Patents Assigned to National University Hospital
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Publication number: 20210214667Abstract: The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.Type: ApplicationFiled: December 10, 2019Publication date: July 15, 2021Applicants: Seoul National University R&DB Foundation, Seoul National University HospitalInventors: Seung Hee YANG, Yon Su KIM, Dong Ki KIM, Sa Ram LEE, Yong Chul KIM, Mi Yeon YU, Ji Eun KIM
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Patent number: 11039800Abstract: An upright posture assisting device for an X-ray inspection of infants, and more particularly to an upright posture assisting device for an X-ray inspection of infants, by which an infant can be X-ray photographed while being safely fixed. The upright posture assisting device for an X-ray inspection of infants includes: a body disposed on the front side of an X-ray detector and having an empty space in the interior thereof; an insertion hole formed on the upper surface of the body such that the legs of an infant are inserted into the insertion hole; and handgrip parts mounted on opposite sides of the upper surface of the body.Type: GrantFiled: May 15, 2018Date of Patent: June 22, 2021Assignee: CHONBUK NATIONAL UNIVERSITY HOSPITALInventors: Ho Tae Lim, Myoung Hwan Ko, Kap Soo Han
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Patent number: 11033598Abstract: A method for preventing or treating hearing loss includes administering a composition comprising an oat extract to a subject. The method may use avenanthramide or a derivative thereof an oat extract. The oat extract has an effect on hair cells of the cochlea, spinal ganglion cells, and angiocytes, and an effect of inhibiting occurrence of hearing loss and can be usefully used for preventing or treating hearing loss. In particular, since the oat extract is a natural product and has stability without cytotoxicity, the composition containing the oat extract as an active ingredient has a safety advantage for long-term use without side effects on the human body.Type: GrantFiled: September 17, 2018Date of Patent: June 15, 2021Assignees: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY, CHONNAM NATIONAL UNIVERSITY HOSPITAL, REPUBLIC OF KOREA (MANAGEMENT : RURAL DEVELOPMENT ADMINISTRATION)Inventors: Hyong Ho Cho, Hyung Seok Kim, Sung Su Lee, Yu Young Lee
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Publication number: 20210170076Abstract: A tacrolimus drug-eluting stent manufacturing method according to the present invention enables a tacrolimus drug to be strongly and stably bound onto a stent, while also not necessarily involving a separate step of introducing a surface-binding functional group for the binding of a drug onto a stent and a step of introducing, into the drug, a functional group capable of binding to the surface-binding functional group, and a tacrolimus drug-eluting stent manufactured by the manufacturing method has a greater total drug elution amount and has a more excellent delayed drug-elution property.Type: ApplicationFiled: December 19, 2018Publication date: June 10, 2021Applicants: Industry Foundation of Chonnam National University, Chonnam National University HospitalInventors: Myung Ho JEONG, Dae Sung PARK, In-Ho BAE, Kyung Seob LIM, Jae Won SHIM, So Youn LEE, Eun Jae JANG, Doo Sun SIM, In Soo KIM, Jun Kyu PARK
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Patent number: 10953070Abstract: The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.Type: GrantFiled: July 24, 2015Date of Patent: March 23, 2021Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY HOSPITALInventors: Desmond Heng, Sie Huey Lee, Jeanette Teo, Wai Kiong Ng, Reginald Tan
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Patent number: 10947241Abstract: The present invention relates to a compound represented by Chemical Formula 1, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of cardiovascular diseases.Type: GrantFiled: October 27, 2017Date of Patent: March 16, 2021Assignee: Seoul National University HospitalInventors: Ja Kyung Yoo, Nora Lee, Chun Ho Lee, Myunggi Jung, Hyo-Soo Kim
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Patent number: 10934303Abstract: The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR?) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.Type: GrantFiled: September 13, 2016Date of Patent: March 2, 2021Assignees: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION, KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL, KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Sung Yeoun Hwang, Sung Jin Cho, Jina Kim, Jungwook Chin, Hayoung Hwang, In-Kyu Lee, Yong-Hyun Jeon, Jaetae Lee, Jae-Han Jeon, Sang Wook Kim
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Patent number: 10932946Abstract: There is provided a device for insertion into a body cavity, the device includes an insertion member configured to be inserted into the body cavity, an expandable member coupled to the insertion member, the expandable member capable of being expanded to apply pressure onto tissue within the body cavity, a first member configured for storing a first endothermic reactant therein, and a second member configured for storing a second endothermic reactant therein. In particular, the first and second members are configured to, in a state of the device (e.g., compressed state), allow the first and second endothermic reactants to cooperate to effect an endothermic reaction to generate an endothermic product. Furthermore, the expandable member is configured to receive at least one of the first or second endothermic reactant and the endothermic product through a channel within the insertion member. There is also provided a method of fabricating a device for inserting into a body cavity.Type: GrantFiled: July 29, 2016Date of Patent: March 2, 2021Assignees: Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd, Singapore Health Services Pte LtdInventors: Prusothman M Sina Raja, Angela Renayanti Dharmawan, Chee Keong Tee, Yao Wang, Sheau Huei Frances Lim, Zhengtao Keith Chong
