Abstract: A computerized information processing method for evaluating blood vessels is provided. The method includes acquiring a series of sequences of measurements, each at different time points in at least one cardiac cycle and at a different point along a blood vessel segment of a subject, generating corresponding profiles, calculating a transfer function for a subsegment between two selected points along a blood flow direction, and based thereon determining the physiological property of the subsegment. The measurements can contain information of blood velocity or blood pressure. A processing device and system implementing the information processing method are also provided. This approach can be used to evaluate arteries or veins and can be applied in screening, diagnosis, or prognosis of a variety of vascular diseases. For example, when combined with MRI scan, this approach can be used for non-invasively diagnosing pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), etc.

Abstract: A binocular device for visualizing optical radiation comprises a support structure, a left camera, and a right camera coupled to the support structure. The left camera comprising left optics and a left image sensor, the right camera comprising right optics and a right image sensor, the left image sensor and the right image sensor being configured to create left and right video signals from detected optical radiation received from the corresponding left and right input optics about a same field of view along respective left and right input optical axes. A specular reflection is detected.

Abstract: Methods and devices for treating erectile dysfunction are disclosed. Methods are aimed at reducing blood outflow from penile tissue by delivering energy to specific penile tissue that controls blood outflow from the penile tissue and causing remodeling of the specific penile tissue. Devices may be configured to generate RF energy and to apply the generated RF energy to a penis to thereby elevate a temperature of internal penile tissue above a predetermined temperature value while maintaining a penile surface below a predetermined temperature threshold. The predetermined temperature value may be set to initiate synthesis and/or a regeneration of collagen fibers in a collagen-rich penile connective tissue and/or to increase oxygenation of endothelial cells, initiate angiogenesis and neovascularization in a vascular penile tissue. Additionally, electrical penile stimulation is disclosed, possibly applicable in conjuncture with the erectile dysfunction treatment.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. The lateral span/cross-sectional area of the marker is configured to change when transitioning between the insertion orientation and the anchored orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: The present invention relates to an inhibitory peptide capable of disrupting a Heparanase/Tissue Factor complex. The invention further provides methods and kits for determining heparanase procoagulant activity in a biological sample. The invention also relates to diagnostic methods for the detection and/or monitoring of a coagulation-related pathologic disorder in a mammalian subject. The invention further relates to compositions comprising heparanase and at least one tissue factor, uses and methods based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions. The invention still further relates to methods for screening a coagulation modulatory compound, methods and uses based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions.

Abstract: Abdominal closure reinforcement methods and tissue anchoring devices for reducing the rate of abdominal wall closure dehiscence are described. The tissue anchors avoid a permanent footprint of foreign material and precluding materials spanning the interior layer of the abdominal closure where risk to visceral structures exists.

Abstract: An implantable medical device includes an implantable coil case that contains a communications coil. A magnet receptacle is located within the coil case at the radial center and has a magnet opening in one of the lateral surface or the medial surface of the coil case. A magnet fitting groove is recessed into one of the lateral or medial surface of the coil case and extends from the magnet opening to the outer circumference of the coil case. A u-shaped implant magnet clip has parallel clip legs that are connected at a closed end of the u-shape, and an implant magnet is attached to one of the clip legs. The coil case and the magnet clip are configured to cooperate for a portion of the coil case to fit between the clip legs and the implant magnet to slide through the magnet fitting groove and fit through the magnet opening into the magnet receptacle.

Abstract: A bilateral hearing implant system has a left side and a right side. Left and right side filter bank pre-processors preprocess left and right microphone signals to generate band pass signals for each side. A bilateral signal processing arrangement processes the band pass signals in a time sequence of stimulation frames. The signal processing module includes a bilateral channel selection module synchronously selects for each stimulation frame a set of stimulation channels for each side based on spectral content of the band pass signals. Left and right side signal processing submodules process for each stimulation frame a limited subset of each side band pass signals corresponding to the selected stimulation channels to generate electrical stimulation signals.

