Patents Assigned to National University Hospital
  • Publication number: 20240077996
    Abstract: A medical treatment system includes a transparent display located between a patient and a medical staff and configured to display, a plurality of interface, first and second gaze trackers respectively mounted on both sides of the transparent display to detect pupils of the medical staff and patient and configured to acquire positional coordinates of the pupils of the medical staff and patient in a three-dimensional space, a region setting unit configured to set a gaze exchange region based on an intersection point where a virtual connection line between the positional coordinates of the pupils of the medical staff and patient intersects a plane of the transparent display, and a control unit configured to rearrange the plurality of interface windows by moving at least one interface window overlapping the gaze exchange region outside the gaze exchange region.
    Type: Application
    Filed: December 30, 2021
    Publication date: March 7, 2024
    Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventor: Hyoun Joong KONG
  • Publication number: 20240074827
    Abstract: A headset of a surgical robot system includes an endoscope image transmission module configured to transmit an endoscope image to a main screen, a surgical assist function transmission module configured to transmit a selected and activated surgical assist function on an auxiliary screen positioned at one side of the main screen, a surgical assist function optional transmission module configured to transmit a list of a plurality of surgical assist functions to be provided on the auxiliary screen to a selection screen, an acceleration sensor and a gyroscope, configured to detect a change in a position of a head of a user, an eye tracking module configured to detect a change in a user gaze and a change in focus, and a controller configured to control a specific surgical assist function selected from among the plurality of surgical assist functions to be provided to the auxiliary screen.
    Type: Application
    Filed: February 16, 2023
    Publication date: March 7, 2024
    Applicants: Seoul National University Hospital, Seoul National University R&DB Foundation
    Inventors: Sungwan KIM, Minwoo CHO, Jonghyeon LEE, Young Gyun KIM, Byeong Soo KIM, Dan YOON
  • Publication number: 20240060992
    Abstract: The present disclosure relates to a kit and an information providing method capable of predicting or diagnosing a cause-specific therapeutic effect of sensorineural hearing loss. The kit and the method according to one aspect of the present invention can diagnose a cause-specific therapeutic effect of sensorineural hearing loss at an early stage and allow selection of the most appropriate treatment method.
    Type: Application
    Filed: October 30, 2023
    Publication date: February 22, 2024
    Applicants: Seoul National University Hospital, The Industry & Academic Cooperation in Chungnam National University (IAC)
    Inventors: Byung Yoon Choi, Bong Jik Kim
  • Patent number: 11883460
    Abstract: The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: January 30, 2024
    Assignees: Agency for Science, Technology and Research, National University Hospital (Singapore) PTE Ltd
    Inventors: Desmond Heng, Sie Huey Lee, Jeanette Teo, Wai Kiong Ng, Reginald Tan
  • Patent number: 11880003
    Abstract: Disclosed is an apparatus for measuring the distribution of radiation dose emitted from a brachytherapy insertion tool, the apparatus including a housing having defined therein a measurement space in which the brachytherapy insertion tool is located, a fluorescent member disposed at the housing, the fluorescent member being configured to react with radiation emitted to the measurement space and to emit light, a camera disposed in the housing, and a cover coupled to one surface of the housing, the cover being configured to cover the fluorescent member. The portion of the fluorescent member to which radiation from a radiation source of the brachytherapy insertion tool is applied reacts with the radiation and generates light, brightness of the light varies depending on distribution of the radiation, and the position at which the light is bright is calculated to measure the direction in which the brachytherapy insertion tool has no shielding.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: January 23, 2024
    Assignees: THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC), CHUNGNAM NATIONAL UNIVERSITY HOSPITAL, NATIONAL CANCER CENTER, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Ui-Jung Hwang, Young Kyung Lim, Sang Hyoun Choi, Youngmoon Goh, Ki Hwan Kim
  • Patent number: 11872228
    Abstract: The present disclosure is a pharmaceutical composition for the prevention or treatment of sepsis containing a thiamine derivative or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical composition of the present disclosure can be used for the prevention, alleviation, or treatment of sepsis by containing fursultiamine or allithiamine to inhibit the expressions of CD40, CD86, and TNF?.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: January 16, 2024
    Assignees: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL
    Inventors: In Kyu Lee, Eun Jung Choi, Chang Hyun Jeon, Tae-Hwan Kwon, Dong Ho Park
  • Publication number: 20240013930
    Abstract: A method for estimating personalized probability of a drug side effect includes identifying a drug taken by a subject, identifying an experience of a side effect, which is produced as the subject takes the drug, and input by the subject, and estimating a probability of the side effect of the subject in relation to the drug, based on the experience of the side effect of the subject, which are executed by a computing device.
