Abstract: A method for producing a liquid extract from food ingredients in a beverage producing device that has a brewing unit driven in centrifugation. The method includes providing food ingredients in the brewing unit, supplying heated liquid in the brewing unit, centrifuging the brewing unit thereby generating centrifugal forces forcing liquid to flow through the food ingredients, and dispensing the liquid, along with an operation for compensating the thermal losses of the liquid extract in the brewing unit or the collecting unit.

Abstract: The invention relates to a code support (60a, 60b) adapted to be associated with or part of a capsule intended for delivering a beverage in a beverage producing device by centrifugation of the capsule. The support comprises a code formed by at least a first sequence of symbols and a second sequence of symbols. The code is represented on the support so that each symbol is sequentially readable by a reading arrangement (100) of an external reading device while the capsule is driven in rotation along an axis of rotation (Z). The first sequence comprises at least one first preamble sequence of symbols, and at least one first data sequence of symbols. The second sequence comprises at least one second preamble sequence of symbols and at least one second data sequence of symbols. The first preamble sequence is distinct from the second preamble sequence.

Abstract: The present invention generally relates to the field of biomarkers. In particular, the present invention relates to biomarkers such as PC-O 44:4 that can be used, for example for detecting and/or quantifying visceral adiposity and/or changes in visceral adiposity. This biomarker may also be used to diagnosing the effect of a change in lifestyle on visceral adiposity in a subject.

Abstract: Disclosed herein are packages for consumer goods that provide additional functionality as an interactive device for encouraging playful interaction with the package contents. In various embodiments, the package includes a lid or top comprising a hollow body defined by a flexible shell, wherein the shell is reversibly deformable or comprises regions that are reversibly deformable, the lid adapted for launching or propelling an item when the item is placed on the shell or on a reversibly deformable region of the shell, wherein when the shell is deformed and thereafter springs back to its undeformed shape, the springing action propels the item away from the lid. Kits and methods for using the interactive packages and particularly the interactive portions of the packages are also disclosed.

Abstract: The present invention relates generally to compositions with a health benefit. In particular, the invention relates to the field of brain health, for example brain protection, maintenance of cognitive function, prevention of cognitive decline and prevention of cognitive disorders. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of cognitive decline.

Abstract: The invention aims to provide a device sensing a capsule inserted in a receptacle in machine and physical parameters of liquid supplied by a beverage production apparatus flowing through the capsule in function of the type of capsule. The capsule containing beverage ingredient is inserted in a cylindrical or conical wide mouthed receptacle having an upper opening for inserting the capsule and a lower bottom closing the receptacle. The receptacle rotates around an axis of a hollow shaft attached at the center and perpendicularly to the external face of the bottom of the receptacle, said shaft forming a hole at the center of the inner face of the bottom of the receptacle. The device comprises a rod sliding in the shaft and passing through the hole of the inner face of the bottom of the receptacle, said rod being provided with a spring maintaining an end of the rod lifted inside the receptacle in contact with the capsule, the other end being inside the shaft.

Abstract: This invention relates to a preparation comprising N-acetyl-lactosamine and/or an oligosaccharide containing N-acetyl-lactosamine and a probiotic Lactobacillus sp. The invention extends to nutritional compositions comprising said preparation and to the use of the preparation in the prevention and treatment of pathogenic infections of the gastro-intestinal and upper respiratory tracts.

Abstract: The present invention relates to a method for producing frozen confectionery products comprising a coagulated protein system which contributes to the improvement of textural and sensorial attributes of the confections, in particular of products based on lower fat formulations. Such a protein system is used according to the invention in frozen confection prepared by conventional freezing alone or combined with low temperature freezing wherein it improves the microstructure and stability on frozen products.

Abstract: A nutritional composition for administration to an infant which composition comprises, on a dry matter basis, from 2.5 to 15.0 wt % of an oligosaccharide mixture consisting of N-acetylated oligosaccharide(s), galacto-oligosaccharide(s) and sialylated oligosaccharide(s) with the proviso that the composition comprises at least 0.02 wt % of an N-acetylated oligosaccharide, at least 2.0 wt % of a galacto-oligosaccharide and at least 0.04 wt % of a sialylated oligosaccharide and that the N-acetylated oligosaccharide(s) comprise 0.5 to 4.0% of the oligosaccharide mixture, the galacto-oligosaccharide(s) comprise 92.0 to 98.5% of the oligosaccharide mixture and the sialylated oligosaccharide(s) comprise 1.0 to 4.0% of the oligosaccharide mixture. The composition is useful for administration to an infant in the first six months of life to reduce the risk of obesity later in life.

Abstract: The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

Abstract: The present invention relates generally to printing processes. In particular the invention relates to processes for printing with edible inks. An aspect of the invention relates to printing an edible ink onto a material using an inkjet printing device. The material may be an edible material. The ink may comprise a colourant, at least 30% water, at least 25% carbohydrate sweeteners and be free from both diols and triols. A further aspect of the invention is a printed foodstuff obtainable by the process of printing edible ink onto a material.

Abstract: The present invention provides methods for selecting a subject as suitable for combination therapy with EGFR and HER2 inhibitors. The present invention also provides methods for predicting whether a subject will benefit from the combination therapy. In some embodiments, the present invention provides methods for determining whether to administer a combination therapy in a subject receiving EGFR inhibitor therapy. In other embodiments, the present invention provides methods for monitoring a subject on EGFR inhibitor therapy to determine whether to administer a combination therapy of EGFR and HER2 inhibitors. The present invention is particularly useful to facilitate the design of personalized therapies for colorectal cancer patients with EGFR inhibitor sensitivity.

Abstract: A method and a device are provided for dispensing multiple portions of a fluid that is stored in a container having a port and a flexible dispensing tube. The flexible dispensing tube includes an inlet and an outlet. The inlet is integrally sealed to the port and a viscoelastic valve is mounted in the outlet. The method includes a compression step and a step of terminating compression. The method also includes a step implemented at the end of the compression step that releases the pressure in a tube portion between a first tube portion and the valve.

Abstract: The present invention relates to a frozen confectionery product comprising a core consisting of a frozen confection, wherein the core is coated with a frozen flexible edible gel layer, characterized in that the gel layer is provided with at least one cutting line extending spirally over the gel layer, said cutting line allowing to peel-off the gel-layer in a spiral. It furthermore relates to an apparatus for manufacturing same, and to a cutting device for use in that method.

Abstract: The invention relates to a capsule for delivering a drink by injecting a pressurized fluid comprising a body (2), an injection wall (3), a chamber (4) containing a bed of food substance to be extracted, means for retaining the internal pressure (5) in the said chamber. The improvement consists in the provision of an injection space (7) allowing a means of injecting fluid in the form of at least one jet of fluid to be introduced through the injection wall and in providing a means (6) for breaking the jet of fluid and distributing the distribution of fluid at a reduced speed across the surface of the bed of substance. These means may adopt various forms such as that of a rigid or flexible perforated wall, or a layer of discrete elements or a spongy layer. Such a capsule improves the flow of liquid extract through the pressure retaining means (5) and improves the extraction conditions.

Abstract: A cassette (1) that is insertable into an infusion pump for delivery of a fluid to a subject that has a housing with two ends for holding flexible tubing (75) through which the fluid is directed. The housing has an open area exposing the tubing, which engages a pumping mechanism when inserted into an infusion pump. An anti-flow valve mechanism (100) associated with the tubing or the cassette and present either in, on or near the housing is made up of a piston (103/105) and spring (110), where the spring biases the piston against the tubing to prevent fluid flow.

Abstract: The invention concerns a beverage production system comprising a capsule (1) and a module (2) for producing a beverage from the capsule, the capsule (1) comprising an enclosure (1a) and a rim (1b), and the module (2) comprising: a first capsule engagement member (3), which can be displaced relative to a second, co-operating capsule engagement member (4) between a capsule discharge position and a beverage production position, the displaceable first capsule engagement member (3) comprising member (13) having the shape of a hollow bell, and the capsule (1) presenting an enclosure outer shape that is conformal to at least a portion of the hollow bell shaped member (13) and the capsule presenting a rim (1b) size such that at least a part of the rim of the capsule extends beyond at least a part of the first capsule engagement member (3) once it is engaged in the first capsule engagement member, wherein the displaceable first capsule engagement member (3) comprises retaining means able to create friction with discre

Abstract: A capsule-based beverage production machine that comprises a module designed for producing a beverage on the basis of ingredients which are contained in a capsule. The module comprises: means for retaining the capsule in a fixed position, and means for perforation of the capsule, wherein the perforation means are controlled to perforate the capsule after the capsule is retained in the fixed position by the retaining means.

Abstract: The present invention relates generally to compositions with a health benefit. In particular, the invention relates to the field of cardiovascular disorders, for example, atherosclerosis, high blood pressure, coronary heart disease, myocardial infarction, angina pectoris, stroke, and heart failure. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of cardiovascular disorders.

Abstract: A liquid purification apparatus (100), comprises a reservoir (101) for liquid (102) and a primary irradiation device (106, 301); characterized in that it has a directional valve (107, 500) which is mobile between a recirculating position and a discharging position where the liquid (102) flows through circulation tubes (105, 305, 501; 115, 306, 502) having at least one portion substantially transparent to ultraviolet light disposed within said primary irradiation device (106, 301); wherein when said directional valve (107, 500) is in the recirculating position, said reservoir (101), said circulation tubes (105, 305, 501), said directional valve (107, 500,115, 306, 502) form a closed loop. This invention eliminates any dead-space or dead-corners from the apparatus and also prevents the re-contamination of the whole system.