Patents Assigned to Massachusetts Institute of Technology
  • Publication number: 20200168605
    Abstract: A high voltage logic circuit for high voltage system application comprises a first device layer formed from a first semiconductor material and comprises a low voltage logic circuit; and a second device layer formed from a second different semiconductor material and comprising one or more components of an additional circuit for generating a high voltage logic output from a low voltage logic input from the low voltage logic circuit; wherein the first and second device layers are integrally formed.
    Type: Application
    Filed: February 16, 2017
    Publication date: May 28, 2020
    Applicants: Massachusetts Institute of Technology, Nanyang Technological University
    Inventors: Pilsoon CHOI, Chirn-Chye BOON, Li-Shiuan PEH
  • Publication number: 20200166503
    Abstract: Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of DNA, among other applications.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 28, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Manning Swager, Qifan Zhang, Lukas Zeininger
  • Publication number: 20200164353
    Abstract: Compositions comprising metal organic frameworks and related methods and uses are generally provided, including use in selective carbonylation of heterocyclic compounds.
    Type: Application
    Filed: October 4, 2017
    Publication date: May 28, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Yuriy Román-Leshkov, Mircea Dinca, Hoyoung Park
  • Publication number: 20200165601
    Abstract: The present invention generally relates to compositions, methods applications and screens used in functional genomics that focus on gene function in a cell and that may use vector systems and other aspects related to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas systems and components thereof. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system.
    Type: Application
    Filed: July 29, 2019
    Publication date: May 28, 2020
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Feng ZHANG, Neville Espi Sanjana, Ophir Shalem
  • Publication number: 20200165594
    Abstract: The present invention offers a new approach for highly multiplexed, programmable antiviral therapies that directly target viral RNA, and can be flexibly adapted to target novel viruses or emerging outbreak pathogens. Class 2, type VI CRISPR system-based therapies can be used in combination with existing antiviral compounds for viruses where such compounds exist, either by increasing their efficacy or by preventing the evolution of specific drug resistance mutations. Perhaps most excitingly, if a virus evolves resistance to a specific guide RNA sequence, it is easy to switch to a different guide RNA sequence, or to design a new guide sequence to target the new mutation. Such approaches should prevent the widespread development of resistance to Class 2, type VI CRISPR system-based therapies.
    Type: Application
    Filed: July 6, 2018
    Publication date: May 28, 2020
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Jonathan S. Gootenberg, Omar O. Abudayyeh, Pardis Sabeti, Cameron Myhrvold, Catherine Amanda Freije
  • Patent number: 10665801
    Abstract: A transparent photovoltaic cell and method of making are disclosed. The photovoltaic cell may include a transparent substrate and a first active material overlying the substrate. The first active material may have a first absorption peak at a wavelength greater than about 650 nanometers. A second active material is disposed overlying the substrate, the second active material having a second absorption peak at a wavelength outside of the visible light spectrum. The photovoltaic cell may also include a transparent cathode and a transparent anode.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: May 26, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Vladimir Bulovic, Richard Royal Lunt
  • Patent number: 10665634
    Abstract: An integrated, superconducting imaging sensor may be formed from a single, meandering nanowire. The sensor is capable of single-photon (or single-event) detection and imaging with ˜10 micron spatial resolution and sub-100-picosecond temporal resolution. The sensor may be readily scaled to large areas.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 26, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Qingyuan Zhao, Karl K. Berggren
  • Patent number: 10662199
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: May 26, 2020
    Assignees: The Broad Institute, Inc., The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen J. Haggarty, Yan-Ling Zhang
  • Patent number: 10666307
    Abstract: A nonlinear compensator is provided to include a decomposition circuit and a plurality of filter elements. The decomposition circuit has a nonlinear frequency response characteristic and the decomposition circuit is configured to receive an input signal and decompose the input signal into decomposed signals corresponding to positive and negative frequency signal components of the input signal. Each of the plurality of filter elements is configured to receive at least portions of the decomposed signals and apply filter element characteristics to the decomposed signals with the filter element characteristics that are matched to the nonlinear frequency response of the decomposition circuit.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: May 26, 2020
    Assignee: Massachusetts Institute of Technology
    Inventor: Xiao-Yu Wang
  • Patent number: 10661180
    Abstract: A digital media system models social categories of a virtual identity. The system, defines a plurality of modeling categories according to the virtual identity and models a degree of a membership in a category for a member of the category. Each category has a feature shared in varying degrees by one or more members of the category. The system simulates changes to the membership and determines a naturalization trajectory having a change of the degree of membership in a category over time of the virtual identity. The degree of membership includes a gradient value in a category feature and an interface configured to represent a category membership that dynamically changes as category membership changes.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: May 26, 2020
    Assignee: Massachusetts Institute of Technology
    Inventor: Douglas Alan Harrell, Jr.