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Publication number: 20210045916Abstract: A liquid medicine administration identifying device according to an embodiment of the present invention comprises: a body including a receiving space for receiving an administration container, through which a liquid medicine can be administrated; a sensing unit installed at the body to sense that the administration container is compressed or overturned; and a transmission unit for transmitting a sensing result of the sensing unit to the outside.Type: ApplicationFiled: February 1, 2019Publication date: February 18, 2021Applicants: SEOUL NATIONAL UNIVERSITY HOSPITAL, RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITYInventors: Tae Woo KIM, Tai Myoung CHUNG
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Patent number: 10881319Abstract: An apparatus for treating dizziness comprises an input unit configured to input a type of dizziness suffered by a patient, a storage unit configured to store different treatment methods respectively corresponding to different types of dizziness, an operation unit configured to search for a treatment method corresponding to the diagnosed type of dizziness among the treatment methods stored in the storage unit based on the diagnosed type of dizziness, and an output unit configured to output the searched treatment method for the inputted type of dizziness to the patient.Type: GrantFiled: June 15, 2015Date of Patent: January 5, 2021Assignee: Seoul National University HospitalInventors: Myung-Whan Suh, Jun Ho Lee, Seung Ha Oh, Chiheon Kwon, Joong Woo Ahn, Yunseo Ku, Hee Chan Kim
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Publication number: 20200390670Abstract: The is provided a compound of formula I or II or physiologically acceptable salts or solvates, or oxidised derivatives thereof: where R1 to R3, R13 and R14 are as defined herein. Also disclosed herein are methods of dyeing hair or (temporarily) tattooing the skin using the compounds of formula I or II (or physiologically acceptable salts or solvates, or oxidised derivatives thereof) in a suitable composition.Type: ApplicationFiled: May 15, 2020Publication date: December 17, 2020Applicants: National University of Singapore, Agency for Science, Technology and Research, National University Hospital (Singapore) Pte LtdInventors: Giorgia Pastorin, Paul Bigliardi, Suresh Valiyaveettil, Gopalakrishnan Venkatesan, Arup Sinha, Yuri Herbert Dancik, Mei Bigliardi-Qi
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Patent number: 10864383Abstract: The present disclosure relates to a respiratory gating system for inducing respiration of a patient during radiation therapy. A respiratory gating system according to one embodiment of the present disclosure comprises: an image management unit for acquiring an MRI image of a patient and processing the acquired image; and a projection unit for displaying the MRI image acquired and processed by the image management unit to the patient in real time, wherein the projection unit may be configured to project an image of a treatment area of the patient in real time using, as a screen, a bore of a radiotherapy equipment which is formed to surround the patient in order to acquire the MRI image.Type: GrantFiled: October 29, 2018Date of Patent: December 15, 2020Assignees: SEOUL NATIONAL UNIVERSITY HOSPITAL, PAPRICA Lab. Co., Ltd.Inventors: Hong Gyun Wu, Jong Min Park, Chang Heon Choi, Jung In Kim
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Publication number: 20200375449Abstract: A system for monitoring a volume of a bladder during a surgical procedure. The system includes one or more processors; and a memory that is communicatively coupled to the one or more processors and stores one or more sequences of instructions, which when executed by one or more processors causes steps to be performed comprising: receiving information of a maximum volume of the bladder before the surgical procedure; receiving one or more ultrasound images from an ultrasonic scanner; based on the one or more ultrasound images, determining a volume of the bladder; comparing a maximum volume of the bladder to the determined volume of the bladder; and responsive to a difference between the maximum volume and determine volume of the bladder exceeding a threshold, issuing a warning associated with the difference.Type: ApplicationFiled: August 19, 2020Publication date: December 3, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Seung-June OH, Hyoun-Joong KONG
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Patent number: 10835323Abstract: A system and an apparatus for guiding an instrument may be provided, the apparatus comprising a main body; a holding member for holding an instrument, the holding member coupled to the main body; and one or more actuating members configured to effect movement of the holding member such that said movement of the holding member is capable of providing rotational movement of an instrument about a pivot point external the apparatus. The holding member may preferably be configured to co-operate with a compliance device, said compliance device capable of holding the instrument.Type: GrantFiled: August 28, 2013Date of Patent: November 17, 2020Assignees: Institute of Technical Education, National University Hospital (Singapore) Pte Ltd., National University of SingaporeInventors: Foo Soo Leong, Ng Ka Wei, Goh Jin Quan, Ting Poh Hua, Lee Teck Kheng, Wu Qinghui, Chiong Edmund, Esuvaranathan Kesavan
