Abstract: The invention relates to a system for displaying information to a user, comprising: an emission device arranged to emit light so as to display information to a user, the emission device being adapted to emit the light in a pulsed manner so that the intensity of the light varies between a high value and a low value, a selective viewing device comprising a panel, the panel being adapted so that the user can view the light which is emitted by the emission device through that panel so as to visually perceive the information being displayed, the panel having a variable transparency which can be varied between a state of high transparency and a state of low transparency, the system being adapted to synchronize the emission device and the selective viewing device so that the states of the emission device emitting light at a high-intensity value and the states of the panel of the selective viewing device of high transparency overlap in time, the emission device being adapted so that the light is emitted in a pulsed m

Abstract: A broadband light source device for creating broadband light pulses includes a hollow-core fiber and a pump laser source device. The hollow-core fiber is configured to create the broadband light pulses by an optical non-linear broadening of pump laser pulses. The hollow-core fiber includes a filling gas, an axial hollow light guiding fiber core configured to support core modes of a guided light field, and an inner fiber structure surrounding the fiber core and configured to support transverse wall modes of the guided light field. The pump laser source device is configured to create and provide the pump laser pulses at an input side of the hollow-core fiber. The transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes.

Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.

Abstract: A broadband light source device for creating broadband light pulses includes a hollow-core fiber and a pump laser source device. The hollow-core fiber is configured to create the broadband light pulses by an optical non-linear broadening of pump laser pulses. The hollow-core fiber includes a filling gas, an axial hollow light guiding fiber core configured to support core modes of a guided light field, and an inner fiber structure surrounding the fiber core and configured to support transverse wall modes of the guided light field. The pump laser source device is configured to create and provide the pump laser pulses at an input side of the hollow-core fiber. The transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes.

Abstract: The present invention relates to the use of a compound in single-molecule localization microscopy (SMLM), in stimulated emission depletion microscopy (STED), in minimal emission fluxes microscopy (MINFLUX) or in structured illumination and localization microscopy (SIMFLUX), wherein the compound is a substituted or unsubstituted polycyclic aromatic hydrocarbon comprising six or more substituted and/or unsubstituted aromatic hydrocarbon rings, wherein each of at least six of the six or more substituted and/or unsubstituted aromatic hydrocarbon rings is fused with at least another one of the at least six substituted and/or unsubstituted aromatic hydrocarbon rings.

Abstract: The present invention refers to material comprising a compound of the formula ABOx wherein x is >1.5 and ?2.5, A is independently selected from a transition metal of IUPAC groups 10 and 11, and B is independently selected from a transition metal of IUPAC group 6, 7, 8 or 9 or a main group element of IUPAC group 13, as highly active catalyst for hydrogen evolution reaction (HER).

Abstract: The present invention relates to immunogenic compositions comprising a conjugate of a saccharide from Streptococcus pneumoniae serotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRM197 carrier protein, or a mixture consisting of capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides from Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide from Streptococcus pneumoniae serotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide from Streptococcus pneumoniae serotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by Streptococcus pneumoniae.

Abstract: An anonymizing method for a database system is provided. The method includes receiving a query, identifying one or more attack components in the query, computing one or more noise elements from the one or more attack components, and computing fixed noise or fixed thresholds from the one or more noise elements.

Abstract: A computer system contains a module configured to receive a query, to request rows and columns from a data store, to add or remove rows in such a way that combinations of queries cannot be used to infer information about individuals in the data store. The module executes a statistical computation over the adjusted rows and columns to produce a perturbed answer so that neither the perturbed answer alone, nor repeats of the perturbed answer can be used to infer information about individuals in the data store.

Abstract: The present invention relates to a compound represented by the formula (E) which is useful for treating or preventing melanoma.

Abstract: The present invention refers to Biodegradable, biocompatible, water-suspensable nanoparticle (1), for generating a second- or third-harmonic light signal upon illumination, as well as a method for preparing an aqueous suspension comprising said nanoparticle, a method for second-harmonic generation imaging of the nanoparticle (1) as and a use of the nanoparticle (1) for second-harmonic generation imaging. The nanoparticle (1) according to the invention comprises —a shell layer (2) comprising a biodegradable polymer (3), wherein the shell layer (2) encloses —a plurality (40) of oligopeptides (4), wherein the plurality (40) of oligopeptides (4) is structured such that a second-harmonic light signal is generated upon illumination of the nanoparticle (1) with light.

Abstract: The present invention relates to a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material. The present invention also relates to a process chamber for a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material. The present invention further relates to a method of coating a substrate of a substrate material with at least one material layer of a layer material in a coating apparatus. A further aspect of the invention relates to a substrate coated with at least one material layer, comprising the substrate of a substrate material that is coated with at least one material layer of a layer material.

