Abstract: An apparatus and method for producing a composite part, such as a reinforced composite part, are provided that enable control over the fiber or other particle orientation within each layer of the part during manufacture. The apparatus and method employ a print head including a dispensing tip and a magnetic assembly controllable to apply a magnetic field at a print location adjacent the dispensing tip outlet.

Abstract: The present technology relates to novel cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools and/or biomarkers. The novel cannabinergic nitrate ester compounds provide medicaments useful in treating a variety of diseases and medical disorders.

Abstract: The invention provides an electric grid state estimation system and method based on a boundary fusion. The system includes an electric grid data acquisition module, a communication module including a local data unit and a state estimation unit, and a data fusion module, wherein the state estimation unit includes a memory storing a state estimation program and a display displaying a program running and outputting a state variable; the state estimation program is performed to realize an electric grid state estimation; the estimation method includes the following steps of dividing a regional electric grid, then establishing a measurement equation for each region, solving an internal quantity and a boundary quantity, fusing the boundary quantities of two regions, correcting the boundary quantity, performing a non-linear transformation on the intermediate variable, solving the estimated values of the state variable by the least square method, and performing outputting.

Abstract: A microfluidic device provides high throughput generation and analysis of defined three-dimensional cell spheroids with controlled geometry, size, and cell composition. The cell spheroids of the invention mimic tumor microenvironments, including pathophysiological gradients, cell composition, and heterogeneity of the tumor mass mimicking the resistance to drug penetration providing more realistic drug response. The device is used to test the effects of antitumor agents.

Abstract: Disclosed are multilayered aerogel nanocomposite materials, and methods of making and using them.

Abstract: An apparatus and a method are provided for selectively and rapidly applying heat to a nanoscale environment in a controlled manner. The technology utilizes laser irradiation of a solid state material to heat a nanoscale point of interest by an optothermal effect. The technology can be used to the tip of an atomic force microscope, a spot on a flat surface, or a nanopore, or molecules in their vicinity. The apparatus and method are capable of rapidly scanning the temperature of a nanoscale object such as a molecule or biomolecular complex and to interrogate properties of the object at high throughput. The methods can be used in nanofabrication processes or to drive single molecule chemistry.

Abstract: A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an electric field generated by electromagnetic activity of the brain. The system provides a medical body area network of a subject including one or more of the sensor assemblies and one or more additional sensors, which may be within a smartphone or other wearable device.

Abstract: The present invention provides a multi-unit rotary system and method for storage, intelligent sorting and picking of express parcels. Through adoption of layered design of a rotary storage unit, different sizes of parcels are stored in a sorting manner, thereby effectively increasing the utilization rate of the storage space; besides, due to the storage design of the subunits, arrangement of storage units of the system is more flexible, and the number of rotary storage unit subunits can be set freely according to the requirements for site space and the storage capacity for express parcels; through adoption of overall unit combination design of the present invention, the mounting, the layout and the maintenance of the system are more convenient, and during the operation of the system, automatic sorting and storage of the express parcels are achieved.

Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

Abstract: Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM.

Abstract: Provided is a highly multiplex approach to disease condition diagnostics that combines nanopore sensing and nucleic acid nanoparticle (NANP) design and synthesis to detect multiple biomarkers to diagnose diseases. The system works by taking a sample containing biomarkers that is mixed with a plurality of nucleic acid nanoparticle (NANP) populations, with each population designed and synthesized to be able to detect a particular biomarker. Upon incubation, the mixture is used with nanopore measurements, with recordings of the ionic current through the nanopore. The ionic current recordings are analyzed, which determines the presence and/or concentration of biomarkers in the sample.

Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.

Abstract: Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.

Abstract: Described are devices, systems and techniques for implementing atomic memory objects in a multi-writer, multi-reader setting. In an embodiment, the devices, systems and techniques use maximum distance separable (MDS) codes, and may be specifically designed to optimize a total storage cost for a given fault-tolerance requirement. Also described is an embodiment to handle the case where some of the servers can return erroneous coded elements during a read operation.

Abstract: The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.

Abstract: A high-power microwave borehole fracturing device for an engineering rock mass includes a high-power microwave generator, a high-power microwave coaxial heater, a high-power low-loss microwave coaxial transmission line, and a microwave power adaptive regulation and control system. The high-power microwave generator includes a continuous wave magnetron, a permanent magnet, a waveguide excitation chamber, a coaxial circulator, a coaxial matching load, a coaxial coupling converter, a waveguide coaxial converter, and an output waveguide. The high-power microwave coaxial heater includes a microwave transmission inner conductor, a microwave transmission outer conductor, a microwave input connector, a microwave short circuit cap, and a conductor supporting cylinder. The high-power low-loss microwave coaxial transmission line includes an input end coaxial line, middle section coaxial lines, and an output end coaxial line.

Abstract: A system and method is provided for transmitting signals ultrasonically among a network of implantable and wearable biological devices. The devices includes one or more implantable nodes, which include a sensing and/or actuating unit, at least one gateway node, and at least one access point node. Ultrasonic signals can be transmitted through the body by the implantable nodes to and from the gateway node, for transmission to and from the access point node. The access point node can be connected to the Internet. In this manner, remote instructions can be transmitted to the implantable nodes and data obtained at the implantable nodes can be transmitted to remote sites.

Abstract: A simplified and efficient method for preparing non-noble metal catalysts for oxygen reduction reaction (ORR) based on nitrogen containing metal organic framework (MOF) is provided. The method includes formation of a first MOF product through a mechano-chemical reaction between a first transition metal compound and a first organic ligand in the presence of a catalyst. It further includes formation of a second MOF product incorporating a second transition metal and a second organic ligand into the first-MOF product. The second MOF product is converted into an electrocatalyst via pyrolysis, and optionally post-treatment. The electrocatalysts are applicable in various electrochemical systems, including oxygen depolarized cathodes (ODC) for chlorine evolution.

Abstract: A universal power converter of the present application may include a link stage between an input stage and an output stage that operates at a higher frequency than the frequency of the input power source. As a result, a more compact capacitor may be used, thus reducing the size of the power converter. In some embodiments, the link stage may be a partially resonant link that permits zero current switching (ZCS). ZCS operation may reduce switching losses during operation. Universal power converters of the present application utilizing ZCS may be implemented using naturally commutated switches, such as silicon controlled rectifiers (SCRs), instead of transistor switches. Such power converters utilizing SCRs may be more reliable than power converters utilizing transistor switches. Additionally, control circuitry required to operate such power converters may be simplified. Accordingly, a more compact, efficient, and reliable universal power converter may be achieved.

Abstract: Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.