Patents Assigned to Merck Patent GmbH
  • Use of ectoine or ectoine derivatives in cosmetic formulations
    Patent number: 6602514
    Abstract: The use of one or more compounds chosen from the compounds of the formulae Ia and Ib the physiologically compatible salts of the compounds of the formulae Ia and Ib and the stereoisomeric forms of the compounds of the formulae Ia and Ib, where R1, R2, R3, R4 and n have the meanings given in claim 1, for the preparation of a cosmetic formulation is advantageously suitable, e.g., for protecting cells, proteins and/or biomembranes of the human skin, for protecting the microflora of the human skin, and/or for stabilizing the skin barrier.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: August 5, 2003
    Assignee: Merck Patent GmbH
    Inventors: Joachim Bünger, Hans-Jürgen Driller, Roland Martin
  • Film
    Patent number: 6599443
    Abstract: The invention relates to an optical retardation film comprising a layer of an anisotropic polymer material with an optical axis substantially parallel to the plane of the layer. The invention furthermore relates to a process of preparing the optical retardation film, to the use of such an optical retardation film in liquid crystal displays, and to a liquid crystal display device comprising a liquid crystal cell and such an optical retardation film.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: July 29, 2003
    Assignees: Rockwell Technologies, LLC, Merck Patent GmbH
    Inventors: Nicholas Sharples, Gabrielle Egan, Young Chung, Zhiming Zhuang, Zili Li, Bruce K. Winker, Jane H. Hanamoto, David Coates
  • Method of establishing synthesis paths
    Patent number: 6600970
    Abstract: A method of establishing a synthesis path in a multiplicity of potentially interlinakable reactions, and a computer program to prepare a synthesis path.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: July 29, 2003
    Assignee: Merck Patent GmbH
    Inventor: Klemens Bley
  • Interference pigments with great color strength
    Patent number: 6599355
    Abstract: The invention relates to interference pigments with a great color strength that are based on multicoated platelet-shaped substrates that have at least one series of layers from (A) a highly refractive coating that consists of a mixture of TiO2 and Fe2O3 in ratio of 1:0.1 to 1:5 and optionally one or more metal oxides in amounts of ≦20% by weight based on layer (A), (B) a colorless coating with a refractive index n≦1.8, (C) a colorless coating with a refractive index of n 1.8, (D) an absorptive coating with a refractive index of n 1.8, and optionally (E) an outer protective layer.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: July 29, 2003
    Assignee: Merck Patent GmbH
    Inventors: Christoph Schmidt, Klaus Bernhardt, Sabine Schoen, Dieter Heinz
  • Electrooptical liquid crystal system
    Patent number: 6596193
    Abstract: To improve switching times, especially at low temperatures, one or more reactive liquid crystalline compounds is added to a liquid crystal mixture used in an electrooptical system. The electrooptical system comprises a PDLC film comprising a liquid crystal mixture forming micro- droplets in an optically isotropic, transparent polymer matrix between 2 electrode layers. The reactive liquid crystalline compounds are of formula II, R′—G′—R″, wherein R′, G′ and R″ are as defined herein. The liquid crystal mixture comprises one or more compounds of the formula I wherein R, A1, A2, Z1, Z2, X1, X2, Q, Y and n are as defined herein.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: July 22, 2003
    Assignee: Merck Patent GmbH
    Inventors: David Coates, Owain Llyr Parri, Simon Greenfield, Martin David Tillin, Mark John Goulding, Patrick Nolan
  • Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process
    Patent number: 6596758
    Abstract: The present invention relates to benzopyrans and benzoxepines of formula (I), wherein X, A, R1, R2 and (R)p have the meanings as given in claim 1, which can be used in the treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: July 22, 2003
    Assignee: Merck Patent GmbH
    Inventors: Michel Brunet, Jean-Jaques Zeiller, Jean-Jaques Berthelon, Francis Contard, Guy Augert, Daniel Guerrier
