Abstract: The present invention relates to a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material. The present invention also relates to a process chamber for a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material. The present invention further relates to a method of coating a substrate of a substrate material with at least one material layer of a layer material in a coating apparatus. A further aspect of the invention relates to a substrate coated with at least one material layer, comprising the substrate of a substrate material that is coated with at least one material layer of a layer material.

Abstract: The present invention relates to a method for the production of a cervix epithelial cell organoid culture. By means of this method, an organoid culture of cervix epithelial cells, and a biobank comprising a plurality of different organoid cultures thereof may be generated. Further, a culture medium suitable for the long-term culture of epithelial stem cells is provided. Furthermore, the use of the organoid culture in the biobank for medical applications, e.g. in the field of diagnostics and therapy and in the fields of drug screening and immunotherapy is described.

Abstract: A system for tracking objects in a temporal sequence of digital images is configured to: detect potential objects in the images, the detected potential objects being indicated as nodes, identify pairs of neighboring nodes, such that for each pair the nodes of said pair potentially represent an identical object and their spatial and/or temporal relationship with each other is within a predetermined range, connect each pair of neighboring nodes with a first type edge, identify at least one supplementary pair of distant nodes whose spatial and/or temporal relationship with each other exceeds the predetermined range, connect the pair of distant nodes with a supplementary second type edge, each of the first and second type edges being assigned a cost value, and determine a track of an object in the temporal sequence of digital images based on a set of connected first type edges and at least one second type edge.

Abstract: The invention relates to a system for displaying information to a user, comprising: an emission device (12, 13) arranged to emit light so as to display information to a user (18), the emission device (12, 13) being adapted to emit the light in a pulsed manner so that the intensity of the light varies between a high value and a low value, a selective viewing device (16) comprising a panel, the panel being adapted so that the user can view the light (11?) which is emitted by the emission device through that panel so as to visually perceive the information being displayed, the panel having a variable transparency which can be varied between a state of high transparency and a state of low transparency, the system being adapted to synchronize the emission device (12, 13) and the selective viewing device (16) so that the states of the emission device emitting light at a high-intensity value and the states of the panel of the selective viewing device of high transparency overlap in time, the emission device being ad

Abstract: A computer-implemented method for automatically obtaining pose and shape parameters of a human body. The method includes obtaining a sequence of digital 3D images of the body, recorded by at least one depth camera; automatically obtaining pose and shape parameters of the body, based on images of the sequence and a statistical body model; and outputting the pose and shape parameters. The body may be an infant body.

Abstract: The invention relates to hard magnets that include an intermetallic compound having the general composition XaX?bYcZd where X and X? independently from one another are representative of a 3d transition metal with unpaired electrons; Y is a 4d or 5d transition metal of groups 5, 8, 9, or 10 Z is a main group element of groups 13, 14 or 15; a and d independently from one another represent a number between 0.1 and 2.0; and b and c independently from one another represent a number between 0.0 and 2.0; such that a+b+c+d is between 3.0 and 4.0.

Abstract: The invention relates to a method for producing a structure with spatial encoded functionality, the method comprising: providing in a volume (114) a first photosensitive material (116) that is two-photon crosslinking compatible, generating in the volume (114) a framework of crosslinked first photo-sensitive material (116), the generating of the framework comprising exposing the first photosensitive material (116) with a first focused laser beam (118) according to a first pattern for specifically initiating a two-photon crosslinking of the first photosensitive material (116) in accordance with the first pattern, removing from the volume (114) any remaining non-crosslinked portions of the first photosensitive material (116), providing to the volume (114) a second photosensitive material (116) that is two-photon crosslinking compatible, generating in the volume (114) the structure, the generating of the structure comprising exposing the second photosensitive material (116) with a second focused laser beam (11

Abstract: The present invention relates to a method for the production of a culture, e.g. an organoid culture of ovarian cancer or cancer precursor cells, particularly of high grade serous ovarian carcinoma cells. By means of this method, an organoid culture of ovarian cancer or cancer precursor cells and a biobank comprising a plurality of different organoid cultures of ovarian cancer or cancer precursor cells may be generated. Further, a culture medium suitable for the long-term culture of ovarian cancer or cancer precursor cells is provided. Furthermore, use of the organoid culture and the biobank for medical applications, e.g. in the field of diagnostics, and therapy and in the field of drug screening is described.

Abstract: A genome-replication-deficient and transcription/competent negative/strand RNA virus, which can be used for the expression of transgenes and in particular for the area of vaccine development. In particular, a recombinant Sendia virus containing a viral genome with a mutation in the gene P, which leads to loss of capacity for replication without loss of capacity for secondary transcription, and at least one sequence coding for a heterologous gene product. Furthermore, a nucleocapsid of the Sendai virus, a genome of the Sendai virus, a DNA molecule that codes for the genome and/or antigenome of the Sendai virus. One aspect is a pharmaceutical composition containing the Sendai virus, the nucleocapsid, or the viral genome as active substance, and a medical use thereof, especially as a vaccine.

