Abstract: The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the skin or hair, and to preparations comprising compounds of the formula (I).
Abstract: A system and a method of receiving object data representing one or more discriminating characteristics of a physical object or group of physical objects is described herein. The method includes: processing the object data by means of a machine-learning-based object recognition process to obtain discriminating data representing one or more collision resistant virtual representations of the physical object or group of physical objects; comparing at least one of the discriminating data and an original hash value derived therefrom by application of a pre-determined cryptographic hash function thereto with corresponding reference data stored in one or more data repositories with restricted access; and, if said comparison with the reference data results in a match, outputting digitally signed identification data comprising said hash value.
Type:
Grant
Filed:
June 29, 2018
Date of Patent:
January 29, 2019
Assignee:
Merck Patent GmbH
Inventors:
Thomas Endress, Daniel Szabo, Frederic Berkermann
Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
Type:
Application
Filed:
December 16, 2016
Publication date:
January 24, 2019
Applicant:
MERCK PATENT GMBH
Inventors:
Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
Abstract: The invention relates to novel compounds containing one or more 1,3-dithiolo[4,5-d]phthalimide (“DTPI”) units, to methods for their preparation preparation and educts or intermediates used therein, to mixtures and formulations containing them, to the use of the compounds, mixtures and formulations as organic semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these compounds, mixtures or formulations.
Type:
Application
Filed:
February 17, 2017
Publication date:
January 24, 2019
Applicant:
Merck Patent GmbH
Inventors:
Changsheng WANG, William MITCHELL, David SPARROWE
Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
January 22, 2019
Assignee:
Merck Patent GmbH
Inventors:
Henry Yu, Thomas E. Richardson, Pandi Bharathi, Brian H. Heasley, Matthew G. Jenks, Robert J. Foglesong
Abstract: The invention relates to anti-TNF? antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNF? antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.
Type:
Grant
Filed:
June 26, 2015
Date of Patent:
January 22, 2019
Assignee:
Merck Patent GmbH
Inventors:
Ralf Guenther, Stefan Becker, Laura Rhiel, Bjoern Hock, Christian Schroeter
Abstract: The present application relates to mixtures which have liquid-crystalline properties. The application furthermore relates to the use of the mixtures in devices which regulate the transmission of light through an area element.
Type:
Application
Filed:
December 12, 2016
Publication date:
January 17, 2019
Applicant:
MERCK PATENT GMBH
Inventors:
Michael JUNGE, Ursula PATWAL, Peer KIRSCH
Abstract: The present invention is directed to the use of at least one kind of inorganic pigments composed of a spherical composite particle comprising an inorganic UV filter to enhance the sun protection of a cosmetic formulation.
Type:
Application
Filed:
December 8, 2016
Publication date:
January 17, 2019
Applicant:
MERCK PATENT GMBH
Inventors:
Michael TERMER, Frank PFLUECKER, Lilia HEIDER, Alexandra AXT-HEIDEMANN, Jutta ZUR LAGE, Sherry WU
Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
Type:
Grant
Filed:
March 22, 2016
Date of Patent:
January 15, 2019
Assignee:
MERCK PATENT GMBH
Inventors:
Dieter Dorsch, Alfred Jonczyk, Mireille Krier
Abstract: The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12, X11, X12 and Sp1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.
Type:
Application
Filed:
September 13, 2018
Publication date:
January 10, 2019
Applicant:
MERCK PATENT GMBH
Inventors:
Kevin ADLEM, Owain Llyr PARRI, Rachel TUFFIN, Patricia Eileen SAXTON, Mariam NAMUTEBI, Benjamin SNOW
Abstract: Compounds of the formula Ia or of the formula Ib in which X, Y, R1 and R2 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
Abstract: The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.
Type:
Grant
Filed:
June 26, 2017
Date of Patent:
January 8, 2019
Assignee:
Merck Patent GmbH
Inventors:
Thomas Fuchss, Ulrich Emde, Hans-Peter Buchstaller, Werner Mederski
Abstract: The present application relates to a compound of a formula (I), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I). The invention furthermore relates to the preparation of the compound of the formula (I) and to a formulation comprising one or more compounds of the formula (I).
