Patents Assigned to Merck Patents GmbH
  • METHODS FOR NON-COVALENT FC-DOMAIN-CONTAINING PROTEIN DISPLAY ON THE SURFACE OF CELLS AND METHODS OF SCREENING THEREOF
    Publication number: 20180298374
    Abstract: The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such as antibodies. The inventive method may be used to screen and select proteins of interest of a desired phenotype. The present invention further discloses polynucleotides and proteins and methods of producing the same, which may be used in carrying out the inventive method.
    Type: Application
    Filed: October 27, 2015
    Publication date: October 18, 2018
    Applicant: Merck Patent GmbH
    Inventors: Laura Rhiel, Stefan Becker, Ralf Guenther, Bjoern Hock, Daniel Helman, Mira Toister-Achituv, Simon Krah
  • Metal complexes
    Patent number: 10103340
    Abstract: The present invention relates to a compound of the formula (1), a process to prepare the compound of formula (1), a formulation containing the compound of formula (1) and an electronic device containing the compound of formula (1).
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: October 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Esther Breuning
  • Method of preparing a birefringent polymer film
    Patent number: 10100253
    Abstract: The invention relates to a method of preparing a polymer film and to the use of such polymer film as in liquid crystal displays (LCDs) or other optical or electrooptical devices, for decorative or security applications, as alignment layer or optical retardation film.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: October 16, 2018
    Assignee: Merck Patent GmbH
    Inventors: Iain Gardiner, Owain Llyr Parri, Tara Perrett, Joseph Sargent, Jack Bradford, Sarah Whitehouse
  • Alkynyl-tolanes, liquid-crystal mixtures containing them and components for high-frequency technology
    Patent number: 10099975
    Abstract: Compounds of formula I their use in liquid-crystalline media, for example, for the phase shifting of microwaves for tunable phased-array antennae, and their use for high-frequency components, in particular antennae, especially for the gigahertz range.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: October 16, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Christian Jasper, Constanze Brocke, Detlef Pauluth, Volker Reiffenrath, Atsutaka Manabe
  • CHIRAL COMPOUNDS
    Publication number: 20180291271
    Abstract: The invention relates to chiral compounds of formula I wherein the parameters have the meaning given in claim 1, to liquid crystal mixtures comprising at least one chiral compound of formula I, to chiral linear or crosslinked liquid crystal polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula I, to the use of chiral compound of formula I and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula I.
    Type: Application
    Filed: September 7, 2016
    Publication date: October 11, 2018
    Applicant: Merck Patent GmbH
    Inventors: Matthias BREMER, Edward PLUMMER, Thomas EICHHORN, Peter SCHREINER, Christian KUEHN
  • PROCESS FOR PREPARING THIADIAZOLO-ISOINDOLE-DIONE DERIVATIVES
    Publication number: 20180291036
    Abstract: The invention relates to a novel process for preparing 5H-[1,2,5]thiadiazolo[3,4-f]isoindole-5,7(6H)-dione (“TID”) derivatives, especially for preparing 4,8-diaryl-TID derivatives, to novel intermediates obtained and/or used in this process, to novel TID derivatives prepared by this process, to the use of these TID derivatives as monomers or building blocks for preparing conjugated polymers, and to the use of these TID derivatives or conjugated polymers as organic semiconductors or in organic electronic (OE) devices.
    Type: Application
    Filed: September 30, 2015
    Publication date: October 11, 2018
    Applicant: Merck Patent GmbH
    Inventors: Nicolas BLOUIN, Michal KROMPIEC, Andreas LOHR
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20180291270
    Abstract: A liquid-crystalline media comprising one or more compounds of formula S where the parameters have the meaning defined in claim 1, and one or more compounds of the formula I and one or more compounds of the formula II or one or more compounds of the formula I and one or more compounds of the formula III or one or more compounds of the formula II and one or more compounds of the formula III or one or more compounds of the formula I and one or more compounds of the formula II and one or more compounds of the formula III: in which the parameters have the meaning indicated in claim 1, and to components comprising these media for high-frequency technology, in particular phase shifters and microwave array antennas.
    Type: Application
    Filed: April 27, 2016
    Publication date: October 11, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Atsutaka MANABE, Rocco FORTTE, Dagmar KLASS, Renate SEEGER
  • Cyclic amides as MetAP-2 inhibitors
    Patent number: 10093623
    Abstract: Described are cyclic amide compounds of the formula (I): in which R1, R3, R5, R6, R7, R, X and Y have the meanings as described. The compounds are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 9, 2018
    Assignee: MERCK PATENT GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
  • A PHOTOSENSITIVE COMPOSITION AND COLOR CONVERTING FILM
    Publication number: 20180284613
    Abstract: The present invention relates to a photosensitive composition, and a color conversion film. The present invention further relates to a use of the photosensitive composition in a color conversion film fabrication process, and to a use of the color conversion film in an optical device. The invention further more relates to an optical device comprising the color conversion film and method for preparing the color conversion film and the optical device.
    Type: Application
    Filed: August 30, 2016
    Publication date: October 4, 2018
    Applicants: Merck Patent GmbH, AZ Electronic Materials (Luxembourg) S.A.R.L.