  • Method of purifying thiamine phosphates
    Patent number: 6596865
    Abstract: The invention relates to a method for removing phosphoric acid, thiamine triphosphate and higher thiamine phosphates from solutions that contain phosphoric acid, thiamine monophosphate, thiamine diphosphate, diamine triphosphate and higher phosphates. The inventive method is characterized by passing the phosphoric acid solution of thiamine phosphates over a non-ionogenic adsorber resin which comprises unsaturated cyclic nitrogen bases and eluting thiamine monophosphate and thiamine diphosphate with a suitable solvent.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: July 22, 2003
    Assignee: Merck Patent GmbH
    Inventors: Holger Krummradt, Klaus Beschmann, Frank-Hardi Wartenberg, Horst Diekmann
  • Liquid-crystalline mixtures
    Publication number: 20030127629
    Abstract: A liquid-crystalline mixture that contains one or more compounds of each of the formulae IA, IB and IC 1
    Type: Application
    Filed: July 26, 2002
    Publication date: July 10, 2003
    Applicant: Merck Patent GmbH
    Inventors: Harald Hirschmann, Volker Reiffenrath, Marcus Reuter, Sabine Schoen, Sven Schupfer, Clarissa Weller
  • Polymer-based material comprising silica particles
    Publication number: 20030129257
    Abstract: The invention describes a process for the preparation of a polymer-based material consisting of a polyolefin matrix and silica particles as filling material, in which the silica particles are incorporated during the polymerization process. In addition, the uses of a polymer-based material for the production of joint implants in the medicotechnical area and also the use for the production of sliding bearings, gearwheels and other applications in the industrial sector are described. The invention furthermore describes an artificial joint of a prosthesis in which the joint partners consist of metallic, polymeric and/or ceramic materials, with at least one of the joint partners consisting of a polymeric material made from polyolefins with addition of from 1 to 50% by weight of SiO2.
    Type: Application
    Filed: December 9, 2002
    Publication date: July 10, 2003
    Applicant: Merck Patent GmbH
    Inventors: Berthold Nies, Matthias Koch, Holger Winkler
  • Process for the preparation of ss-mannitol for direct compression
    Publication number: 20030114717
    Abstract: The present invention relates to a process for the preparation of mannitol for direct compression having a content of the &bgr;-modification of greater than 90%.
    Type: Application
    Filed: December 12, 2002
    Publication date: June 19, 2003
    Applicant: Merck Patent GmbH
    Inventors: Martin Erdmann, Walter Hamm
  • &bgr;-alanine derivatives
    Patent number: 6576637
    Abstract: The invention relates to &bgr;-alanine derivatives of formula (I), wherein Q1, Q2, Q3, Q4, R1, R2, R3, R4, R5, R6 and n have the meaning as disclosed in the disclosure, and to their physiologically acceptable salts or solvates. Said substances are integrin inhibitors and can be used in the treatment of thrombosis, heart infarct, coronary heart diseases, arteriosclerosis, inflammations, tumors, osteoporosis, infections and restenosis after angioplasty or in pathological processes induced or propagated by angiogenesis.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: June 10, 2003
    Assignee: Merck Patent GmbH
    Inventors: Günter Hölzemann, Simon Goodmann, Alfred Jonczyk, Wolfgang Stähle
  • TN and STN liquid-crystal displays
    Publication number: 20030104143
    Abstract: The invention relates to TN and STN liquid-crystal displays and to the novel nematic liquid-crystal mixtures used therein, characterized in that they comprise one or more compounds of the formula I 1
    Type: Application
    Filed: June 27, 2002
    Publication date: June 5, 2003
    Applicant: Merck Patent GmbH
    Inventor: Juliane Suermann
  • Anisotrpic polymer film
    Publication number: 20030104144
    Abstract: An anisotropic polymer film comprising a polymerised chiral liquid crystal material with helically twisted structure and having areas with different helical twist sense is useful for decorative or security applications.
    Type: Application
    Filed: September 24, 2002
    Publication date: June 5, 2003
    Applicant: Merck Patent GmbH
    Inventors: Robert Hammond-Smith, John Patrick, Alison Linda May
  • Purification of battery electrolytes by means of chemical adsorption
    Patent number: 6573002
    Abstract: The present invention relates to the removal of protic impurities from battery electrolytes which are suitable for lithium cells by chemical adsorption.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: June 3, 2003
    Assignee: Merck Patent GmbH
    Inventors: Michael Jungnitz, Holger Wiederhold
  • Method for producing ortho-alkylated benzoic acid derivatives
    Patent number: 6573404
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I characterized in that an aryl bromide of the formula II is reacted with a secondary or tertiary organolithium compound and CO2.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: June 3, 2003
    Assignee: Merck Patent GmbH
    Inventors: Ekkehard Bartmann, Ingeborg Stein
  • New substituted 2,4-thiazolidinedione derivatives, processes for producing them and pharmaceutical compositions containing them
    Publication number: 20030100587
    Abstract: The present invention generally relates to a process for producing Compounds of formula I: 1
    Type: Application
    Filed: June 27, 2002
    Publication date: May 29, 2003
    Applicant: Merck Patent GmbH.
    Inventors: Gerard Moinet, Gerard Botton, Etienne Prugnard, Liliane Doare, Micheline Kergoat, Didier Mesangeau
  • Coloured interference pigments
    Publication number: 20030097965
    Abstract: The present invention relates to coloured interference pigments based on multicoated, platelet-shaped substrates, which are distinguished in that they comprise
    Type: Application
    Filed: October 24, 2002
    Publication date: May 29, 2003
    Applicant: Merck Patent GmbH
    Inventors: Lilia Heider, Manuela Loch, Nicole Schupp, Helge Kniess
  • Liquid crystalline medium
    Publication number: 20030098443
    Abstract: The invention relates to a liquid-crystalline medium with positive dielectric anisotropy and high optical anisotropy, characterized in that it contains one or more biphenyl derivatives comprising a terminal alkenyl group, and its use in electrooptical displays and projection systems, in particular reflective displays and displays based on a birefringence effect, such as OCB displays.
    Type: Application
    Filed: June 26, 2002
    Publication date: May 29, 2003
    Applicant: Merck Patent GmbH
    Inventors: Atsutaka Manabe, Volker Reiffenrath
  • Electrooptical liquid crystal system
    Patent number: 6565769
    Abstract: To improve switching times, especially at low temperatures, one or more reactive liquid crystalline compounds is added to a liquid crystal mixture used in an electrooptical system. The electrooptical system comprises a PDLC film comprising a liquid crystal mixture forming micro- droplets in an optically isotropic, transparent polymer matrix between 2 electrode layers, one of the refractive indices of the liquid crystal mixture is matched to the refractive index of the polymer matrix, the PDLC film exhibits an electrically switching transparency essentially independent of the polarization of the incident light, the precursor of the PDLC film comprises one or more monomers, oligomers and/or prepolymers and a photoinitiator, and is cured photoradically, the liquid crystal mixture comprises one or more compounds of the formula I  wherein R, A1, A2, Z1, Z2, X1, X2, Q, Y and n are as defined herein.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: May 20, 2003
    Assignee: Merck Patent GmbH
    Inventors: David Coates, Owain Llyr Parri, Simon Greenfield, Martin David Tillin, Mark John Goulding, Patrick Nolan
  • Liquid-crystalline medium
    Patent number: 6565933
    Abstract: Liquid-crystalline mediums based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that they comprise one or more compounds of the general formula I in which R, A1, Z1, Y and L are as defined herein, are suitable for use in MLC, TN and STN displays.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: May 20, 2003
    Assignee: Merck Patent GmbH
    Inventors: Kazuaki Tarumi, Brigitte Schuler, Eike Poetsch, Volker Reiffenrath, Yukiomi Tanaka