Abstract: A hollow-core photonic crystal fiber (HC-PCF) (10) for guiding at least one mode of a light field (1) along a mode guiding section (11) of the HC-PCF (10), comprises an outer jacket (12), an inner cladding (13) and a hollow core (14), which extend along the HC-PCF (10), wherein the inner cladding (13) is arranged on an interior surface of the outer jacket (12) and comprises anti-resonant structures (15) surrounding the hollow core (14), and the hollow core (14) has a mode guiding core diameter (d) provided along the mode guiding section of the HC-PCF (10), and wherein at least one fiber end (16) of the HC-PCF (10) has a light field coupling section (17) in which the hollow core (14) is tapered over an axial coupling section length from a fiber end core diameter (D) at the at least one fiber end (16) to the mode guiding core diameter (d). Furthermore, methods of using the HC-PCF and manufacturing the HC-PCF are described.

Abstract: The present invention relates to a method for the production of a cervix epithelial cell organoid culture. By means of this method, an organoid culture of cervix epithelial cells, and a biobank comprising a plurality of different organoid cultures thereof may be generated. Further, a culture medium suitable for the long-term culture of epithelial stem cells is provided. Furthermore, the use of the organoid culture in the biobank for medical applications, e.g. in the field of diagnostics and therapy and in the fields of drug screening and immunotherapy is described.

Abstract: A system for tracking objects in a temporal sequence of digital images is configured to: detect potential objects in the images, the detected potential objects being indicated as nodes, identify pairs of neighboring nodes, such that for each pair the nodes of said pair potentially represent an identical object and their spatial and/or temporal relationship with each other is within a predetermined range, connect each pair of neighboring nodes with a first type edge, identify at least one supplementary pair of distant nodes whose spatial and/or temporal relationship with each other exceeds the predetermined range, connect the pair of distant nodes with a supplementary second type edge, each of the first and second type edges being assigned a cost value, and determine a track of an object in the temporal sequence of digital images based on a set of connected first type edges and at least one second type edge.

Abstract: The invention relates to a system for displaying information to a user, comprising: an emission device (12, 13) arranged to emit light so as to display information to a user (18), the emission device (12, 13) being adapted to emit the light in a pulsed manner so that the intensity of the light varies between a high value and a low value, a selective viewing device (16) comprising a panel, the panel being adapted so that the user can view the light (11?) which is emitted by the emission device through that panel so as to visually perceive the information being displayed, the panel having a variable transparency which can be varied between a state of high transparency and a state of low transparency, the system being adapted to synchronize the emission device (12, 13) and the selective viewing device (16) so that the states of the emission device emitting light at a high-intensity value and the states of the panel of the selective viewing device of high transparency overlap in time, the emission device being ad

Abstract: A computer-implemented method for automatically obtaining pose and shape parameters of a human body. The method includes obtaining a sequence of digital 3D images of the body, recorded by at least one depth camera; automatically obtaining pose and shape parameters of the body, based on images of the sequence and a statistical body model; and outputting the pose and shape parameters. The body may be an infant body.

Abstract: The invention relates to hard magnets that include an intermetallic compound having the general composition XaX?bYcZd where X and X? independently from one another are representative of a 3d transition metal with unpaired electrons; Y is a 4d or 5d transition metal of groups 5, 8, 9, or 10 Z is a main group element of groups 13, 14 or 15; a and d independently from one another represent a number between 0.1 and 2.0; and b and c independently from one another represent a number between 0.0 and 2.0; such that a+b+c+d is between 3.0 and 4.0.

Abstract: The invention relates to a method for producing a structure with spatial encoded functionality, the method comprising: providing in a volume (114) a first photosensitive material (116) that is two-photon crosslinking compatible, generating in the volume (114) a framework of crosslinked first photo-sensitive material (116), the generating of the framework comprising exposing the first photosensitive material (116) with a first focused laser beam (118) according to a first pattern for specifically initiating a two-photon crosslinking of the first photosensitive material (116) in accordance with the first pattern, removing from the volume (114) any remaining non-crosslinked portions of the first photosensitive material (116), providing to the volume (114) a second photosensitive material (116) that is two-photon crosslinking compatible, generating in the volume (114) the structure, the generating of the structure comprising exposing the second photosensitive material (116) with a second focused laser beam (11

Abstract: The present invention relates to a method for the production of a culture, e.g. an organoid culture of ovarian cancer or cancer precursor cells, particularly of high grade serous ovarian carcinoma cells. By means of this method, an organoid culture of ovarian cancer or cancer precursor cells and a biobank comprising a plurality of different organoid cultures of ovarian cancer or cancer precursor cells may be generated. Further, a culture medium suitable for the long-term culture of ovarian cancer or cancer precursor cells is provided. Furthermore, use of the organoid culture and the biobank for medical applications, e.g. in the field of diagnostics, and therapy and in the field of drug screening is described.