Patents Assigned to Merck
  • Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection
    Patent number: 11976069
    Abstract: The present invention relates to Compounds of Formula I and Ia and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, X, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I or Ia, and methods of using the compounds of Formula I or Ia for treating or preventing HIV infection in a subject.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: May 7, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Wensheng Yu, Joseph A. Kozlowski, Dane James Clausen, Jian Liu, James Fells
  • Methods of vapor deposition of ruthenium using an oxygen-free co-reactant
    Patent number: 11976352
    Abstract: Methods of forming ruthenium-containing films by atomic layer deposition and/or chemical vapor deposition are provided. The methods comprise delivering at least one precursor and an oxygen-free co-reactant, such as hydrazine or alkylhydrazine, to a substrate to form a ruthenium-containing film, wherein the at least one precursor corresponds in structure to Formula (I): (L)Ru(CO)3, wherein L is selected from the group consisting of a linear or branched C2-C6-alkenyl and a linear or branched C1-C6-alkyl; and wherein L is optionally substituted with one or more substituents independently selected from the group consisting of C2-C6-alkenyl, C1-C6-alkyl, alkoxy and NR1R2; wherein R1 and R2 are independently alkyl or hydrogen; and annealing the ruthenium-containing film under vacuum or in the presence of an inert gas such as Ar, N2, or a reducing gas such as H2 or a combination thereof.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: May 7, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Jacob Woodruff, Guo Liu, Ravindra Kanjolia
  • Preparation of benzimidazolone derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors
    Patent number: 11976061
    Abstract: Invented are compounds of Formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: May 7, 2024
    Assignee: Merck Sharp & Dohme, LLC
    Inventors: Yeon-Hee Lim, Eric R. Ashley, Jianming Bao, Chen Cheng, James P. Roane, Emma Helen Southgate
  • Process for preparing pharmaceutical compositions
    Patent number: 11975100
    Abstract: A process for preparing and isolating pharmaceutical active ingredient particles having a particle size of between about 0.1 and 30 microns, wherein a slurry comprising the active ingredient and one or more pharmaceutically acceptable excipients is fed into a thin film evaporator under suitable conditions for less than 10 minutes sufficient to generate solid matrix particles comprising active ingredient and one or more excipients, wherein the particles have less than 5% residual solvent.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: May 7, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Luke R. Schenck, David J. Lamberto, Joseph L. Kukura, II, Francisco J. Guzman, Aaron Cote, Athanas Koynov
  • SYNTHESIS OF URIDINE
    Publication number: 20240140920
    Abstract: The present invention relates to efficient synthetic processes useful in the preparation of uridine, which is useful in the production of nucleosides and nucleotides that may be active as antiviral agents, as well as compositions and methods thereof.
    Type: Application
    Filed: December 17, 2021
    Publication date: May 2, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Tamas Benkovics, Anna Fryszkowska, Mark A. Huffman, Tetsuji Itoh, Kevin M. Maloney, John McIntosh, Grant S. Murphy
  • ENHANCING IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20240139303
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
    Type: Application
    Filed: June 22, 2023
    Publication date: May 2, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Julie M. Skinner, Patrick McHugh
  • RECIPROCAL INJECTION DEVICE AND METHODS OF USING SAME
    Publication number: 20240142356
    Abstract: In some embodiments, a reciprocal injection device includes a platform having a motor, a gearbox operatively coupled to the motor, an actuation slide driven by the motor, a pair of clamp fixtures for supporting two syringes, a pair of axially translatable syringe plunger fixtures, and an interface in communication with the platform and configured and arranged to actuate the motor.
    Type: Application
    Filed: October 19, 2023
    Publication date: May 2, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Guangli Hu, Steven Carl Persak, Yongchao Su, Edward Yeung
  • PREPARATION OF TETRAHYDROINDAZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
    Publication number: 20240140938
    Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof.
    Type: Application
    Filed: December 17, 2021
    Publication date: May 2, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jianming Bao, Chen Cheng, Faben A. Cruz, Yeon-Hee Lim, Cedric L. Hugelshofer, Jinlong Jiang, Victor W. Mak, Emma Helen Southgate
  • Device for the regulation of light transmission
    Patent number: 11971634
    Abstract: Disclosed is a device for the regulation of light transmission. In particular, switchable windows and methods for their preparation are disclosed. The switchable windows include electrically switchable devices which in one optical switching state are capable of portraying closed patterns or images without the need for providing complex electrical contacting.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: April 30, 2024
    Assignee: MERCK PATENT GmbH
    Inventors: Chuan Nie, Ties De Jong, Johan Osenga
  • 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor
    Patent number: 11970479
    Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: April 30, 2024
    Assignees: Merck Sharp & Dohme LLC, MSD R&D (China) Co. LTD.
