Abstract: The present application is directed to the use of electrophoresis with UV detection in the determination of iodine nutritional status in human biological specimens, specifically for monitoring iodine deficiency/inadequacy in large-scale epidemiological studies. In particular, the present application is directed to a method for determining iodide and iodide uptake inhibitors in a human biological sample when using sample self-stacking with capillary electrophoresis and UV detection.

Abstract: Various embodiments are described herein for an extended-speed low-ripple torque control of a switched reluctance motor (SRM) using online torque sharing function (TSF). Two operational modes of an online TSF are defined during the commutation: In Mode I, absolute value of rate of change of flux linkage (ARCFL) of incoming phase is higher than outgoing phase; in Mode II, ARCFL of outgoing phase is higher than incoming phase. To compensate the torque error produced by imperfect tracking of phase current, a proportional and integral compensator with torque error is added to the torque reference of outgoing phase in Mode I and incoming phase in Mode II. Therefore, the total torque is determined by the phase with lower ARCFL rather than the phase with higher ARCFL as in conventional TSFs.

Abstract: The disclosure relates to a method of generating catalytic nucleic acid probes useful for detecting microorganisms such as bacterial pathogens. In one embodiment, the catalytic nucleic acid probes are fluorogenic DNAzymes. The disclosure also relates to catalytic nucleic acid probes and methods of using the probes for detecting microorganisms.

Abstract: A double-rotor switched reluctance machine includes a stator, a first rotor, and a second rotor. The stator and the first rotor operate as a first electric machine and the stator and the second rotor operate as a second electric machine. Each electric machine has an output torque profile that fluctuates periodically between a maximum and a minimum instantaneous torque. The double-rotor switched reluctance machine is configured so that when the first and second electric machines are operated at a common electrical frequency, the first and second maximum instantaneous torques are temporally offset, thereby reducing the overall torque ripple of the switched reluctance machine. Additionally, or alternatively, a double-rotor switched reluctance machine is configured so that the first and second rotors are radially offset from each other to reduce a net radial force imposed on the stator by the operation of the first and second electric machines.

Abstract: An artificial placenta oxygenating device for use with an infant is provided. The device comprises a first layer comprising a gas permeable membrane; and a second layer comprising a vascular network that permits circulation of fluid therethrough, wherein a portion of the gas permeable membrane is attached to and covers the vascular network, wherein the vascular network comprises an inlet that permits fluid flow into the vascular network and an outlet that permits fluid to flow out of the vascular network and wherein the inlet and outlet are positioned so that fluid flows through the vascular network and in contact with the gas permeable membrane to permit gas exchange to occur. Assemblies comprising a plurality of single artificial placenta devices is also provided.

Abstract: Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer.

Abstract: Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

Abstract: The present application discloses a biosensor that comprises a nucleic acid probe absorbed on reduced graphene oxide, the nucleic acid probe comprising an RCA primer sequence linked to a recognition moiety for an analyte to be detected by the biosensor.

Abstract: The present application provides circular templates that are high in adenine and cytosine and methods and uses thereof for rolling circle amplification (RCA). These templates are particularly suitable for biosensing applications involving RCA.

Abstract: The present application is directed to methods of performing chemical reactions, including multi-step chemical reactions in which two or more of the reagents in the chemical reaction are incorporated or entrapped in a solid polymeric structure comprising pullulan. In certain embodiments, the chemical reaction or multi-step reaction serves as a sensor. Accordingly the present application is also directed to sensors for performing the methods of the application. In certain embodiments, at least one of the reagents is a biomolecule and the sensor is a biosensor. In certain other embodiments, the solid polymeric structure comprising pullulan and the reagents for performing a chemical reaction form a convenient device for performing a chemical reaction.

