Abstract: The present invention relates to the purification of target molecules like immunoglobulins from plasma. The use of a certain type of ion exchanger based on a crosslinked polyvinylether results in especially high yields of the target molecule.
Abstract: The present invention relates to a liquid-crystalline medium based on a mixture of polar compounds having negative dielectric anisotropy (??), which is distinguished by the fact that it has a value for the ratio ?1/?n2 in the range 6-45 with a clearing point of >60° C. and a ?? of ??2.3. Media of this type are particularly suitable for electro-optical displays having active-matrix addressing based on the ECB, PA LCD, FFS or IPS effect.
Abstract: The invention relates to solid state forms of N—((S)-2,3-Dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide, processes for their preparation, and medical uses thereof.
Type:
Grant
Filed:
May 7, 2013
Date of Patent:
February 16, 2016
Assignee:
Merck Patent GmbH
Inventors:
Axel Becker, Christoph Saal, Clemens Kuehn, Donald Bankston, Marco Poma
Abstract: Liquid crystal mixture comprising one or several compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, M1, M2, X, A, and m are defined herein.
Type:
Grant
Filed:
August 11, 2005
Date of Patent:
February 16, 2016
Assignee:
Merck Patent GmbH
Inventors:
Ji Li, Toshiaki Nonaka, Ayako Ogawa, Hans-Rolf Dübal, Barbara Hornung, Wolfgang Schmidt, Rainer Wingen
Abstract: The present invention relates to liquid-crystalline media comprising one or more compounds selected from the group of compounds of formulae I, II and III, in which the parameters R1-R3, Z21, Z31, Z32 and rings A11, A12, A13, A21, A22, A31, and A32 are as defined herein, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
Type:
Application
Filed:
August 7, 2015
Publication date:
February 11, 2016
Applicant:
MERCK PATENT GMBH
Inventors:
Michael WITTEK, Dagmar KLASS, Atsutaka MANABE, Christian JASPER, Volker REIFFENRATH, Constanze BROCKE, Detlef PAULUTH
Abstract: The invention relates to mononuclear neutral copper(I) complexes with a bidentate ligand which is bonded via nitrogen and two phosphine or arsine ligands, to the use thereof for the production of electronic components, and to electronic devices comprising these complexes.
Abstract: The invention relates to 1,1-disubstituted cyclohexane derivatives containing one or more polymerizable groups, and to liquid-crystalline media comprising at least one compound of the formula I. At least one of the polymerizable groups is located at the geminally substituted position of the cyclohexane ring. The compounds are suitable for the stabilization of liquid-crystalline phases. Examples of polymer-stabilized blue phases are indicated.
Type:
Grant
Filed:
December 23, 2010
Date of Patent:
February 9, 2016
Assignee:
Merck Patent GmbH
Inventors:
Axel Jansen, Thorsten Kodek, Helmut Haensel, Erdal Durmaz
Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerisable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment type.
Abstract: The present application relates to a device for regulating the passage of light through a light-transmitting area which comprises a switching layer comprising a liquid-crystalline medium comprising at least one dichroic dye, where the parameters degree of light transmission and degree of anisotropy of the device are selected in a certain manner.
Type:
Application
Filed:
February 7, 2014
Publication date:
February 4, 2016
Applicant:
Merck Patent GmbH
Inventors:
Michael JUNGE, Andreas BEYER, Ursula PATWAL
Abstract: The present invention relates, inter alia, to metal complexes having improved solubility, to processes for the preparation of the metal complexes, to devices comprising these metal complexes and to the use of the metal complexes. M(L)n(L?)m formula 1 where the compound contains a moiety M(L)n of the formula (2) W is equal to the formula (3).
Type:
Grant
Filed:
June 28, 2011
Date of Patent:
February 2, 2016
Assignee:
Merck Patent GmbH
Inventors:
Rémi Manouk Anémian, Bernd Schröder, Claire De Nonencourt
Abstract: The present invention relates to a method for the characterization of pigments and fillers in which the luminance of a pigmented transparent medium is determined against a dark background. This measurement method is particularly suitable for determining the optical properties of cosmetic fillers.
