Abstract: The contamination-free introduction of a sterile object from a vessel, which has been closed by means of a semipermeable cover, into a working chamber, which is surrounded by a wall, of a containment firstly comprises a portal unit having an access flange which is arranged in the wall and which forms a passage from the outside into the working chamber, and a door which sealingly closes the passage and which, in order to be opened, can be moved into the working chamber. A vessel receptacle has a repository for holding a vessel that has been introduced into the vessel receptacle, an opening for the introduction of the vessel into the repository, and a flange for interacting with the access flange. A decontamination unit is designed to decontaminate an outer surface of the cover when the door has been closed. Based on this arrangement, a method for introduction is also disclosed.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: A prize mixer is provided for a prize capture and dispensing device. The prize mixer is configured to change the location and/or orientation of prizes within a prize area of the device, preferably by contacting one or more of the prizes. The prize mixer may be located at or near a bottom of the prize area and be configured to move relative to the prizes, such as in a linear or rotating motion. The prize mixer may comprise a plurality of rotatable arms which define ramped surfaces, the arms rotated by a drive shaft. The prize mixer may be activated automatically or by a player of the device, such as for payment, as a bonus, or upon a triggering event.

Abstract: An amusement-type prize-play device is provided. The device includes a housing defining a prize area for containing one or more prizes for winning as a result of the play of the device, a moveable prize play mechanism, at least one player input device, a prize collection area, at least one optical prize collection sensor configured to detect the presence of a prize at the prize collection area, and a controller configured to receive the input from the player and cause the moveable prize play mechanism to move at least in part based upon the input. The controller is also configured to receive an output of the optical prize collection sensor and generate a prize-winning outcome when the optical prize collection sensor detects the prize at the prize collection area.

Abstract: A casting furnace for low pressure casting comprises a furnace chamber, an insert disposed within the furnace chamber, a valve in the insert, a riser to expose a much lower surface of a melt to compressed gas, and a channel for supplying and/or discharging gas into and out of the insert.

Abstract: A grooving tool holder includes a lower portion, an upper portion, and a cutting insert receptacle. The upper portion is pivotable relative to the lower portion. The upper portion includes a rake face. The cutting insert receptacle is disposed between the lower portion and the upper portion. The cutting insert receptacle includes an upper clamping jaw disposed in the upper portion and a lower clamping jaw disposed in the lower portion. The cutting insert receptacle extends widthwise between opposed sidewalls of the lower portion and opposed sidewalls of the upper portion. The rake face is disposed adjacent to and over the cutting insert receptacle. The rake face extends between the opposed sidewalls of the upper portion. The rake face is disposed non-perpendicularly to the opposed sidewalls of the upper portion.

Abstract: The present application describes a method for joining two anodized elements by friction stir welding. This method for joining a first element to a second element comprises a step of anodizing the first element, a step of anodizing the second element, and a step of producing a weld seam by friction stir welding the first element to the second element.

Abstract: A telescopic boom for a working device, in particular a crane or mobile crane, includes at least three telescopic sections. A first telescopic section is arranged at least partially around a second telescopic section, and the second telescopic section is arranged at least partially around a third telescopic section. A drive device is provided for telescopically retracting and/or extending the second telescopic section relative to the first telescopic section, and a synchronizing device is configured to allow the third telescopic section to be telescopable relative to the second telescopic section, in particular synchronously. The synchronizing device is arranged substantially completely within the second telescopic section.

Abstract: A microfluidic device includes a microfluidic channel formed in the microfluidic device and defined by a floor and a ceiling positioned vertically above the floor, wherein the microfluidic channel includes at least one fluid inlet configured to receive a fluid flow and at least one fluid outlet, and wherein at least one of the ceiling and the floor of the microfluidic channel is sloped relative to a horizontal plane.

Abstract: In a method for preparing lithium sulfide, a solid sulfur layer and a lithium source layer are sequentially arranged in a reactor. A gas feed is injected into the reactor in a single direction to obtain a lithium sulfide-containing product. The lithium sulfide-containing product is dissolved in an anhydrous solvent to form a lithium sulfide-containing solution. Lithium sulfide is separated from the lithium sulfide-containing solution. The gas feed sequentially passes through the solid sulfur layer and the lithium source layer, such that high-purity lithium sulfide may be efficiently prepared.

Abstract: An object of the present disclosure is to provide coating film-attached glass having a glass substrate, and a coating film provided on at least a part of a surface of the glass substrate. The coating film-attached glass includes a modified layer in a region at a depth of 100 nm from the surface of the glass substrate on the coating film side in the depth direction. The modified layer has a microcrystalline structure at least in part. The coating film is a silicon-free and fluorine-containing diamond-like carbon film or an amorphous fluorine resin film. Another object of the present disclosure is to provide a production method for coating film-attached glass in which a coating film is formed on at least a part of a surface of a glass substrate.