Abstract: The present application relates to biosensors, for example comprising an high-molecular weight, tandem repeating, structure-switching nucleic acid aptamers (concatemeric aptamers) to rapidly create patterned sensors via, for example, inkjet printing. These concatemeric aptamer reporters remain immobilized at the point of printing through strong adsorption but retain sufficient segmental mobility to undergo structure switching and reporter signalling to provide both qualitative and quantitative detection of one or more analytes. In certain embodiments, inkjet printing allows for the patterning of internally referenced sensors with multiplexed detection, and provides a generic platform for on-demand printing of sensors even in remote locations.

Abstract: Unbonded fiber reinforced elastomeric isolators (FREIs) have desirable characteristics for seismic isolation, but the unbonded application also introduces several design limitations in comparison to bonded elastomeric isolators. Unbonded FREIs are not capable of resisting tensile forces, making this type of isolator inappropriate for situation where overturning is of concern or regions where large vertical accelerations are anticipated. Furthermore, since unbonded FREIs rely on friction to transfer horizontal forces, permanent slip could occur. Concerns over both transfer of tensile forces and permanent displacement can be obviated by partially bonding the FREI to the supports. In this way, partially bonded FREIs (PB-FREIs) retain the beneficial characteristics of an unbonded FREI, but also demonstrate characteristics of a bonded isolator, notably tensile forces can be transferred and potential permanent displacement is inhibited.

Abstract: A powertrain system for a vehicle is provided. The powertrain system includes an internal combustion engine, a first gearset connected to the internal combustion engine, a first electric machine connected to the first gearset, a drivetrain gear for connection to a drivetrain of the vehicle, a second gearset connecting the first gearset to the drivetrain gear, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the first electric machine, the first gearset, and the second gearset. In a first mode of operation, the at least one dynamic clutch couples the second electric machine and the first electric machine. In a second mode of operation, the at least one dynamic clutch couples the second electric machine and the first gearset. In a third mode of operation, the at least one dynamic clutch couples the second electric machine and the second gearset.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: Technologies and implementations for de-interlacing an interlaced digital video and up-converting a frame rate of a digital video are generally disclosed.

Abstract: The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor cells, without traversing the pluripotent state. Also provided is a method of isolating a subpopulation of fibroblasts with reprogramming potential comprising providing fibroblasts that express an Oct-4-reporter and isolating cells that are positive for the reporter. Further provided is a method of generating reprogrammed fibroblast-derived induced pluripotent stem cells. Also provided are uses and assays of the cells produced by the methods of the disclosure.

Abstract: An electrified vehicle and method for estimating peak power of a battery system of the electrified vehicle are presented. In one exemplary implementation, the method includes receiving, at a controller of the electrified vehicle, measured current, voltage, and temperature of the battery system and determining, at the controller, operating parameters for the battery system based on the measured current, voltage, and temperature. An initial peak current at a start of a current prediction period for the battery system is determined, at the controller, based on the operating parameters, and an instantaneous peak current of the battery system is determined based on its initial peak current by performing voltage-limited extrapolation of resistances and open-circuit voltage (VLERO) of a battery model for the battery system. The battery system and an electric motor of the electrified vehicle are controlled, by the controller, based on the instantaneous peak current.

Abstract: Technologies and implementations for de-interlacing an interlaced digital video and up-converting a frame rate of a digital video are generally disclosed.

Abstract: A thin layer substrate has a plurality of micron sized electrically conductive whisker components which are arranged in parallel and extending from one surface of the substrate to another surface to provide electrically conductive paths through the substrate. Such a substrate may be usable for micron sized LEDs.

Abstract: A double-rotor switched reluctance machine includes a stator, a first rotor, and a second rotor. The stator and the first rotor operate as a first electric machine and the stator and the second rotor operate as a second electric machine. Each electric machine has an output torque profile that fluctuates periodically between a maximum and a minimum instantaneous torque. The double-rotor switched reluctance machine is configured so that when the first and second electric machines are operated at a common electrical frequency, the first and second maximum instantaneous torques are temporally offset, thereby reducing the overall torque ripple of the switched reluctance machine. Additionally, or alternatively, a double-rotor switched reluctance machine is configured so that the first and second rotors are radially offset from each other to reduce a net radial force imposed on the stator by the operation of the first and second electric machines.