    Type: Application
    Filed: June 30, 2023
    Publication date: January 11, 2024
    Applicant: CHUNGBUK NATIONAL UNIVERSITY HOSPITAL
    Inventor: Min Gyu KANG
  • Patent number: 11845951
    Abstract: The present invention relates to a composition for gene manipulation for treating or improving a retinal dysfunction disease or a method using the same. More particularly, the present invention relates to a composition for gene manipulation including a guide nucleic acid capable of targeting a retinal function-forming gene and a method of treating or improving a disease caused by retinal dysfunction by artificially manipulating and/or correcting a retinal function-forming gene using the same.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: December 19, 2023
    Assignees: TOOLGEN INCORPORATED, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Dong Woo Song, Jung Min Lee, Un Gi Kim, Jeong Hun Kim, Dong Hyun Jo
  • Patent number: 11785922
    Abstract: Provided are a protein complex in which estrogen receptor 2 (-ERT2) is fused to CRISPR associated protein 9 (Cas9), and a recombinant vector carrying a gene coding the protein complex, wherein ERT2 is bonded to the N-terminus and C-terminus of nuclear localization sequence (NLS)-removed Cas9 and the complex has the advantage of translocating from the cytosol into the nucleus at a certain time point upon treatment with tamoxifen and modifying a specific DNA with the aid of guide RNA (gRNA), ultimately enabling a more elaborate DNA modification operation in a desired part at a desired time point.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: October 17, 2023
    Assignee: SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Eun Ju Lee, Hyo-Soo Kim
  • Patent number: 11771318
    Abstract: The present invention relates to a method for supporting reading of a fundus image of a subject, and a computing device using the same. Specifically, the computing device according to the present invention acquires the fundus image of the subject, extracts attribute information from the fundus image on the basis of a machine learning model for extracting the attribute information of the fundus image, and provides the extracted attribute information to an external entity. In addition, when evaluation information on the extracted attribute information or modification information on the attribute information is acquired, the computing device according to the present invention can also update the machine learning model on the basis of the acquired evaluation information or modification information.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: October 3, 2023
    Assignees: VUNO, INC., SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Sang Jun Park, Joo Young Shin, Jae Min Son, Sang Keun Kim, Kyuhwan Jung, Hyun-Jun Kim
  • Publication number: 20230296583
    Abstract: Provided are an apparatus for diagnosing a disease and a method for diagnosing same. The apparatus includes a pump for pumping respiratory gas, a first pre-treatment portion connected to the pump and removing moisture and bad breath in the respiratory gas, and a volatile organic compound detector connected between the first pre-treatment portion and the pump and detecting volatile organic compounds in the respiratory gas.
    Type: Application
    Filed: October 31, 2022
    Publication date: September 21, 2023
    Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Dae-Sik LEE, Sang Hoon JHEON, Hyung-Kun LEE, Yoohwa HWANG, Doyeob KIM, Chang-Beom KIM, Jin Oh LEE
  • Publication number: 20230288582
    Abstract: The disclosure relates to a device for detecting therapeutic radiation based on an optical disk with solar cells. The radiation detecting device may include at least one optical disk formed of a water-equivalent material, disposed perpendicular to a first direction in which the radiation is incident, and converting the radiation into visible light; a solar cell disposed on one side of the at least one optical disk, converting the visible light into an electrical signal; and a processing module for collecting and processing the electrical signal outputted from the solar cell.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 14, 2023
    Applicants: NATIONAL CANCER CENTER, SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Dongho SHIN, Tae Hyun KIM, Tae-Ho KIM, Haksoo KIM, Dong-Seok SHIN, Se Byeong LEE, Youngkyung LIM, Jonghwi JEONG, Jaeman SON
  • Patent number: 11744461
    Abstract: The present disclosure relates to a retina imaging method in which a light from a light source into two lights is dispersed, at least one eyeground image of the eyeball at a first magnification is obtained by adjusting the paths of the two lights incident on the eyeball, and a plurality of DIC images are obtained at a second magnification higher than the first magnification with respect to the retina of the entirety of the obtained at least one eyeground image by adjusting the paths of the two lights incident on the eyeball.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: September 5, 2023
    Assignees: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, SEOUL NATIONAL UNIVERSITY HOSPITAL, INHA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Jae Hun Kim, Dae Yu Kim, Seok Hwan Kim, Youngho Cho, Byeongho Park, Hyo-suk Kim, Subeen Park, Kyoung Min Lee
  • Patent number: 11737917
    Abstract: An eye drop bottle storage unit for eye drop administration compliance includes a memory, a processor, and one or a plurality of eye drop bottle pods, where each eye drop bottle pod of the one or said plurality of eye drop bottle pods is configured to hold an eye drop bottle, and comprises one or a plurality of sensors. The memory is configured to store data of an eye drop administration regime of a subject. The processor is configured to receive signals from the one or said plurality of sensors of each eye drop bottle pod, and to determine from the received signals whether the subject administered eye drops into eyes of the subject from each eye drop bottle respectively held in each eye drop bottle pod of the one or said plurality of eye drop bottle pods in accordance with the eye drop administration regime data.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 29, 2023
    Assignees: NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Victor Teck Chang Koh, Muhammad Azri Bin Razali, Teri Danielle You Ying Yeoh, Min Li Tey, Hui Chen Charmaine Chai, Yien Lai
  • Publication number: 20230248665
    Abstract: Provided is a composition comprising a dimethylchalcone derivative for prevention or treatment of metabolic diseases and, more specifically, to a compositioncomprising a derivative of 2?,4?-dihydroxy-6?-methoxy-3?,5?-dimethylchalcone as an active ingredient for the alleviation, prevention, or treatment of various metabolic diseases.