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Patent number: 10786147Abstract: A system for controlling a pressure inside a bladder through an endoscope, where the distal end portion of the endoscope is located inside the bladder and the endoscope has an inlet port through which fluid to enter the bladder and an outlet port through which fluid in the bladder to exit the bladder. The system includes one or more processors that receive a first signal from a first pressure sensor installed in a first fluid passageway that is in fluid communication with the inlet port; receives a second signal from a second pressure sensor installed in a second fluid passageway that is in fluid communication with the outlet port; and based on at least one of the first and second signals, actuates a valve installed in the first fluid passageway of fluid so as to adjust the flow rate into the bladder through the inlet port.Type: GrantFiled: June 17, 2018Date of Patent: September 29, 2020Assignee: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Seung-June Oh, Hyoun-Joong Kong
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Publication number: 20200292553Abstract: The present invention relates to a composition for predicting or diagnosing a liver disease, and a liver disease prediction or diagnosis method using same, and more specifically, to a marker for predicting or diagnosing liver fibrosis in non-alcoholic fatty liver disease (NAFLD), and a prediction or diagnosis method using same. By using the composition for predicting or diagnosing a liver disease, according to the present invention, the level of the GDF15 protein, having a positive correlation with liver fibrosis in NAFLD, may be checked, and thus an effect is achieved whereby same may be effectively used for predicting and diagnosing liver fibrosis in NAFLD.Type: ApplicationFiled: August 20, 2018Publication date: September 17, 2020Applicant: Seoul National University HospitalInventor: Won KIM
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Patent number: 10767230Abstract: Disclosed are methods of determining the likelihood of a subject having or developing a gastric cancer. The methods comprise measuring the expression level of at least one miRNA having at least 90% sequence identity with an miRNA as described herein in a non-cellular biofluid sample obtained from the subject, wherein differential expression of miRNA expression in the sample obtained from the subject, as compared to a control, may be indicative of the subject having gastric cancer and wherein the miRNA may be either an miRNA listed as “up-regulated” or an miRNA listed as “down-regulated”. Also disclosed is a method of determining the likelihood of a subject having or developing a stage of a gastric cancer.Type: GrantFiled: August 11, 2015Date of Patent: September 8, 2020Assignees: Agency for Science, Technology and Research, National University of Singapore, National University Hospital (Singapore) Pte Ltd.Inventors: Heng-phon Too, Lihan Zhou, Ruiyang Zou, Khay Guan Yeoh, Bok Yan So, Feng Zhu, Wei Peng Yong
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COMPOSITION FOR SURFACE MODIFICATION OF MEDICAL IMPLANT AND MEDICAL IMPLANT SURFACE-MODIFIED THEREBY
Publication number: 20200268937Abstract: Disclosed are a composition for surface modification of a medical implant and a medical implant surface-modified thereby, and according to a medical implant according to one embodiment, itaconic acid may be bound to the surface of the medical implant with high binding stability, and fibrosis inhibition and inflammatory response inhibition effects at an implantation site are exhibited.Type: ApplicationFiled: July 18, 2018Publication date: August 27, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Chan Yeong Heo, Han Soo Park, Byung Hwi Kim, Byung Ho Shin, Jung Hee Shim, Mallinath S Birajdar, Hyun Joo Cho, Chanutchamon Sutthiwanjampa -
Publication number: 20200268302Abstract: A non-transitory tangible computer-readable medium or media include one or more sequences of instructions which, when executed by one or more processors, causes steps to be performed, where the steps include receiving data obtained from baseline clinical evaluation and a urodynamic test for a patient, the diagnostic engine having been trained to associate a data obtained from a urodynamic test with one or more lower urinary tract dysfunction; extracting one or more features from the received data; identifying one or more urodynamic parameters of the patient's lower urinary tract dysfunction, based on the one or more extracted features; and generating an output that includes information of one or more lower urinary tract dysfunction associated with the one or more identified urodynamic parameters.Type: ApplicationFiled: September 10, 2019Publication date: August 27, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventor: Seung-June Oh
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Patent number: 10722202Abstract: The present invention comprises: a first X-ray irradiation apparatus and a second X-ray irradiation apparatus for irradiating a subject with X-rays; an X-ray generation unit supporting so that first and second X-rays irradiated onto the subject are detected by a set detector when the subject is irradiated with the first and second X-rays from the first and second X-ray irradiation apparatuses, respectively; and a mode selection unit for allowing selection of any one mode from among a 2D imaging mode and 3D imaging mode, wherein the angles with respect to the subject of the first and second X-ray irradiation apparatuses are determined on the basis of said any one mode selected by means of the mode selection unit from among the 2D imaging mode and 3D imaging mode. According to the present invention, the mode can be easily selected according to need from among the 2D imaging mode and 3D imaging mode.Type: GrantFiled: April 26, 2017Date of Patent: July 28, 2020Assignee: Seoul National University HospitalInventors: Chang Hwan Yoon, Dong Hoon Han