Patents Assigned to NOF Corporation
  • Narrowly distributed multi-armed polyethylene glycol compounds, hydrogels, and methods
    Patent number: 10526457
    Abstract: Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: January 7, 2020
    Assignees: NOF Corporation, Massachusetts Institute of Technology
    Inventors: Elazer Edelman, Natalie Artzi, Hyun Seok Song, Yuji Yamamoto, Hiroki Yoshioka, Ken-ichiro Nakamoto
  • HETEROBIFUNCTIONAL MONODISPERSED POLYETHYLENE GLYCOL AND CONJUGATE USING SAME
    Publication number: 20200000933
    Abstract: A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure: wherein X1 and Y1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule. R1 is a hydrocarbon group or the like. n is an integer of 3 to 72. A1 represents -L1-(CH2)m1— or the like, L1 and L2 represent each an ether bond or the like, and m1 and m2 each independently represent an integer of 1 to 5. B1 represents -L3-(CH2)m3— or the like, L3 and L4 represent an amide bond or the like, and m3 and m4 each independently represent an integer of 1 to 5. Also disclosed is an antibody-drug conjugate including the heterobifunctional monodispersed polyethylene glycol.
    Type: Application
    Filed: March 23, 2018
    Publication date: January 2, 2020
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Kohei YOSHIMURA, Mika HAMURA
  • Method for suppressing protein adsorption
    Patent number: 10520486
    Abstract: Provided is a novel method of suppressing non-specific protein adsorption. The above-mentioned object can be achieved by treating a solid phase with a solid phase-treating liquid containing a phosphorylcholine group-containing polymer as a main component, and treating a specimen with a specimen-treating liquid containing, as a main component, a polymer having a phosphorylcholine group, a hydroxy group, and a hydrophobic group, followed by addition of the treated specimen to the treated solid phase.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 31, 2019
    Assignees: National University Corporation Kyoto Institute of Technology, NOF Corporation
    Inventors: Yoichi Kumada, Yasutaka Kawaguchi, Aranna Nemoto, Fumio Nakashima, Nobuyuki Sakamoto
  • Toner for developing electrostatic images
    Patent number: 10503089
    Abstract: There is provided a toner for developing electrostatic images, including an external additive and colored resin particles containing a binder resin, a colorant and softening agents. The colored resin particles contain a monoester compound A represented by formula (1) and a monoester compound B represented by formula (2) as softening agents. A content of the monoester compound A is in the range from 95 to 99% by mass, a content of the monoester compound B is in the range from 1 to 5% by mass, and a content of the softening agents is in the range from 10 to 30 parts by mass, with respect to 100 parts by mass of the binder resin. Formula (1) is R1—COO—R2. Formula (2) is R3—COO—R4.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: December 10, 2019
    Assignees: ZEON CORPORATION, NOF CORPORATION
    Inventors: Azusa Masuda, Ryuji Ohta, Munehiro Yamada, Norifumi Itako, Ryosuke Uemura
  • Branched hetero polyethylene glycol and intermediate
    Patent number: 10494340
    Abstract: A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20?n?2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: December 3, 2019
    Assignee: NOF CORPORATION
    Inventors: Yuji Yamamoto, Hiroki Yoshioka, Fumiaki Manabe
  • Method for producing container for forming embryoid body
    Patent number: 10494595
    Abstract: An object is to provide a method of manufacturing a vessel for embryoid body formation excellent in formability of an embryoid body and suitable for optical observation.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: December 3, 2019
    Assignee: NOF CORPORATION
    Inventors: Tomozumi Noda, Fumio Nakashima, Satoshi Yamada, Nobuyuki Sakamoto
  • Ophthalmic solution
    Patent number: 10471171
    Abstract: Provided is an ophthalmic solution of which preservative component, hexamethylene biguanide, contained therein is inhibited from being adsorbed on soft contact lenses and eye droppers. The ophthalmic solution contains, at a specific ratio, (A) hydroxypropyl methylcellulose having 28.0 to 30.0 mass % methoxy groups and 7.0 to 12.0 mass % hydroxypropoxy groups, both with respect to the total amount of the hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass % aqueous solution of the hydroxypropyl methylcellulose at 20° C. has a viscosity of 50 to 4000 mPa·s; (B) sodium chloride or potassium chloride; (C) hexamethylene biguanide or a salt thereof; (D) 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer; and (E) water.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: November 12, 2019
    Assignee: NOF Corporation
    Inventors: Shunsuke Sakurai, Koji Miyamoto, Yohei Takada, Yoshihisa Shimamura, Mao Maruhashi, Nobuyuki Sakamoto
  • SLIPPERINESS-IMPARTING AGENT AND SLIPPERINESS-IMPARTING METHOD
    Publication number: 20190316054
    Abstract: Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 17, 2019
    Applicants: NOF CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Kazuhiko ISHIHARA, Tomozumi NODA, Masaru MATSUDA, Satoshi YAMADA, Nobuyuki SAKAMOTO