Abstract: A hollow-core photonic crystal fiber (HC-PCF) (10) for guiding at least one mode of a light field (1) along a mode guiding section (11) of the HC-PCF (10), comprises an outer jacket (12), an inner cladding (13) and a hollow core (14), which extend along the HC-PCF (10), wherein the inner cladding (13) is arranged on an interior surface of the outer jacket (12) and comprises anti-resonant structures (15) surrounding the hollow core (14), and the hollow core (14) has a mode guiding core diameter (d) provided along the mode guiding section of the HC-PCF (10), and wherein at least one fiber end (16) of the HC-PCF (10) has a light field coupling section (17) in which the hollow core (14) is tapered over an axial coupling section length from a fiber end core diameter (D) at the at least one fiber end (16) to the mode guiding core diameter (d). Furthermore, methods of using the HC-PCF and manufacturing the HC-PCF are described.

Abstract: The invention relates to a magneto-optical light modulator (100) for modulating light based on a physical property provided as an input to the modulator (100), the modulator (100) comprising a substrate (114) with a region of material (130) comprising a film of Eu(1-x)Sr(x)MO3 (112), an optical waveguide (106; 108) adapted for directing light through the region of material (130) and a first control unit, the first control unit being adapted to—maintain the region of material (130) at a constant predefined temperature in case the physical property is an input magnetic field subject to the region of material (130) or—maintain the region of material (130) subjected to a constant predefined magnetic field in case the physical property is an input temperature of the region of material (130), the light modulator (100) being adapted to perform the modulation of the light using the birefringence of the region of material (130), the birefringence depending on the physical property.

Abstract: The invention comprises a learned model of human body shape and pose dependent shape variation that is more accurate than previous models and is compatible with existing graphics pipelines. Our Skinned Multi-Person Linear model (SMPL) is a skinned vertex based model that accurately represents a wide variety of body shapes in natural human poses. The parameters of the model are learned from data including the rest pose template, blend weights, pose-dependent blend shapes, identity-dependent blend shapes, and a regressor from vertices to joint locations. Unlike previous models, the pose-dependent blend shapes are a linear function of the elements of the pose rotation matrices. This simple formulation enables training the entire model from a relatively large number of aligned 3D meshes of different people in different poses. The invention quantitatively evaluates variants of SMPL using linear or dual quaternion blend skinning and show that both are more accurate than a BlendSCAPE model trained on the same data.

Abstract: The present invention provides a stable synthetic saccharide of Hib polyribosylribitol-phosphate (PRP) derivative and conjugate thereof. Said saccharide, said conjugate and pharmaceutical compositions thereof are hydrolysis-resistant, long-term stable and useful for the prevention and/or treatment of diseases associated with Haemophilus influenzae, and more specifically of diseases associated with Haemophilus influenzae type b, preferably diseases selected from meningitis, pneumonia, and epiglotitis. They have general formula (I): wherein A is formula (II) or formula (III); B is formula (IV); C is formula (V); D is formula (VI); E is formula (VII); F is formula (VIII) or formula (IX).

Abstract: The invention relates to a method of determining an association of a first plant with an arbuscular mycorrhizal fungus (AMF), said method comprising comparing the amount of a blumenol in an aerial part of said first plant to the amount of said blumenol in an aerial part of a second plant, wherein said second plant belongs to the same species as said first plant, and wherein an increased amount is indicative of increased association in said first plant as compared to said second plant, and a decreased amount is indicative of decreased association.

Abstract: A method for encoding high dynamic range (HDR) images involves providing a lower dynamic range (LDR) image, generating a prediction function for estimating the values for pixels in the HDR image based on the values of corresponding pixels in the LDR image, and obtaining a residual frame based on differences between the pixel values of the HDR image and estimated pixel values. The LDR image, prediction function and residual frame can all be encoded in data from which either the LDR image of HDR image can be recreated.

Abstract: The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6? and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6? to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: A method for devising an optimum control policy of a controller for controlling a system includes optimizing at least one parameter that characterizes the control policy. A Gaussian process model is used to model expected dynamics of the system. The optimization optimizes a cost function which depends on the control policy and the Gaussian process model with respect to the at least one parameter. The optimization is carried out by evaluating at least one gradient of the cost function with respect to the at least one parameter. For an evaluation of the cost function a temporal evolution of a state of the system is computed using the control policy and the Gaussian process model. The cost function depends on an evaluation of an expectation value of a cost function under a probability density of an augmented state at time steps.

Abstract: The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as forster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.

Abstract: The invention relates to a system for displaying information to a user, comprising: an emission device (12, 13) arranged to emit light so as to display information to a user (18), the emission device (12, 13) being adapted to emit the light in a pulsed manner so that the intensity of the light varies between a high value and a low value, a selective viewing device (16) comprising a panel, the panel being adapted so that the user can view the light (11?) which is emitted by the emission device through that panel so as to visually perceive the information being displayed, the panel having a variable transparency which can be varied between a state of high transparency and a state of low transparency, the system being adapted to synchronize the emission device (12, 13) and the selective viewing device (16) so that the states of the emission device emitting light at a high-intensity value and the states of the panel of the selective viewing device of high transparency overlap in time, the emission device being ad