    Inventors: John J. Acton, III, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Timothy J. Henderson, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, James Mulhearn, Vanessa L. Rada, Jeffrey W. Schubert, Oleg B. Selyutin, David M. Tellers, Ling Tong, Fengqi Zhang, Jianming Bao, Chunsing Li
  • FORMULATIONS OF DENGUE VIRUS VACCINE COMPOSITIONS
    Publication number: 20240131144
    Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a glycol or sugar alcohol, optionally an alkali or alkaline salt and an amino acid; and formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar of at least 150 mg/ml, a carrier, and optionally an alkali or alkaline salt and an amino acid.
    Type: Application
    Filed: December 6, 2023
    Publication date: April 25, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Michael S. Ryan, Sherrie-Ann P. Martin, Morrisa Jones, Justin Stanbro, Akhilesh Bhambhani, Jeffrey Thomas Blue, Heidi Joanne Pixley, Erin J. Green-Trexler, Lynne Ann Isopi
  • BLOW-FILL SEALING METHOD FOR FILLING AND PACKAGING
    Publication number: 20240131265
    Abstract: A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the effects of the blow-fill sealing on the biopharmaceutical product, providing a parison to a blow-fill sealing machine for accepting the biopharmaceutical product during the blow-fill sealing, predicting a temperature of at least one the biopharmaceutical product, the parison, and a component of the blow-fill sealing machine at a stage in the blow-fill sealing, and adjusting a parameter of the blow-fill sealing machine to reduce damage to the biopharmaceutical product.
    Type: Application
    Filed: October 10, 2023
    Publication date: April 25, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Carl Chew, Matthew H. Flamm, Jeremy A. Haddock, Rikhabh Jain, Atul Karande, Brit L. Rudeen
  • NOVEL CRYSTALLINE FORMS OF 1-(4-{[6-AMINO-5-(4-PHENOXY-PHENYL)-PYRIMIDIN-4-YLAMINO]-METHYL}-4-FLUORO-PIPERIDIN-1-YL)-PROPENONE, SALT FORMS THEREOF, AND PROCESSES TO OBTAIN
    Publication number: 20240132472
    Abstract: A solid form of 1-(4-{[6-Amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, or pharmaceutically acceptable salts thereof, is useful as a BTK inhibitor.
    Type: Application
    Filed: December 7, 2023
    Publication date: April 25, 2024
    Applicant: Merck Patent GmbH
    Inventors: Michael LANGE, Clemens Kuetin, Tobias Schiueter, Werner Mederski, David Maillard, Edoardo Burini
  • CHEMOVACCINATION AGAINST PLASMODIUM INFECTION WITH SELECTIVE PLASMEPSIN X INHIBITORS
    Publication number: 20240131028
    Abstract: The present invention relates to a method of chemovaccination against Plasmodium infection comprising administering to a patient an effective amount of a selective inhibitor of plasmepsin X, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 2, 2022
    Publication date: April 25, 2024
    Applicants: Merck Sharp & Dohme LLC, The Walter and Eliza Hall Institute of Medical Research
    Inventors: Justin A. Boddey, David B. Olsen, Ryan Steel, John A. McCauley, Manuel De Lera Ruiz
  • DEVICE FOR THE REGULATION OF LIGHT TRANSMISSION
    Publication number: 20240134218
    Abstract: The present invention relates to devices for the regulation of light transmission and in particular to switchable windows. The present invention in particular relates to window elements which comprise electrically switchable optical cells with a switchable layer containing a liquid-crystalline medium having a clearing point which is within the working temperature of the window element. The present invention also relates to liquid-crystalline media for use in the window elements.
    Type: Application
    Filed: December 9, 2021
    Publication date: April 25, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Michael JUNGE, Andreas BEYER, Ewa Dominika PTAK
  • Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
    Patent number: 11964023
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: April 23, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
  • Optical medium composition with nanosized light emitting material and (meth)acrylic polymer
    Patent number: 11965049
    Abstract: Photosensitive compositions containing nanosized light emitting materials and (meth)acrylic polymer are suitable for use in a variety of optical applications, for example the preparation of quantum material doped photoresist films, especially for optical devices. Optical films can be prepared be by: a) providing the photosensitive composition onto a substrate, and b) polymerizing the photosensitive composition by exposing the photosensitive composition to radiation.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: April 23, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Tadashi Kishimoto, Yuko Arai, Masayoshi Suzuki, Daishi Yokoyama, Katsuto Taniguchi
  • Fluorinated aromatic compounds
    Patent number: 11964933
    Abstract: The present invention relates to aromatic isothiocyanates of formula U as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula U and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: April 23, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Constanze Brocke, Dmitry Ushakov, Carsten Fritzsch, Dagmar Klass
  • HETEROAROMATIC ISOTHIOCYANATES
    Publication number: 20240124780
    Abstract: The present invention relates to heteroaromatic isothiocyanates of formula N as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula N and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.
    Type: Application
    Filed: December 13, 2021
    Publication date: April 18, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Amir Hossain PARHAM, Constanze BROCKE, Carsten FRITZSCH, Dagmar KLASS
  • Removable display for a water purifier with docking station
    Patent number: D1025285
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: April 30, 2024
    Assignee: Merck Patent GmbH
    Inventors: Camillo König, Dény Saraliev, Fabien Jeannerot, Gérald Lelong