Abstract: The invention relates to a process for preparing compounds of the formula I
In this process a 2-aminobenzothiophene-3-carboxylic ester of the formula II
is reacted with a nitrile of the formula III
N≡C—R1 III
in solution or suspension in a solvent in the presence of an acid.
Type:
Grant
Filed:
October 21, 2002
Date of Patent:
February 10, 2004
Assignee:
Merck Patent GmbH
Inventors:
Horst Juraszyk, Peter Wendel, Markus Woissyk
Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it comprises one or more compounds of the general formula I
in which R, A1, Z1, Y and L are as defined in claim 1.
Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
Type:
Grant
Filed:
November 7, 2001
Date of Patent:
February 3, 2004
Assignee:
Merck Patent GmbH
Inventors:
Herwig Buchholz, Ralf Anselmann, Hansjuergen Driller, Michael Kirschbaum, Frank Pflücker
Abstract: The present invention relates to a novel process for removing sidewall residue after dry-etching process. Conventionally, after dry-etching, photoresist and sidewall residues are removed by ozone ashing and hot sulfuric acid. Normally, they are hard to be removed completely. It was found in the present invention that the addition of fluorine-containing compound, preferably hydrogen fluoride and ammonium fluoride, in sulfuric acid results in complete removal of photoresist and sidewall residue without the need for stripper. The process is simple and does not affect the original procedures or the other films on the substrate. The present invention also relates to a novel solution for removing sidewall residue after dry-etching, which comprises sulfuric acid and a fluorine-containing compound, preferably hydrogen fluoride and ammonium fluoride, in the range of from 10:1 to 1000:1 by weight.
Type:
Application
Filed:
July 17, 2003
Publication date:
January 29, 2004
Applicant:
Merck Patent GmbH
Inventors:
Ming-Chi Liaw, Tieng-Sheng Chao, Tan-Fu Lei
Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I 1
Type:
Application
Filed:
May 27, 2003
Publication date:
January 29, 2004
Applicant:
Merck Patent GmbH
Inventors:
Michael Heckmeier, Brigitte Schuler, Izumi Saito, Volker Reiffenrath, Georg Luessem, Christian Hock
Abstract: The invention relates to a pharmaceutical preparation [lacuna] cyclo(Arg-Gly-Asp-D-Phe-NMe-Val) and/or one of its physiologically acceptable salts and at least one chemotherapeutic agent and/or one of its physiologically acceptable salts and/or an angiogenesis inhibitor and/or one of its physiologically acceptable salts.
Type:
Grant
Filed:
June 4, 2001
Date of Patent:
January 27, 2004
Assignee:
Merck Patent GmbH
Inventors:
Alfred Jonczyk, Astrid Perschl, Simon Goodman, Sigrid Rösener, Jutta Haunschild
Abstract: The invention relates to a method for recovering high-purity isoquerectin from bioflavonoid pastes, that is from mother-liquor residues which are produced during the recovery of flavonoids, by extraction with a solvent mixture of methyl acetate and water.
Type:
Grant
Filed:
May 10, 2002
Date of Patent:
January 27, 2004
Assignee:
Merck Patent GmbH
Inventors:
Herwig Buchholz, Michael Jungnitz, Michael Grund, Ralf Rosskopf, Hartmut Härtner
Abstract: The present invention relates to the colored inscription or marking of plastics and surface coatings, including powder coatings, in which a colorant is transferred into the plastic or surface coating by laser radiation with the aid of a laser light-absorbent substance.
Abstract: The present invention relates to a liquid-crystalline medium based on a mixture of compounds of negative dielectric anisotropy comprising one or more polymerizable compounds, and to the use thereof for electro-optical purposes, and to displays containing this medium.
Abstract: The present invention relates to a novel supply system for chemicals which permits the preparation of solid-containing suspensions, which are required, inter alia, for polishing wafers or in semiconductor production, directly at the point of use.
Type:
Grant
Filed:
February 27, 2001
Date of Patent:
January 20, 2004
Assignee:
Merck Patent GmbH
Inventors:
Ulrich Finkenzeller, Claus Dusemund, Thomas Schwortschik
Abstract: The invention relates to polymer beads comprising an anisotropic polymer material with helically twisted structure, to their use in reflective films, spraying or printing inks or as pigments, for optical or electrooptical, decorative or security applications, to a reflective film comprising one or more polymer beads in a transmissive binder, and to a security marking or security device comprising one or more polymer beads or comprising a reflective film.
Type:
Grant
Filed:
September 18, 2001
Date of Patent:
January 13, 2004
Assignee:
Merck Patent GmbH
Inventors:
Matthias Kuntz, David Coates, Simon Greenfield, John Patrick
Abstract: An Oxide Precursor Powder from the Pb—Bi—Sr—Ca—Cu—O 2223 System can be produced by heat treating powder, produced using the Spray Pyrolysis Process as described in: GB2210605 or EP0681989 between 700° C. and 850° C. in an atmosphere containing between 0.1% and 21% O2. Heat Treatment of the pyrolysis powder under controlled conditions produces a powder with a particular phase composition, that is highly homogeneous and has a small particle size distribution, that is inherently more reactive than powders heat treated in the same way but produced using other processes.
Type:
Grant
Filed:
June 6, 2002
Date of Patent:
January 13, 2004
Assignee:
Merck Patent GmbH
Inventors:
Lee Woodall, Ru-Shi Liu, Ya-Wei Hsueh, Wolfgang Wilhelm Schmahl, Sebastian Raeth
Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
Type:
Application
Filed:
March 17, 2003
Publication date:
January 8, 2004
Applicant:
Merck Patent GmbH
Inventors:
Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
Type:
Grant
Filed:
November 7, 2001
Date of Patent:
January 6, 2004
Assignee:
Merck Patent, GmbH
Inventors:
Herwig Buchholz, Eike Poetsch, Ralf Rosskopf, Ralf Anselmann, Michael Kirschbaum, Frank Pflücker
Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterised in that it comprises one or more ester compounds of the formula I 1
Abstract: The invention describes a wet-chemical process for the preparation of alpha- and beta-tricalcium phosphate (TCP) powders. The procedure simply comprises immediate addition of di-ammonium hydrogen phosphate to an aqueous solution of calcium nitrate tetrahydrate, or vice versa. Calcination of the recovered precursor powders at 800° C. in air produces beta-TCP, whereas the calcination of the same at 1200° C., followed by rapid cooling to room temperature yields submicron-particulated alpha-TCP powders. These powders can be the raw materials for bioceramics, such as artificial bones, artificial joints, artificial tooth roots, and calcium phosphate-based self-setting, self-hardening cements.
Abstract: The invention relates to galenic formulations which contain a) one or more compounds selected from biotin, its physiologically compatible salts, biotin esters and the steroisomeric forms of these compounds; and b) one or more compounds selected from urea and urea derivatives. The above formulations are suitable for use as topically administered formulations for the cosmetic and/or medical treatment of the skin, hair and/or nails.
Type:
Grant
Filed:
July 27, 2001
Date of Patent:
December 9, 2003
Assignee:
Merck Patent GmbH
Inventors:
Joachim Bünger, Hansjürgen Driller, Wolfgang Wohlrab, Lothar Motitschke, Christoph Huschka, Reinhard Neubert