Abstract: Disclosed are methods of identifying compounds that suppress the growth of target cells. In certain embodiments, the methods comprise providing a panel of target cells and the panel of target cells comprises a plurality of populations of target cells. Each population comprises cells that are resistant to one or more compounds known to suppress the growth of cells sensitive to the one or more compounds. Each population of target cells grows in the presence of a candidate compound and a determination of whether the candidate compound suppresses the growth of one or more populations of target cells.

Abstract: Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also disclosed. Methods of targeted delivery to an antigen-presenting cell, and methods of treating or preventing a disease or condition susceptible to treatment by immunomodulation are disclosed.

Abstract: A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject.

Abstract: A resonator including a piezoelectric plate and an interdigital electrode is provided. A ratio between a thickness of the plate and a pitch of the interdigital electrode may be from about 0.5 to about 1.5. A radiation detector including a resonator and an absorber layer capable of absorbing at least one of infrared and terahertz radiation is provided. A resonator including a piezoelectric plate and a two-dimensional electrically conductive material is provided.

Abstract: Disclosed herein is a process and system to correct reflective distortions of an optical spectrum. In addition, a spectroscopy system that compensates for reflective distortions is disclosed.

Abstract: Provided is a co-polymer of formula A-L-D, or a pharmaceutically acceptable salt thereof, wherein A is a linear, branched or dendritic polyamine; D is a lipid; and L is a linker comprising a water soluble polymer; wherein L is connected to A at a first end through a first covalent bond and connected to D at a second end through a second covalent bond.

Abstract: A resonator includes a piezoelectric plate and interdigitated electrode(s). The interdigitated electrode includes a plurality of conductive strips disposed over a top surface of the piezoelectric plate. A two-dimensional mode of mechanical vibration is excited in a cross sectional plane of the piezoelectric plate in response to an alternating voltage applied through the interdigitated electrode. The two-dimensional mode of mechanical vibration is a cross-sectional Lamé mode resonance (CLMR) or a degenerate cross-sectional Lamé mode resonance (dCLMR).

Abstract: Disclosed herein are hydrogel compositions and methods of making hydrogel compositions. Furthermore, methods of specifically capturing and releasing biological materials from a sample using the disclosed hydrogel compositions are disclosed, including methods of utilizing the compositions in microfluidic devices.

Abstract: Devices and methods for directing a magnetic field into a body party of a subject are provided. The devices include at least one electromagnetic coil, a magnetic core or yoke, and a pair of flux concentrators. The flux concentrators are separated by a gap into which the body part fits and through which the flux concentrators focus the magnetic field. The devices allow magnetic fields to be transmitted through the gap with higher intensity at greater distances from the device than possible with previous designs. The methods of using such devices allow the delivery of magnetic fields with higher intensity to the interior of a body part without exposing interposed proximal regions to magnetic fields of unduly high intensity. The devices and methods are useful for deep transcranial magnetic stimulation of the brain to treat various medical conditions.

Abstract: The present technology relates to compounds and compositions of Formulas I, II, VII, and VIII, and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of addiction, metabolic syndrome, obesity, and/or a CB1 receptor-mediated disorder.

Abstract: A coexistence scheme enables spectrally-efficient and fair spectrum sharing between a first wireless network and a coexisting wireless network in the same frequency bands. The spectrum sharing problem is modeled as a fairness constrained mixed integer nonlinear optimization problem, by jointly determining dynamic channel selection, carrier aggregation and fractional spectrum access for the first wireless networks, while guaranteeing fair spectrum access for the coexisting wireless network based on a cross-technology fairness criterion. An algorithm based on a combination of branch and bound and successive convex relation techniques is provided to optimally solve the problem, i.e., maximize the utility of the first wireless network with guaranteed optimality precision that can be set arbitrarily at the expense of computational complexity.

Abstract: A non-contact testing system and method using acoustic sensors and a mobile sensing system using this system and method is disclosed. The leaky surface wave is recorded with directional microphones. A fast inversion analysis algorithm is introduced to estimate the shear velocity profile and elastic modulus for the subsurface layers of pavement structures, using the dispersion curves obtained from the acoustic signals. An electrical hammer is used to produce impact impulses automatically. A mobile sensing system is integrated on a mobile cart to perform the mobile subsurface sensing for pavement structures.

Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.

Abstract: The invention provides a compact, high-frequency, transmit and receive millimeter-wave radar sensor device, system, and method of use. The sensor can operate at a variety of distances, speeds, and resolutions depending on the hardware components selected in a given implementation. The hardware and software architecture is generic and can be tailored to required applications.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

Abstract: Mechanically flexible and optically transparent thin film solid state supercapacitors are fabricated by assembling nano-engineered carbon electrodes in porous templates. The electrodes have textured graphitic surface films with a morphology of interconnected arrays of complex shapes and porosity. The graphitic films act as both electrode and current collector, and when integrated with solid polymer electrolyte function as thin film supercapacitors. The nanostructured electrode morphology and conformal electrolyte packaging provide enough energy and power density for electronic devices in addition to possessing excellent mechanical flexibility and optical transparency.

Abstract: An instrumentation amplifier that includes input capacitance cancellation is provided. The architecture includes programmable capacitors between the input stage and a current feedback loop of the instrumentation amplifier to cancel input capacitances from electrode cables and a printed circuit board at the front end. An on-chip calibration unit can be employed to calibrate the programmable capacitors and improve the input impedance.

Abstract: Methods and devices for tissue remodeling and repair of collagenous tissues, including tendons, ligaments, and bone, as well as scalable connective tissue manufacturing, are provided. Collagen fibers are assembled by extensional strain-induced flow crystallization of collagen monomers. Extensional strain also drives the fusion of already formed short collagen fibrils to produce long-range, continuous fibers. Wearable devices for controlled tissue remodeling and wound healing deliver a tissue remodeling solution to a tissue repair site. The remodeling solution, together with appropriate application of strain to the tissue remodeling site, accelerate healing, prevent injury, and reduce scar formation.

Abstract: A simple, economical method of producing nanowire arrays is described. The method produces high density arrays having nanowires with diameters below 10 nm and does not require templating, catalysts, or surface pre/post-treatment. The disclosed methods and systems can be used, for example, for optoelectronic devices and photovoltaic cells, Li-ion batteries, chemical/bio sensors and transistors.

Abstract: The present invention relates to an intelligent adaptive system and method for monitoring leakage of oil pipeline networks based on big data. The present invention effectively analyzes a large amount of data collected on site within a reasonable time period and obtains a state of a pipeline network by an intelligent adaptive method, thereby obtaining a topological structure of a pipeline network. The present invention specifically adopts a flow balance method in combination with information conformance theory to analyze whether the pipeline network has leakage; small amount of leakage and slow leakage can be perfectly and accurately alarmed upon detection; as a generalized regression neural network is adopted to locate a leakage of the pipeline network, an accuracy of a result is increased. Therefore, the present invention adopts a policy and intelligent adaptive method based on big data to solve problems of detecting and locating leakage of the pipeline network.