Patents Assigned to Monash University
  • ANAESTHETIC FORMULATION
    Publication number: 20120316146
    Abstract: The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
    Type: Application
    Filed: January 19, 2011
    Publication date: December 13, 2012
    Applicants: MONASH UNIVERSITY, GOODCHILD INVESTMENTS PTY LTD.
    Inventors: Juliet Marguerite Goodchild, Colin Stanley Goodchild, Benjamin James Boyd
  • METHODS FOR REGULATING BLOOD GLUCOSE LEVELS
    Publication number: 20120309677
    Abstract: The invention relates to methods and compositions for reducing blood glucose levels in hyperglycaemic subjects. The methods and compositions may therefore be suitable for treating a disease or condition associated with hyperglycaemia such as, for example, obesity (particularly diet induced obesity (DIO)), weight gain, Type II diabetes mellitus, insulin sensitivity, impaired glucose tolerance and inflammation. In some embodiments, the methods comprise administering a melanocortin-5 receptor (MC5R) agonist to one or more skeletal muscle cells of the subject. Preferred MC5R agonists are those that specifically activate MC5R and/or enhance expression of MC5R, such as the melanocortin analogue, Ac-Nle-c[Asp-Pro-D-Nal(2?)-Arg-Trp-Lys]-NH2.
    Type: Application
    Filed: January 25, 2011
    Publication date: December 6, 2012
    Applicant: Monash University
    Inventors: Michael Alexander Cowley, Pablo Jose Enriori, Russell Deputy Brown, Iain James Clarke, Belinda Anne Henry, Maria Cecilia Garcia-Rudaz
  • ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE
    Publication number: 20120302586
    Abstract: Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
    Type: Application
    Filed: September 28, 2010
    Publication date: November 29, 2012
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, MONASH UNIVERSITY, CLAYTON, GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO, S.L, UNIVERSITY OF WASHINGTON, MEDICINES FOR MALARIA VENTURE
    Inventors: Pradipsinh K. Rathod, David Floyd, Jeremy Burrows, Alka Marwaha, Ramesh Gujjar, Jose Coteron-Lopez, Margaret Phillips, Susan A. Charman, David Matthews
  • NAVIGABLE SYSTEM FOR CATHETER BASED ENDOVASCULAR NEUROSURGERY
    Publication number: 20120289897
    Abstract: A navigable system for catheter based endovascular neurosurgery including: a micro-motor (3) including a piezoelectric actuator (5) mounted to a free end of a guidewire or micro-catheter (2), the piezoelectric actuator (5) including a piezoelectric element (7), and an elongate transducer (9) mounted on the piezoelectric element (7) and extending therefrom, the transducer (9) being formed from an asymmetric hollow member, and an end member (15) located at a free end of the transducer (9); wherein electrical excitation of the piezoelectric element (7) induces one or both orthogonal flexural and axial vibration modes within the transducer (9), the coupling of the induced vibration modes thereby resulting in rotation of the end member (15) with three degrees of freedom (DOF).
    Type: Application
    Filed: September 3, 2010
    Publication date: November 15, 2012
    Applicant: Monash University
    Inventors: James Friend, Leslie Yeo, Bernard Yan
  • PARTICLE IMAGE VELOCIMETRY SUITABLE FOR X-RAY PROJECTION IMAGING
    Publication number: 20120237104
    Abstract: A 2D or 3D velocity field is reconstructed from a cross-correlation analysis of image pairs of a sample, without first reconstructing images of the sample spatial structure. The method can be implemented via computer tomographic X-ray particle image velocimetry, using multiple projection angles, with phase contrast images forming dynamic speckle patterns. Estimated cross-correlations may be generated via convolution of a measured autocorrelation function with a velocity probability density function, and the velocity coefficients iteratively optimised to minimise the error between the estimated cross-correlations and the measured cross-correlations. The method may be applied to measure blood flow, and the motion of tissue and organs such as heart and lungs.
    Type: Application
    Filed: September 16, 2010
    Publication date: September 20, 2012
    Applicant: MONASH UNIVERSITY
    Inventors: Andreas Fouras, Stephen Dubsky
  • CROSSLINKING METHOD
    Publication number: 20120238693
    Abstract: The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerization by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products.
    Type: Application
    Filed: June 1, 2012
    Publication date: September 20, 2012
    Applicants: MONASH UNIVERSITY, DELUXGROUP (AUSTRALIA) PTY. LTD
    Inventors: Christopher Henry SUCH, Jim Patel, William Roy Jackson, Andrea Jane Robinson, Algirdas Kazimieras Serelis
  • INSULIN ANALOGUES
    Publication number: 20120225811
    Abstract: A dicarba analogue of insulin comprising an A-chain and a B-chain or fragments, salts, solvates, derivatives, isomers or tautomers of the A-chain, the B-chain or both, provided that the dicarba analogue is not [A7,B7-(2,7-diaminosuberoyl]-des-(B26-B30)-insulin B25-amide.
    Type: Application
    Filed: May 25, 2011
    Publication date: September 6, 2012
    Applicants: POLYCHIP PHARMACEUTICALS PTY LTD, MONASH UNIVERSITY
    Inventors: Andrea Robinson, Bianca Van Lierop
  • METHOD FOR THE N-DEMETHYLATION OF N-METHYL HETEROCYCLES
    Publication number: 20120226043
    Abstract: The present invention provides methods of N-demethylating, N-methylated heterocycles and N-methyl, N-oxide heterocycles using a transition metal with an oxidation state of zero, ferrocene or substituted derivatives thereof, or Cr3+. N-demethylated heterocycles prepared by the methods of the present invention are also provided.
    Type: Application
    Filed: September 16, 2010
    Publication date: September 6, 2012
    Applicant: MONASH UNIVERSITY
    Inventors: Peter John Scammells, Gaik Orbell
  • MOLECULARLY IMPRINTED POLYMERS, METHODS FOR THEIR PRODUCTION AND USES THEREOF
    Publication number: 20120225962
    Abstract: The present invention relates to methods of preparing molecularly imprinted polymers (MIPs) which facilitate chemical hydrolysis and more particularly the hydrolysis of chemical substrates which possess hydrolytically labile bonds such as peptides and proteins. The present invention is thus directed to MIPs designed to possess hydrolytic activity, methods for preparing such MIPs and uses of the MIPs.
    Type: Application
    Filed: August 5, 2010
    Publication date: September 6, 2012
    Applicant: MONASH UNIVERSITY
    Inventors: Milton T.W. Hearn, Jamil M. Chowdhury, Reinhard Ingemar Boysen, Yididya B. Banti
  • THREE-DIMENSIONAL MICROFLUIDIC SYSTEMS
    Publication number: 20120192952
    Abstract: A three-dimensional microfluidic system including: at least one hydrophilic thread along which fluid can be transported through capillary wicking; and at least one hydrophobic substrate for supporting the hydrophilic thread. A method of transporting and mixing a plurality of fluids within a microfluidic system including at least two hydrophilic threads and a hydrophobic substrate having at least two zones, each of the hydrophilic threads supported on a different hydrophobic substrate zone, including: delivering each said fluid to a different hydrophilic thread; and bringing the at least two hydrophilic threads into contact to cause mixing of the fluids.
    Type: Application
    Filed: July 20, 2010
    Publication date: August 2, 2012
    Applicant: Monash University
    Inventors: Wei Shen, Xu Li, David Robert Ballerini, Junfei Tian
  • MICROFLUIDIC APPARATUS FOR THE ATOMISATION OF A LIQUID
    Publication number: 20120187209
    Abstract: An apparatus (1) for the atomisation of a liquid including: a piezoelectric substrate (5) having at least one working surface (7), at least one electrode (9) supported on the piezoelectric substrate (5), a signal generating means (21) for applying an ultrasonic signal to said electrode (9) for generating a surface acoustic wave (SAW) in the working surface (7) of the piezoelectric substrate (5); a liquid delivery arrangement (11) including a wick (17) in contact with the working surface (7) for delivering liquid thereof, wherein liquid delivered to the working surface (7) is atomised by SAW irradiation.
    Type: Application
    Filed: May 11, 2010
    Publication date: July 26, 2012
    Applicant: Monash University
    Inventors: James Friend, Leslie Yeo, David Morton, Michelle Mclntosh, Aisha Qi, Jenny Ho, Anushi Rajapaksa
  • NEURAL ANALYSIS SYSTEM
    Publication number: 20120191002
    Abstract: A neural analysis system, including: a neural event extractor for generating Sp/Ap curve data and field potential data for background and initial response segments obtained from a person; a correlator for correlating the Sp/Ap curve data and field potential data with pathology data for a condition, and generating biomarker data points for axes of a biomarker display; and a display module for providing display data to generate the display with the points for use in assessing the person relative to the condition.
