Patents Assigned to Massachusetts Institute of Technology
  • Patent number: 11002741
    Abstract: A single chirality single walled carbon nanotubes (SWNT), and combinations thereof, can be used to detect trace levels of chemical compounds in vivo with high selectivity.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: May 11, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Juan Pablo Giraldo Gomez, Markita Patricia Landry, Michael S. Strano
  • Patent number: 11000944
    Abstract: A foot touch position following apparatus includes a foot touch position detection part configured to detect a position where a human foot touches a surface; and a moving part configured to move the foot touch position following apparatus based on the detected result of the foot touch position detection part.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Haruhiko Harry Asada, Kosuke Takeuchi
  • Patent number: 11001319
    Abstract: A class of robots specifically adapted to climb periodic lattices. These “relative robots” are designed for a specific lattice structure and use the regularity of the structure to simplify path planning, align with minimal feedback, and reduce the number of degrees of freedom (DOF) required to locomote. These robots can perform vital inspection and repair tasks within the structure that larger truss construction robots cannot perform without modifying the structure. A particular embodiment is a robot designed to traverse a cubooctahedral (CubOct) cellular solids lattice using only two motions: climbing and turning.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: May 11, 2021
    Assignees: Massachusetts Institute of Technology, United States of America, as Represented by the Administrator of NASA
    Inventors: Benjamin Jenett, Daniel Cellucci, Kenneth Cheung, Neil Gershenfeld
  • Patent number: 11005413
    Abstract: A near-field ThermoPhotoVoltaic system comprises a hot emitter and a cold absorbing PhotoVoltaic cell separated by a small gap. The emitter emits hot photons and includes a polaritonic material that supports a surface-polaritonic mode. The PhotoVoltaic cell has a metallic back electrode and includes a semiconductor that absorbs the photons and supports guided photonic modes. The surface-polaritonic mode and the first guided photonic mode resonantly couple at a frequency slightly above the semiconductor bandgap. The system material and geometrical parameters are such that the surface-polaritonic mode and the first guided photonic mode are approximately impedance-matched, so that power is transmitted at frequencies just above the semiconductor bandgap, even for relatively large gap widths, while the power transmitted at other frequencies is relatively small, leading to high system efficiency.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Aristeidis Karalis, John D. Joannopoulos
  • Patent number: 11001016
    Abstract: Layers of composite material, such as pre-peg, may be deposited on a reconfigurable polymer mold. An array of actuated pins may deform the polymer mold into a desired 3D shape. The composite material may be inside a cavity formed by the mold and a flexible bag. A vacuum pump may remove air from the cavity, creating a partial vacuum. The partial vacuum may cause the flexible bag to press the composite tightly against the mold, so that the composite conforms to the desired 3D shape. One or more heating elements may be embedded in the mold and may heat the composite to cure the composite. Ball joints may connect the actuated pins to the polymer mold.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Nikolaos Vlavianos, Christoph Schumann
  • Patent number: 11000945
    Abstract: Wearable robotic systems including robotic limbs for supporting a load while a user moves through an environment and their methods of use are described. In one embodiment, a robotic system includes robotic limbs with first and second robotic limb segments that are movable between different configurations to support a load while a user is standing or crawling. In another embodiment, a robotic system includes first and second robotic limbs that are substantially located within a plane parallel to a frontal plane of a user when the robotic system is worn. In another embodiment, a wearable robotic system includes first and second robotic limbs and an associated base that is attachable to a user's torso. The first and second robotic limbs may include a plurality of actuators and associated robotic limb segments to couple the robotic legs to the base and control their movement.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Haruhiko Harry Asada, Daniel J. Gonzalez
  • Patent number: 11001622
    Abstract: Described herein are methods for suppressing an immune response in a subject, e.g., a subject with an autoimmune disease, by administering to the subject a therapeutically effective amount of recombinant CD5L, CD5L homodimers and/or CD5L:p40 heterodimers, or nucleic acids encoding any of these. Also described are methods for enhancing an immune response in a subject, e.g., a subject with cancer, infection, or an immune deficiency, by administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that binds specifically to CD5L, D5L homodimers and/or CD5L:p40 heterodimers, and inhibits their binding to the IL-23 receptor, or inhibits formation of the CD5L homodimer and/or CD5L:p40 heterodimer, or inhibitory nucleic acids that target CD5L and/or p40.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: May 11, 2021
    Assignees: The Brigham and Women's Hospital, Inc., The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Vijay K. Kuchroo, Chao Wang, Aviv Regev, Karthik Shekhar
  • Patent number: 11005507
    Abstract: According to some embodiments, in a multi-user detection (MUD) receiver, a method for identifying a beam which produces a specific signal-to-interference-plus-noise ratio (SINR) can include: determining a maximum output SINR; determining beam weights to achieve a target SINR using the determined maximum output SINR; applying the beam weights to one or more received signals to generate a beamformed signal having the target SINR, one or more of the received signals having a signal of interest (SOI), one or more interfering signals, and noise; and providing the beamformed signal to a multi-user detection unit to recover the SOI.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventor: Michael Dowling
  • Patent number: 11001829
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: May 11, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Silvana Konermann, Mark D. Brigham, Alexandra Trevino
  • Patent number: 11005108