Type:
Grant
Filed:
April 12, 2012
Date of Patent:
January 8, 2019
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Arne Buesing, Christof Pflumm, Teresa Mujica-Fernaud, Philipp Stoessel, Thomas Eberle
Abstract: Magnetic pigments containing a transparent flaky homogeneously composed substrate having two parallel major surfaces and a coating containing maghemite, a process for the production of said pigments as well as their use.
Abstract: The invention relates to a method of manufacturing a liquid crystal display device wherein a liquid crystal mixture having positive dielectric anisotropy or negative dielectric anisotropy is interposed between a first substrate and a second substrate, the liquid crystal mixture comprising liquid crystal molecules, a self assembling photoalignment agent, a polymerisable compound, and wherein said LC mixture is photoaligned by irradiation with linearly polarised ultraviolet light and then cured by irradiation with ultraviolet light.
Type:
Application
Filed:
November 18, 2016
Publication date:
January 3, 2019
Applicant:
MERCK PATENT GMBH
Inventors:
Kevin ADLEM, Alex DAVIS, Rachel TUFFIN, Mark GOEBEL, Graziano ARCHETTI, Rocco FORTTE, Karl SKJONNEMAND, Ian Charles SAGE
Abstract: The present invention relates to compounds according to formula (I), which are suitable for use in electronic devices, preferably organic electroluminescent devices.
Type:
Application
Filed:
November 28, 2016
Publication date:
January 3, 2019
Applicant:
Merck Patent GmbH
Inventors:
Stefan Riedmueller, Oliver Kaufhold, Sebastian Meyer
Abstract: The invention relates to a liquid-crystalline medium, preferably having a nematic phase and dielectric anisotropy of 0.5 or more, which comprises one or more compounds of formula S in which denotes and to the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the use of the compounds of formula S for the improvement of the transmission and/or response times of a liquid-crystalline medium which comprises one or more additional mesogenic compounds.
Abstract: The present invention relates to new separation materials with improved binding capacity, its manufacturing, and application, especially for binding protein A.
Type:
Grant
Filed:
October 2, 2013
Date of Patent:
January 1, 2019
Assignee:
MERCK PATENT GMBH
Inventors:
Santosh Rahane, Nanying Bian, Daniel Scheid
Abstract: The present invention relates to formulations for the preparation of organic electronic devices (OLEDs) which comprise (A) at least one specific ester solvent containing an aromatic group and (B) at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earth metals, lanthanides and actinides.
Type:
Application
Filed:
November 15, 2016
Publication date:
December 27, 2018
Applicant:
Merck Patent GmbH
Inventors:
Gaëlle BÉALLE, Christoph LEONHARD, Hsin-Rong TSENG, Irina MARTYNOVA, Aurélie LUDEMANN, Edgar KLUGE, Anja JATSCH, Manuel HAMBURGER, Li Wei TAN, Pawel MISKIEWICZ, Philip Edward MAY, Daniel WALKER
Abstract: The invention relates to cinnamic acid derivatives of formula S wherein the radicals have the meaning indicated in claim 1, to a process for their preparation and their use as self assembling photoalignment agent in liquid crystal mixtures. The invention further relates to a process for the fabrication of a liquid crystal (LC) display device with homogeneous alignment by photoaligning a liquid crystal mixture with positive or negative dielectric anisotropy comprising one or more compounds of formula S and optionally a polymerisable compound, to the liquid crystal mixture comprising the self assembling photoaligning agent and optionally the polymerisable compound and to the LC display produced by said process.
Type:
Application
Filed:
November 18, 2016
Publication date:
December 27, 2018
Applicant:
MERCK PATENT GMBH
Inventors:
Kevin ADLEM, Alex DAVIES, Hassan ARASI, Joseph SARGENT, Rachel TUFFIN, Ian Charles SAGE