Abstract: A middle ear implant system includes a bone conduction transducer configured for fixed attachment to skull bone of a patient beneath the skin behind the ear, and for generating sound vibrations from an external communications signal received through the skin for coupling to the skull bone for bone conduction sound perception by the patient. A malleable ossicle connector is connected to the bone conduction transducer and a middle ear hearing structure of the patient. And one or more isolation springs are configured for placement at the fixed attachment of the bone conduction transducer to the skull bone to acoustically decouple the bone conduction transducer from the skull bone to avoid bone conduction sound perception so that sound perception from the external communications signal is solely via the middle ear sound perception from vibrations coupled to the middle ear hearing structure by the ossicle connector.

Abstract: Provided is an infusion system including: a liquid container that accommodates a blood derivative; a heating device that heats the blood derivative; an air bubble removal chamber that removes air bubbles in the blood derivative; a first flow path that connects the liquid container and the heating device to each other; a second flow path that connects the heating device and the air bubble removal chamber to each other; a third flow path that connects the air bubble removal chamber and an infusion unit to each other; a fourth flow path that connects the air bubble removal chamber and the liquid container to each other; a first pump provided in the first flow path; and a second pump provided in the third flow path. The heating device has a heating flow path where the blood derivative flows and a heat supply body that contacts the heating flow path.

Abstract: A coating for an expandable portion of a catheter comprising a lipophilic matrix and a plurality of micro-reservoirs dispersed in the lipophilic matrix is disclosed. The plurality of micro-reservoirs comprises an active agent. A coating formulation and a method for forming the coating are also disclosed. A catheter comprising the coating on the expandable portion and a method for treating a condition are also provided.

Abstract: A respiration sensor is described of a respiration implant system for an implanted patient with impaired breathing. A sensor body is made of electrically insulating material and is configured to fit between two adjacent ribs and between the pectoralis muscle and the parasternal muscle of the implanted patient, with the bottom surface adjacent to an superficial surface of the parasternal muscle and the top surface adjacent to a profound surface of the pectoralis muscle. At least one parasternal sensor electrode is located on the bottom surface of the sensor body and is configured to cooperate with the electrically insulating material of the sensor body to sense a parasternal electromyography (EMG) signal representing electrical activity of the adjacent parasternal muscle with minimal influence by electrical activity of the nearby pectoralis muscle.

Abstract: Provided is a precision variable flow rate infusion system and method for delivering a liquid from a reservoir having an initial potential outflow rate to a patient. The system includes at least a first flexible flow rate tubing having a pre-defined flow rate selected at a maximum dosage flow rate for the liquid from the reservoir, the pre-defined flow rate being less than the initial potential outflow rate of the reservoir. Also provided is an adjustable flow rate controller having an inlet and an outlet, at least one internal fluid pathway there between and a fluid pathway modifier structured and arranged to modify the internal fluid pathway from the inlet to the outlet from a closed pathway to a maximum flow pathway with a plurality of different flow rate pathways there between.

Abstract: This application concerns a retractor device for breast reconstruction surgery. Specifically, the present patent application relates to a retractor type medical device which entails the effective exposure and visibility of the breast pocket and, at the same time, does not compromise the integrity of the subcutaneous flap, resulting in a positive outcome of the breast reconstruction procedure generally, but not exclusively, performed using a prepectoral (or sub-cutaneous) acellular biological matrix.

Abstract: A method of enhancing distorted signal having a speech and noise component, with a processing device having memory with stored training information T, comprising a step of removing noise in spectrum domain according to a noise and speech model to obtain a clear signal spectrum, wherein the training information T comprises dictionaries of compact spectra prototypes of speech and noise, speech gains and noise gains forming together composite states and it comprises probabilities of state history. Dictionaries of compact spectra prototypes comprise compact spectra prototypes of a first dimension P1 and of a second dimension P2 where second dimension P2 is higher or equal to the first dimension P1.

Abstract: Methods enabling prediction, screening, early diagnosis, and recommended intervention or treatment selection of autoimmune conditions using artificial intelligence operating in conjunction with large medical datasets. Logic is applied to historic population data to extract medical features and identify subjects with diagnosed autoimmune conditions, and the pre-diagnosis medical data is used to train a diagnosis classification algorithm. A self-supervised learning mechanism is separately used to generate a feature embedding transformation of the patients medical history into representational feature vectors. These patient feature vectors together with their expected diagnoses are used to train a multi-label classifier model using supervised learning. The embedding transformation and the multi-label classifier are then applied to a current subjects data to generate a patient diagnosis probability vector, predicting the existence of autoimmune conditions.