Abstract: The present invention relates to liquid-crystal (LC) media as defined in claim 1, having negative dielectric anisotropy and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays.
Abstract: The present invention relates to a liquid-crystal material (LC media) comprising thiophene derivatives which are stabilised by sterically hindered amines or amine derivatives (HALS, hindered amine light stabilisers), and to liquid-crystal displays (LC displays) which contain these LC materials.
Type:
Application
Filed:
April 11, 2023
Publication date:
October 12, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Atsutaka MANABE, Rocco FORTTE, Harald HIRSCHMANN
Abstract: A method can treat a patient suffering from at least one of fibrosis and a fibrotic disorder. The method includes administering a therapeutically effective amount of an anti-?v integrin antibody DI17E6, or a biologically active variant or modification thereof, to the patient.
Abstract: The present invention relates to an LC medium comprising and a liquid-crystalline host consisting of an LC component H) comprising one or more mesogenic or liquid-crystalline compounds and an optically active component D) and optionally a polymerizable component P) comprising one or more polymerizable compounds; and to the use of the polymerizable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment type.
Abstract: The present invention provides a calibration device for an optical detector comprising a light emitting diode 1, and an electronic circuit 3 for driving the light emitting diode 1, wherein the electronic circuit 3 is a constant current generator configured to supply a constant driving current to the light emitting diode 1 in the range of 0.5 to 25 ?A. Furthermore, the present invention provides a setting device for setting at least one calibration point for a calibration device as described above. The setting device comprises a light detector 51 configured to output a signal representing the light emission intensity of a calibration device under examination, a controller 53 for controlling the constant driving current of the calibration device under examination, and a calibration point setting means 55 for setting at least one calibration point for the calibration device under examination.
Type:
Grant
Filed:
May 29, 2019
Date of Patent:
October 10, 2023
Assignee:
MERCK PATENT GmbH
Inventors:
Fabrice Comini, Frederick G. Bargoot, Victor Etre
Abstract: The present invention relates to an optical component comprising a liquid crystal (LC) medium, operable in the infrared region of the electromagnetic spectrum. The invention further relates to the use of said LC medium in the infrared (IR) region and to devices comprising said optical component. The present invention further relates to an LC medium comprising one or more compounds of the formulae I, II, and III in which the occurring groups and parameters have the meanings defined in claim 1, and preferably one or more compounds of the formula RO in which the occurring groups and parameters have the meanings defined in claim 2.
Type:
Application
Filed:
July 6, 2021
Publication date:
October 5, 2023
Applicant:
Merck Patent GmbH
Inventors:
Izumi SAITO, Owain Llyr PARRI, Andreas TAUGERBECK, Carsten FRITZSCH, Dagmar KLASS
Abstract: The present invention relates to a device and processes for producing liquid media for cell cultures, whereby the liquid media are produced automatically by dissolving ingredients in water. The present invention also relates to a device for producing media used in cell cultures or a substance produced by cell cultures using a bioreactor process.
Type:
Application
Filed:
July 5, 2021
Publication date:
October 5, 2023
Applicant:
Merck Patent GmbH
Inventors:
Jochen Bastian SIECK, Christian SCHULTHEISS
Abstract: The present invention relates to immunoglobulins that specifically bind Aggrecan and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of Aggrecan.
Type:
Application
Filed:
December 23, 2022
Publication date:
October 5, 2023
Applicants:
Ablynx N.V., Merck Patent GmbH
Inventors:
Soren Steffensen, Gerald Beste, Guy Hermans, Hans Gühring, Christoph Ladel, Lars Toleikis
Abstract: The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network.
Type:
Application
Filed:
August 19, 2021
Publication date:
October 5, 2023
Applicant:
MERCK PATENT GMBH
Inventors:
Rene REINBIGLER, Denis DUBRET, Steve MILLER
Abstract: The present disclosure relates to amino acid sequences that are directed against (as defined herein) any of IL-17A, IL-17F and/or IL-17A/F including combinations thereof, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
October 3, 2023
Assignee:
Merck Patent GmbH
Inventors:
Heidi Rommelaere, Joost Alexander Kolkman, Michael John Scott Saunders, Ann Union, Yolande Chvatchko, Amanda E. I. Proudfoot, Alain Vicari, Denis Bruniquel, Laurent Chevalet, Olivier Leger
Abstract: The present invention relates to a composition comprising a bipolar host and an electron-transporting host, especially for use as matrix material in electronic devices, especially organic electroluminescent devices, and especially in an organic light-emitting diode (OLED). The invention further relates to electronic devices comprising said composition.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
October 3, 2023
Assignee:
Merck Patent GmbH
Inventors:
Amir Parham, Jonas Kroeber, Christian Eickhoff, Tobias Grossmann, Aurélie Ludemann, Dominik Joosten
Abstract: The present invention relates to effect pigments which are based on flake-form substrates having a circular form factor of 1.2-2 and are coated with at least one high-refractive-index layer, and to the use thereof, inter alia in paints, coatings, printing inks, plastics and in cosmetic formulations.
Type:
Grant
Filed:
July 6, 2020
Date of Patent:
October 3, 2023
Assignee:
MERCK PATENT GMBH
Inventors:
Gerhard Pfaff, Stephanie Andes, Klaus Ambrosius, Ralf Petry, Michael Roesler, Sabine Schoen
Abstract: The present invention encompasses ATR inhibitor for use in the treatment of coronavirus infections, including COVID-19, alone or in combination with one or more additional therapeutic agents.
Abstract: The present invention relates to formulations for the preparation of organic electronic devices (OLEDs) which comprise (A) at least one specific ester solvent containing an aromatic group and (B) at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earth metals, lanthanides and actinides.
Type:
Grant
Filed:
October 11, 2021
Date of Patent:
September 26, 2023
Assignee:
Merck Patent GmbH
Inventors:
Gaëlle Béalle, Christoph Leonhard, Hsin-Rong Tseng, Irina Martynova, Aurélie Ludemann, Edgar Kluge, Anja Jatsch, Manuel Hamburger, Li Wei Tan, Pawel Miskiewicz, Philip Edward May, Daniel Walker
Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
September 26, 2023
Assignee:
Merck Patent GmbH
Inventors:
Ilona Stengel, Kathy Vinokurov, Frank Voges, Aurélie Ludemann
Abstract: The present invention relates to a composition comprising; components a) b) and d); wherein, component a) is a metal compound having the structure (I), component b) is a spin on high carbon polymer, having a polymer backbone comprising mono-cyclic aromatic hydrocarbon, fused-ring ring hydrocarbon moieties, or mixtures of these, having a wt. % of carbon from about 81 wt. % to about 94 wt. %, which is soluble to at least about 5 wt. % in a spin casting solvent, and wherein at least one, of said mono-cyclic aromatic hydrocarbon or said fused-ring ring hydrocarbon moieties, present in said spin on high carbon polymer, is functionalized with at least one alkynyloxy moiety of structure (VIII), and component d) is a spin casting solvent.