  • Patent number: 10665529
    Abstract: The present invention generally relates to a modular microjet cooler. The modular microjet cooler may be attached to a packaged heat generating device that is mounted on a printed circuit board. The modular microjet cooler has an inlet allowing supply fluid to be directed through microjet nozzles toward an impingement surface on the packaged device. The modular microjet cooler also has one or more outlets that allow exhaust fluid to be removed. The modular microjet cooler is attached to the device after it has been packaged. Further, the modular microjet cooler may be attached to the packaged device either before or after it is mounted to the printed circuit board.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: May 26, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: James Paul Smith, Bernard A. Malouin, Jr., Eric A. Browne
  • Patent number: 10660561
    Abstract: A personal skin lesion scanner system that can facilitate early detection of changes in the appearance of a user's skin is described. The system includes a handheld device for home use, to record images of a user's skin, and software for analyzing the images. The system can automatically detect changes in the user's skin, such as changes in the size, shape, or color of a skin lesion, and alert the user if any changes are detected.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: May 26, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Jie Bao, Moungi G. Bawendi
  • Patent number: 10666091
    Abstract: Described herein are embodiments of a source high-Q resonator, optionally coupled to an energy source, a second high-Q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-Q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. The source resonator and at least one of the second resonator and third resonator may be coupled to transfer electromagnetic energy from said source resonator to said at least one of the second resonator and third resonator.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: May 26, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: John D. Joannopoulos, Aristeidis Karalis, Marin Soljacic
  • Patent number: 10663579
    Abstract: A method for extending a surface penetrating radar (SPR) footprint for performing localization with an SPR system is disclosed. The method may include may include transmitting at least one SPR signal from at least one SPR transmit element. The method may further include receiving a response signal via at least two SPR receive elements, the response signal including, at least in part, a reflection of the SPR signal from an object. The method may also include determining that the object is in a region of interest outside a footprint of the SPR system based on a difference in phase at which the response signal is received at the at least two SPR receive elements. The method may additionally include performing localization of a vehicle using the SPR system based at least in part on the object.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: May 26, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Byron McCall Stanley, Matthew Tyler Cornick
  • Patent number: 10662210
    Abstract: Compositions and methods comprising osmium are provided. In some embodiments, the osmium compounds comprise a bidentate ligand. In some embodiments, the osmium compounds are used in method for treating cancer.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: May 26, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Kogularamanan Suntharalingam
  • Publication number: 20200158431
    Abstract: The disclosure in some aspects relates to systems and related methods for the continuous freeze-drying of materials (e.g., pharmaceuticals) with high speed and control.
    Type: Application
    Filed: May 2, 2018
    Publication date: May 21, 2020
    Applicants: Massachusetts Institute of Technology, Politecnico di Torino
    Inventors: Bernhardt Levy Trout, Roberto Pisano, Luigi Carlo Capozzi
  • Publication number: 20200155821
    Abstract: Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken and/or disassemble the residence device.
    Type: Application
    Filed: November 15, 2019
    Publication date: May 21, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital,Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Sahab Babaee, Simo Pajovic, Jiuyun Shi
  • Patent number: 10655173
    Abstract: The present invention relates to molecular microscopy or volumetric imaging by proximal unique molecular identifiers (“UID”) reaction (“VIPUR”) microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with nucleic sequences. The method involves one or both of two DNA sequence-components such as an ?-UID, which may identify the targeted sequences-of-interest themselves and/or spatial beacons relative to which their distances are measured, and a- ?-UID, which labels ?-UID association events.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 19, 2020
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Joshua Asher Weinstein, Aviv Regev
  • Patent number: 10658169
    Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: May 19, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Ian W. Hunter, Brian D. Hemond, Harold F. Hemond
  • Patent number: 10653993
    Abstract: Compositions and methods for adsorption of a species (e.g., ammonia, water, a halogen) comprising metal organic frameworks (MOFs) are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two unsaturated N-heterocyclic aromatic groups arranged about an organic core.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: May 19, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Mircea Dinca, Adam J. Rieth, Yuri Tulchinsky