Patents by Assignee Massachusetts Institute of Technology
  • Publication number: 20170271459
    Abstract: Methods for forming nanoporous semiconductor materials are described. The methods allow for the formation of micron-scale arrays of sub-10 nm nanopores in semiconductor materials with narrow size distributions and aspect ratios of over 400:1.
    Type: Application
    Filed: March 17, 2017
    Publication date: September 21, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Jeffrey C. Grossman, Brendan Derek Smith, Jatin Jayesh Patil, Nicola Ferralis
  • Publication number: 20170271604
    Abstract: A method of improving performance of a photovoltaic device can include modifying a surface energy level of a nanocrystal through ligand exchange. A photovoltaic device can include a layer that includes a nanocrystal with a surface energy modified through ligand exchange.
    Type: Application
    Filed: May 8, 2015
    Publication date: September 21, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Patrick R. Brown, Donghun KIM, Moungi G. Bawendi, Jeffrey C. Grossman, Vladimir Bulovic
  • Publication number: 20170267616
    Abstract: The present invention generally relates to apparatuses, systems, and methods for oxidation of an alkane (e.g., methane) into an alcohol (e.g., methanol) in the presence of a catalyst.
    Type: Application
    Filed: November 11, 2016
    Publication date: September 21, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Yuriy Román-Leshkov, Karthik Narsimhan
  • Publication number: 20170266114
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Application
    Filed: March 8, 2017
    Publication date: September 21, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Publication number: 20170271201
    Abstract: A method of manufacturing a germanium-on-insulator substrate is disclosed. The method comprises: providing (102) a first semiconductor substrate, and a second semiconductor substrate formed with a germanium layer; bonding (102) the first semiconductor substrate to the second semiconductor substrate using at least one dielectric material to form a combined substrate, the germanium layer being arranged intermediate the first and second semiconductor substrates; removing (104) the second semiconductor substrate from the combined substrate to expose at least a portion of the germanium layer with misfit dislocations; and annealing (106) the combined substrate to enable removal of the misfit dislocations from the portion of the germanium layer.
    Type: Application
    Filed: May 22, 2015
    Publication date: September 21, 2017
    Applicants: Massachusetts Institute of Technology, Nanyang Technological University
    Inventors: Kwang Hong Lee, Chuan Seng Tan, Yew Heng Tan, Gang Yih Chong, Eugene A. Fitzgerald, Shuyu Bao
  • Publication number: 20170266112
    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.
    Type: Application
    Filed: December 16, 2016
    Publication date: September 21, 2017
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Omar Abouzid, Ameya R. Kirtane
  • Publication number: 20170266931
    Abstract: Compositions and articles comprising omniphobic materials for bio-related and other applications are generally provided. In some embodiments, the compositions and articles described herein may be introduced internally of a subject (e.g., in the esophagus, in the gastrointestinal tract, in the rectum). In some aspects, the compositions and articles comprise a releasable therapeutic agent In some embodiments, the compositions and articles described herein may be configured to have a relatively short retention time at the location internal of the subject (e.g., less than 2 seconds) such as a capsule comprising an omniphobic coating. In alternative embodiments, the compositions and articles described herein may be configured to have relative long retention times at the location internal of the subject (e.g., greater than 10 minutes) and include a mucoadhesive portion as well as an omniphobic portion. Such articles may have an omniphobic portion which resists adhesion and/or fouling (e.g.
    Type: Application
    Filed: March 21, 2017
    Publication date: September 21, 2017
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Shiyi Zhang, Young-Ah Lucy Lee
  • Publication number: 20170266317
    Abstract: Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining viable after attachment of the functional patch. Functional payloads carried by the patch can include a drug. The patch can include one or more polyelectrolyte multilayers (PEMs).
    Type: Application
    Filed: March 14, 2017
    Publication date: September 21, 2017
    Applicants: Massachusetts Institute of Technology, University of North Carolina Chapel Hill
    Inventors: Roberta Polak, Robert E. Cohn, Michael F. Rubner, Elena V. Batrakova, Matthew J. Haney, Natalya L. Klyachko, Yuling Zhao
  • Patent number: 9763617
    Abstract: A system and a method for assessing a condition in a subject. Phones from speech of the subject are recognized, one or more prosodic or speech-excitation-source features of the phones are extracted, and an assessment of a condition of the subject, is generated based on a correlation between the features of the phones and the condition.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Thomas Francis Quatieri, Nicolas Malyska, Andrea Carolina Trevino
  • Patent number: 9764212
    Abstract: In exemplary implementations of this invention, a basketball net or flat net measures the translational kinetic energy of a ball that passes through an aperture in the net or impacts the net. The net includes one or more electrically conductive cords, which have a resistance that varies depending on the degree to which the cord is stretched. From sensor measurements, a processor determines: (a) instantaneous rate of change of resistance, and (b) duration of a time period that begins when resistance exceeds a baseline (with hysteresis). In the case of a basketball net, a processor may calculate the translational kinetic energy of the ball as equal to a sum of two terms. The first term is inversely proportional to the square of the duration; the second is proportional to the square of the integral of the instantaneous rate of change of resistance over the time period.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Victor Michael Bove, Jr., Jared Markowitz, Daniel Novy, Santiago Alfaro
  • Patent number: 9764220
    Abstract: A reconfigurable device comprises flexible bladder that encloses a jammable material. The geometry of the device can be altered by unjamming the jammable material (making it flexible), changing the shape of the device while it is flexible, and then jamming the jammable material (making it rigid). In some applications of this invention, a joint connects rigid arms. The ends of the rigid arms are enclosed in the bladder. By varying the stiffness of the jammable material in the bladder, the stiffness of the joint can be controlled.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Steven Keating, Neri Oxman
  • Patent number: 9767226
