Patents Assigned to NOF Corporation
  • Composition for nanoemulsion emulsification, bicontinuous microemulsion, cosmetic, and method for producing same
    Patent number: 10357437
    Abstract: A nanoemulsion emulsification composition including the following components (A) to (D), in which the mass ratios of the components satisfy the following condition, [(A)+(B)]:(C):(D)=1:4 to 8:0.4 to 0.8; component (A) is a copolymer including a constitutional unit (a1) represented by Formula (1) and a constitutional unit (a2) represented by Formula (2), the molar ratio of the constitutional units (a1):(a2) being 5:95 to 60:40, and the weight average molecular weight being 5,000 to 5,000,000; R1 represents a hydrogen atom or a methyl group R2 represents a hydrogen atom or a methyl group, and R3 represents a hydrocarbon group having 12 to 24 carbons; component (B) is a nonionic surfactant having an HLB value of 10 to 14, component (C) is a polyhydric alcohol, and component (D) is water.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: July 23, 2019
    Assignee: NOF CORPORATION
    Inventors: Yusuke Hara, Kazuaki Wakita
  • Polymer and crosslinked body thereof
    Patent number: 10323132
    Abstract: Provided are a copolymer having enough biocompatibility to be used in a medical material application, and a method of forming a crosslinked body, which involves modifying a substrate surface with the copolymer so that the surface may be biocompatible. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that the object is achieved by a copolymer containing a phosphorylcholine constitutional unit, a hydrophobic constitutional unit, and a photoreactive constitutional unit at a specific ratio.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: June 18, 2019
    Assignees: NOF Corporation, The University of Tokyo
    Inventors: Kazuhiko Ishihara, Yuuki Inoue, Kyoko Fukazawa, Masaru Matsuda, Satoshi Yamada, Tomozumi Noda
  • LUBRICANT BASE OIL AND LUBRICATING OIL COMPOSITION
    Publication number: 20190161695
    Abstract: A lubricant base oil composed of an ester. The ester includes a component (A) derived from trimethylolpropane in a molar percentage Amol% of 25 to 42 mol %; components (B) derived from monovalent straight-chain saturated fatty acids each having a carbon number of 8 to 12 in a molar percentage Bmol% of 33 to 55 mol %: and a component (C) derived from adipic acid in a molar ratio Cmol% of 12 to 34 mol %. The components (B) include lauric acid in a molar percentage of 5 to 50 mol %, and (BCOOH+CCOOH)/AOH is 0.90 to 1.02. AOH represents a hydroxyl equivalent of the component (A), BCOOH represents a carboxyl group equivalent of the components (B); and CCOOH represents a carboxyl group equivalent of the component (C).
    Type: Application
    Filed: June 7, 2017
    Publication date: May 30, 2019
    Applicant: NOF CORPORATION
    Inventors: Hideki KAWAMOTO, Shunsuke MONJIYAMA
  • COPOLYMER AND APPLICATION THEREFOR
    Publication number: 20190153137
    Abstract: Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.
    Type: Application
    Filed: June 28, 2017
    Publication date: May 23, 2019
    Applicants: NOF CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Kazuhiko ISHIHARA, Masaru MATSUDA, Tomozumi NODA, Satoshi YAMADA, Nobuyuki SAKAMOTO
  • POLYOXYETHYLENE COMPOUND HAVING MULTIPLE HYDROXYL GROUPS AT END, AND CONTACT LENS
    Publication number: 20190136085
    Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. It has been confirmed that a silicone contact lens including, on its surface, a graft polymer chain derived from a polyoxyethylene compound having a plurality of hydroxyl groups at a terminal thereof has surface hydrophilicity and surface lubricity.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 9, 2019
    Applicant: NOF CORPORATION
    Inventors: Yoshihisa SHIMAMURA, Yosuke MATSUOKA
  • WIRELESS DETONATOR, WIRELESS DETONATION SYSTEM, AND WIRELESS DETONATION METHOD
    Publication number: 20190137249
    Abstract: A wireless detonator (10) includes a detonation side receiving antenna (11), a detonation side transmitting antenna (18), an initiator (14) and a detonation side electronic circuit. The detonation side receiving antenna (11) receives energy for driving the detonation side electronic circuit, a control signal and an initiation signal. The detonation side electronic circuit receives the energy, the control signal and the initiation signal via the detonation side receiving antenna (11), transmits a response signal via the detonation side transmitting antenna (18) and ignites the initiator (14) in accordance with the initiation signal. A response frequency of the response signal is set to be greater than or equal to 100 MHz and less than or equal to 1 GHz.
