Abstract: Highly anion resistant electrocatalysts suitable for catalyzing an oxygen reduction reaction (ORR) and methods of synthesizing the same are provided. The catalysts contain a transition metal, a heteroatom, and carbon. Preferred catalysts include N as the heteroatom and Fe as the transition metal, with active sites having Fe—N4 stoichiometry (FexNyCz) as part of a metal organic framework (MOF) or sequestered within a MOF. Electrocatalysts further including Fe nanoparticles (FeNPs) are also provided. The catalysts described herein are applicable in the preparation of oxygen decoupled cathodes (ODC) for chlorine evolution processes such as in chlor-alkali cells or HCl electrolyzers. The catalysts are also useful in preparing ODC for use in fuel cells, including phosphoric acid fuel cells.
Type:
Grant
Filed:
January 7, 2014
Date of Patent:
September 17, 2019
Assignee:
Northeastern University
Inventors:
Urszula Tylus, Sanjeev Mukerjee, Elise Miner, Kara Strickland
Abstract: A system and method for transmitting data ultrasonically through biological tissue employs a network of a plurality of nodes, at least a portion of the nodes implantable within the biological tissue. At least one implanted node includes a transmitter having an orthogonal frequency division multiplex signal generator to encode an ultrasonic signal for transmission through the biological tissue to an ultrasonic receiver at another node.
Type:
Grant
Filed:
June 14, 2017
Date of Patent:
August 27, 2019
Assignee:
Northeastern University
Inventors:
Tommaso Melodia, Giuseppe Enrico Santagati
Abstract: Compounds useful for molecular imaging of cells expressing estrogen receptors are provided. Also provided are intermediates for making the compounds and methods of making the compounds using a modular convergent strategy. Further, methods of making the intermediates are described, as well as methods of diagnosing disease in a subject by using the compounds as imaging agents.
Abstract: Systems, methods and components of a joint actuating gait training system are provided. The gait training system includes a base support frame and an upper flexion actuation assembly movably coupled to the base support frame and a lower flexion actuation assembly movably coupled to the base support frame.
Type:
Grant
Filed:
July 29, 2014
Date of Patent:
August 20, 2019
Assignee:
Northeastern University
Inventors:
Patrick Murphy, Michelle Cleary, Shawn Gelsinger, Melanie Jessel, Steven McKanas, Robert Struble, Maciej Pietrusinski, Sheng-Che Yen, Qingchao Kong, Constantinos Mavroidis
Abstract: Ultrasensitive, miniaturized, and inexpensive ion and ionizing radiation detection devices are provided. The devices include an insulating substrate, metallic contact pads disposed on a surface of the substrate, and a strip of an ultrathin two-dimensional material having a thickness of one or a few atomic layers. The strip is in contact with the contact pads, and a voltage is applied across the two-dimensional sensor material. Individual ions contacting the two-dimensional material alter the current flowing through the material and are detected. The devices can be used in a network of monitors for high energy ions and ionizing radiation.
Type:
Application
Filed:
September 11, 2017
Publication date:
August 8, 2019
Applicant:
Northeastern University
Inventors:
Ji HAO, Swastik KAR, Yung Joon JUNG, Daniel RUBIN
Abstract: A method and system for providing a recovery sequence for a network from a state of disruption to a state of partial or complete functionality are provided. The method and system can measure the response of a network to one or multiple hazards and can generate and compare the effectiveness of multiple recovery strategies in a quantitative and generalizable manner, providing a user with practical tools to implement an efficient restoration of the network.
Type:
Grant
Filed:
April 21, 2016
Date of Patent:
July 23, 2019
Assignee:
Northeastern University
Inventors:
Udit Bhatia, Devashish Kumar, Evan Kodra, Auroop R. Ganguly
Abstract: A fault diagnosis method for an electrical fused magnesia furnace includes steps of: 1) arranging six cameras; 2) obtaining video information by the six cameras and sending the video information to a control center; then analyzing the video information by a chip of the control center; wherein a multi-view-based fault diagnosis method is used by the chip, comprising steps of: 2-1) comparing a difference between two consecutive frame histograms for shots segmentation; 2-2) computing a set of characteristic values for each shot obtained by the step 2-1), and then computing color, texture, and motion vector information; finally, evaluating shot importance via entropy; 2-3) clustering shots together by calculating similarity; 2-4) generating and optimizing a multi-view video summarization with a multi-objective optimization model; and 2-5) providing fault detection and diagnosis; and 3) displaying results of the fault detection and diagnosis on a host computer inter face of the control center.
Abstract: A system and method are provided to detect, analyze and digitally remove makeup from an image of a face. An autoencoder-based framework is provided to extract attractiveness-aware features to perform an assessment of facial beauty.
Abstract: A method for assembling colloidal particles onto a substrate surface through fluid transport. The method comprises placing a first fluid placed adjacent to the substrate surface, applying a colloidal dispersion on top of the first fluid layer and removal of the first fluid layer. The method is extremely versatile, and is especially useful in depositing colloidal materials in high aspect ratio channels and vias without the need for prior treatment of the surface.
Type:
Grant
Filed:
June 7, 2011
Date of Patent:
June 25, 2019
Assignee:
Northeastern University
Inventors:
Nam-Goo Cha, Yolanda Echegoyen, Ahmed Busnaina, Taehoon Kim
Abstract: The invention provides rare earth-free permanent magnetic materials and methods of making them. The materials can be used to produce magnetic structures for use in a wide variety of commercial applications, such as motors, generators, and other electromechanical and electronic devices. Magnets fabricated using the materials can be substituted for magnets requiring rare earth elements that are costly and in limited supply. The invention provides two different types of magnetic materials. The first type is based on an iron-nickel alloy that is doped with one or more doping elements to promote the formation of L10 crystal structure. The second type is a nanocomposite particle containing magnetically hard and soft phases that interact to form an exchange spring magnetic material. The hard phase contains Fe or FeCo, and the soft phase contains AlMnC.