Type:
Grant
Filed:
August 16, 2011
Date of Patent:
February 2, 2016
Assignee:
Merck Patent GmbH
Inventors:
Christoph Schmidt, Christoph Hoffmann, Sabine Schoen
Abstract: The present invention relates to liquid-crystalline media (LC media) comprising self-aligning additives which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the liquid-crystalline medium (LC medium) without conventional imide alignment layers. The LC media are optionally supplemented by a polymerisable or polymerised component, which serves for stabilisation of the alignment, for adjustment of the tilt angle and/or as passivation layer.
Abstract: Electroluminescent devices are disclosed comprising a transparent anode; a layer of a hole transporting material; a layer of an electroluminescent material; a layer of an electron transporting material; a layer of a substituted lithium quinolate; and a metal cathode. The electroluminescent device may be an organic light-emitting diode having a cathode, an electron injection layer in contact with the cathode and an electron transport layer in contact with the electron injection layer and comprising aluminum, zirconium or hafnium quinolate or a mixture thereof or a mixture of any of them with a quinolate of a metal of group 1, 2, 3, 13 or 14 of the periodic table. Such devices may be made by the steps of forming a substituted lithium quinolate having one or more substituents and depositing the substituted lithium quinolate on a cathode of the device to provide an electron injection layer.
Abstract: The invention relates to the use of a multinuclear metal or transition metal complex in an organic electronic device, said complex having a small ?E spacing, particularly between 50 cm?1 and 2000 cm?1, between the lowest triplet state and the singlet state that is higher and is achieved by thermal backfilling from the triplet. The invention further relates to the use of the strong absorptions of such multinuclear metal complexes, particularly in OSCs.
Abstract: Compounds of the formula I in which R, R1, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKK? and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.
Type:
Grant
Filed:
April 12, 2012
Date of Patent:
February 2, 2016
Assignee:
Merck Patent GmbH
Inventors:
Srinivasa R. Karra, Wolfgang Staehle, Eike Staub, Margarita Wucherer-Plietker
Abstract: Compounds of the formula I, in which X1, X2, X3, X4, X5, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumors.
Type:
Grant
Filed:
July 26, 2012
Date of Patent:
February 2, 2016
Assignee:
MERCK PATENT GMBH
Inventors:
Timo Heinrich, Felix Rohdich, Christina Esdar, Mireille Krier, Hartmut Greiner
Abstract: An apparatus for performing sonication on liquid samples comprises a rack for holding an array of sample vials, an ultrasonic probe with an arrangement of recesses corresponding to the array of sample vials and adapted to respectively receive and contact an outer surface of a bottom portion of a respective one of the sample vials, and a counter-holder with an arrangement of pushing members corresponding to the array of sample vials and adapted to respectively apply a force to a respective one of the sample vials so as to push the bottom portion of each vial into contact with the associated recess of the probe. The apparatus can be used in a method of preparing a sample for detection of cell components (e.g. cell analyte, proteins, nucleid acids etc.) and applying sonication within certain parameter ranges which can provide a universal lysis method that can be applied to a large variety of cells or organisms like all bacteria, viruses, spores, yeast and mold within the same apparatus and process.
Type:
Application
Filed:
February 20, 2014
Publication date:
January 28, 2016
Applicant:
MERCK PATENT GMBH
Inventors:
Luc FELDEN, David LEHMANN, Marisa HOHNADEL, Sebastien JOUETTE
Abstract: The present invention relates to organic electroluminescent devices which, in addition to the emitting layer, have a further layer which comprises the same materials as the emitting layer.
Type:
Grant
Filed:
August 25, 2010
Date of Patent:
January 26, 2016
Assignee:
Merck Patent GmbH
Inventors:
Joachim Kaiser, Horst Vestweber, Simone Leu
Abstract: The present invention relates inter alia to oligomers and/or polymers with functionalized side groups which are bound to the backbone of the polymer via spacer.
Type:
Grant
Filed:
June 28, 2012
Date of Patent:
January 26, 2016
Assignee:
Merck Patent GmbH
Inventors:
Junyou Pan, Frank Egon Meyer, Niels Schulte, René Peter Scheurich
Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
Type:
Application
Filed:
March 10, 2014
Publication date:
January 21, 2016
Applicant:
Merck Patent GmbH
Inventors:
Ruoxi LAN, Xiaoling CHEN, Yufang XIAO, Bayard R. HUCK, Andreas GOUTOPOULOS