    Type: Application
    Filed: March 16, 2023
    Publication date: August 10, 2023
    Applicants: SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL, CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kyong Soo PARK, Sung Soo CHUNG, Ji Seon LEE, Kwang Yong PARK
  • Publication number: 20230235405
    Abstract: A marker composition, a kit, a gene panel, and a method which are for providing information for predicting the occurrence of, diagnosing, or treating age-related macular degeneration are disclosed. The marker composition, kit, gene panel, and method are novel tools that can provide information for predicting the occurrence of, diagnosing, or treating age-related macular degeneration, and has excellent sensitivity and can be easily analyzed without the use of a biopsy, and thus can be effectively used for the early diagnosis of age-related macular degeneration.
    Type: Application
    Filed: February 21, 2023
    Publication date: July 27, 2023
    Applicants: Genome Opinion Inc., Seoul National University Hospital
    Inventors: Choong Hyun Sun, Su Gyeong Kim, Ho Gune Im, Han Song, Baek Lok Oh, Su-Yeon Choi
  • Publication number: 20230235402
    Abstract: A composition suitable for diagnosing a musculoskeletal disease and a composition suitable for preventing or treating a musculoskeletal disease are disclosed. The composition contains zinc finger protein with KRAB and SCAN domains 8 (Zkscan8) protein, which can be effectively used as an excellent biomarker for obtaining accurate information about the occurrence and progression stages of a musculoskeletal disease, specifically a tendon disease or a ligament disease. The compositions containing Zkscan8 can be effectively used for preventing or treating a musculoskeletal disease through Zkscan8 overexpression.
    Type: Application
    Filed: July 2, 2021
    Publication date: July 27, 2023
    Applicants: SEOUL NATIONAL UNIVERSITY HOSPITAL, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, CHEONGJU UNIVERSITY INDUSTRY & ACADEMY COOPERATION FOUNDATION
    Inventors: Hyun Chul JO, Young-il HWANG, Jin-Hee KIM, Jin-Hong KIM, Jae-Hyung LEE, Hyun-Ju LIM, Ah-Young LEE, Seung Yeon LEE, Ji-Hye YEA, Yeasol KIM
  • Publication number: 20230226201
    Abstract: The present invention relates to a unit drug conjugate wherein a binding group capable of binding to another unit drug conjugate is additionally linked to a unit drug conjugate in which a targeting substance, which binds specifically to target cells, and a drug, are linked together. When the unit drug conjugates according to the present invention are sequentially administered in vivo, complexes form a cluster by in vivo crosslinking, and the cluster promotes endocytosis of the drug conjugate, thereby significantly enhancing cellular internalization of the drug included in the drug conjugate.
    Type: Application
    Filed: June 1, 2021
    Publication date: July 20, 2023
    Applicants: BIK THERAPEUTICS INC., SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Sang Eun KIM, Byung Chul LEE, Hewon YOUN, Ji Young CHOI, Jae Ho JUNG, In Ho SONG
  • Patent number: 11690761
    Abstract: Systems, devices, and methods for treating a glaucomatous eye are provided. An amount of pulsed laser energy is delivered to the pars plana of the eye by a hand-holdable device which comprises a hand-holdable elongate member and a contact member disposed on an end of the elongate member. A contact surface of the contact member is placed in direct contact with the eye so that a reference edge of the contact member aligns with the limbus and a treatment axis defined by the elongate member is angularly offset from the optical axis of the eye. The amount of pulsed laser energy delivered is insufficient to effect therapeutic photocoagulation but is sufficient to increase uveoscleral outflow so as to maintain a reduction from pre-laser treatment intraocular pressure. Amounts of pulsed laser energy will be transmitted to a circumferential series of tissue regions of the eye.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: July 4, 2023
    Assignees: IRIDEX Corporation, National University Hospital (Singapore) PTE LTD, National University of Singapore
    Inventors: Paul T. K. Chew, David M. Buzawa, Giorgio Dorin
  • Patent number: 11690727
    Abstract: The present disclosure relates to an artificial ankle joint tibial component and, more particularly, to an artificial ankle joint tibial component of an implant that is implanted into a body, the implant including: a body part having a contact surface in contact with a resected surface of a distal end of a tibia of a joint and a joint surface facing a joint; and a fixing part formed to extend a predetermined length upwards from the contact surface, wherein the fixing part is configured as a single body formed to extent a predetermined length upwards from the center in the front area of the contact surface and includes a wing extending to one side, and wherein the wing includes at least one posterior wing that extends at a predetermined angle relative to an AP line, thereby preventing stress from being concentrated on one wing to avoid a fracture thereof and increasing the contact area between a bone and an implant to strengthen fixing force, prevent rotation, and disperse stress, so that bone resorption aroun
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: July 4, 2023
    Assignees: CORENTEC CO., LTD., CHONNAM NATIONAL UNIVERSITY HOSPITAL, INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Keun-Bae Lee, Tae-Jin Shin