Abstract: Metal-nitride nanowires are amongst the candidates for very high efficiency electronics, solid state light sources, photovoltaics, photoelectrochemical devices, and photobiological devices. Enhanced performance typically requires heterostructures, quantum dots, etc within structures that are grown with relatively few defects and in a controllable reproducible manner. Additionally device design flexibility requires that the nanowire at the substrate be either InN or GaN. Methods of growing relatively defect free nanowires and associated structures for group IIIA-nitrides are presented without foreign metal catalysts thereby overcoming the non-uniform growth of prior art techniques and allowing self-organizing quantum dot, quantum well and quantum dot-in-a-dot structures to be formed, thereby supporting variety of high efficiency devices.

Abstract: The present application relates to the compounds of formula I (I) as well as their use for inhibiting at least one of AKT-1, FAK and PKC? and in the treatment and/or prevention of metastatic diseases.

Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, prodrugs, precursors thereof, and/or salts thereof, are described.

Abstract: The present relates to a system for providing vibration feedback to at least one foot. The system comprises at least one rigid surface for receiving the at least one foot, one vibrotactile actuator for each of the at least one rigid surface, and a suspension mechanism. The vibrotactile actuator is installed underneath the corresponding rigid surface and provides vibration feedback there through. The suspension mechanism supports the at least one rigid surface.

Abstract: The invention concerns a peptide derived from intermediate filaments and an intermediate filament fragment capable of altering tubulin polymerization and used for inhibiting cell proliferation, and more particularly for obtaining medicines designed to prevent or treat diseases involving cell proliferation, such as cancers for example.

Abstract: Cost, electronic circuitry limitations, and communication channel behaviour yield communication systems with strict bandwidth constraints. Hence, maximally utilizing available bandwidth is crucial, for example in wireless networks, to supporting ever increasing numbers of users and their demands for increased data volumes, low latency, and high download speeds. Accordingly, it would be beneficial for such networks to support variable bandwidth allocations such that smaller frequency sub-bands are allocated to users, as their number increases, but the individual users/nodes insert more data-carrying signals in order to compensate pensate for the loss of operating bandwidth arising from the accommodation of more users. It would further be beneficial for transmitters and receivers according to embodiments of such a network architecture to be based upon low cost design methodologies allowing their deployment within a wide range of applications including high volume, low cost consumer electronics for example.

Abstract: A soil analysis apparatus includes at least one sensor element for measuring a property of the soil; a blade assembly having at least one blade and being displaceable between a raised position and an excavation position, the at least one blade being operable to excavate the soil at a test location when the blade assembly is in the excavation position, the blade assembly being further operable to enter a sensor permitting configuration; and a first actuator operable to displace the at least one sensor element between an initial position and a sensing position along a sensor displacement path, the sensor element being proximate the soil at the test location when in the sensing position.

Abstract: A bone screw is described which includes a one-piece threaded screw body composed at least partially of a rigid foam. The screw body is headless and includes a bore extending therethrough to define a cannula and thereby providing the screw body with an annular shape defining a radial wall thickness. At least a central portion of the screw body is formed of the rigid foam which defines a matrix having a plurality of inter-connected pores therein. The inter-connected pores are disposed throughout the complete radial wall thickness of the screw body from an outer surface of the screw body to an inner surface thereof within the cannula, such as to permit bone in-growth through the complete radial wall thickness of the annular screw body. The inter-connected pores and the cannula thereby respectively allow bone in-growth through the complete radial wall thickness and the full axial length of the screw body.

Abstract: A method of providing microelectromechanical structures (MEMS) that are compatible with silicon CMOS electronics is provided. The method providing for processes and manufacturing sequences limiting the maximum exposure of an integrated circuit upon which the MEMS is manufactured to below 350° C., and potentially to below 250° C., thereby allowing direct manufacturing of the MEMS devices onto electronics, such as Si CMOS circuits. The method further providing for the provisioning of MEMS devices with multiple non-conductive structural layers such as silicon carbide separated with small lateral gaps. Such silicon carbide structures offering enhanced material properties, increased environmental and chemical resilience while also allowing novel designs to be implemented taking advantage of the non-conductive material of the structural layer.

Abstract: The present invention relates to a new process for producing a doped synthetic monodispersed hematin anhydride (HA) crystals useful as a slow release vehicle and immune modulator. As the preparation comprises embedded in the crystals one or more antigens and/or one or more biologically active entities, the preparation can be useful in numerous medical indications such as vaccine or any therapy where it is desired that a biologically active entity maintains its activity over time due to its slow-release. The process comprises the steps of (i) providing a substantially pure iron(III) protoporphyrin-IX, in solution in an alkaline solution substantially free of oxygen (ii) adjusting the pH of the solution to an acidic pH of between about 4.0, by slowly adding a medium strong organic acid, (iii) during step b) above, adding one or more antigens and/or one or entities having a biological activity, at a pH of about 5.0.