    Abstract: According to some aspects, a method of designing an object based on a three-dimensional model representing a shape of the object is provided. The object may be fabricated from a plurality of materials having one or more known physical properties, wherein the object is designed to exhibit one or more target properties. The method may comprise determining a first composition of the object by providing the three-dimensional model as input to a reducer tree, determining one or more physical properties of the object with the first composition by simulating the object with the first composition, comparing the determined one or more physical properties with the one or more target properties, and determining a second composition of the object based on a result of comparing the determined one or more physical properties with the one or more target properties.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Desai Chen, Pitchaya Sitthi-Amorn, David I. W. Levin, Piotr Didyk, Wojciech Matusik
  • Patent number: 9766181
    Abstract: Nitrogen vacancies in bulk diamonds and nanodiamonds can be used to sense temperature, pressure, electromagnetic fields, and pH. Unfortunately, conventional sensing techniques use gated detection and confocal imaging, limiting the measurement sensitivity and precluding wide-field imaging. Conversely, the present sensing techniques do not require gated detection or confocal imaging and can therefore be used to image temperature, pressure, electromagnetic fields, and pH over wide fields of view. In some cases, wide-field imaging supports spatial localization of the NVs to precisions at or below the diffraction limit. Moreover, the measurement range can extend over extremely wide dynamic range at very high sensitivity.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: September 19, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Dirk Robert Englund, Matthew Edwin Trusheim
  • Patent number: 9768881
    Abstract: Devices and techniques for integrated optical data communication. An optical receiver may include a photodetector and a differential amplifier. The photodetector is coupled to an optical waveguide. The optical waveguide is configured to provide an optical signal encoding data. A first terminal of the differential amplifier is coupled to receive a photodetection signal from the photodetector. A second terminal of the differential amplifier is coupled to receive, from a noise measurement unit, a reference signal representing a noise component of the photodetection signal. The differential amplifier is configured to provide an amplifier signal encoding at least some of the data.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Stephen Georgas, Jason Scott Orcutt, Vladimir Marko Stojanovic
  • Patent number: 9766931
    Abstract: A method of determining schedulability of tasks for uniprocessor execution includes defining a well-formed, non-preemptive task set having a plurality of tasks, each task having at least one subtask. A determination of whether the task set is schedulable is made, such that a near-optimal amount of temporal resources required to execute the task set is estimated. Further, a method of determining schedulability of a subtask for uniprocessor execution includes defining a well-formed, non-preemptive task set having a plurality of tasks, each task having at least one subtask. A determination of whether a subtask in the task set is schedulable at a specific time is made in polynomial time. Systems for implementing such methods are also provided.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Julie Ann Shah, Matthew Craig Gombolay
  • Patent number: 9768785
    Abstract: Digital focal plane arrays (DFPAs) with multiple counters per unit cell can be used to convert analog signals to digital data and to filter the digital data. Exemplary DFPAs include two-dimensional arrays of unit cells, where each unit cell is coupled to a corresponding photodetector in a photodetector array. Each unit cell converts photocurrent from its photodetector to a digital pulse train that is coupled to multiple counters in the unit cell. Each counter in each unit cell can be independently controlled to filter the pulse train by counting up or down and/or by transferring data as desired. For example, a unit cell may perform in-phase/quadrature filtering of homodyne- or heterodyne-detected photocurrent with two counters: a first counter toggled between increment and decrement modes with an in-phase signal and a second counter toggled between increment and decrement modes with a quadrature signal.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: September 19, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Kenneth I. Schultz, Brian Tyrrell, Michael W. Kelly, Curtis B. Colonero, Lawrence M. Candell, Daniel Mooney
  • Patent number: 9764378
    Abstract: In exemplary implementations of this invention, an actuated fabricator deposits structural elements (e.g., tensile structural elements) in a 3D pattern over large displacements. The fabricator is supported by at least three elongated support members. It includes onboard actuators that translate the fabricator relative to the ends of the support members. The fabricator is configured, by actuating different translations along different support members, to translate itself throughout a 3D volume. In some implementations, each of the actuators use fusible material to fuse metal tapes together, edge-to-edge, to form a hollow structure that can be shortened or lengthened.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: September 19, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Benjamin Peters, Neri Oxman
  • Publication number: 20170259427
    Abstract: Robotic systems for supporting a human in stationary and/or mobile applications and related methods of operation are described.
    Type: Application
    Filed: March 10, 2017
    Publication date: September 14, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Haruhiko Harry Asada, Daniel A. Kurek
  • Publication number: 20170263408
    Abstract: Embodiments related to the use and production of porous carbon materials in ion emitters and other applications are described
    Type: Application
    Filed: May 30, 2017
    Publication date: September 14, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Paulo C. Lozano, Carla Perez Martinez, Corey P. Fucetola, Jimmy Andrey Rojas Herrera
  • Patent number: 9759727
    Abstract: In this invention, polyimidazole ligands (PILs) incorporating pendant imidazole moieties for nanocrystal binding and either sulfonatebetaine, carboxybetaine, or phosphocholinebetaine moieties for water-solubilization have been developed. Greatly enhanced stability of nanocrystals (both over time and in wide pH range) was achieved by incorporating multi-dentate imidazole moieties which provide strong coordination of the ligand to the nanocrystal surface and prevent aggregation of nanocrystals. Synthesis of betaine PILs was developed by modifying the synthesis of recently developed PEG containing poly imidazole ligands (PEG PILs). These nanocrystals are compact, water soluble, and biocompatible.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: September 12, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Hee-Sun Han, Wenhao Liu, Moungi G. Bawendi