type: Application
    Filed: April 28, 2017
    Publication date: July 12, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Javier E. Ramos, Pitchaya Sitthi-Amorn, Wojciech Matusik, Yuwang Wang
  • Publication number: 20180196058
    Abstract: Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. The reagents and methods provided herein have general utility in analyte detection and encoding, for example, in biomolecular profiling, molecular diagnostics, and biochemical encoding.
    Type: Application
    Filed: December 14, 2017
    Publication date: July 12, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Gabriel A. Kwong, Sangeeta N. Bhatia
  • Publication number: 20180196025
    Abstract: A chemical sensor for heavy metal detection is provided. The chemical sensor includes an inlet, a chamber in fluid communication with the inlet, and an outlet in fluid communication with the chamber. A working electrode is provided in the chamber. The working electrode includes a plurality of protrusions extending into a fluid flow path in the chamber beyond a boundary layer of the fluid flow path. The chemical sensor also includes a reference electrode, a counter electrode, and a plurality of contact pads electrically connected to respective ones of the working electrode, the reference electrode and the counter electrode.
    Type: Application
    Filed: July 5, 2016
    Publication date: July 12, 2018
    Applicants: Nanyang Technological University, Massachusetts Institute of Technology
    Inventors: Nan WANG, Jianmin MIAO, Michael S. TRIANTAFYLLOU
  • Publication number: 20180198256
    Abstract: In a method for electrically doping a semiconducting material, a layer of germanium is formed having a germanium layer thickness, while in situ incorporating phosphorus dopant atoms at a concentration of at least about 5×1018 cm?3 through the thickness of the germanium layer during formation of the germanium layer. Additional phosphorus dopant atoms are ex situ incorporated through the thickness of the germanium layer, after formation of the germanium layer, to produce through the germanium layer thickness a total phosphorus dopant concentration of at least about 2×1019 cm?3.
    Type: Application
    Filed: May 1, 2017
    Publication date: July 12, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Jonathan T. Bessette, Yan Cai, Rodolfo E. Camacho-Aguilera, Jifeng Liu, Lionel Kimerling, Jurgen Michel
  • Patent number: 10017388
    Abstract: Dihydrogen metaphosphate can be synthesized via protonation, and can react with a dehydrating agent to afford tetrametaphosphate anhydride. A monohydrogen tetra-metaphosphate organic ester can be derived from the anhydride. A metal tetrametaphosphate complex can be prepared using a metal salt and a dihydrogen tetrametaphosphate.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: July 10, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Yanfeng Jiang, Khetpakorn Chakarawet, Julia Megan Stauber, Christopher Colin Cummins
  • Patent number: 10017520
    Abstract: The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc inhibitors) and may be useful in treating in a subject in need thereof diseases associated with Myc and proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: July 10, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Angela N. Koehler, Eric Stefan, Francisco Caballero
  • Patent number: 10017724
    Abstract: A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may further comprise one or more endothelial cells, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, and a second three dimensional scaffold comprising one or more stromal cells, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold. The second three dimensional scaffold is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: July 10, 2018
    Assignees: Arizona Board of Regents on Behalf of Arizona State University, Massachusetts Institute of Technology
    Inventors: Mehdi Nikkhah, Roger D. Kamm, Danh Truong
  • Publication number: 20180185286
    Abstract: Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or dissolution rates for pharmaceutically active species having poor aqueous solubility.
    Type: Application
    Filed: March 31, 2015
    Publication date: July 5, 2018
    Applicants: NOVARTIS PHARMA AG, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Allan Stuart Myerson, Xiaochuan Yang, Marcus O'Mahony, Markus Krumme, Norbert Rasenack, Leia Dwyer
  • Publication number: 20180187186
    Abstract: The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or Cas system components. Compositions comprising modified ribonucleic acids have been designed with chemical modification for even higher efficiency as unmodified native strand of sgRNA. Administration of modified ribonucleic acids will allow decreased immune response when administered to a subject, increased stability, increased editing efficiency and facilitated in vivo delivery of sgRNA via various delivery platforms. The disclosure also relates to methods of decreasing off-target effect of CRISPR and a CRISPR complex.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 5, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Hao Yin, Daniel G. Anderson, Robert Samuel Langer
  • Publication number: 20180185473
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Application
    Filed: August 9, 2017
    Publication date: July 5, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon