Patents Assigned to Monash University
  • Antibodies directed to the receptor tyrosine kinase c-Met
    Patent number: 9169329
    Abstract: The present invention relates to antibodies that specifically bind to unprocessed c-Met present on the surface of tumor cells. These antibodies are useful in the diagnosis and treatment of cancer or as agents for delivering moieties to cancer cells. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: October 27, 2015
    Assignees: Ludwig Institute for Cancer Research, Monash University
    Inventors: Terrance Grant Johns, Ermanno Gherardi, Andrew Mark Scott
  • GRAPHENE-BASED MATERIALS
    Publication number: 20150259212
    Abstract: The present invention relates to graphene-based foam, the graphene-based foam having a structure defined by a three-dimensional network of interconnected and ordered open cells, the open cells being defined by cell walls, the cell walls (i) being formed of graphene sheets, partially reduced graphene oxide sheets, reduced graphene oxide sheets, or a combination thereof, and (ii) having a thickness defined by the thickness of a plurality of graphene sheets, partially reduced graphene oxide sheets, reduced graphene oxide sheets, or a combination thereof.
    Type: Application
    Filed: August 23, 2013
    Publication date: September 17, 2015
    Applicant: MONASH UNIVERSITY
    Inventors: Dan Li, Ling Qiu
  • Quantitative and self-calibrating chemical analysis using paper-based microfluidic systems
    Patent number: 9116146
    Abstract: A method of determining the concentration of a test fluid sample using a paper-based microfluidic system having a plurality of hydrophilic testing zones, including: a) depositing said test fluid sample on at least one said testing zone; b) depositing a plurality of standard fluid samples or reactives of differing known concentrations on other said testing zones; c) introducing an indicator solution to each said test zone to thereby react with the deposited fluid sample and result in a color intensity change which is a function of the fluid sample concentration; and d) comparing the differences in color intensity between the test fluid sample and the standard fluid samples or reactives to thereby determine the concentration of said test fluid sample.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: August 25, 2015
    Assignee: Monash University
    Inventors: Wei Shen, Xu Li, Junfei Tian, Gil Garnier
  • Antimicrobial compounds
    Patent number: 9108978
    Abstract: A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: August 18, 2015
    Assignees: Monash University, Adelaide Research & Innovation Pty Ltd
    Inventors: Andrew Abell, Steven Polyak, Grant Booker, John Wallace, Tatiana Soares da Costa, Angie Jarrad, William Tieu, Kelly Lee Keeling, Daniel Sejer Pedersen, Nicole Pendini, Matthew Wilce, Min Yin Yap
  • Modified arthropod and method of use
    Patent number: 9090911
    Abstract: A modified arthropod, an arthropod-modifying bacterium, and use thereof as an agent for control of diseases transmitted by arthropods, particularly mosquitoes, is provided. More specifically, an isolated arthropod-adapted Wolbachia bacterium capable of modifying one or more biological properties of a mosquito host is provided. The modified arthropod may be characterized as having a shortened life-span, a reduced ability to transmit disease, a reduced susceptibility to a pathogen, a reduced fecundity, and/or a reduced ability to feed from a host, when compared to a corresponding wild-type arthropod.
    Type: Grant
    Filed: June 14, 2014
    Date of Patent: July 28, 2015
    Assignee: Monash University
    Inventors: Scott Leslie O'Neill, Conor James McMeniman, Karyn Nicole Johnson, Elizabeth Ann McGraw, Luciano A. Moreira, Peter Anthony Ryan, Brian Herbert Kay, Jeremy Colin Brownlie
  • Neural response system
    Patent number: 9078576
    Abstract: A neural response system, including a plurality of filters for each receiving and filtering a plurality of tilt response signals obtained from a person; a segmenter for segmenting the filtered response signals into time segments; and a neural event extractor for performing a neural event extraction process on each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: July 14, 2015
    Assignee: Monash University
    Inventor: Brian John Lithgow
  • Method for the N-demethylation of N-methyl heterocycles
    Patent number: 9073934
    Abstract: The present invention provides methods of N-demethylating, N-methylated heterocycles and N-methyl, N-oxide heterocycles using a transition metal with an oxidation state of zero, ferrocene or substituted derivatives thereof, or Cr3+. N-demethylated heterocycles prepared by the methods of the present invention are also provided.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: July 7, 2015
    Assignee: MONASH UNIVERSITY
    Inventors: Peter John Scammells, Gaik Orbell
  • OPTIMISING CURRENT DIRECTION AND INTENSITY OF TRANSCRANIAL MAGNETIC STIMULATION
    Publication number: 20150174423
    Abstract: A method of optimising transcranial magnetic stimulation is described. An electrical signal is applied to a coil to generate one or more magnetic field pulses for transcranial magnetic stimulation of a target cortical region of a patient. The transcranial magnetic stimulation has stimulation parameters including orientation of the coil relative to the patient and intensity of the magnetic stimulation. At least the orientation of the coil relative to the patient is varied. At different orientations of the coil relative to the patient, neuron activation at the target cortical region is determined by monitoring changes in blood flow and/or blood oxygenation, e.g. using near infra-red spectroscopy. Based on information obtained during the monitoring, one or more optimal coil orientations for the transcranial magnetic stimulation are determined. Apparatus for carrying out the method is also described.