    Abstract: Disclosed are surface immobilized (electro)catalysts that may be prepared by a condensation reaction that generates an aromatic unit that is robust to acid and base and elevated temperatures. Among their many desirable characteristics, the catalysts are far less prone to the bimolecular deactivation pathways commonly observed for homogeneous catalysts, and may be used in solvents with a range of polarities and dielectric strengths. The catalysts are suitable for a wide array of thermal catalytic reactions (polymerization, oxidation, hydrogenation, cross-coupling etc.) and as anodes and/or cathodes in fuel cells, electrolyzers, and in batteries and supercapacitors.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: May 11, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Yogesh Surendranath, Tomohiro Fukushima, Matthew E. O'Reilly, Seokjoon Oh, Alexander T. Murray, Corey Jarin Kaminsky, Sterling Ben Chu, Megan N. Jackson
  • Patent number: 11002597
    Abstract: A solar spectrum sensor, a consumer device and a method for determining an ambient solar spectrum. The solar spectrum sensor comprises a sensor unit configured for generating respective photo current outputs responsive to different parts of the solar spectrum; a measurement unit configured for measuring the respective photo current outputs from the sensor unit; and a processing unit for determining an average photon energy, APE, value of the solar spectrum from the measured photo current outputs and for determining the solar spectrum based on the determined APE.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: May 11, 2021
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Ian Marius Peters, Tonio Buonassisi, Haohui Liu, Sterling Watson, Nasim Sahraei Khanghah, Anthony Pennes, Zekun Ren
  • Patent number: 11003852
    Abstract: In an embodiment, a method includes presenting, on a display, sample text in a given language to a user. The method further includes recording eye fixation times for each word of the sample text for the user and recording saccade times between each pair of fixations of the sample text. The method further includes comparing features of the gaze pattern of the user to features of a gaze pattern of a plurality of training readers. Each training reader (e.g., training user) has a known native language. The method further generates a probability of at least one an estimated native language of the user based on the results of the comparison.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Yevgeni Berzak, Boris Katz
  • Patent number: 11004943
    Abstract: Methods for forming porous or nanoporous semiconductor materials are described. The methods allow for the formation of arrays pores or nanopores in semiconductor materials with advantageous pore size, spacing, pore volume, material thickness, and other aspects. Porous and nanoporous materials also are provided.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 11, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Brendan Derek Smith, Jeffrey C. Grossman
  • Publication number: 20210130833
    Abstract: Engineered systems comprising components of defense systems identified in prokaryotes are provided.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 6, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Linyi Gao
  • Publication number: 20210129088
    Abstract: Compositions, devices, and methods relating to the use of mixed-matrix membranes containing metal-organic frameworks to separate gases are generally described. In some embodiments, branched nanoparticles made at least in part of metal-organic frameworks are described. In some embodiments, the morphology and size of the branched nanoparticles are controlled by the presence of a chemical modulator during synthesis. In some embodiments, the branched nanoparticles are uniformly distributed in a mixed-matrix membrane. In some embodiments, the mixed-matrix membrane is configured to separate one or more gases from a gas mixture. In some embodiments, the branched nanoparticles contribute at least in part to an increase in permeability, selectivity, and/or resistance to plasticization of the mixed-matrix membrane.
    Type: Application
    Filed: June 11, 2019
    Publication date: May 6, 2021
    Applicants: Massachusetts Institute of Technology, Aramco Services Company
    Inventors: Zachary Smith, Lucas Chi, Benjamin James Sundell, Ke Zhang, Steven C. Hayden, Daniel J. Harrigan, Hyunhee Lee
  • Publication number: 20210130800
    Abstract: The present disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the present disclosure provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
    Type: Application
    Filed: October 23, 2018
    Publication date: May 6, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Jonathan Gootenberg, David Benjamin Turitz Cox, Omar Abudayyeh, Ian Slaymaker
  • Publication number: 20210130372
    Abstract: Compositions and methods relating to compositions that include metal-organic frameworks are generally described. In some embodiments, branched nanoparticles made at least in part of metal-organic frameworks are described. In some embodiments, the morphology and size of the branched nanoparticles are controlled by the presence of a chemical modulator during synthesis.
    Type: Application
    Filed: June 11, 2019
    Publication date: May 6, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Zachary Smith, Lucas Chi, Hyunhee Lee
  • Publication number: 20210128460
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: December 18, 2020
    Publication date: May 6, 2021
    Applicants: Massachusetts Institute of Technology, The Brigham and Women't Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
  • Publication number: 20210135265
    Abstract: A major challenge in the development of anion exchange membranes for fuel cells is the design and synthesis of highly stable (chemically and mechanically) and conducting membranes. Membranes that can endure highly alkaline environments while rapidly transporting hydroxides are desired. A design for using cross-linked polymer membranes is disclosed to produce ionic highways along charge delocalized pyrazolium and homoconjugated triptycenes. The ionic highway membranes show improved performance in key parameters. Specifically, a conductivity of 111.6 mS cm?1 at 80° C. was obtained with a low 7.9% water uptake and 0.91 mmol g?1 ion exchange capacity. In contrast to existing materials, these systems have higher conductivities at reduced hydration and ionic exchange capacities, emphasizing the role of the highway. The membranes retain more than 75% of initial conductivity after 30 days of alkaline stability test.
    Type: Application
    Filed: November 3, 2020
    Publication date: May 6, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Manning Swager, Jeffrey C. Grossman, Sibo Lin, Yoonseob Kim, Yanming Wang, Arthur France-Lanord, You-Chi Wu, Yifan Li, Yichong Wang
  • Publication number: 20210130375
    Abstract: Preparation of sulfur fine chemicals from sulfur sources is described.
    Type: Application
    Filed: November 8, 2018
    Publication date: May 6, 2021
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Christopher C. CUMMINS, Michael Bailey GEESON, Wesley TRANSUE, Pablo RIOS MORENO