  • ANTIBODY-DRUG CONJUGATE HAVING CYCLIC BENZYLIDENE ACETAL LINKER
    Publication number: 20190309102
    Abstract: An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Z1 and Z2 are each independently a selected divalent spacer:
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Yuji YAMAMOTO
  • Hetero type monodispersed polyethylene glycol, intermediate for production of hetero type monodispersed polyethylene glycol, methods for producing same, and hetero type monodispersed polyethylene glycol conjugate
    Patent number: 10435509
    Abstract: A hetero type monodispersed polyethylene glycol containing a compound represented by the following formula (1): NH2—(CH2CH2O)a—CH2CH2COOH??(1) (in the formula (1), a represents an integer from 6 to 40); wherein any of (A) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using reverse phase chromatography, (B) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using cation exchange chromatography, and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by the formula (1) shown above is derivatized and separated using anion exchange chromatography satisfy specific relational expressions, respectively.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: October 8, 2019
    Assignees: TOHOKU TECHNO ARCH CO., LTD., NOF CORPORATION
    Inventors: Kazushi Kinbara, Takahiro Muraoka, Adam Marcin Wawro, Tomoyuki Ohtake, Eui-chul Kang, Tomoki Uruga, Ryutaro Imamura
  • POLYPROPYLENE RESIN COMPOSITION
    Publication number: 20190300687
    Abstract: A polypropylene resin composition contains components (A), (B) and (C). A content of (A) is from 70 to 90 parts by weight, a content of (B) is from 10 to 30 parts by weight, and a content of (C) is from 1 to 5 parts by weight, when the total of the content of (A) and (B) is taken as 100 parts by weight. (A) polypropylene, (B) talc having an average particle diameter of 1 ?m to 8 ?m, (C) polyethylene glycol, wherein a molecular weight at the maximum point of refractive index intensity in a chromatogram obtained by gel permeation chromatography using a differential refractometer is from 2,000 to 4,000, and S2/S1 is from 1.3 to 2.0, where peak areas S2 and S1 are as defined herein.
    Type: Application
    Filed: July 24, 2017
    Publication date: October 3, 2019
    Applicant: NOF CORPORATION
    Inventors: Kazuomi MOTTATE, Toru TAMURA
  • Method for producing polyethylene glycol having terminal carboxyl group
    Patent number: 10407543
    Abstract: A method for producing polyethylene glycol having a terminal carboxyl group including oxidizing polyethylene glycol represented by formula (I): CH3O(CH2CH2O)n(CH2)m—CHO with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from a carbonate, a phosphate, a citrate and an acetate at 5 to 40° C. to produce polyethylene glycol represented by formula (II): CH3O(CH2CH2O)n(CH2)m—COOH, wherein n is a number from 10 to 1,100, and m is 2 or 3.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 10, 2019
    Assignee: NOF CORPORATION
    Inventors: Akiko Doi, Takashi Ichikawa, Tsuyoshi Takehana, Takuma Tsubusaki
  • Matrix-assisted laser desorption mass spectrometry of high molecular weight polyoxyethylene derivative
    Patent number: 10410851
    Abstract: A matrix-assisted laser desorption (MALDI) mass spectrometry in which a mixture comprising a polyethylene glycol derivative having a molecular weight of 40,000 or more and a matrix is irradiated with laser beam to vaporize the polyethylene glycol derivative together with the matrix, thereby measuring a molecular weight of the polyethylene glycol derivative, wherein as the matrix, a low polar matrix having a 1-octanol/water partition coefficient (logPow) of 4.1 to 4.8 is used. Also disclosed is a matrix for use in the matrix-assisted laser desorption (MALDI) mass spectrometry.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: September 10, 2019
    Assignee: NOF CORPORATION
    Inventors: Masaki Kamiya, Ryota Matsuki
  • Lacrimal oily layer stabilizer and eye drops comprising same
    Patent number: 10391119
    Abstract: Provided is a tear lipid layer stabilizer that is capable of stabilizing a tear lipid layer and allowing the tear lipid layer to sufficiently spread over a corneal surface, to thereby prevent the evaporation of a tear aqueous layer on the corneal surface, and hence is suitable for amelioration, alleviation, or treatment of evaporative dry eye symptoms caused by Meibomian gland dysfunction, an ophthalmic solution having blended therein the tear lipid layer stabilizer, and a tear lipid layer-stabilizing method using the tear lipid layer stabilizer. The tear lipid layer stabilizer includes a copolymer that has a weight-average molecular weight of from 10,000 to 5,000,000, and contains 10 mol % to 90 mol % of a constituent unit (A) based on 2-(meth)acryloyloxyethyl phosphorylcholine and 90 mol % to 10 mol % of a constituent unit (B) based on an alkyl group-containing (meth)acrylic monomer.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 27, 2019
    Assignee: NOF Corporation
    Inventors: Shunsuke Sakurai, Koji Miyamoto, Yoshihisa Shimamura, Nobuyuki Yamamoto
  • Cationic lipid
    Patent number: 10385030
