Abstract: Provided are methods for efficiently and comprehensively screening antibody repertoires from B cells to obtain and produce molecules with binding characteristics and functional activities for use in human therapy.

Abstract: The present disclosure is directed to a microfluidic die that includes a plurality of heaters above a substrate, a plurality of chambers and nozzles above the heaters, a plurality of first contacts coupled to the heaters, and a plurality of second contacts coupled to the heaters. The plurality of second contacts are coupled to each other and coupled to ground. The die includes a plurality of contact pads, a first signal line coupled to the plurality of second contacts and to a first one of the plurality of contact pads, and a plurality of second signal lines, each second signal line being coupled to one of the plurality of first contacts, groups of the second signal lines being coupled together to drive a group of the plurality of heaters with a single signal, each group of the second signal lines being coupled to a remaining one of the plurality of contact pads.

Abstract: The invention relates to an insert (10) for an apparatus (100) for preparing food by circulation of a flow of hot air in a food basket (14) placed inside a food preparation chamber and having a bottom part (108) with a lower opening area (26) for the circulation of the flow of hot air. The insert comprises an upper surface (12) intended to be arranged below the food basket. The upper surface (12) defines an inclined surface (16) having a downward inclination extending outwards from a middle zone towards a perimeter of the insert. The inclined surface (16) is provided such that the inclination extends at least beyond a vertical projection of the lower opening area (26). The insert further comprises spacers (40) provided on a lower side (42) of the insert to create a clearance gap (44) between the lower side (42) and a bottom surface (46) of the food preparation chamber. This invention allows improving food preparation while minimizing the emission of cooking oil fumes.

Abstract: A system and computer-implemented method for collaborative markup of digital media such as an Internet website are disclosed. In one embodiment, multiple users can collaboratively and create, view, markup, and revise the contents and layout of a retrieved web site or webpage in real-Ume prior to publication or production release.

Abstract: A non-volatile memory is organized in pages and has a word writing granularity of one or more bytes and a block erasing granularity of one or more pages. Logical addresses are scrambling into physical addresses used to perform operations in the non-volatile memory. The scrambling includes scrambling logical data addresses based on a page structure of the non-volatile memory and scrambling logical code addresses based on a word structure of the non-volatile memory.

Abstract: A method for brewing coffee involves providing two separate quantities of coffee particles, wherein only a first quantity of coffee particles is used for an actual process of brewing coffee by causing this quantity to interact with an extracting medium, and wherein another, secondary quantity of coffee particles is heated for enhanced aroma release. The second quantity may be small compared to the first quantity. The two separate quantities of coffee particles may be obtained by first providing a single quantity of coffee particles, for example by grinding a number of coffee beans in a grinding module (20), and then dividing the single quantity into the two quantities. In a device (1) which is suitable for carrying out the method, a dividing arrangement (40) may be applied for realizing a suitable distribution of coffee particles over a brewing chamber (10) and a heating module (30) of the device (1).

Abstract: A plaque detection system is presented including a dental implement and a multi-mode optical waveguide for receiving fluorescence light from a plurality of angles, the fluorescence light traveling along a core of the multimode optical waveguide at different path lengths resulting in modal dispersion. The plaque detection system also includes a detector configured to receive the fluorescence light for detecting plaque, calculus, and/or caries, and communicating plaque identification information of teeth based on frequency domain lifetime measurements. The modal dispersion is used to detect at least one plaque, calculus, and or caries fluorescence area on the teeth. The plaque fluorescence area detected with modal dispersion includes different levels of plaque with respect to a center point of the plaque fluorescence area. Thus, a plaque detection signal depends on a radial distance from the center point of the plaque fluorescence area.

Abstract: Disclosed is a horizontal juice extractor (100) comprising a main body delimiting a food processing chamber (110) comprising a juice outlet (140), a food entry section (112) having a food inlet (130) and a food compression section (114) extending from the food entry section and having a food pulp outlet (150); a spindle (120) extending through the food processing chamber for transporting food from the food entry section through the food compression section, said spindle comprising a body (122) and a helical member (123) extending from said body; and a drivetrain (160) adapted to rotate the spindle, wherein the food compression section (114) is located in between the food entry section (112) and said drivetrain (160). The food entry section (112) comprises said juice outlet (140) at or near a distal end of said main body relative to the drivetrain, wherein the juice outlet (140) is vertically displaced relative to the food inlet (130).

Abstract: A bedside patient monitor comprises a clinician support system. The clinician support system comprises at least one of the following modules of: a disease-specified decision module (11), disease-specified treatment module (13) or disease-specified observation module (15). The bedside monitor comprises a first interface (105) for manual patient-related input and a second interface (107) for continuous input of a sensor signal. The clinician is supported to deliver requested information and execute the treatment in a predetermined way supported by the clinician support system.