    Type: Application
    Filed: April 19, 2017
    Publication date: May 9, 2019
    Applicants: NOF CORPORATION, FUTABA CORPORATION
    Inventors: Yoji TASAKI, Satoshi HIKONE, Shinya TANAKA, Kohichi SHIMAZAKI, Kazuhito WATANABE, Michihiro TAKAYASU
  • O/W TYPE EMULSION
    Publication number: 20190110986
    Abstract: The present invention provides an O/W type emulsion having a volume median diameter of not more than 100 nm and containing a compound represented by the formula (1) wherein Xa and Xb are each independently X1, X2 or a 1,4-piperazinediyl group; s is 1 or 2, R4 is an alkyl group having 1-6 carbon atoms, na and nb are each independently 0 or 1, R1a, R1b, R2a and R2b are each independently an alkylene group having 1-6 carbon atoms, Ya and Yb are each independently an ester bond, or the like, and R3a and R3b are each independently a liposoluble vitamin residue or the like.
    Type: Application
    Filed: June 29, 2016
    Publication date: April 18, 2019
    Applicants: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Kota TANGE, Yuta NAKAI, Hidetaka AKITA, Hiroki TANAKA, Ayaka WATANABE, Naoya MIURA, Hideyoshi HARASHIMA
  • BRANCHING-TYPE POLYOXYETHYLENE COMPOUND AND CONTACT LENS
    Publication number: 20190106539
    Abstract: Provided is a silicone contact lens having surface hydrophilicity and surface lubricity. The silicone contact lens includes, on its surface, a graft polymer chain derived from a branched polyoxyethylene compound represented by the formula (1): where n represents from 3 to 1,150, a represents 0 or 2, and R1 represents a hydrogen atom or a methyl group.
    Type: Application
    Filed: April 27, 2017
    Publication date: April 11, 2019
    Applicant: NOF CORPORATION
    Inventors: Yoshihisa SHIMAMURA, Yosuke MATSUOKA
  • BIODEGRADABLE HYDROGEL HAVING CYCLIC BENZYLIDENE ACETAL STRUCTURE
    Publication number: 20190092906
    Abstract: A biodegradable hydrogel having an acetal structure whose hydrolysis rate under different pH environments in the living body can be accurately controlled. The hydrogel is obtained by crosslinking a polyalkylene glycol derivative having a cyclic benzylidene acetal structure represented by formula (1) shown below with a crosslinking agent: where R1 and R6; R2, R3, R4 and R5; s; t; s+t; P1; Z1 and Z2; W1 and X1 are as defined herein.
    Type: Application
    Filed: March 29, 2017
    Publication date: March 28, 2019
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Mika SHISHIDO
  • METHOD FOR PRODUCING POLYETHYLENE GLYCOL HAVING TERMINAL CARBOXYL GROUP
    Publication number: 20190055353
    Abstract: A method for producing polyethylene glycol having a terminal carboxyl group including oxidizing polyethylene glycol represented by formula (I): CH3O(CH2CH2O)n(CH2)m—CHO with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from a carbonate, a phosphate, a citrate and an acetate at 5 to 40° C. to produce polyethylene glycol represented by formula (II): CH3O(CH2CH2O)n(CH2)m—COOH, wherein n is a number from 10 to 1,100, and m is 2 or 3.