    Inventors: Yuki HIRAYAMA, Tadashi KISHIMOTO, Masayoshi SUZUKI, Daishi YOKOYAMA, Katsuto TANIGUCHI, Toshiaki NONAKA
  • SOLID DISPERSIONS OF COMPOUNDS USING POLYVINYL ALCOHOL AS A CARRIER POLYMER
    Publication number: 20180280302
    Abstract: The present invention refers to a method for producing storage-stable solid dispersions of poorly soluble pharmaceutically active compounds comprising polyvinyl alcohol as carrier matrix. The invention also refers to the prepared compositions and their use.
    Type: Application
    Filed: December 22, 2015
    Publication date: October 4, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Shawn KUCERA, Dieter LUBDA, Dave MILLER, Chris BROUGH
  • Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer
    Publication number: 20180282415
    Abstract: The present disclosure describes combination therapies useful for the treatment of cancer. In particular, the invention relates to a combination therapy which comprises a PD-1 axis binding antagonist and an ALK inhibitor for treating cancer.
    Type: Application
    Filed: September 27, 2016
    Publication date: October 4, 2018
    Applicants: Merck Patent GmbH, Pfizer Inc.
    Inventors: Chia-Yang LIN, Wei Wei Wu PRIOR, Yan QU, Changyu WANG
  • Implant comprising FGF-18
    Patent number: 10086112
    Abstract: The invention relates to the field of pharmaceutical compositions. More particularly it is directed to substance delivery system (or implant), such as scaffolds and membranes, comprising an anabolic drug, such as a Fibroblast Growth Factor 18 (FGF-18) compound, to methods of producing such delivery system, as well as use thereof. The implants according to the invention are for use for the treatment of cartilage disorders, such as osteoarthritis, cartilage injury or osteochondral defects.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: October 2, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Christoph H. Ladel, Hans Guehring
  • Mesogenic media and liquid crystal display
    Patent number: 10087370
    Abstract: The invention relates to mesogenic media comprising a first component, component A, consisting of bimesogenic compounds selected from the group of compounds of formulae A-I to A-III a second component, component B, consisting of nematogenic compounds, preferably selected from the group of compounds of formulae B-I to B-III and a third component, component C, consisting of one or more chiral molecules, wherein the parameters have the meaning given in claim 1, to the use of mesogenic media in flexoelectric liquid crystal devices and to those devices comprising a liquid crystal medium according to the present invention.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: October 2, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Rachel Tuffin, Benjamin Snow, Owain Llyr Parri, Simon Siemianowski, Rebecca Proctor, Kevin Adlem
  • Cyclic amine azaheterocyclic carboxamides
    Patent number: 10087166
    Abstract: The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: October 2, 2018
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Xiaoling Chen, Constantin Neagu, Reinaldo Jones, Yufang Xiao, Igor Mochalkin
  • LASER-MARKABLE AND LASER-WELDABLE POLYMERIC MATERIALS
    Publication number: 20180273730
    Abstract: The present invention relates to coloured laser-markable and laser-weldable polymeric materials which are distinguished by the fact that they comprise, as absorber, at least one doped tin oxide or indium oxide having a large specific surface area.
    Type: Application
    Filed: October 15, 2015
    Publication date: September 27, 2018
    Applicant: Merck Patent GmbH
    Inventors: Reinhold RUEGER, Ulrich QUITTMANN
  • BISMUTH PERFLUOROALKYLPHOSPHINATES AS LEWIS ACID CATALYSTS
    Publication number: 20180273561
    Abstract: The invention relates to bismuth perfluoroalkylphosphinates as Lewis acid catalysts, the compounds, and processes for the preparation thereof. ArxBi[OP(O)(Rf)2]3-x??(Ia), Ar3Bi[OP(O)(Rf)2]2??(Ib).
    Type: Application
    Filed: September 7, 2016
    Publication date: September 27, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Berthold Theo HOGE, Sven Joerg-Ruediger August SOLYNTJES, Nikolai (Mykola) IGNATIEV
  • PERFLUOROALKYL GROUP-CONTAINING BISMUTH COMPOUNDS AS LEWIS ACID CATALYSTS
    Publication number: 20180272325
    Abstract: The invention relates to perfluoroalkyl group-containing bismuth compounds as Lewis acid catalysts, to specific compounds, and to the method for the production thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 27, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Berthold Theo HOGE, Sven Joerg-Ruediger August SOLYNTJES, Anne Julia BADER, Nikolai IGNATIEV
  • Liquid-crystalline medium
    Patent number: 10081765
    Abstract: The invention relates to a liquid-crystalline medium comprising at least one compound of the formula I, in which R1 and R2 have the meanings indicated in Claim 1, and to the use thereof in electro-optical liquid-crystal displays.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 25, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Harald Hirschmann, Volker Reiffenrath
  • Aminopyrimidine derivatives for use as modulators of kinase activity
    Patent number: 10080750
    Abstract: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: September 25, 2018
    Assignee: Merck Patent GmbH
    Inventors: Ruoxi Lan, Bayard R. Huck, Xiaoling Chen, Lizbeth C. Deselm, Hui Qiu, Yufang Xiao, Constantin Neagu, Igor Mochalkin, Theresa L. Johnson
  • Heterocyclic carboxamides as modulators of kinase activity
    Patent number: 10080753
    Abstract: The invention provides novel heterocyclic carboxamide compounds according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 25, 2018
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Xiaoling Chen, Yufang Xiao, Ruoxi Lan, Lizbeth Celeste De Selm, Constantin Neagu, Justin Potnick, Srinivasa R. Karra, Theresa L Johnson