    Type: Application
    Filed: May 22, 2013
    Publication date: June 25, 2015
    Applicant: Monash University
    Inventors: Paul B. Fitzgerald, Richard H. Thomson
  • BREATHABLE ELECTRODE AND METHOD FOR USE IN WATER SPLITTING
    Publication number: 20150167185
    Abstract: The present invention relates to a water splitting cell having at least one electrode comprising a porous membrane, wherein gas produced at the electrode diffuses out of the cell via the porous membrane, separating the gas from the reaction at the electrode without bubble formation.
    Type: Application
    Filed: June 12, 2012
    Publication date: June 18, 2015
    Applicant: Monash University
    Inventors: Bjorn Winther-Jensen, Douglas MacFarlane, Orawan Winther-Jensen
  • METHOD AND SYSTEM FOR IMAGING
    Publication number: 20150150482
    Abstract: A method for dynamic investigation of a subject lung, the method comprising the steps of: (i) imparting an oscillation to the lung at one or more forcing frequencies so as to elicit a lung response, (ii) sensing the response of the lung simultaneously with the imparting of the oscillation to elicit a lung response, (iii) choosing at least one parameter used in the sensing to define the lung motion associated with the lung response, (iv) comparing one of the chosen parameters at each forcing frequency with the response at the forcing frequency in at least one region of the lung, and (v) recording the comparison of step (iv).
    Type: Application
    Filed: April 16, 2013
    Publication date: June 4, 2015
    Applicant: MONASH UNIVERSITY
    Inventors: Andreas Fouras, Jordan Thurgood
  • Particle image velocimetry suitable for X-ray projection imaging
    Patent number: 9036887
    Abstract: A 2D or 3D velocity field is reconstructed from a cross-correlation analysis of image pairs of a sample, without first reconstructing images of the sample spatial structure. The method can be implemented via computer tomographic X-ray particle image velocimetry, using multiple projection angles, with phase contrast images forming dynamic speckle patterns. Estimated cross-correlations may be generated via convolution of a measured autocorrelation function with a velocity probability density function, and the velocity coefficients iteratively optimized to minimize the error between the estimated cross-correlations and the measured cross-correlations. The method may be applied to measure blood flow, and the motion of tissue and organs such as heart and lungs.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: May 19, 2015
    Assignee: Monash University
    Inventors: Andreas Fouras, Stephen Dubsky
  • Partical image velocimetry suitable for X-ray projection imaging
    Patent number: 9025849
    Abstract: A 2D or 3D velocity field is reconstructed from a cross-correlation analysis of image pairs of a sample, without first reconstructing images of the sample spatial structure. The method can be implemented via computer tomographic x-ray particle image velocimetry, using multiple projection angles, with phase contrast images forming dynamic speckle patterns. Estimated cross-correlations may be generated via convolution of a measured autocorrelation function with a velocity probability density function, and the velocity coefficients iteratively optimized to minimize the error between the estimated cross-correlations and the measured cross-correlations. The method may be applied to measure blood flow, and the motion of tissue and organs such as heart and lungs.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: May 5, 2015
    Assignee: Monash University
    Inventors: Andreas Fouras, Stephen Dubsky
  • PROCESS AND CATALYST-ELECTROLYTE COMBINATION FOR ELECTROLYSIS
    Publication number: 20150108006
    Abstract: The invention relates to a process for electrolysis comprising a cathode and an anode comprising a catalyst, both the cathode and anode at least partly immersed in an electrolyte, the process characterised in that the electrolyte at least partly inhibits further oxidation of a product formed at the anode. Typically the catalyst comprises one or more metal-(Group VIb) semiconductors, and one or more metal-(GroupVIb))-phosphorous species.
