Patents Assigned to National Research Council of Canada
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Patent number: 11104815Abstract: A single-walled carbon nanotube composition includes single-walled carbon nanotubes substantially enriched in semiconducting single-walled carbon nanotubes in association with a polymer having one or more oligoether side groups. The oligoether side groups render the composition dispersable in polar organic solvents, for example alkyl carbitols, permitting formulation of ink compositions containing single-walled carbon nanotubes substantially enriched in semiconducting single-walled carbon nanotubes. Such ink compositions may be readily printed using common printing methods, such as inkjet, flexography and gravure printing.Type: GrantFiled: June 22, 2020Date of Patent: August 31, 2021Assignee: National Research Council of CanadaInventors: Jianfu Ding, Zhao Li, Patrick Malenfant
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Patent number: 11091523Abstract: Recombinant transforming growth factor (TGF)-? monomers modified to inhibit dimerization and block TGF-? signaling are described. The recombinant TGF-? monomers lack the ability to bind and recruit TGF-? type I receptor (T?RI), but retain the capacity to bind the high affinity TGF-? type II receptor (T?RII), and in some instances, include mutations that increase their affinity for T?RII. Nucleic acid molecules and vectors encoding the recombinant TGF-? monomers are also described. Isolated cells, such as T cells, can be re-programmed with a TGF-? monomer-encoding nucleic acid or vector to secrete the monomer. Use of the recombinant TGF-? monomers and/or cells producing the recombinant TGF-? monomers, to inhibit TGF-? signaling, such as to treat disorders associated with aberrant TGF-? signaling, are also described.Type: GrantFiled: November 17, 2017Date of Patent: August 17, 2021Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, National Research Council of CanadaInventors: Andrew Peterson Hinck, Traian Sulea
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Patent number: 11092553Abstract: A method for characterizing an aggregate sample involves using a first laser pulse to create a crater on the surface of a sample, using a second laser pulse to produce a plasma emission spectrum on the prepared crater surface, and detecting the emission spectrum to collect spectral data. Laser application, and detecting spectral emission are repeated on different points on the sample, then non-representative spectral data is discarded based on a ratio of ions to atoms in the data. Finally a calibration loading is used to determine a property characteristic of the aggregate sample. The sample may be an oil sands sample, and the properties detected may be percentages of bitumen, water, and solids. A laser-based system is provided for carrying out the characterization method.Type: GrantFiled: November 29, 2017Date of Patent: August 17, 2021Assignee: National Research Council of Canada (NRC)Inventors: Aissa Harhira, Mohamad Sabsabi, Josette El Haddad, Alain Blouin
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Patent number: 11091536Abstract: Polypeptides with biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human heavy and light chain variable domains (VHs and VLs), are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human VHs and VLs are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human VHs and VLs are also identified. The VHs and VLs identified may be used to create further libraries for identifying additional polypeptides. Further, the VHS and VLs may be subjected to DNA shuffling to select for improved biophysical properties.Type: GrantFiled: December 5, 2018Date of Patent: August 17, 2021Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventor: Jamshid Tanha
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Publication number: 20210238750Abstract: A new spray process allows for deposition below a critical velocity limit of cold spray, while providing adhesion. Post deposition heat treatment has shown excellent coating strength. A wide variety of materials can be deposited. The spray process is based on ShockWave Induced Spraying (SWIS) but with much slower spray jet projection velocities. High porosity, pore size control, and porosity control are demonstrated to be controllable. Preheating of feedstock and uniform temperature of the SWIS delivery allow for the deposition below critical velocity.Type: ApplicationFiled: May 5, 2017Publication date: August 5, 2021Applicant: National Research Council of CanadaInventors: Eric IRISSOU, Louis-Philippe LEFEBVRE
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Patent number: 11071985Abstract: A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part (18) that couples to, or defines, a blade (10) of a centrifuge at a radial distance from a centrifuge axis (12); a chip part (20) that holds the chip at an orientation having a normal not perpendicular to the axis; a one degree of freedom (DoF) joint (16) between the blade part and the chip part; and a force applicator (28) which bears on the chip part at a fixed set of one or more points, which do not surround, and are not surrounded by, the joint.Type: GrantFiled: May 26, 2015Date of Patent: July 27, 2021Assignee: National Research Council of CanadaInventors: Liviu Clime, Teodor Veres, Keith Morton