    Type: Application
    Filed: June 24, 2010
    Publication date: July 26, 2012
    Applicant: Monash University
    Inventor: Brian John Lithgow
  • QUANTITATIVE AND SELF-CALIBRATING CHEMICAL ANALYSIS USING PAPER-BASED MICROFLUIDIC SYSTEMS
    Publication number: 20120171702
    Abstract: A method of determining the concentration of a test fluid sample using a paper-based microfluidic system having a plurality of hydrophilic testing zones, including: a) depositing said test fluid sample on at least one said testing zone; b) depositing a plurality of standard fluid samples or reactives of differing known concentrations on other said testing zones; c) introducing an indicator solution to each said test zone to thereby react with the deposited fluid sample and result in a colour intensity change which is a function of the fluid sample concentration; and d) comparing the differences in colour intensity between the test fluid sample and the standard fluid samples or reactives to thereby determine the concentration of said test fluid sample.
    Type: Application
    Filed: June 30, 2010
    Publication date: July 5, 2012
    Applicant: Monash University
    Inventors: Wei Shen, Xu Li, Junfei Tian, Gil Garnier
  • Crosslinking method
    Patent number: 8211989
    Abstract: The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerization by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: July 3, 2012
    Assignees: Monash University, Duluxgroup (Austrailia) Pty. Ltd
    Inventors: Christopher Henry Such, Jim Patel, William Roy Jackson, Andrea Jane Robinson, Algirdas Kazimleras Serelis
  • RADIO FREQUENCY TRANSPONDER SYSTEM
    Publication number: 20120161931
    Abstract: A radio frequency transponder is disclosed. In one embodiment, the transponder includes: a substrate and at least one planar antenna on the substrate, the antenna having a shape determining a corresponding resonant frequency of the antenna, wherein the antenna is configured to cause a phase difference between backscattered signals generated in response to excitation of the antenna by orthogonally polarized interrogation signals at the resonant frequency, and the phase difference represents a code of the antenna.
    Type: Application
    Filed: May 19, 2011
    Publication date: June 28, 2012
    Applicant: Monash University
    Inventors: Nemai Chandra Karmakar, Isaac Balbin
  • CONTOXIN ANALOGUES AND METHODS FOR SYNTHESIS OF INTRAMOLECULAR DICARBA BRIDGE-CONTAINING PEPTIDES
    Publication number: 20120142892
    Abstract: According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.
    Type: Application
    Filed: February 16, 2012
    Publication date: June 7, 2012
    Applicants: POLYCHIP PHARMACEUTICALS PTY LTD., MONASH UNIVERSITY
    Inventors: Andrea Robinson, Jomana Elaridi
  • Methods for the synthesis of dicarba bridges in organic compounds
    Patent number: 8188217
    Abstract: The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: May 29, 2012
    Assignees: Monash University, Polychip Pharmaceuticals Pty Ltd.
    Inventors: Andrea Jane Robinson, William Roy Jackson, Jim Patel, Jomana Elaridi
  • PLATELET AGGREGATION USING A MICROFLUIDICS DEVICE
    Publication number: 20120058500
    Abstract: A microfluidics device to provide real time monitoring of platelet aggregation of a biological sample obtained from a subject. The device comprises a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region of shear deceleration and defining there-between a region of peak rate of shear, the downstream region of shear deceleration defining a zone of platelet aggregation. The device further comprises a platelet detection means for detecting aggregation of platelets in the zone of aggregation as a result of passage of the biological sample through the channel. Methods to assess real time platelet aggregation of a biological sample obtained from a subject are further described.
    Type: Application
    Filed: March 10, 2010
    Publication date: March 8, 2012
    Applicant: Monash University
    Inventors: Arnan Deane Mitchell, Francisco Javier Tovar Lopez, Shaun Phillip Jackson, Warwick Scott Nesbitt, Josie Carberry
  • MOLECULARLY IMPRINTED POLYMERS
    Publication number: 20120052757
    Abstract: The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.
    Type: Application
    Filed: January 29, 2010
    Publication date: March 1, 2012
    Applicant: MONASH UNIVERSITY
    Inventors: Milton T. W. Hearn, Steven Langford, Kellie Louise Tuck, Simon Harris, Reinhard Ingemar Boysen, Victoria Tamara Perchyonok, Basil Danylec, Lachlan Schwarz, Jamil Chowdhury
  • Contoxin analogues and methods for synthesizing same
    Patent number: 8124726
    Abstract: According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: February 28, 2012
    Assignees: Monash University, Polychip Pharmaceuticals Pty Ltd.
    Inventors: Andrea Robinson, Jomana Elaridi