Abstract: The invention relates to interference pigments based on SiO2 flakes having a broad layer-thickness distribution, and to the use thereof in paints, coatings, powder coatings, plastics and in particular in cosmetic formulations and for colouring food and pharmaceutical products.
Type:
Grant
Filed:
September 25, 2020
Date of Patent:
September 5, 2023
Assignee:
Merck Patent GmbH
Inventors:
Stephanie Andes, Ulrich Schoenefeld, Thomas Krasemann, Manfred Thon, Martina Welsch, Ralf Schweinfurth, Melanie Mechthild Breidung
Abstract: The present invention relates to liquid-crystal (LC) media having negative dielectric anisotropy comprising one or more compounds of formula I and one, two, three or more compounds of formula III as defined in claim 1, and to the use of the LC media for optical, electro-optical and electronic purposes, in particular useful to enable energy-saving LC displays of the VA, IPS or FFS type.
Type:
Application
Filed:
October 17, 2022
Publication date:
August 31, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Harald HIRSCHMANN, Kaja Christina DEING, Brigitte SCHULER, Sabine SCHOEN
Abstract: Substituted amide derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.
Abstract: LC media and LC displays containing an LC medium with positive dielectric anisotropy, which contains one or more compounds of formula I in a concentration of >0 and ?10% and displays addressed by an active matrix and in particular displays of the IPS, PS-IPS, FFS, PS-FFS, HB-FFS, U-IPS, TN, PS-TN, STN or TN-TFT mode.
Type:
Grant
Filed:
June 26, 2020
Date of Patent:
August 29, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Yeon-Jeong Han, Dong-Hyun Kim, Heui-Seok Jin, Chang-Suk Choi
Abstract: A process for the preparation of colored solar cells or colored solar cell modules containing a colored polymer film with oriented effect pigments, and colored solar cells or colored solar cell modules prepared by this process.
Type:
Grant
Filed:
April 29, 2022
Date of Patent:
August 29, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Marc Hunger, Sebastian Barth, Laurent Deloux
Abstract: The present invention relates to mixtures of serine or threonine together with at least one further amino acid or amino acid derivative and with at least one calcium salt or its hydrate and methods including this mixture including specific mixtures of such components and a formulations consisting of the mixture and a solvent.
Type:
Grant
Filed:
February 20, 2020
Date of Patent:
August 29, 2023
Assignee:
Merck Patent GmbH
Inventors:
Alexander Paul Schiller, Lisa Eckelhoefer, Julia Bleifuss, Andrew Philip Salazar, Joerg von Hagen
Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerisable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment (PS, PSA) and self-aligning (SA) type.
Type:
Grant
Filed:
December 4, 2019
Date of Patent:
August 29, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Qiong Tong, Rocco Fortte, Helmut Haensel, Edward Plummer, Timo Uebel, Oliver Heppert
Abstract: The present invention relates to aromatic isothiocyanates of formula U as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula U and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
Abstract: The invention relates to a polymerisable LC material comprising at least one di- or multireactive mesogenic compound and at least one compound of formula I, in which the parameter R1, A1, Z1, Z2, n, Sp, P, p1, p2, L1, L2, r1, r2, m and R2 have one of the meanings as given in claim 1. Furthermore, the present invention relates also to a method for the preparation of a polymerisable LC material, a polymer film obtainable from the corresponding polymerisable LC material, to a method of preparation of such polymer film, and to the use of such polymer film and said polymerisable LC material for optical, electro-optical, decorative or security devices.
Abstract: The present invention relates to a radar-compatible coating comprising metal-effect pigments on a substrate, to a process for the production of such a coating, and to the use of a substrate coated in this manner, in particular in vehicle construction.
Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
Abstract: The invention concerns a filtration assembly for microbiological testing and a method of using the filtration assembly for that purpose. The filtration assembly (1) comprises a ring-like membrane support (10) holding a filtration membrane (11), a cylindrical reservoir (20) of which opposite axial ends have openings and one axial opening is removably and fluid-tightly attachable to the membrane support (10) to define a sample volume adjacent to the filtration membrane (11) on one axial side of the membrane support (10); and a lid device (40) removably and fluid tightly attachable to the other axial opening of the reservoir (20) to close the opening. Further, the lid device (40) is removably and fluid tightly attachable to the membrane support (10) so as to seal the one axial side of the membrane support (10) from the environment.
Type:
Grant
Filed:
September 4, 2018
Date of Patent:
August 22, 2023
Assignee:
Merck Patent GmbH
Inventors:
Philippe Rivat, Mathieu Arrault, Vincent Schaal
Abstract: The present invention relates to compounds of the formulae (1) to (4), which are suitable for use in electronic devices, in particular organic electroluminescent devices, to intermediate compounds for the compounds or formulae (1) to (4) and to electronic devices, which comprise the compounds of formulae (1) to (4).
Type:
Grant
Filed:
January 22, 2018
Date of Patent:
August 22, 2023
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Nils Koenen, Christian Ehrenreich, Philipp Harbach, Lara-Isabel Rodriguez, Rouven Linge, Sebastian Meyer, Aaron Lackner
Abstract: The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. It relates more particularly to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used as biomarkers for the diagnosis, pre-treatment of patients and during therapy of cartilage disorders. The invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment or during the treatment. It could be used for selecting/identifying subjects to be treated according to specific doses and/or dosing regimens by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk-benefit ratio in subjects.
Type:
Application
Filed:
September 1, 2022
Publication date:
August 17, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Christoph H. LADEL, Hans GUEHRING, Anne-Christine BAY-JENSEN, Morten KARSDAL, Per QVIST
Abstract: The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. The present invention more particularly relates to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used for the diagnosis and treatment of cartilage disorders. The invention further discloses specific proteins that are related to cartilage response to an FGF-18 compound treatment as well as diagnostic tools and kits based on their expression profile. Thus, the invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment with FGF-18 or during the treatment. It could be used for selecting/identifying subjects to be treated by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk in subjects.
Type:
Application
Filed:
September 7, 2022
Publication date:
August 10, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Christoph H. LADEL, Hans GUEHRING, Anne-Christine BAY-JENSEN, Morten KARSDAL, Per QVIST
Abstract: Combinations of (S)-3-Hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide and a VEGFR/VEGF inhibitor, or their physiologically acceptable salts are disclosed. Such combination are useful for the prophylaxis or treatment of cancer.
Type:
Application
Filed:
July 6, 2021
Publication date:
August 10, 2023
Applicant:
Merck Patent GmbH
Inventors:
Manja FRIESE-HAMIM, Felix Rohdich, Claude Gimmi, Christoph Schultes, Olga Bogatyrova
Abstract: A method of manufacturing a fine pattern using the following steps of: (1) coating a resist composition containing a novolak resin having an alkali dissolution rate of 100 to 3,000 ? on a substrate to form a resist composition layer; (2) subjecting said resist composition layer to exposure; (3) developing said resist composition layer to form a resist pattern; (4) subjecting said resist pattern to flood exposure; (5) coating a fine pattern forming composition on the surface of said resist pattern to form a fine pattern forming composition layer; (6) heating said resist pattern and said fine pattern forming composition layer to cure the regions of said fine pattern forming composition layer in the vicinity of said resist pattern and to form an insolubilized layer; and (7) removing uncured regions of said fine pattern forming composition layer.
Abstract: The present invention relates to a method for the preparation of a homogeneous aligned liquid crystal polymer film, a polymer film obtainable from the corresponding method of production, and to the use of such polymer film for optical components and electro-optical decorative, as well as to components and devices comprising such polymer film.
Type:
Grant
Filed:
January 20, 2020
Date of Patent:
August 8, 2023
Assignee:
Merck Patent GmbH
Inventors:
Stephen Mulcahy, Eduardo Beltran Gracia, Owain Parri, Vicki Poole, James Allen, Kevin Adlem, Hassan Arasi