Abstract: A device, system and a method extract physiological information indicative of at least one vital sign of a subject. To provide a high motion robustness, an input interface is configured to obtain at least two detection signals derived from detected electromagnetic radiation transmitted through or reflected from a skin region of a subject. Each detection signal includes wavelength-dependent reflection or transmission information in a different wavelength channel. At least two pulse signals are computed from said at least two detection signals using different signature vectors for the computation of each pulse signal. Quality indicator values are computed for the pulse signals indicating a characteristic of the respective pulse signal. Physiological information indicative of at least one vital sign is derived from the signature vector resulting in the pulse signal with the best quality indicator value and/or from the pulse signal.

Abstract: The present invention relates to an apparatus for determining an effective energy spectrum of an X-ray tube. It is described to provide (210) a temporally varying acceleration voltage of an X-ray tube for a time period. A temporally varying X-ray tube current is also provided (220) for the time period. At least one product of the temporally varying X-ray tube current and a time interval is determined (230). An effective energy spectrum of the X-ray tube processing the X-ray tube is determined (250) as a function of the at least one product of the temporally varying X-ray tube current and the time interval and as a function of the voltage of the X-ray tube.

Abstract: A circuit includes an input terminal and a regulated supply line for supplying an electronic device with an electrostatic discharge protection and driver circuit for the electronic device. The supply line is coupled to the input terminal via the circuitry, so that current injected into the input terminal may produce a voltage increase on the regulated supply line. A comparator sensitive to the voltage at the input terminal and the voltage on the supply line is provided. A current sink coupled with the supply line and being activatable to sink current from the supply line is also provided. The comparator is configured for activating the current sink as a result of the voltage at the input terminal exceeding the voltage on the supply line of a certain intervention threshold.

Abstract: The present invention relates to an apparatus and a process for subjecting oleaginous vegetable material to a continuous prepressing for extracting at least part of the oil contained in said oleaginous vegetable material and producing a cake comprising an at least partially de-oiled oleaginous vegetable material. The apparatus comprises a mechanical prepress for mechanically compressing said oleaginous vegetable material, wherein the prepress is provided with a cake discharge for discharging the cake to a cooler. The cooler comprising means for subjecting the cake to a downward movement, and means for supplying a coolant gas, preferably air, in a counter-current flow to the downward movement of the cake with the purpose of cooling the cake.

Abstract: Methods and systems are described for retrieving segmented content originating from two or more content delivery networks. The method may comprise the steps of: retrieving a manifest file template associated with said segmented content comprising one or more pointers to database entries of said first content location database; using said one or more database entries for determining a location of a delivery node in said first or second content delivery network, said delivery node being configured for delivering a segment associated with said database entry; and, generating a manifest file for locating said segmented content by replacing pointers with said determined locations.

Abstract: A data signal is transmitted in a wireless communication system from a primary station to a secondary station. The data signal comprising a medium access control header (MAC-hs header) and a protocol data unit associated with the medium access control header. The medium access control header comprising a set at least one field (e.g. TSN, SEG, LI, FMT, LCid), wherein a size allocated to at least one field of the set is determined based on a length of the protocol data unit.

Abstract: The present invention relates to a wearable device and a system. The wearable device (20, 40) comprises an electronic circuit (21), a power supply (22), a switching circuit (23, 43) coupled between the electronic circuit and the power supply, and an electromagnetic field detection circuit (24) coupled to the switching circuit (23, 43) for detecting an electromagnetic field generated by an NFC transmitter within the detection range of the electromagnetic field detection circuit and for generating a trigger signal if an electromagnetic field generated by an NFC transmitter is detected within the detection range of the electromagnetic field detection circuit. The switching circuit (23, 43) comprises a flip-flop (231) or a transistor circuit (431) including an input transistor (432) and a fuse (433) to switch the connection between the electronic circuit and the power supply on in response to the trigger signal.

Abstract: A method includes for non-invasively determining an instantaneous wave-free ratio metric includes receiving electronically formatted image data generated by an imaging system. The image data includes voxels with intensities representative of a vessel with a stenosis. The method further includes computing peripheral resistances of outlets of the vessel from the image data. The method further includes calculating a stenosis resistance of the stenosis between an inlet of the vessel inlet and the outlets of the vessel based on a set of boundary conditions and a computational fluid dynamics algorithm. The method further includes calculating the instantaneous wave-free ratio metric. The metric is a numerical value, based on the stenosis resistance and generating a signal indicative of the calculated instantaneous wave-free ratio metric.

Abstract: A control unit is provided for a surgical robot system, including a robot configured to operate an end-effector in a surgical site of a patient. The control unit includes a processor configured to transmit acquired live images of a patient, received from an image acquisition device, to a virtual reality (VR) device for display; to receive input data from the VR device, including tracking data from a VR tracking system of the VR device based on a user's response to the live images displayed on a viewer of the display unit of the VR device; to process the input data received from the VR device to determine a target in the patient; to determine a path for the end-effector to reach the target based upon the live images and the processed input data; and to transmit control signals to cause the robot to guide the end-effector to the target via the determined path.