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Publication number: 20210187618Abstract: A technique for improving cold spray deposition conditions for cold spray additive manufacture of parts involves providing an in-situ temperature feedback controller with a remote instantaneous temperature sensor supplying surface temperature measurements of the deposition surface, and a (preferably long pulse) laser for heating. Temperature feedback allows for control over deposition conditions yielding predictable deposition properties.Type: ApplicationFiled: December 14, 2020Publication date: June 24, 2021Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Eric IRISSOU, Jean-Gabriel LEGOUX, Cristian Victor COJOCARU, Florin ILINCA, Sylvain BOURNIVAL
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Publication number: 20210171613Abstract: The present invention is directed to Clostridium difficile toxin-specific antibodies, compositions, and uses thereof. The anti-toxin antibodies may be specific for TcdA. The invention also includes methods of treating a Clostridium difficile infection, methods of capturing Clostridium difficile toxins, and methods of detecting Clostridium difficile toxins.Type: ApplicationFiled: July 9, 2018Publication date: June 10, 2021Applicant: National Research Council of CanadaInventors: Traian SULEA, Gregory HUSSACK, Jamshid TANHA, Enrico O. PURISIMA
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Publication number: 20210165147Abstract: There is described a multilayer optical thin film structure comprising multiple optically absorbing layers and multiple optically non-absorbing layers. The optically absorbing layers and the optically non-absorbing layers are configured such that light incident on the structure is reflected with a red colour at a first angle, and light incident on the structure is reflected with a yellow colour at a second angle. There is also described an item having applied thereto such a multilayer structure.Type: ApplicationFiled: April 3, 2019Publication date: June 3, 2021Applicant: National Research Council of CanadaInventor: Penghui Ma
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Publication number: 20210159116Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.Type: ApplicationFiled: June 29, 2018Publication date: May 27, 2021Applicants: Quantum Silicon Inc., The Governors of the University of Alberta, National Research Council of CanadaInventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
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Publication number: 20210143475Abstract: Provided is a solid polymer electrolyte (SPE) comprising a dissociable metal salt; a metal ion conductive polymer system; and a phosphonium salt having the general formula [PR1R2R3R4]X, where each of R1, R2, R3 and R4 are independently selected from C1 to C12 hydrocarbons, which hydrocarbons may be optionally substituted by 1 to 5 heteroatoms selected from N, O, and S, and X is an anion. Further provided are a method for preparing the solid polymer electrolyte and an electrochemical cell comprising the solid polymer electrolyte.Type: ApplicationFiled: March 9, 2018Publication date: May 13, 2021Applicant: National Research Council of CanadaInventors: Asmae Mokrini, Alexis Laforgue
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Patent number: 10981817Abstract: A technique for wastewater treatment involves ensuring that all paths for wastewater must pass through at least one porous microbial support to go from the inlet to the outlet, and allowing a biofilm to grow on the porous microbial support under microaerobic conditions (concentration of oxygen between 0.05 and 0.35 mg/L). The biofilm formed comprises a population of anaerobic microbes for digesting organics in the wastewater including methanogenic microbes, and an aerobic methanotrophic and heterotrophic population that catabolizes methane from the methanogenic microbes, and oxygen from the injector, to produce heat. The support may be an electrode, and the technique is applied in a microbial electrolysis cell, with substantial COD removal rates.Type: GrantFiled: January 19, 2018Date of Patent: April 20, 2021Assignee: National Research Council of CanadaInventors: Boris Tartakovsky, Yehuda Kleiner
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Publication number: 20210087102Abstract: The present application relates to boron nitride nanotube (BNNT)-silicate glass composites and to methods of preparing such composites. The methods comprise mixing BNNTs that are coated with a glass former such as boron oxide with a silicate glass precursor to create a mixture; heating the mixture under conditions to obtain a molten silicate glass; and cooling the molten silicate glass under conditions to obtain the BNNT-silicate glass composite.Type: ApplicationFiled: August 1, 2018Publication date: March 25, 2021Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Benoit SIMARD, Yadienka MARTINEZ-RUBI, Christopher Thomas KINGSTON, Keun Su KIM, Morag CLARK-HEPTINSTALL, Maxime GAUTHIER
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Publication number: 20210087298Abstract: The present invention relates to compounds, compositions, and methods are provided for covalently linking a cargo molecule, such as a therapeutic or a diagnostic agent, to a glycan in the Fab region of an antibody. Also provided are methods of modeling and producing antibodies having de novo Fab glycosylation sites. Also provided are antibody carrier conjugates, methods of using the conjugates.Type: ApplicationFiled: November 8, 2018Publication date: March 25, 2021Applicant: National Research Council of CanadaInventors: Michel GILBERT, Traian SULEA, Maria L. JARAMILLO, Yves DUROCHER, Maurizio ACCHIONE