    Type: Application
    Filed: November 17, 2016
    Publication date: February 21, 2019
    Applicant: NOF CORPORATION
    Inventors: Akiko DOI, Takashi ICHIKAWA, Tsuyoshi TAKEHANA, Takuma TSUBUSAKI
  • Oral composition for alleviation of dentin hypersensitivity
    Patent number: 10195131
    Abstract: An oral composition for reducing dentinal hypersensitivity according to the present invention comprises a phosphorylcholine-containing polymer as an active ingredient. A general consumer can use the oral composition routinely in various forms. The oral composition is brought into contact with an oral cavity of a user to reduce the dentinal hypersensitivity.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: February 5, 2019
    Assignee: NOF CORPORATION
    Inventors: Koji Miyamoto, Nobuyuki Yamamoto, Shunsuke Sakurai, Yoshihisa Shimamura
  • Mold-preventing air filter filtration medium and mold-preventing air filter
    Patent number: 10173159
    Abstract: A mold-preventing air filter filtration medium loaded with a water-retaining macromolecule polymer, a mold-preventing agent, and a binder resin, is formed by immersing a filter material or a reinforcing nonwoven fabric (a backing material) in a mold-preventing composition in which the water-retaining macromolecule polymer, the mold-preventing agent and the binder resin are dissolved, and drying the filter material or the reinforcing nonwoven fabric. The reinforcing nonwoven fabric (a backing material) may be bonded to a filter material to form a mold-preventing air filter filtration medium. A mold-preventing air filter includes the mold-preventing air filter filtration medium that is pleated and accommodated in a frame.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: January 8, 2019
    Assignees: Fine Tech Co., Ltd., NOF CORPORATION, DAIKIN INDUSTRIES, LTD.
    Inventors: Yukimitsu Ichikawa, Kanya Goto, Narumi Dosaka, Yumiko Fukushima, Yasuhito Fujimaki, Satoshi Yamada, Osamu Tanaka
  • LACRIMAL OILY LAYER STABILIZER AND EYE DROPS COMPRISING SAME
    Publication number: 20180360872
    Abstract: Provided is a tear lipid layer stabilizer that is capable of stabilizing a tear lipid layer and allowing the tear lipid layer to sufficiently spread over a corneal surface, to thereby prevent the evaporation of a tear aqueous layer on the corneal surface, and hence is suitable for amelioration, alleviation, or treatment of evaporative dry eye symptoms caused by Meibomian gland dysfunction, an ophthalmic solution having blended therein the tear lipid layer stabilizer, and a tear lipid layer-stabilizing method using the tear lipid layer stabilizer. The tear lipid layer stabilizer includes a copolymer that has a weight-average molecular weight of from 10,000 to 5,000,000, and contains 10 mol % to 90 mol % of a constituent unit (A) based on 2-(meth)acryloyloxyethyl phosphorylcholine and 90 mol % to 10 mol % of a constituent unit (B) based on an alkyl group-containing (meth)acrylic monomer.
    Type: Application
    Filed: December 21, 2016
    Publication date: December 20, 2018
    Applicant: NOF Corporation
    Inventors: Shunsuke SAKURAI, Koji MIYAMOTO, Yoshihisa SHIMAMURA, Nobuyuki YAMAMOTO
  • Metal soap and manufacturing method therefor
    Patent number: 10144695
    Abstract: A metal soap, including metal soap particles in which a fatty acid has from 6 to 22 carbons, and an inorganic crystal nucleating agent with an average particle size of 0.01 to 20 ?m absorbed internally into the metal soap particles, wherein the cumulative diameter at 50% of the metal soap particles on a volumetric basis is 1.0 to 30.0 ?m, and the internal absorption rate A, represented by formula (1) below, is 30% or greater. Internal absorption rate A=100?(X/X?)=100??Formula (1) X; amount of inorganic crystal nucleating agent contained within metal soap X?; amount of inorganic crystal nucleating agent contained within pulverized metal soap passed through a 325-mesh filter (wherein X and X? are average values obtained by elemental analysis at three locations in an area of 15 ?m square, using a scanning electron microscope/energy dispersive X-ray spectroscopy (SEM/EDX).
