Patents Assigned to Northwestern University
  • Patent number: 11367474
    Abstract: A new type of two-terminal magnetic memory device, referred to as antiferromagnetic voltage-controlled memory (AVM) device is disclosed. Antiferromagnetic (AFM) materials have zero magnetization, which makes it immune to external magnetic fields and opens to the possibility to implement high-density arrays without dipole coupling between adjacent devices. The AVM device combines a new state variable e.g., Néel vector l in a metallic (or non-metallic) AFM material with an electric-field-induced switching mechanism for writing of information. Utilizing electric fields E via an interfacial voltage-controlled magnetic anisotropy (VCMA) effect is a more efficient writing mechanism. The AVM device implements an antiferromagnetic tunnel junction (AFM-TJ) structure to exhibit high or low resistance states (HR, LR) corresponding to binary logic states of zero (0) or one (1). Both the AVM device structure and methods of writing a signal to the AVM device are disclosed.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: June 21, 2022
    Assignee: NORTHWESTERN UNIVERSITY
    Inventor: Pedram Khalili Amiri
  • Patent number: 11367874
    Abstract: Provided is a Li+battery comprising an anode comprising an anode active material comprising a plurality of transition metal (TM1)-substituted binary transition metal (TM2) oxide nanocrystals, a cathode in electrical communication with the anode, a separator between the anode and the cathode, and an electrolyte in contact with the anode and the cathode. The anode active material, in a lithiated state, is characterized by a three-dimensional network of the TM1 and nanoparticles of Li2O and nanoparticles of the TM2, both types of nanoparticles distributed throughout the network. In a delithiated state, the anode active material is characterized by the network of the TM1 and nanoparticles of an oxide of the TM1 and nanoparticles of an oxide of the TM2, both types of nanoparticles distributed throughout the network. The TM1-substituted binary TM2 oxide may be characterized by a ratio of TM2/TM1 of at least about 5.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: June 21, 2022
    Assignee: Northwestern University
    Inventors: Jinsong Wu, Vinayak P. Dravid
  • Patent number: 11364304
    Abstract: Methods of preparing crosslinked spherical nucleic acids (SNAs) using thermoresponsive traceless templates, such as PEO-PPO-PEO block copolymers. The crosslinks can be added between oligonucleotides within the same SNA or oligonucleotides between multiple different SNAs.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: June 21, 2022
    Assignee: Northwestern University
    Inventors: Chad A. Mirkin, SonBinh T. Nguyen, Resham J. Banga
  • Patent number: 11359039
    Abstract: A method for forming polar-functionalized polyolefins may comprise contacting an unsubstituted ?-olefin monomer and an amino-olefin monomer of formula H2C?CH(CH2)n(CHR)mNR?2, wherein R is H or an unsubstituted linear or branched alkyl group having from 1 to 10 carbons, each R? is an independently selected unsubstituted linear or branched alkyl group having from 1 to 10 carbons, m is an integer from 1 to 11, and n is an integer from 1 to 11, in the presence of a rare earth catalyst and a cocatalyst under conditions to induce a heteropolymerization reaction between the unsubstituted oc-olefin and amino-olefin monomers to provide a polar-functionalized poly olefin.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: June 14, 2022
    Assignee: Northwestern University
    Inventors: Tobin J. Marks, Jiazhen Chen, Tracy L. Lohr
  • Publication number: 20220168591
    Abstract: Disclosed is a cochlear implant (Cl) and a method of generating stimulations for the CI. The Cl may include, at least one optical signal generator configured to generate a plurality of optical signals having a wavelength of at most 1600 nm, and a plurality of light emitters, for delivering the optical signals to different locations along a cochlear nerve. The method may further include optimizing the stimulation energy through selection of stimulation wavelengths and stimulation pulse shapes.
    Type: Application
    Filed: February 6, 2020
    Publication date: June 2, 2022
    Applicants: Nurotone Medical Ltd., NORTHWESTERN UNIVERSITY
    Inventors: Dan David ALBECK, Claus Peter RICHTER, Yingyue XU, Xiaodong TAN, Natan DAVIDOVICS
  • Patent number: 11344569
    Abstract: The invention relates to compositions and methods of treating a sleep-wake disorder or neurodegenerative diseases using modified resistant maltodextrin.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: May 31, 2022
    Assignee: Northwestern University
    Inventors: Kazuhiro Shimomura, Martha Hotz Vitaterna, Phyllis C. Zee
  • Patent number: 11338348
    Abstract: Flanges formed on sheet metal parts to increase the part stiffness or create mating surface for further assembly are created in an incremental sheet forming process using forming tool and supporting tool that move along a specified tool path so as to gradually deform a peripherally-clamped sheet metal work piece into the desired geometry. With two universal tools moving along the designed toolpath on the both sides of the part, the process is very flexible. Process time is can also be reduced by utilizing an accumulative double-sided incremental hole-flanging strategy, in which the flange is formed in only one step.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: May 24, 2022
    Assignees: NORTHWESTERN UNIVERSITY, SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Huan Zhang, Jian Cao, Kornel Ehmann, Jun Chen
  • Patent number: 11339378
    Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: May 24, 2022
    Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College
    Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
  • Patent number: 11340057
    Abstract: A system to generate image representations includes a first objective that receives a first light beam emitted from a sample and a second objective that receives a second light beam emitted from the sample, where the first light beam and the second light beam have conjugate phase. The system also includes a first diffractive element to receive the first light beam and separate it into a first plurality of diffractive light beams that are spatially distinct, and a second diffractive element to receive the second light beam and separate it into a second plurality of diffractive light beams that are spatially distinct. The system further includes a detector that receives the first and second plurality of diffractive light beams. The first plurality of diffractive light beams and the second plurality of diffractive light beams are simultaneously directed and focused onto different portions of an image plane of the detector.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: May 24, 2022
