Patents Assigned to Merck
  • HETEROAROMATIC ISOTHIOCYANATES
    Publication number: 20240124779
    Abstract: The present invention relates to heteroaromatic isothiocyanates of formula N as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula N and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
    Type: Application
    Filed: December 14, 2021
    Publication date: April 18, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Constanze BROCKE, Dagmar KLASS, Carsten FRITSCH, Amir Hossain PARHAM
  • LIPID NANOPARTICLE ADJUVANT COMPOSITION FOR PNEUMOCOCCAL CONJUGATE VACCINES
    Publication number: 20240123047
    Abstract: The present invention relates generally to the prevention of pneumococcal disease. More specifically, the invention relates to compositions comprising pneumococcal conjugates and a lipid nanoparticle (LNP).
    Type: Application
    Filed: February 2, 2022
    Publication date: April 18, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Julie M. Skinner, William J. Smith
  • PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3
    Publication number: 20240124451
    Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by NLPR3. The compounds of the present invention may be useful in the treatment, prevention or management of diseases, disorders and conditions mediated by NLRP3 such as, but not limited to, gout, pseudogout, CAPS, NASH fibrosis, heart failure, idiopathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease and traumatic brain injury.
    Type: Application
    Filed: September 21, 2023
    Publication date: April 18, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Donna A.A.W. Hayes, Prabha Karnachi, Madeleine Eileen Kieffer, Kyle S. McClymont, Rohan Rajiv Merchant, Essam Metwally, Anilkumar G. Nair, Ning Qi, Jillian Rose Sanzone, Nunzio Sciammetta, Emma H. Southgate, Zheng Tan, Brandon M. Taoka
  • Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc-region
    Patent number: 11959118
    Abstract: The present invention is directed to methods and compositions for the production of Fc-containing polypeptides having improved properties and comprising mutations at positions 243 and 264 of the Fc region.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: April 16, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Terrance A. Stadheim, Dongxin Zha, Liming Liu
  • Tetracyclic heterocycle compounds useful as HIV integrase inhibitors
    Patent number: 11958864
    Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein R1 is as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: April 16, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Timothy John Hartingh, John A. McCauley, Tao Yu, Yonglian Zhang
  • Materials for electronic devices
    Patent number: 11963442
    Abstract: The application relates to compounds having functional substituents in a specific spatial arrangement, to devices comprising same, and to the preparation and use thereof.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: April 16, 2024
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Tobias Grossmann, Anja Jatsch, Thomas Eberle, Jonas Kroeber, Christof Pflumm, Lars Dobelmann-Mara
  • Anti-TIGIT antibodies
    Patent number: 11958902
    Abstract: The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: April 16, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Sybil M. G. Williams, Wolfgang Seghezzi, Laurence Fayadat-Dilman, Linda Liang, Veronica Juan
  • Dielectric materials
    Patent number: 11959007
    Abstract: The present invention relates to a novel class of polymers which can be used as dielectric material for the preparation of passivation layers in electronic devices. The polymers are prepared from polymerizable compounds having mesogenic groups and they provide excellent film forming capability and excellent mechanical properties and have a low dielectric constant and a low coefficient of thermal expansion (CTE). There is further provided a method for forming said polymers and an electronic device containing said polymers as dielectric material. Beyond that, the present invention relates to a manufacturing method for preparing a packaged microelectronic structure and to a microelectronic device comprising said packaged microelectronic structure formed by said manufacturing method.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: April 16, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Frank Meyer, Gregor Larbig, Karsten Koppe
  • AROMATIC ISOTHIOCYANATES
    Publication number: 20240117249
    Abstract: The present invention relates to a compound of formula G as defined in claim 1, to a liquid crystal medium comprising a compound of formula G and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
    Type: Application
    Filed: October 25, 2021
    Publication date: April 11, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Constanze BROCKE, Carsten FRITZSCH, Dagmar KLASS
  • METHODS AND COMPOSITIONS COMPRISING AN ANTI-CTLA4 MONOCLONAL ANTIBODY WITH REDUCED HOST CELL PROTEINS AND INCREASED POLYSORBATE-80 STABILITY
    Publication number: 20240115701
    Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.