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: December 4, 2018
    Assignee: NOF CORPORATION
    Inventor: Takeshi Yoshimura
  • Ethylene vinyl acetate copolymer resin composition, graft copolymer, thermoplastic resin composition, and molded resin article
    Patent number: 10131778
    Abstract: An ethylene-vinyl acetate copolymer resin composition includes: an (A) ethylene-vinyl acetate copolymer; a (B) vinyl copolymer; and a (C) organic peroxide. The (B) vinyl copolymer and the (C) organic peroxide are impregnated in the (A) ethylene-vinyl acetate copolymer. The (A) ethylene-vinyl acetate copolymer includes 1 to 20 wt % of a vinyl acetate. The (B) vinyl copolymer is formed of a (b-1) styrene, (b-2) at least one of acrylonitrile and glycidyl methacrylate, a (b-3) t-butylperoxymethacryloyloxyethyl carbonate, and a (b-4) polymerization initiator. A content of the (C) organic peroxide is 0.1 to 3 parts by weight relative to 100 parts by weight of the (A) ethylene-vinyl acetate copolymer.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: November 20, 2018
    Assignee: NOF CORPORATION
    Inventors: Shingo Moriyasu, Tomohisa Tasaka, Kazuaki Mima
  • LIPID DERIVATIVE IN WHICH HYDROPHILIC POLYMER IS BOUND THROUGH CYCLIC BENZYLIDENE ACETAL LINKER
    Publication number: 20180312633
    Abstract: A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker, and which can accurately control a hydrolysis rate in the weakly acidic environment of a living body to detach the hydrophilic polymer from a lipid membrane structure. The lipid derivative is represented by formula (1): wherein, R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; R7 is a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; and Z1 and Z2 are each independently a selected divalent spacer.
    Type: Application
    Filed: September 29, 2016
    Publication date: November 1, 2018
    Applicant: NOF CORPORATION
    Inventors: Masaki OTA, Takuma TSUBUSAKI, Yuji YAMAMOTO
  • DRUG SUSTAINED-RELEASING MEDICAL CONTACT LENS
    Publication number: 20180314077
    Abstract: Provided is a drug sustained-releasing medical contact lens in which a component that is water-insoluble and has pharmacological activity is retained to impart drug sustained-releasability, and which is excellent in oxygen permeability. It has been found that a drug sustained-releasing medical contact lens containing a specific amount of each of a silicone-based polymer having a specific structure and a drug having a specific solubility can achieve the above-mentioned contact lens.
    Type: Application
    Filed: October 28, 2016
    Publication date: November 1, 2018
    Applicant: NOF CORPORATION
    Inventors: Shunsuke Sakurai, Kei Sato, Masatomo Takahashi, Mitsuyasu Nakashima, Yosuke Matsuoka, Yoshihisa Shimamura, Koji Miyamoto, Nobuyuki Yamamoto
  • BRANCHED HETERO POLYETHYLENE GLYCOL AND INTERMEDIATE
    Publication number: 20180312466
    Abstract: A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20?n?2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.
    Type: Application
    Filed: June 29, 2018
    Publication date: November 1, 2018
    Applicant: NOF CORPORATION
    Inventors: Yuji YAMAMOTO, Hiroki YOSHIOKA, Fumiaki MANABE
  • HYDROPHILIC POLYMER DERIVATIVE HAVING BENZYLIDENE ACETAL LINKER
    Publication number: 20180298143
    Abstract: A hydrophilic polymer derivative having a benzylidene acetal linker whose hydrolysis rate at the pH of a weakly acidic environment in the living body can be accurately controlled. A hydrophilic polymer derivative having a benzylidene acetal linker, which is represented by the following formula (1): wherein R1 is a hydrogen atom or a hydrocarbon group; R2, R3, R4, R5, and R6 are each independently a hydrogen atom or a substituent and at least one of R3, R4, and R5 is an electron-withdrawing substituent or at least one of R2 and R6 represents a substituent; X1 is a chemically reactive functional group; P is a hydrophilic polymer; w is an integer of 1 to 8; and Z1 and Z2 are an independently selected divalent spacer.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 18, 2018
    Applicant: NOF CORPORATION
    Inventors: Takuma TSUBUSAKI, Yuji YAMAMOTO
  • Cationic lipid for nucleic acid delivery
    Patent number: 10092655
    Abstract: The invention provides a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. The cationic lipid is represented by the formula (1): wherein each symbol is as defined herein.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: October 9, 2018
    Assignees: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Shota Sasaki, Masaki Ota, Kazuhiro Kubo, Hideyoshi Harashima, Hidetaka Akita, Hiroto Hatakeyama, Yuki Noguchi, Kota Tange, Yuta Nakai, Nayuta Shimizu