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Publication number: 20210079248Abstract: A flake-less molecular ink suitable for printing (e.g. screen printing) conductive traces on a substrate has 30-60 wt % of a C8-C12 silver carboxylate and 0.1-10 wt % of a polymeric binder, or 5-75 wt % of bis(2-ethyl-1-hexylamine) copper (II) formate, bis(octylamine) copper (II) formate or tris(octylamine) copper (II) formate and 0.25-10 wt % of a polymeric binder, and balance of at least one organic solvent, wherein the binder has ethyl cellulose, and the ethyl cellulose has an average weight molecular weight in a range of 60,000-95,000 g/mol and a bimodal molecular weight distribution.Type: ApplicationFiled: November 24, 2020Publication date: March 18, 2021Applicants: National Research Council of Canada, Groupe Graham International Inc.Inventors: Arnold J. KELL, Sylvie LAFRENIÈRE, Chantal PAQUET, Patrick MALENFANT, Olga MOZENSON
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Patent number: 10921579Abstract: A security device that elicits at least one dynamic response upon acceleration, or upon change of orientation with respect to gravity, wherein the dynamic response continues after cessation of the acceleration or the change of orientation. In addition, the dynamic response can be optical, such that it is visually observable by an unaided human eye. Alternatively, the response can be machine readable. In some cases, the dynamic response has duration of from about 0.01 s to about 100 s, or from about Is to about 10 s.Type: GrantFiled: December 23, 2015Date of Patent: February 16, 2021Assignees: National Research Council of Canada, Bank of CanadaInventors: Daniel Brassard, Lidija Malic, Keith J. Morton, Teodor Veres, Charles D. MacPherson, Theodoros Garanzotis
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Patent number: 10906973Abstract: The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an existing antibody fragment and uses thereof, and methods of making such molecules. The polypeptides of the present invention show enhanced blood-brain barrier crossing and brain exposure levels in vitro and in vivo.Type: GrantFiled: December 12, 2017Date of Patent: February 2, 2021Assignees: National Research Council of Canada, Cephalon, Inc.Inventors: Danica Stanimirovic, Traian Sulea, Kristin Kemmerich, David Wilson, Jennifer Stratton, Matthew Pollard, Adam Clarke
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Publication number: 20210023597Abstract: A metallic extruded profile has two parallel skins interconnected by a set of at least two webs running between extrusion edges of the profile and snap-fit features on joining edges permitting two instances of the profile to snap fit together along the joining edges, where a first web that is closest to snap-fit features of a first joining edge, is a curved web viewed from the extrusion edges. The curvature allows for both the curved web and skins to participate in snap-fit deformation, allowing for the deformation to be distributed over a large area, for a stiffer snap fit, and reduced plastic deformation.Type: ApplicationFiled: July 23, 2020Publication date: January 28, 2021Applicant: National Research Council of CanadaInventors: Jean-Francois BELAND, Francois Nadeau
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Publication number: 20210013424Abstract: The development of air-stable unipolar n-type semiconductors with good solubility in organic solvents at room temperature remains a critical issue in the field of organic electronics. Moreover, most of the existing semiconducting materials exhibit LUMO energy levels higher than ?4.0 eV, making electron transport sensitive to both moisture and oxygen. Bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are disclosed herein. More specifically, bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof for use in organic electronics are disclosed. A process for the preparation of bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide and derivatives is also disclosed. The bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are characterized by high electron mobilities and are suitable for use as n-type semiconductors in organic electronics.Type: ApplicationFiled: March 13, 2019Publication date: January 14, 2021Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Jianping LU, Afshin DADVAND, Mark BORTOLUS, Salima ALEM, Ye TAO, Yuning LI, Jesse QUINN
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Publication number: 20210001972Abstract: A bridging structure for a deforming foil, such as a morphing wing, that provides a fluid-dynamic surface throughout foil deformation that forms a curved fluid-dynamic surface with a relatively low drag. A high extent of foil deformation can be provided, with lower actuation force, providing a fluid-dynamic surface with a simple or complex curve in one direction, by providing a set of rail-mounted members that are joined at one end to a deforming sheet. By coupling the members with high elongation, resilient bodies, adjacent members can support each other, while permitting extension, and accommodating curvature.Type: ApplicationFiled: July 3, 2020Publication date: January 7, 2021Applicant: National Research Council of CanadaInventors: Jaye MANGIONE, Amin FEREIDOONI, Yong CHEN, Viresh WICKRAMASINGHE, Jan MARCHWICA