Abstract: Time-Mode Signal Processing (TMSP) offers a means for offsetting some of the challenges for analog circuit designs when exploiting CMOS circuit processes designed for digital applications. It would therefore be beneficial to provide a digital method for the storage, addition and subtraction of Time-Mode variables as these offer significant benefit to providing TMSP techniques and expanding their exploitation within devices, systems, and applications. While driven by CMOS process challenges the TM circuits outlined may exploit essentially any digital circuit technology since they are based upon delay. The inventors present an approach to TM variables wherein a switched delay unit is exploited and adopted such that the instantaneous phase difference between two rising signal edges can be latched and used to perform various arithmetic operations. Beneficially, the technique allows analog sampled-data signal processing to be implemented within digital circuitry.

Abstract: Portable wireless devices are ubiquitous in modern society and many of these have integral sensors such as accelerometers, microphones, and Global Positioning Systems (GPS) that can collect data. This creates potential for intelligent applications to recognize the user, or aspects of the user and take appropriate action. According to embodiments of the invention there are presented techniques for representing such time series data which reduce the memory and computational complexity of performing the analysis and classifying the results. The techniques exploit time-delay embedding is to reconstruct the state and dynamics of an unknown dynamical system, Geometric Template Matching to build nonparametric classifiers, and algorithms to address the problem of selecting segments of data from which to build the time-delay models for classification problems.

Abstract: Low-Density Parity-Check (LDPC) codes offer error correction at rates approaching the link channel capacity and reliable and efficient information transfer over bandwidth or return-channel constrained links with data-corrupting noise present. LDPC codes also offer error correction performance approaching channel capacity exponentially fast in terms of the code length, linear processing complexity, and parallelism that scales with the code length. They also offer challenges relating to the decoding complexity of the binary error-correction codes themselves and error floors limiting achievable bit-error rates. A new Relaxed Half-Stochastic (RHS) decoding algorithm is presented that reduces decoding complexity for high decoding throughput applications. The RHS algorithm uses an approach based on stochastic decoding algorithms but differs significantly from the conventional approaches of LDPC decoder implementation.

Abstract: The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion.

Abstract: The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A11-A12-A13-Gly-Ser-A14-Phe-Leu-A15-A16-A17-A18 (SEQ ID NO: 93), wherein each of A11, A12, and A13 is independently absent, an amino acid, or an amino protecting group; each of A15, A16, A17, and A18 is independently absent or an amino acid; and A14 is a serine conjugated with a —(O)C1-C20alky or a diaminopropionic acid conjugated with a —C(O)C1-C20alkyl group, provided that at least one of A11, A12, or A13 is present.

Abstract: Stabilizing the visual system for any sighted mobile system increases immunity of the mobile system's gaze and reduces information processing task complexity. Two human reflexes are the optokinetic reflex and vestibulo-ocular reflex (VOR). The VOR stabilizes retinal images during head movement by producing eye movements in the opposite direction. Improved analysis of the VOR in humans would improve the diagnosis/treatment of patients, provide improvements in visual prosthesis performance for patients, and also vision systems performance for mobile robotic systems. However, an important issue for prior art mathematical analysis techniques is the requirement to classify the nystagmus segments before applying any analysis techniques, wherein this classification should be preferably performed non-subjectively. Accordingly the inventors overcome these limitations by performing classification, i.e.

Abstract: Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, such as Onaway, Russet Burbank, Purple Valley or Bora Valley cultivars. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.

Abstract: A scar reducing device for stretching skin having a closed wound therein is provided. The device is for reducing scar formation. The device comprises first and second fasteners removably attachable to skin regions located proximate to the wound. The device also comprises an extension mechanism cooperating with said first and second fasteners. The extension mechanism is movable between contracted and extended configurations. When the fasteners are affixed to the skin, the mechanism forces the first and second fasteners away from one another with a predetermined tensile force, stretching the skin proximate to the wound. Use of the device is also provided, along with a method for reducing scarring of a closed wound.

Abstract: Two dimensional (2D) optical spectroscopy, wherein the spectrum has an excitation and an emission axis, reveals information formerly hidden in one-dimensional (1D) optical spectroscopy. However, current two dimensional optical spectroscopy systems are complex laboratory arrangements and accordingly limited in deployment. According to embodiments of the invention a monolithic platform providing significantly reduced complexity and increased robustness is provided allowing for “black-box” modules allowing commercial deployment of 2D optical spectroscopy instruments. Additionally, the invention supports high pulse repetition rates as well as one quantum and two quantum measurements under electronic control.

Abstract: A method and a circuit are provided for providing phase or frequency synthesis using sigma-delta modulation bit-stream techniques in which data is encoded utilizing sigma-delta modulation and then digital-to-time conversion (DTC) or digital-to-frequency conversion (DFC). In some embodiments this encoded data stream is further subjected to phase or frequency domain filtering, which in some embodiments is carried out by a higher-order phase-locked loop (PLL).