Patents Assigned to Nagasaki University
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Patent number: 8765952Abstract: The present invention provides a metal complex containing a cation represented by [(MII)2(MI)2(LC)2(LB)4]2+ [in the aforementioned formula, MII is PtII or PdII, MI is H+, AuI, AgI, CuI, HgI, TlI or PbI, and LC and LB are ligands]. The metal complex of the present invention is useful as a light emitting material of an organic EL device.Type: GrantFiled: September 15, 2011Date of Patent: July 1, 2014Assignee: Nagasaki UniversityInventors: Keisuke Umakoshi, Ami Higashitani, Kazutoyo Kimura, Shoji Ishizaka, Noboru Kitamura
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Publication number: 20140130190Abstract: The present invention provides a non-human mammal deficient in the expression of prothymosin ? gene in the striatum and a screening method for a prophylactic/therapeutic drug for Huntington's disease and the like, which uses the animal.Type: ApplicationFiled: May 18, 2012Publication date: May 8, 2014Applicant: NAGASAKI UNIVERSITYInventor: Hiroshi Ueda
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Publication number: 20130323763Abstract: The present invention provides a useful examination method and diagnostic reagent, which are capable of diagnosing acute lung injury in clear distinction from chronic progressive interstitial pneumonia. Specifically, the present invention provides a method of determining whether or not a test subject is affected with acute lung injury, which comprises quantifying heat shock protein 47 in a biological sample derived from the test subject.Type: ApplicationFiled: February 10, 2012Publication date: December 5, 2013Applicants: SAPPORO MEDICAL UNIVERSITY, NAGASAKI UNIVERSITYInventors: Tomoyuki Kakugawa, Shin-ichi Yokota
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Patent number: 8598858Abstract: The first sampling measurement value compares whether to exceed a prescribed threshold and judges the control part at the sampling time. The control part compares whether the first sampling measurement value exceeds a prescribed threshold. When the actual measurement value doesn't exceed a prescribed threshold, the control part predict the first sampling value at the next sampling time. [1] When the first sampling the predicting value doesn't exceed the threshold value, the status of the switch is maintained, [2] When the first sampling the predicting value exceeds the threshold value, the time when the movement of the switch should be changed is calculated and the status of the switch is changed at time concerned.Type: GrantFiled: April 30, 2008Date of Patent: December 3, 2013Assignee: Nagasaki University, National University CorporationInventor: Fujio Kurokawa
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Publication number: 20130253189Abstract: The present invention provides a metal complex containing a cation represented by [(MII)2(MI)2(LC)2(LB)4]2+ [in the aforementioned formula, MII is PtII or PdII, MI is H+, AuI, AgI, CuI, HgI, TlI or PbI, and LC and LB are ligands]. The metal complex of the present invention is useful as a light emitting material of an organic EL device.Type: ApplicationFiled: September 15, 2011Publication date: September 26, 2013Applicant: Nagasaki UniversityInventors: Keisuke Umakoshi, Ami Higashitani, Kazutoyo Kimura, Shoji Ishizaka, Noboru Kitamura
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Publication number: 20130203738Abstract: The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain. The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g.Type: ApplicationFiled: February 9, 2011Publication date: August 8, 2013Applicants: NAGOYA CITY UNIVERSITY, NAGASAKI UNIVERSITYInventors: Yoshifumi Nishimura, Aritaka Nagadoi, Yuuka Hirao, Yoshio Goshima, Naoya Yamashita, Naoki Miyata, Takayoshi Suzuki, Ryuta Hiraishi, Hiroshi Ueda
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Patent number: 8493046Abstract: Disclosed herein is a control device for a DC/DC converter, in which FB control and FF control are combined to estimate an output voltage of a nonlinear dynamic system while guaranteeing stability. The control device includes a FB controller which generates a first time value for switch-off timing as the amount of feedback control, a machine learning controller which generates a second time value for switch-off timing as the amount of FF control, and a difference time calculator which obtains a difference between the first time value and the second time value and transmits a difference signal to the drive circuit.Type: GrantFiled: September 30, 2010Date of Patent: July 23, 2013Assignees: Nagasaki University, National University Corporation, Mitsubishi Electric CorporationInventors: Fujio Kurokawa, Hiroyuki Osuga
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Patent number: 8478395Abstract: The invention provides a method for evaluating a corneal disorder quantitatively and is applicable to living eyes. In particular, the invention provides a method for measuring a corneal transepithelial electric resistance, which method comprises: (1) a step of placing a first electrode on the cornea and a second electrode on the conjunctiva; and (2) a step of flowing an electric current between the first electrode and the second electrode to measure the electric resistance. The invention also provides a device for measuring a corneal transepithelial electric resistance value.Type: GrantFiled: March 3, 2009Date of Patent: July 2, 2013Assignees: Nagasaki University, Tohoku UniversityInventors: Masafumi Uematsu, Takashi Kitaoka, Koji Nishida, Yuji Tanaka, Matsuhiko Nishizawa, Hirokazu Kaji, Soichiro Sekine
