Abstract: Alpha-Alumina flakes having a particle thickness of 130-400 nm, a D50-value of 15-30 ?m, a D90-value of 30-45 ?m and a D10-value of <9.5 ?m. Use of the alumina flakes in varnishes, paints, automotive coatings printing inks, masterbatches, plastics and cosmetic formulations. Also, use of the alumina flakes as a substrate for effect pigments and in organic dyes.
Abstract: Isothiocyanato tolane derivatives of formula I-1 and liquid-crystalline media comprising same are suitable for use in high-frequency components, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, in particular for microwave phased-array antennas.
Type:
Grant
Filed:
September 11, 2018
Date of Patent:
February 6, 2024
Assignee:
MERCK PATENT GMBH
Inventors:
Dmitry Ushakov, Beate Schneider, Carsten Fritzsch, Michael Wittek, Dagmar Klass
Abstract: The present invention describes carbazole, dibenzofuran, dibenzothiophene and fluorene derivatives which are substituted by electron-deficient heteroaryl groups, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising these compounds.
Type:
Grant
Filed:
November 25, 2022
Date of Patent:
February 6, 2024
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Anja Jatsch, Thomas Eberle, Tobias Grossmann, Jonas Valentin Kroeber, Lars Dobelmann-Mara
Abstract: A method for processing digital image recognition of invariant representations of hierarchically structured entities can be performed by a computer using an artificial neural network. The method involves learning a sparse coding dictionary on an input signal to obtain a representation of low-complexity components. Possible transformations are inferred from the statistics of the sparse representation by computing a correlation matrix. Eigenvectors of the Laplacian operator on the graph whose adjacency matrix is the correlation matrix from the previous step are computed. A coordinate transformation is performed to the base of eigenvectors of the Laplacian operator, and the first step is repeated with the next higher hierarchy level until all hierarchy levels of the invariant representations of the hierarchically structured entities are processed and the neural network is trained. The trained artificial neural network can then be used for digital image recognition of hierarchically structured entities.
Abstract: A liquid-crystalline medium having least one compound of the formula I, and at least one compound of the formulae ST-1 to ST-17, in which R1 and R1*, A1 and A1*, Z1 and Z1*, X, L1 and L2, RST, ring A, ZST, p and q have the meanings indicated in claim 1, and the use thereof for an active-matrix display, in particular based on the VA, PSA, PA-VA, SS-VA, SA-VA, PS-VA, PALC, IPS, PS-IPS, UB-FFS, U-IPS, FFS or PS-FFS effect.
Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.
Type:
Grant
Filed:
August 4, 2020
Date of Patent:
January 30, 2024
Assignee:
Merck Patent GmbH
Inventors:
Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
Abstract: The present invention relates to a process for manufacturing an optoelectronic device, wherein a layer of a formulation containing a silazane polymer and a wavelength converting material is applied to an optoelectronic device precursor, precured by exposure to radiation and then cured. There is further provided an optoelectronic device, preferably a light emitting device (LED) or a micro-light emitting device (micro-LED), which is prepared by said manufacturing process.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
January 30, 2024
Assignee:
MERCK PATENT GMBH
Inventors:
Ralf Grottenmueller, Abraham Casas Garcia-Minguillan, Fumio Kita, Christoph Landmann, Fabian Blumenschein
Abstract: Compounds of the formula I in which R1 is alkyl or alkoxy in which CH2 groups are optionally replaced, and X1 is alkyl OCF3, CF3, CHF2, OCF2CF3, CCF2CHFCF3, OCF?CF2, OCH?CF2 or F, a liquid-crystalline medium containing a compound of formula I, and use thereof in electro-optical liquid-crystal displays, in particular in TN, STN, TN-TFT, OCB, IPS, PS-IPS, FFS, HB-FFS or PS-FFS-, positive VA displays and in shutter spectacles for 3D effects and LC lenses.
Type:
Grant
Filed:
August 4, 2016
Date of Patent:
January 30, 2024
Assignee:
MERCK PATENT GMBH
Inventors:
Achim Goetz, Christian Hock, Lars Lietzau, Mark Goebel
Abstract: A solid form of 1-(4-{[6-Amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methy}-4-fluoro-piperidin-1-yl)-propenone, or pharmaceutically acceptable salts thereof, is useful as a BTK inhibitor.
