Abstract: Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable sulfinyl or arylsulfonyl group attached to the benzimidazole nitrogen, or include a group that forms a Mannich base with the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under physiological conditions to provide the proton pump inhibitors with a half life measurable in hours, and are capable of providing sustained plasma concentrations of the proton pump inhibitor drugs for longer time than presently used drugs. The generation of the proton pump inhibitor drugs from the prodrugs of the invention under physiological conditions allows for more effective treatment of several diseases and conditions caused by gastric acid secretion.
Type:
Grant
Filed:
August 10, 1998
Date of Patent:
July 25, 2000
Assignee:
Partnership of Michael E. Garst, George Sachs, and Jai Moo Shin
Inventors:
Michael E. Garst, George Sachs, Jai Moo Shin
Abstract: This device is a cleaning tool for cleaning the inside of gun barrels. The device consists of a metal brush which is enclosed within a tubular sheath of material, typically a woven fabric. The bristles of the brush extend through the wall of the woven sheath of fabric. The tubular sheath is pulled through a gun barrel and the bristles of the brush clean the inside of the gun barrel. Also enclosed within the tubular sheath are one or more foam inserts, or one or more cleaning regions formed by folding the cord within itself, either of which creates a bulge in the tubular sheath and cleans debris from the gun barrel, spreads gun cleaning solvent in the gun barrel, absorbs solvent and combustion and bullet residues, and spreads a layer of gun oil in the gun barrel.
Abstract: An ergonomic workstation for supporting the arms of a computer operator. Arm cradles are suspended from telescoping booms which are pivotally attached to a computer monitor stand.
Abstract: A tool includes a handle in which a cassette is received and a shank extending from the handle with a bit or a socket connected to the shank. The cassette has batteries received therein and two tubes extending from the first end thereof so that two bulbs are received in the two tubes. A button device is connected to the second end of the cassette and contacts the batteries. The button device and the cassette are a one-piece member which is conveniently received in and removed from the handle.
Type:
Grant
Filed:
February 11, 1999
Date of Patent:
July 11, 2000
Assignees:
Paul L. Lee, Hsin-Yen Lin, Michael C. Wu
Abstract: A die set used in pipe tongs in the oil and gas industry for gripping pipe while threadably coupling pipe joints, the die having electroless nickel plated, non-interrupted knurled teeth having a special shape which reduces die penetration, thereby reducing wall loss due to die penetration, stress cracking and carbon transfer to oil and gas field tubular pipe and especially to corrosive resistive alloy pipe, thus further reducing pipe corrosion.
Abstract: The present invention provides a game and training device which can be played in a game-like setting to develop skills such as ball handling, passing, and shooting. A primary goal forms a target opening in a generally vertical plane through which a ball may be kicked by the player. In addition, a plurality of intermediate goals are arranged on the playing field in spaced relation to one another. Each intermediate goal defines a respective target opening through which the ball is to be passed as the player advances the ball to the primary goal. Each intermediate goal comprises a pair of base members positioned on laterally spaced apart relation to one another and a hoop member supported by the pair of base members.
Type:
Grant
Filed:
March 5, 1998
Date of Patent:
May 30, 2000
Assignee:
Michael N. Sinsheimer
Inventors:
Michael N. Sinsheimer, Richard W. Turner, Holger Schleife
Abstract: A device for machining workpieces of wood or plastic has at least one spindle having a spindle axis and being moveable transverse to the spindle axis relative to a reference plane. A machining tool having cutting edges is provided. The machining tool is seated on the spindle. At least one measuring device is provided for correctly positioning the cutting edges relative to the reference plane. Correct positioning is achieved by moving the spindle in a direction transverse to the spindle axis and detecting by the measuring device a preset position of the cutting edges of the machining tool relative to the reference plane and generating a switch-off signal when the cutting edges of the matching tool are in the preset position.
Type:
Grant
Filed:
December 18, 1998
Date of Patent:
May 9, 2000
Assignee:
Michael Weinig Aktiengesellschaft
Inventors:
Adolf Albert, Albrecht Dawidziak, Martin Horn, Hubert Klein, Albin Korner, Rainer Kurz, Uwe Lindemann, Heinrich Englert
Abstract: A machine is described for performing a draw-down operation in which a carriage for supporting a scraper is mounted on the base so as to travel along it, an electric motor is coupled to the carriage for moving it and a scraper is pivotally mounted on said carriage with a means for pushing the scraper against the top of the base with a selectable force.
Abstract: An interior or exterior design lighting assembly with a photosensitive sheet member in spaced relation to said assembly capable of aesthetically concealing its inner componentry by having said photosensitive sheet member adapting a darkened appearance when said assembly is in its de-energized state. When the light assembly is energized said photosensitive sheet member will render its darkened state to adapt a transparent state allowing for full light transmission to occur.
Abstract: A coupon dispenser is provided with at least one suction cup and, preferably, a pair of suction cups, connected to the dispenser box so that the box can be directly mounted on a window, refrigerator/freezer door, or any other substantially flat and smooth surface capable of supporting a suction cup.
Abstract: This invention relates to a case with a variable capacity, comprising a central part (10) which has two stable frame halves (20,30) hinged to one another which serve as supports for a single pair of various size sheet pairs (41,42;51,52) defining the interior of the case, the shells (41,42;51,52) being detachably connected to the frame halves (20,30) of the central part (10), so that shells of different depths may be used together with the same central part. The invention also relates to a set of cases, comprising a central part and two or several pairs of shells.
Type:
Grant
Filed:
January 17, 1997
Date of Patent:
April 18, 2000
Assignee:
MP Michael Pfeiffer Design & Marketing GmbH
Abstract: A method for controlling deformation of an erected structural metal plate culvert or underpass during backfilling of the erected structure comprises: building progressively a reinforced earth retaining system on each side of the erected structure by alternately layering a plurality of compacted layers of earth with interposed layers of reinforcement to form reinforced earth on each side of the erected structure and securing to each side of the structure each said layer of reinforcement in the reinforced earth, whereby such securement of each said layer of reinforcement to said structure controls deformation of the erected structure during backfilling with the reinforced earth on each side of the structure. The layer of reinforcement may be a plurality of strips extending away from the structure, or a reinforcement mat of interconnected rods.
Abstract: A method is provided to ensure that a combustion turbine power generation system may operate at maximum allowable power at elevated ambient temperature and/or at low air density. The method includes providing at least one combustion turbine assembly including a compressor, an expansion turbine operatively associated with the compressor, a generator coupled with the expansion turbine; a combustor feeding the expansion turbine; flow path structure fluidly connecting an outlet of the compressor to an inlet of the combustor.