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Patent number: 8451631Abstract: To detect a peak time of an exciting current of a transformer, a primary current corresponding to the peak time, or a variation time of the primary voltage, and to switch a switch after expiration of a predetermined period from the peak time, after the peak time occurs. A control apparatus 1 is applied to a power conversion circuit 2 which includes a switch circuit 23 including one switch or a plurality of switches and a transformer 21. The control apparatus includes: an output voltage detector 11 detecting a value of an output voltage of the power conversion circuit; an exciting current peak time generator 12 detecting a peak time of an exciting current of the transformer; a timing generator 13 generating a switching timing of the one switch or the plurality of switches. The timing generator 13 generates the switching timing of the one switch or the plurality of switches on the basis of the output voltage and the peak time.Type: GrantFiled: October 31, 2008Date of Patent: May 28, 2013Assignee: Nagasaki UniversityInventor: Fujio Kurokawa
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Publication number: 20130106383Abstract: By adding a suppression amount for suppressing an overshoot or undershoot that attenuates with time during an overshoot or undershoot period, the overshoot or undershoot can be suppressed within a short time and the output can be made close to a normal value. When an output has overshot, an overshoot suppression amount including a time-dependent attenuation suppression amount is added to an output feedback control amount, the time-dependent attenuation suppression amount being defined in a period during which the output overshoots. Alternatively, when the output has undershot, an undershoot suppression amount including a time-dependent attenuation suppression amount is added to the output feedback control amount, the time-dependent attenuation suppression amount being defined in a period during which the output undershoots.Type: ApplicationFiled: January 31, 2011Publication date: May 2, 2013Applicants: NAGASAKI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, MITSUBISHI ELECTRIC CORPORATIONInventors: Fujio Kurokawa, Hiroyuki Osuga
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Publication number: 20130094259Abstract: It provides the effective power conversion control technique which it can control which it made use of a characteristic (nature) of each A/D converter in. It comprises the third control part including the third operating circuit it inputs signal from third A/D converter inputting the detecting signal which is different from the detecting signal which is the same as the detecting signal or the detecting signal and above third A/D converter, and to generate the third operating signal, and the above actuating management circuit manages the actuating of an above first control part and the second above control part and the third above control part.Type: ApplicationFiled: March 31, 2011Publication date: April 18, 2013Applicant: Nagasaki University, National University CorporationInventor: Fujio Kurokawa
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Patent number: 8415893Abstract: Provided is a discharge lamp lighting device, which can control a load precisely while improving the practicability. When the difference of a count number (Nn) becomes a predetermined threshold value or less, a predictor circuit (35) predicts the timing, at which a current value (iQ1) becomes a peak value, on the basis of the rate of change of the difference. A switch selecting circuit (38), which is driven with a clock frequency higher than the sampling frequency of a first converter unit (32), turns off a field effect transistor (Q1) at the turn-off timing, and turns on a field effect transistor (Q2). A plurality of A/D converters (37a) are subjected to a multi-rate control, thereby to correct the threshold value of the predictor circuit (35) on the basis of the peak value of a lamp current (iOUT).Type: GrantFiled: October 17, 2008Date of Patent: April 9, 2013Assignee: Nagasaki UniversityInventor: Fujio Kurokawa
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Patent number: 8415399Abstract: An infection inhibitor of retrovirus, particularly human immunodeficiency virus, comprising, as an active ingredient, at least one compound selected from the group consisting of a compound represented by the formula (I) (GGA) or a salt thereof, a compound represented by the formula (II) (NIK-333) or a salt thereof, and derivatives thereof.Type: GrantFiled: September 27, 2011Date of Patent: April 9, 2013Assignees: Nagasaki University, Kowa Company, Ltd.Inventors: Yoshinao Kubo, Haruka Kamiyama
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Publication number: 20130060015Abstract: The present invention relates to methods for producing glucosides directly from glucose or a polysaccharide comprising glucose as a structural unit. The present invention provides a method comprising reacting glucose or a polysaccharide comprising glucose as a structural unit with a compound represented by R—OH in the presence of a supercritical or subcritical carbon dioxide to produce glucosides and a method comprising dissolving or suspending glucose or a polysaccharide comprising glucose as a structural unit in an organic solvent containing a compound represent by R—OH and reacting the glucose or polysaccharide with the compound represented by R—OH in the presence of a supercritical or subcritical carbon dioxide to produce glucosides.Type: ApplicationFiled: May 13, 2011Publication date: March 7, 2013Applicants: JX NIPPON OIL & ENERGY CORPORATION, NAGASAKI UNIVERSITYInventors: Suguru Motokucho, Toshio Inoue