    Type: Application
    Filed: September 18, 2020
    Publication date: April 11, 2024
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Rebecca A. Chmielowski, Francis K. Insaidoo, Justin B. Miller, David J. Roush, Darshini Shah, John P. Welsh
  • EXATECAN-DERIVED TOPOISOMERASE-1 INHIBITORS PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Publication number: 20240116945
    Abstract: The present disclosure is directed to alcohol and amine containing exatecan derivatives, and pharmaceutically acceptable salts or solvates thereof, comprising a structure of formula I: wherein X is defined in the disclosure. The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of cancers and/or tumors.
    Type: Application
    Filed: August 31, 2023
    Publication date: April 11, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Vlad Bacauanu, Manoj B. Charati, Rebecca Elizabeth Johnson, Simon B. Lang, Ryan Quiroz, W. Michael Seganish, Song Yang, Nancy S. Zepeda
  • LC medium
    Patent number: 11952526
    Abstract: The present invention relates to liquid-crystalline (LC) media and to LC displays (LCDs) containing these media, in particular to LCDs of the twisted nematic (TN) mode, preferably to displays of the LCOS (LC on silicon) mode.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: April 9, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Nicole (I-Yun) Huang, Eason (Chi-Shun) Huang, Ray (Kuang-Ting) Chou
  • Switching layers for use in a switching element
    Patent number: 11952528
    Abstract: The present invention relates to an assembly of switching layers for dimming and scattering of light and to window elements comprising the arrangement of switching layers.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: April 9, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Henriette Bakker, Ties De Jong, Michael Junge, Andreas Beyer, Jasper Van Den Muijsenberg
  • Liquid crystal medium
    Patent number: 11952527
    Abstract: A liquid crystal medium containing a compound of formula I and one or more compounds of the formulae IIA, IIB, IIC and IID, useable in optical, electro-optical and electronic purposes, in particular in LC displays.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: April 9, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Sven Christian Laut, Harald Hirschmann, Juergen Radestock
  • METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F
    Publication number: 20240108742
    Abstract: The present invention provides a method of producing a polysaccharide—protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation step prior to filtration to remove free polysaccharide.
    Type: Application
    Filed: December 15, 2023
    Publication date: April 4, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Michael Albert Winters, John E. MacNair
  • COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20240108711
    Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
    Type: Application
    Filed: November 9, 2023
    Publication date: April 4, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: William J. Smith, Patrick McHugh, Michael Albert Winters, Julie M. Skinner, Jian He, Luwy Musey, Chitrananda Abeygunawardana, Yadong Adam Cui, Michael J. Kosinski
  • NANOEMULSION ADJUVANT COMPOSITION FOR PNEUMOCOCCAL CONJUGATE VACCINES
    Publication number: 20240108710
    Abstract: The present invention relates generally to the prevention of pneumococcal disease. More specifically, the invention relates to a composition comprising pneumococcal conjugates and a stable nanoemulsion (SNE).
    Type: Application
    Filed: February 2, 2022
    Publication date: April 4, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: William J. Smith, Patrick L. Ahl, Randal J. Soukup, Julie M. Skinner
  • Method for providing a casing for a chromatography column and chromatography column
    Patent number: 11946914
    Abstract: A method for providing a casing (11) for a prefabricated column (1) of chromatography column material in order to manufacture a chromatography column, wherein the casing (11) is generated by additive manufacturing, includes the steps of rotating the column (1) of chromatography column material with respect to a casing material feed in a manner to successively cover a casing surface (8) of the chromatography column material along a contact area path (12), and of arranging an amount of flowable casing material (9) at a current contact area (7) along the contact area path (12) at the casing surface (8) of the column (1) of chromatography column material in order to generate the casing (11) for the chromatography column by successively adding the solidified amount of casing material (9) at the contact area (7).
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: April 2, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Pedro Buehner, Philipp Knoth, Benjamin Peters, Michael Ukelis
  • FACTOR XIA INHIBITORS
    Publication number: 20240101567
    Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 28, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: John S. Debenham, Cheng Zhu, Amjad Ali, Sung-Sau So, Ying-Duo Gao
  • HETEROCYCLIC COMPOUNDS FOR LIQUID CRYSTALS
    Publication number: 20240101903
    Abstract: Compounds of formula I liquid crystal media containing these compounds, and high-frequency components containing these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, phased array antennas, and devices containing these components, and furthermore optical components containing these liquid-crystalline media, operable in the infrared region of the electromagnetic spectrum.
    Type: Application
    Filed: August 25, 2023
    Publication date: March 28, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Amir Hossain PARHAM, Constanze BROCKE, Carsten Fritzsch, Dagmar KLASS, Matthias JOST