Type:
Grant
Filed:
July 16, 2012
Date of Patent:
June 25, 2019
Assignees:
Northeastern University, Carnegie Mellon University
Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
Type:
Application
Filed:
December 19, 2018
Publication date:
June 20, 2019
Applicants:
TargaGenix, Inc., The Research Foundation for The State University of New York, Northeastern University
Inventors:
James E. Egan, Mansoor Amiji, Iwao Ojima
Abstract: A device for controlling apical flow to a cell culture includes an apical insert that defines at least one inlet channel extending from an inlet port to an apical feed port and at least one outlet channel extending from an apical effluent port to an outlet port. The apical insert includes a projecting portion configured to extend into a cell culture insert to a depth that is less than a depth of the cell culture insert, and a contact surface configured to maintain a spatial relationship between the projecting portion and the cell culture insert.
Type:
Grant
Filed:
January 5, 2017
Date of Patent:
June 18, 2019
Assignees:
Northeastern University, Massachusetts Institute of Technology
Inventors:
Transon V. Nguyen, Collin D. J. Edington, Emily C. Suter, Rebecca Lyn Carrier, David L. Trumper, Linda G. Griffith
Abstract: Methods and devices for monitoring the viability of a biofilm comprising Pseudomonas Aeruginosa bacteria are provided by detecting pyocyanin. The invention relates to electrochemical methods and devices that offer a simple and inexpensive alternative for immediate identification of bacterial infection due to the presence of Pseudomonas aeruginosa. In some embodiments, an inexpensive, disposable electrochemical sensor can be used to rapidly screen for the presence of P. aeruginosa in clinical wound effluent samples.
Type:
Grant
Filed:
September 16, 2015
Date of Patent:
June 11, 2019
Assignee:
Northeastern University
Inventors:
Edgar D. Goluch, Hunter J. Sismaet, Thaddaeus A. Webster
Abstract: Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
Type:
Grant
Filed:
July 27, 2011
Date of Patent:
June 11, 2019
Assignees:
Trustees of Boston University, Northeastern University, Boston Medical Center Corporation
Inventors:
David H. Sherr, Michael Pollastri, Jennifer Schlezinger, Sarah Haigh Molina, Scott Schaus, Joshua Robert Giguere
Abstract: In some aspects, the disclosure is directed methods and systems for screening an unconstrained subject. A plurality of transmitters may be spatially distributed on two sides along a path of movement of a subject. Each of the transmitters may transmit, in sequence, radiation to be scattered from the subject. A plurality of sensors may be spatially distributed on the two sides and coherently configured with respect to the plurality of transmitters. The plurality of sensors may collect measurements of scattered radiation corresponding to the radiation transmitted by each of the plurality of transmitters. An imaging module may generate, based on the collected measurements, a two-dimensional or three-dimensional reconstruction estimate of body surface of the subject with one or more attached foreign objects.
Type:
Grant
Filed:
December 5, 2014
Date of Patent:
May 21, 2019
Assignee:
Northeastern University
Inventors:
Borja Gonzalez Valdes, Carey Rappaport, Jose Martinez
Abstract: An ultrasonic communication system and method provide a networking framework for wearable devices based on ultrasonic communications. The ultrasonic communication system and method incorporate a set of physical, data link, network and application layer functionalities that can flexibly adapt to application and system requirements to efficiently distribute information between ultrasonic wearable devices.
Type:
Grant
Filed:
January 26, 2016
Date of Patent:
April 30, 2019
Assignee:
Northeastern University
Inventors:
Tommaso Melodia, Giuseppe Enrico Santagati
Abstract: Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
Type:
Grant
Filed:
March 3, 2016
Date of Patent:
April 16, 2019
Assignees:
Trustees of Boston University, Boston Medical Center, Northeastern University
Inventors:
David H. Sherr, Michael Pollastri, Jennifer Schlezinger, Sarah Haigh Molina, Scott Schaus, Joshua Robert Giguere
Abstract: Power conversion devices with control algorithms that can solve the double frequency harmonic problem are provided, as are techniques for controlling power converters when the instantaneous values of input and output power are not the same.
Abstract: A balanced planetary gearbox including an assembly having an input stage and an output stage. The assembly includes two grounds, each with ground rollers and ground rings. The two grounds are fixedly attached to one another. The assembly includes a sun gear and planet sub-assemblies between the two grounds. The planet sub-assemblies include at least one input planet gear and one output planet gear. The sun gear and the input planet gears include rollers. An abutment of rollers in the gearbox keeps the sun gear and the planet gears in alignment. The output gear meshes with an output ring disposed in between the two ground rings, such that a combination of the at least one input planet gears from each of the plurality of planet sub-assemblies provides a structural symmetry to the planetary gearbox.
Type:
Grant
Filed:
June 8, 2015
Date of Patent:
April 2, 2019
Assignee:
Northeastern University
Inventors:
Elias Brassitos, Brian Weinberg, Qingchao Kong, Constantinos Mavroidis
Abstract: The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
Type:
Grant
Filed:
January 26, 2017
Date of Patent:
April 2, 2019
Assignee:
Northeastern University
Inventors:
Ganeshsingh A. Thakur, Pushkar M. Kulkarni