Type:
Grant
Filed:
June 17, 2019
Date of Patent:
January 23, 2024
Assignee:
Merck Patent GmbH
Inventors:
Michael Lange, Clemens Kuehn, Tobias Schlueter, Werner Mederski, David Maillard, Edoardo Burini
Abstract: A method for evaluation of a thin-layer chromatography plate after performing a separation process that separates components of a sample on the thin-layer chromatography plate comprises a digitization step, wherein at least two digital images are taken that differ with respect to the wavelength range of illumination of the thin-layer chromatography plate. The method further comprises a position identification step wherein the position of the thin-layer chromatography plate is identified for each of the at least two digital images. Furthermore, the method comprises an evaluation step wherein an image information of the at least two digital images is superimposed for at least all regions with at least one visible spot within at least one of the at least two digital images, so that the superimposition of image information from identical regions of at least two digital images can be used for evaluation of the thin-layer chromatography.
Type:
Application
Filed:
November 12, 2021
Publication date:
January 18, 2024
Applicant:
MERCK PATENT GMBH
Inventors:
Michaela OBERLE, Eric SCHUNDA, Robert FISCHER
Abstract: A window pane includes a transmission control layer including a first glass sheet, a second glass sheet, and a liquid crystal material disposed between the first glass sheet and the second glass sheet. Each of the first glass sheet and the second glass sheet has a thickness of about 1 mm or less. A first panel is bonded to the first glass sheet of the transmission control layer. A second panel is bonded to the second glass sheet of the transmission control layer. The transmission control layer is disposed between the first panel and the second panel. The liquid crystal material is controllable to adjust a transmittance of the window pane.
Abstract: The present invention describes carbazole, dibenzofuran, dibenzothiophene and fluorene derivatives which are substituted by electron-deficient heteroaryl groups, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising these compounds.
Type:
Grant
Filed:
November 25, 2022
Date of Patent:
January 16, 2024
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Anja Jatsch, Thomas Eberle, Tobias Grossmann, Jonas Valentin Kroeber, Lars Dobelmann-Mara
Abstract: A liquid-crystalline medium with one or more compounds of the formula IA and, one or more compounds of formula BS and the use thereof in an active-matrix display, in particular in a VA, IPS, U-IPS, FFS, UB-FFS, SA-VA, SA-FFS, PS-VA, PS-OCB, PS-IPS, PS-FFS, PS-UB-FFS, PS-poli-VA, PS-TN, polymer stabilized SA-VA or polymer stabilized SA-FFS display.
Type:
Grant
Filed:
December 18, 2019
Date of Patent:
January 16, 2024
Assignee:
MERCK PATENT GMBH
Inventors:
Rachel Tuffin, Matthias Bremer, Marcus Reuter
Abstract: The invention relates to a polymerisable LC material comprising one or more di- or multireactive mesogenic compounds and one or more compounds of formula UVI, wherein the individual radicals have one of the meaning as given in the claims. Furthermore, the present invention relates also to a method for its preparation, a polymer film with improved thermal durability and UV stability obtainable from a corresponding polymerisable LC material, to a method of preparation of such polymer film, and to the use of such polymer film and said polymerisable LC material for optical, electro-optical, decorative or security devices.
Abstract: The present invention relates to a new class of dielectric polymer material, which is particularly suitable for the manufacturing of electronic devices. The dielectric polymer material is formed by reacting bismaleimide compounds and shows an advantageous well-balanced profile of favorable material properties. The bismaleimide compounds have an oligomeric structure with a cardo and/or spiro moiety containing repeating unit in the middle part of the molecule and maleimide groups at each terminal end of the molecule. There is further provided a method for forming said dielectric polymer material and an electronic device comprising the same as dielectric material.
Type:
Application
Filed:
December 2, 2021
Publication date:
January 11, 2024
Applicant:
MERCK PATENT GMBH
Inventors:
Gregor LARBIG, Frank Egon MEYER, Pawel MISKIEWICZ
Abstract: The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network.
Type:
Application
Filed:
August 19, 2021
Publication date:
January 11, 2024
Applicant:
MERCK PATENT GMBH
Inventors:
Rene REINBIGLER, Denis DUBRET, Steven MILLER
Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.
Type:
Application
Filed:
August 13, 2021
Publication date:
January 11, 2024
Applicant:
Merck Patent GmbH
Inventors:
Jan ANDERL, Sabine RAAB-WESTPHAL, Stefan HECHT, Carl DEUTSCH, Min SHAN, Doreen KÖNNING, Willem N. SLOOT, Felix HART, Christian SCHRÖTER, Lars TOLEIKIS, Nir BERGER
Abstract: Substituted tetrazole derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.