    Type: Application
    Filed: September 22, 2014
    Publication date: April 23, 2015
    Applicant: MONASH UNIVERSITY
    Inventors: Douglas MACFARLANE, Alexey IZGORODIN
  • Switches for microfluidic systems
    Patent number: 9011798
    Abstract: A microfluidic system including a substrate in sheet form, at least one hydrophilic microfluidic channel supported on a surface of the substrate, and at least one functional component formed as part of the substrate for providing a functional component for the microfluidic channel wherein the functional component comprises at least one cut within the substrate for providing a switch or filter component for the microfluidic channel.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: April 21, 2015
    Assignee: Monash University
    Inventors: Wei Shen, Xu Li, Junfie Tian, Thanh Huynh Nguyen, Gil Garnier
  • Microfluidic apparatus for the atomisation of a liquid
    Patent number: 8991722
    Abstract: An apparatus (1) for the atomisation of a liquid including: a piezoelectric substrate (5) having at least one working surface (7), at least one electrode (9) supported on the piezoelectric substrate (5), a signal generating means (21) for applying an ultrasonic signal to said electrode (9) for generating a surface acoustic wave (SAW) in the working surface (7) of the piezoelectric substrate (5); a liquid delivery arrangement (11) including a wick (17) in contact with the working surface (7) for delivering liquid thereof, wherein liquid delivered to the working surface (7) is atomised by SAW irradiation.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: March 31, 2015
    Assignee: Monash University
    Inventors: James Friend, Leslie Yeo, David Morton, Michelle McIntosh, Aisha Qi, Jenny Ho, Anushi Rajapaksa
  • TEMPERATURE-RESPONSIVE POLYMER PARTICLES IN PROTEIN SEPARATION APPLICATIONS
    Publication number: 20150018440
    Abstract: The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperature-responsive copolymer, and to methods of preparing such particles.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 15, 2015
    Applicants: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, MONASH UNIVERSITY
    Inventors: Brad William WOONTON, Milton Thomas William HEARN, Pankaj MAHARJAN, Kirthi DE SILVA, William Roy JACKSON
  • PARTICLE IMAGE VELOCIMETRY SUITABLE FOR X-RAY PROJECTION IMAGING
    Publication number: 20140334710
    Abstract: A 2D or 3D velocity field is reconstructed from cross-correlation analysis of image pairs of a sample, without first reconstructing images of the sample spatial structure. The method can be implemented via computer tomographic X-ray particle image velocimetry, using multiple projection angles, with phase contrast images forming dynamic speckle patterns. Estimated cross-correlations may be generated via convolution of a measured autocorrelation function with a velocity probability density function, and the velocity coefficients iteratively optimised to minimise the error between the estimated cross-correlations and the measured cross-correlations. The method may be applied to measure blood flow, and the motion of tissue and organs such as heart and lungs.
    Type: Application
    Filed: May 15, 2014
    Publication date: November 13, 2014
    Applicant: MONASH UNIVERSITY
    Inventors: Andreas FOURAS, Stephen DUBSKY
  • Temperature-responsive polymer particles in protein separation applications
    Patent number: 8877477
    Abstract: The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperature-responsive copolymer, and to methods of preparing such particles.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: November 4, 2014
    Assignees: Commonwealth Scientific and Industrial Organisation, Monash University
    Inventors: Brad William Woonton, Milton Thomas William Hearn, Pankaj Maharjan, Kirthi De Silva, William Roy Jackson
  • Ectopic pregnancy treatment
    Patent number: 8858939
    Abstract: The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method comprising the administration of an EGFR inhibitor alone or in combination with an anti-metabolite e.g. methotrexate (MTX). The methodology is potentially applicable to treatment of unruptured ectopic pregnancies of all sizes.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: October 14, 2014
    Assignee: Monash University
    Inventors: Stephen Tong, Ulrika W. Nilsson, Terence Grant Johns
  • Method of fabricating microfluidic systems
    Patent number: 8852526
    Abstract: A method of fabricating a microfluidic system having microfluidic channels on a surface of a hydrophilic substrate, the method including the steps of: hydrophobizing the substrate surface; locating a mask defining the substrate surface, the mask having open areas defining the periphery of the microfluidic channels; and applying an irradiation treatment to areas of the substrate surface exposed by the open areas of the mask, said exposed areas becoming hydrophilic to therefore form said microfluidic channels.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: October 7, 2014
    Assignee: Monash University
    Inventors: Wei Shen, Xu Li, Junfei Tian, Mohidus Samad Khan, Gil Garnier