Abstract: An object of the present invention is to provide a method for manufacturing an aminolipid compound, in which a yield in a carbonate esterification reaction is improved, and an intermediate compound used in the method for manufacturing an aminolipid compound. According to the present invention, there is provided a compound represented by Formula [1] or a salt thereof. In the formula, R1 represents a hydrogen atom or a hydrocarbon group having 1 to 12 carbon atoms, R2 represents a divalent hydrocarbon group having 2 to 12 carbon atoms, and R3 represents a hydrocarbon group having 6 to 22 carbon atoms.

Abstract: The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).

Abstract: The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions containing such compounds, or pharmaceutically acceptable salts thereof. Methods of preparing these compounds and compositions, and methods of using these compounds and compositions to treat or prevent a disease or a condition mediated by GLP-1R, are also provided.

Abstract: The present invention is in the field of transactive response DNA binding protein with a molecular weight of 43 kDa (TARDB or also TDP-43). The invention relates to humanized TDP-43 specific binding molecules, in particular to humanized anti-TDP-43 antibodies or antigen-binding fragment or a derivative thereof and uses thereof. The present invention provides means and methods to diagnose, prevent, alleviate and/or treat a disease, disorder and/or abnormality associated with TDP-43 aggregates including but not limited to Frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Chronic Traumatic Encephalopathy (CTE), and limbic-predominant age-related TDP-43 encephalopathy (LATE).

Abstract: The present disclosure includes engineering methods and polypeptide libraries that are useful for introducing non-native binding sites into polypeptides. Also provided herein are polypeptides that bind to a CD98hc or transferrin receptor (TfR) protein, methods of generating such polypeptides, and methods of using the polypeptides to target a composition across the blood-brain barrier or to a CD98hc-expressing or TfR-expressing cell.

Abstract: Poly(cyclic vinyl ethers) (PCVEs), compositions of same, methods of making same, and uses of same. In various examples, PCVEs (e.g., homopolymers and/or copolymers) comprise repeat units comprising cyclic vinyl ether (CVE) groups in the backbone (e.g., poly(2,3-dihydrofuran) and/or poly(3,4-dihydropyran)). In various examples, PCVE homopolymers comprise molecular weights (Mn and/or Mw) of 200 kilodalton (kD) or greater. In various examples, PCVE copolymers (e.g., random or block) comprise one or more CVE group(s) and/or additional (e.g., acyclic vinyl ether (AVE) and/or styrenic) group(s)). A method of preparing PCVEs comprises polymerizing monomers comprising CVE groups (e.g., 2,3-dihydrofuran and/or 3,4-dihydropyran). In various examples, pentakis(carbonylcyclopentadienes) (PCCPs) and/or hydrogen bond donors are polymerization catalysts and/or initiators. various examples, PCVEs are biorenewable, recyclable, thermoplastic materials that exhibit desirable optical clarity, desirable barrier properties to, e.

Abstract: There is provided a resin film including a resin layer having chemical permeability, and a chemical layer, in which at least one chemical selected from the group consisting of a carboxylic acid having 1 to 36 carbon atoms, a carboxylic acid ester having 2 to 36 carbon atoms, a sulfonic acid ester having 1 to 36 carbon atoms, a siloxane compound having 1 to 36 carbon atoms, a benzophenone compound having 13 to 38 carbon atoms, a phosphoric acid ester having 1 to 80 carbon atoms, and a phosphorous acid ester having 1 to 80 carbon atoms permeates the resin layer and the chemical is present on a first surface of the resin layer, and the chemical layer containing the chemical is provided on a second surface of the resin layer.

Abstract: [Problems] An object of the present invention is to provide a polyester resin having excellent curability and further having processability, retort resistance, and dent resistance, and a coating composition in which the polyester resin is used. [Solution] A polyester resin comprising a polyvalent carboxylic acid component and a polyhydric alcohol component as copolymerization components, wherein the polyester resin satisfies the following requirements (i) to (iii), (i) the polyvalent carboxylic acid component constituting the polyester resin has 10 mol % or more of a polyvalent carboxylic acid component having a furan skeleton, (ii) the number of kinds of polyhydric alcohol components constituting the polyester resin is two or more, and (iii) the polyester resin has an acid value of 70 eq/t or more and 400 eq/t or less.

Abstract: An object of the present invention is to provide an epoxy-based adhesive having excellent toughness and heat resistance as well as excellent adhesiveness to a substrate. The adhesive composition according to the present invention can suitably be used as an adhesive excellent in adhesiveness, toughness, and heat resistance, is therefore expected to greatly contribute to industry, especially in the field of structural adhesives. An adhesive composition containing an epoxy resin (A), a curing agent (B), a curing catalyst (C), a thixotropic agent (D), and a crystalline polyester (E).