    Assignees: Northwestern University, UChicago Argonne, LLC, The University of Chicago
    Inventors: Kuan He, Oliver Strider Cossairt, Aggelos K. Katsaggelos, Norbert Scherer, Mark Hereld
  • Patent number: 11337808
    Abstract: An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 24, 2022
    Assignee: Northwestern University
    Inventor: Patrick M. McCarthy
  • Patent number: 11340585
    Abstract: A method for creating metadevices includes receiving, at a computing device, one or more boundary conditions for a metadevice. The method also includes processing, with an inverse-design algorithm stored in a memory of the computing device, the one or more boundary conditions to generate a metadevice structure design that satisfies the one or more boundary conditions. The method also includes converting, by a processor of the computing device, the metadevice structure design into a file that is compatible with an additive manufacturing device. The method further includes providing the file of the metadevice structure design to the additive manufacturing device.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: May 24, 2022
    Assignee: Northwestern University
    Inventors: Koray Aydin, Francois Callewaert, Alan Varteres Sahakian
  • Publication number: 20220151928
    Abstract: Disclosed herein are spherical high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core). Also disclosed herein are methods for synthesizing the spherical HDL-NPs. Also disclosed herein are methods for treating disorders such as cardiovascular disease, cancer, inflammatory disorders or reducing NF-kB activity with the spherical HDL-NPs.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 19, 2022
    Applicant: Northwestern University
    Inventors: Stephen E. Henrich, C. Shad Thaxton, Sonbinh T. Nguyen, Bong Jin Hong
  • Publication number: 20220153589
    Abstract: In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density.
    Type: Application
    Filed: November 19, 2021
    Publication date: May 19, 2022
    Applicants: The Regents of the University of California, Northwestern University
    Inventors: Andre E. Nel, Tian Xia, Ruibin Li, Mark C. Hersam, Nikhita D. Mansukhani, Linda Guiney
  • Patent number: 11336883
    Abstract: A three-dimensional (3D) imaging system includes a mobile device that has a display screen configured to display a series of patterns onto an object that is to be imaged. The mobile device also includes a front-facing camera configured to capture reflections of the series of patterns off of the object. The system also includes a controller that is configured to control a timing of the series of patterns that appear on the display screen and activation of the front-facing camera in relation to the appearance of the series of patterns.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: May 17, 2022
    Assignee: Northwestern University
    Inventors: Florian Willomitzer, Oliver Strider Cossairt, Marc Walton, Chia-Kai Yeh, Vikas Gupta, William Spies, Florian Schiffers
  • Patent number: 11336823
    Abstract: A camera system includes a camera configured to capture first video of a scene in the form of first image frames. The camera system also includes an infrared sensor configured to capture second video of the scene in the form of second image frames. The system also includes a processor in communication with the camera and the infrared sensor. The processor is configured to obfuscate one or more portions of the scene.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 17, 2022
    Assignee: Northwestern University
    Inventors: Nabil I. Alshurafa, Josiah D. Hester
  • Publication number: 20220144899
    Abstract: The present disclosure relates generally to modified bacteria, such as E. coli, with modification in the expression of at least one gene encoding a type I and/or type II toxin-antitoxin (TA) system protein and/or at least one gene encoding a structural protein that modulates ribosomes and methods of using the disclosed bacteria for producing a biological compound of interest. The modifications of the bacteria result in enhanced bioproduction.
    Type: Application
    Filed: November 9, 2021
    Publication date: May 12, 2022
    Applicant: Northwestern University
    Inventors: William H. Bothfeld, Keith E.J. Tyo
  • Publication number: 20220144896
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Applicant: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • Patent number: 11328790
    Abstract: Provided herein are biomarkers of endogenous biological time (e.g. circadian time). In particular compositions and methods are provided for assessing the biological time of a subject, and diagnosis of diseases/conditions and/or providing treatments based thereon.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: May 10, 2022
    Assignee: Northwestern University
    Inventors: Rosemary Braun, Ravi Aliada, Phyllis Zee
  • Patent number: 11311485
    Abstract: The present invention provides for delivery of therapeutic drug in a polymeric delivery system comprising a PEG-bl-PPS di-block polymer formed in a micelle, filomicelle, or polymersome structure, wherein the structure effectively binds and/or interacts through shape-based targeting with a targeted cell type.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: April 26, 2022
    Assignees: University of Maryland, Baltimore County, University of Maryland, Baltimore, Northwestern University
    Inventors: Marilyn Allen, Evan Scott, Amit Golding, Gregory Szeto, Nicholas B. Karabin
  • Patent number: 11312958
    Abstract: Disclosed are components and methods for producing toxic RNAs and/or extracellular vesicles comprising the toxic RNAs in cells that are resistant to the toxic RNAs, which toxic RNAs may include toxic shRNA/siRNA and/or toxic pre-miRNA/miRNA. The disclosed components may include engineered cells that can be utilized to express the toxic RNAs, in which the engineered cells do not express one or more genes that are required for processing the toxic RNAs for RNA interference (RNAi) and/or one or more genes that are required for executing RNAi. The toxic RNAs and/or extracellular vesicles comprising the toxic RNAs may be utilized in methods for treating diseases and disorders through RNAi.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 26, 2022
    Assignee: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann