Patents Assigned to Merck Patent GmbH
  • Composition comprising nanosized light emitting material
    Patent number: 11814560
    Abstract: The present invention relates to a composition comprising at least one nanosized light emitting material and at least compound represented by the following general formula (1) or (2), wherein Z is P, As or Sb and R1, R2, R3, R4, R5 and R6 are, identically or differently, selected from alkyl groups, aryl groups, heteroaryl groups, aralkyl groups, heteroaralkyl groups, alkaryl groups and alkheteroaryl groups,
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: November 14, 2023
    Assignee: Merck Patent GmbH
    Inventor: Sanaa Khalil
  • Method for producing fluorinated compounds
    Patent number: 11814347
    Abstract: The present invention relates to a process for the preparation of fluorinated compounds, to novel compounds containing fluorinated end groups, to the use thereof and to compositions comprising novel compounds containing fluorinated end groups.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: November 14, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Reiner Friedrich, Fabian Koch
  • Polypeptides binding ADAMTS5, MMP13 and aggrecan
    Patent number: 11813307
    Abstract: The present invention relates to polypeptides binding Aggrecan as well as ADAMTS5 and/or MMP13, more in particular to polypeptides that comprise or essentially consist of immunoglobulins binding Aggrecan as well as immunoglobulins binding ADAMTS5 and/or immunoglobulins binding MMP13 (also referred to herein as “polypeptides of the invention”, and “immunoglobulin(s) of the invention”, respectively).
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: November 14, 2023
    Assignees: MERCK PATENT GMBH, ABLYNX NV
    Inventors: Soren Steffensen, Gerald Beste, Hans Guehring, Lars Toleikis, Christoph Ladel, Sven Lindemann, Roland Kellner, Ralf Guenther
  • LIQUID-CRYSTAL MEDIUM
    Publication number: 20230357637
    Abstract: A liquid crystal medium containing a) one or more compounds of formula I b) one or more compounds of the formula IIBa and c) one or more compounds of the formula IIDa and the use thereof for optical, electro-optical and/or electronic purposes, in particular in LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Application
    Filed: May 4, 2023
    Publication date: November 9, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Harald HIRSCHMANN, Sabine SCHOEN
  • Method for producing ultrapure water
    Patent number: 11807556
    Abstract: The present invention relates to a method for producing purified water comprising a step (a) of passing water through a mixed bed ion exchanger comprising beads having a diameter between 0.2 and 0.7 mm and a step (b) of passing water through a fibrous ion-exchange material. The invention further relates to a module comprising the mixed bed ion exchange resin and the fibrous material and to a water treatment system for producing ultrapure water comprising the mixed bed ion exchange resin and the fibrous material.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: November 7, 2023
    Assignee: Merck Patent GmbH
    Inventors: Ichiro Kano, Gabriela Dima, Julien Gross, Yann Ratieuville
  • LMP7-SELECTIVE INHIBITORS FOR THE TREATMENT OF BLOOD DISORDERS AND SOLID TUMORS
    Publication number: 20230346815
    Abstract: Alpha-amino boronic acid derivatives are useful for selectively inhibiting the activity of immunoproteasome subunit LMP7 and for the treatment of medical conditions affected by immunoproteasome activity such as blood disorders and solid tumors, which are defined by specific genetic alterations and/or inadequate responsiveness to other therapeutic treatments. In particular, the compounds disclosed herein are selective LMP7 inhibitors, which may be useful alone or in combination for the treatment of blood disorders, such as multiple myeloma, and certain solid tumors.
    Type: Application
    Filed: October 5, 2021
    Publication date: November 2, 2023
    Applicant: Merck Patent GmbH
    Inventors: Christina ESDAR, Manja FRIESE-HAMIM, Michael SANDERSON, Gina WALTER-BAUSCH
  • Liquid-crystal medium
    Patent number: 11802243
    Abstract: A liquid-crystal (LC) media having a negative dielectric anisotropy containing a compound of formula I and the use of the LC media for optical, electro-optical and electronic purposes, in particular in energy-efficient LC displays, especially in IPS, FFS, VA or PS-VA displays.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: October 31, 2023
    Assignee: Merck Patent GmbH
    Inventors: Jing Wang, Ping Zhao, Chang-Suk Choi
  • POLYMERIZABLE LIQUID CRYSTAL MATERIAL AND POLYMERIZED LIQUID CRYSTAL FILM
    Publication number: 20230340329
    Abstract: The invention relates to a polymerizable LC material comprising one or more reactive mesogenic compounds, one or more chiral compounds and one or more compounds of formula I, wherein the individual radicals have one of the meaning as given in the claims. Furthermore, the present invention relates also to a method for its preparation, a polymer film with improved thermal and UV stability obtainable from a corresponding polymerizable LC material, to a method of preparation of such polymer film, and to the use of such polymer film and said polymerizable LC material in optical, electro-optical, decorative or security devices.
    Type: Application
    Filed: September 23, 2021
    Publication date: October 26, 2023
    Applicant: Merck Patent GmbH
    Inventors: Stephen MULCAHY, Owain Llyr PARRI, Sarabjot KAUR
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20230340328
    Abstract: A liquid-crystalline (LC) media having positive dielectric anisotropy and tliquid-crystal displays (LCDs) containing these media, especially to displays addressed by an active matrix and in particular to energy efficient LC displays of the TN, PS-TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, HB-FFS, XB-FFS, PS-FFS, SA-HB-FFS, SA-XB-FFS, polymer stabilised SA-HB-FFS, polymer stabilised SA-XB-FFS, positive VA or positive PS-VA type.
    Type: Application
    Filed: March 20, 2023
    Publication date: October 26, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Sven Christian LAUT, Hee-Kyu LEE, Jing WANG
  • COMBINED INHIBITION OF PD-1, TGFB AND TIGIT FOR THE TREATMENT OF CANCER
    Publication number: 20230340122
    Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF? inhibitor, and a TIGIT inhibitor to treat cancer.
    Type: Application
    Filed: November 5, 2020
    Publication date: October 26, 2023
    Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 4) LTD., MERCK PATENT GmbH
    Inventors: Chunxiao XU, Feng JIANG, Dong ZHANG
  • SYSTEM FOR TREATING A BIOTECHNOLOGICAL FLUID
    Publication number: 20230340395
    Abstract: The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network
    Type: Application
    Filed: August 19, 2021
    Publication date: October 26, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Rene REINBIGLER, Denis DUBRET, Steven MILLER
  • METAL EFFECT PIGMENT-FREE RADAR-COMPATIBLE COATING ON A SUBSTRATE
    Publication number: 20230340282
    Abstract: The present invention relates to a metal effect pigment-free radar-compatible coating on a substrate, to a process for the production of such a coating, and to the use of such a coating, in particular in vehicle construction.
    Type: Application
    Filed: September 27, 2021
    Publication date: October 26, 2023
    Applicant: Merck Patent GmbH
    Inventors: Udo GUMSHEIMER, Kevin KAISER
  • Sanitation assembly and method
    Patent number: 11793898
    Abstract: A sanitation assembly (1) comprising a first chamber (2) with a first volume (2a) for receiving a first fluid, and a second chamber (3) with a second volume (3a) for receiving a second fluid, wherein the first volume (2a) communicates with an outlet (6) of the assembly (1) via a first valve mechanism (4) configured to allow discharge of the fluid from the first volume (2a) to the outlet (6) at a predefined first opening pressure, wherein the second volume (3a) communicates with the outlet (6) of the assembly (1) via a second valve mechanism (5) configured to allow discharge of the fluid from the second volume (3a) to the outlet (6) at a predefined second opening pressure, and wherein the predefined second opening pressure of the second valve mechanism (5) is higher than the predefined first opening pressure of the first valve mechanism (4).
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: October 24, 2023
    Assignee: Merck Patent GmbH
    Inventor: Fabrice Comini
  • Liquid-crystalline medium and liquid-crystal display comprising the same and compounds
    Patent number: 11795398
    Abstract: The invention relates to a liquid-crystalline medium having a nematic phase comprising one or more compounds of formula X wherein the parameters have the meaning given in the text, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type and to the use of the compounds of formula X for improvement of the transmission and/or response times of a liquid-crystalline medium which comprises one or more additional mesogenic compounds, as well as to the compounds of formula X.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: October 24, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Atsutaka Manabe, Constanze Brocke, Brigitte Schuler
  • UV curable adhesion promoters based on functionalised polyvinyl alcohols
    Patent number: 11795399
    Abstract: Suggested are new adhesion promoters, which are particular suitable for use in displays. Its inclusion in the polymerisable LC mixture results in an excellent adhesion on substrate without colouration over time i.e. compared to amino siloxanes. The new additives have no effect on alignment of LC on the substrate while improving the adhesion.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: October 24, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Hassan Arasi, Kevin Adlem, Stephen Mulcahy, Iain Gardiner
  • Dual UV blockers containing stable photoactive mass polymerizable polycycloolefin compositions as optical materials
    Patent number: 11795285
    Abstract: Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium compound, a photosensitizer, one or more monomers which undergo ring open metathesis polymerization (ROMP) and at least two distinct types of UV blockers, where when said composition is exposed to suitable actinic radiation forms a substantially transparent film or a three dimensional object. Surprisingly, the compositions are very stable at ambient conditions to temperatures up to 80° C. for several weeks and undergo mass polymerization only when subjected to actinic radiation under inert atmosphere such as for example a blanket of nitrogen. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as 3D printing materials, coatings, encapsulants, fillers, leveling agents, among others.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: October 24, 2023
    Assignees: Promerus, LLC, Merck Patent GmbH
    Inventors: Oleksandr Burtovyy, Pawel Miskiewicz, Hyun-Jin Yoon, Patrick Schellin, Manuel Hamburger
  • PHARMACEUTICAL PREPARATION
    Publication number: 20230330027
    Abstract: The present invention relates to a solid pharmaceutical preparation of of 8-(1,3-Dimethyl-1 H-pyrazol-4-yl)-1-(Sa)-(3-fluoro-5-methoxy-pyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one, as well as a method of making same, as well as medical uses thereof.
    Type: Application
    Filed: September 15, 2021
    Publication date: October 19, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Alessandra AMBRUOSI, Riccardo MANNINI, Markus RIEHL, Axel BECKER
  • MEROXAPOLS FOR CELL CULTURE
    Publication number: 20230332100
    Abstract: The present invention relates to the use of meroxapols, also called “reverse poloxamers”, as cell culture media additives. The meroxapols are suitable for foam reduction as well as for shear stress protection.
    Type: Application
    Filed: April 12, 2023
    Publication date: October 19, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Alice ANTONELLO, Tim Hofmann, Almut RAPP
  • Connecting mechanism for a water purification cartridge
    Patent number: 11786867
    Abstract: A connecting mechanism (1) for a cartridge-type replaceable module (2) that has at least one fluid port (2a,2b) at each of opposite sides of the module (2) in a longitudinal direction of the module (2). The connecting mechanism (1) comprises two connector elements (3) spaced apart in the longitudinal direction of the module (2) and each provided with at least one fluid connector (3b) configured to releasably inter-engage with a complementary fluid port (2a,2b) of the module (2) at the respective side thereof, wherein at least one of the connector elements (3) is movable to perform a translational movement in the longitudinal direction of the module (2).
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: October 17, 2023
    Assignee: Merck Patent GmbH
    Inventors: Pascal Roitel, Germain Gaydier, Thierry Cassou, Christian Berducat
  • Liquid-crystalline medium for use in a switching element
    Patent number: 11788009
    Abstract: Liquid-crystalline media containing one or more mesogenic compounds, one or more chiral compounds, and one or more polymerizable mesogenic compounds, wherein the media exhibit a pitch of 0.55 ?m or more and a clearing point of 80° C. or more and wherein the one or more polymerizable mesogenic compounds are contained in an amount, based on the overall contents of the media, of 5% by weight or less, are suitable as modulation materials. Such modulation materials can be used in switching layers and window elements.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: October 17, 2023
    Assignee: MERCK PATENT GMBH
    Inventors: Paul Verbunt, Ties De Jong, Michael Junge, Mila Fischer