    Abstract: The present invention aims to provide a cationic lipid that can be used as a nucleic acid delivery carrier, a lipid membrane structure using a cationic lipid, a nucleic acid-introducing agent using a cationic lipid, and a method of achieving nucleic acid introduction by using a nucleic acid-introducing agent containing a cationic lipid. A lipid membrane structure containing a cationic lipid represented by the formula (1) wherein each symbol is as defined in the DESCRIPTION, is superior in the stability in blood and tumor accumulation property. A nucleic acid-introducing agent using the cationic lipid can achieve high nucleic acid delivery efficiency of nucleic acid to be delivered into the cytoplasm.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: August 20, 2019
    Assignees: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yuta Nakai, Kota Tange, Hidetaka Akita, Hideyoshi Harashima, Ryohei Togashi, Naoya Miura, Mio Maeta
  • Antibody-drug conjugate having cyclic benzylidene acetal linker
    Patent number: 10377837
    Abstract: An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Z1 and Z2 are each independently a selected divalent spacer:
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: August 13, 2019
    Assignee: NOF CORPORATION
    Inventors: Takuma Tsubusaki, Yuji Yamamoto
  • Flavoring agent and composition for oral cavity containing same
    Patent number: 10376460
    Abstract: Provided by the present invention is a corrigent composed of a copolymer having a weight average molecular weight of 10,000-5,000,000 and comprising 10-90 mol % of a constitution unit based on 2-(meth)acryloyloxyethylphosphoryl choline, and 90-10 mol % of a (meth)acrylic monomer containing an alkyl group, a (meth)acrylic monomer containing a quaternary ammonium group and a constitution unit based on a (meth)acrylamide monomer. The present invention also provides a composition for mouth cavity containing the corrigent.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 13, 2019
    Assignee: NOF CORPORATION
    Inventors: Koji Miyamoto, Nobuyuki Yamamoto, Shunsuke Sakurai, Yoshihisa Shimamura
  • Fouling inhibitor, filtration membrane and method for producing same
    Patent number: 10376848
    Abstract: Provided are: a fouling inhibitor that is capable of effectively inhibiting fouling of porous filtration membranes use as water purification membranes or the like, that has resistance to chemicals, such as alkali used when the membrane is fouled, and that is capable of maintaining such effects sufficiently even after chemical wash; a filtration membrane provided with the inhibitor; and a method for producing the same. The inhibitor contains: (A) a copolymer having a weight average molecular weight of 10000 to 300000 and contains a MPC unit (a1) and a BMA unit (a2), wherein the ratio of (a1) to (a2) ((a1)/(a2)) by mole is 10/90 to 70/30; and (B) PVA having a saponification degree of 72 to 93 mol % and a polymerization degree of 300 to 1000, wherein the ratio of component (A) to component (B) ((A)/(B)) by mass is 25/75 to 75/25.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: August 13, 2019
    Assignee: NOF Corporation
    Inventors: Mitsuyasu Nakashima, Hideyuki Nomura, Satoshi Yamada
  • LUBRICANT BASE OIL
    Publication number: 20190241823
    Abstract: A lubricant base oil which contains an ester. The ester constituting the lubricant base oil includes: a component (A) derived from pentaerythritol in a molar percentage Amol % of 20 to 30 mol %; a component (B) derived from a straight-chain fatty acid having a carbon number of 14 to 22 in a molar percentage Bmol % of 55 to 79 mol %; and a component (C) derived from adipic acid in a molar percentage Cmol % of 1 to 15 mol %. A molar ratio (Cmol/Cmol) of the component (C) derived from adipic acid and the component (B) derived from the straight-chain fatty acid having a carbon number of 14 to 22 is 0.02 to 0.25, and the ester has a hydroxyl value of 10 to 100 mgKOH/g.
    Type: Application
    Filed: June 7, 2017
    Publication date: August 8, 2019
    Applicant: NOF CORPORATION
    Inventors: Shunsuke MONJIYAMA, Hideki KAWAMOTO
  • Surface-coated copper filler, method for producing same and conductive composition
    Patent number: 10357825
    Abstract: There are provided a surface-coated copper filler having an excellent oxidation resistance for use in a conductive composition, a method for producing the surface-coated copper filler, and a conductive composition containing the surface-coated copper filler. The surface-coated copper filler comprises: a copper particle; a first coating layer containing an amine compound, which is bonded to copper on a surface of the copper particle via a chemical bond and/or a physical bond; and a second coating layer containing an aliphatic monocarboxylic acid having 8 to 20 carbon atoms, which is bonded to the amine compound via a chemical bond. The amine compound is represented by the following formula (1): H2NCH2mNHnCH2mNH2??(1) wherein m is an integer of 0 to 3, n is an integer of 0 to 2, m is 0 to 3 when n is 0, and m is 1 to 3 when n is 1 or 2.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: July 23, 2019
    Assignee: NOF CORPORATION
    Inventors: Yasunobu Tagami, Naoshi Takahashi, Masayuki Saitoh, Kouhei Sawada