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Publication number: 20130052678Abstract: The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a fluorescent compound represented by the formula (II).Type: ApplicationFiled: March 1, 2011Publication date: February 28, 2013Applicant: NAGASAKI UNIVERSITYInventors: Masaaki Kai, Takayuki Shibata
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Publication number: 20130052127Abstract: The invention provides an antigen or drug delivery complex containing a complex of an antigen or drug and a cationic molecule, and an anionic molecule encapsulating the same. The antigen or drug delivery complex can be used as a main component of a drug delivery system that delivers various antigens and drugs to a particular cell or organ.Type: ApplicationFiled: February 24, 2011Publication date: February 28, 2013Applicants: NAGASAKI UNIVERSITY, National University Corporation Hamamatsu University School of Medicine, KYUSYU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Hitoshi Sasaki, Tomoaki Kurosaki, Takashi Kitahara, Hideto To, Katsuyuki Yui, Kenji Hirayama, Kouichi Morita, Takahiro Mukai, Yasuhiro Magata, Mikako Ogawa, Kohei Sano
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Publication number: 20120326751Abstract: The frequency decision device determines frequency of the measured rectangular signal by simple and easy means. The frequency decision device inputs the measured rectangular signal that frequency (or period) changes dynamically. It generates a rectangular reference signal of predetermined on width ? synchronizing to the edge based on a positive going edge of this measured rectangle signal. And it watches the order of measured rectangle signal and falling edges of the rectangular reference signal. When this sequential order reversed, it detects that length of the ON time of ON time of the measured rectangle signal and the measured rectangular signal reversed.Type: ApplicationFiled: September 30, 2010Publication date: December 27, 2012Applicant: Nagasaki University, National University CorporationInventor: Fujio Kurokawa
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Patent number: 8314642Abstract: A rising edge or a falling edge is finely adjusted, or a dead time and a period are adjusted with high accuracy. A waveform processing circuit includes: an integration circuit 11 receiving a rectangular or substantially-rectangular pulse and outputting a gradually increasing or decreasing signal obtained by integrating the pulse signal; a reference signal output circuit 12 outputting a constant value or a varying value as a reference signal; and a comparison circuit 13 comparing the output of the integration circuit with the output of the reference signal output circuit and outputting a pulse rising or falling at a timing when the difference between the outputs varies.Type: GrantFiled: June 1, 2008Date of Patent: November 20, 2012Assignee: Nagasaki UniversityInventor: Fujio Kurokawa
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Publication number: 20120243265Abstract: Disclosed herein is a control device for a DC/DC converter, in which FB control and FF control are combined to estimate an output voltage of a nonlinear dynamic system while guaranteeing stability. The control device includes a FB controller which generates a first time value for switch-off timing as the amount of feedback control, a machine learning controller which generates a second time value for switch-off timing as the amount of FF control, and a difference time calculator which obtains a difference between the first time value and the second time value and transmits a difference signal to the drive circuit.Type: ApplicationFiled: September 30, 2010Publication date: September 27, 2012Applicants: MITSUBISHI ELECTRIC CORPORATION, NAGASAKI UNIVERSITY NATIONAL UNIVERSITY CORPORATIOInventors: Fujio Kurokawa, Hiroyuki Osuga
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Patent number: 8248131Abstract: There are provided a timing generating circuit which can generate the rising edge or the falling edge of pulses with a resolution higher than the frequency of a repeat signal generating circuit, and a phase shift circuit which can be applied to the timing generating circuit. The phase shift circuit receiving a repeat signal generates a signal of which a phase is shifted by a predetermined quantity on the basis of the repeat signal, the phase shift controller controls what phase of signal the phase shift circuit output among first to M-th signals, and the counter circuit counts the number of output signals of the phase shift circuit and generates a count end signal when the count value reaches a set value, and thereby the counter circuit outputs a synthesized timing signal of the timing of the repeat signal and the timing shifted by the phase shift circuit.Type: GrantFiled: June 1, 2008Date of Patent: August 21, 2012Assignee: Nagasaki University, National University CorporationInventor: Fujio Kurokawa