Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.

Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.” The disclosed toxic RNAi active seed sequences may be referred to as “dual activity super toxic RNAi active dsRNAs” that include a toxic first strand and a toxic second strand that is complementary to the toxic first strand. As such, the disclosed dsRNAs may be expressed as shRNAs which are processed for RNA interference (RNAi) and either of the toxic first strand and the toxic second strand can function as a guide strand to initiate RNAi.

Abstract: Methods of reducing microbial attachment to a surface are provided, including methods comprising illuminating a surface comprising a substrate and a coating on the substrate with ultraviolet light, wherein the coating comprises anatase titanium dioxide nanoparticles functionalized with silver nanoparticles and is optically transparent to visible light; and exposing the illuminated surface to microbes. The coating exhibits a reduction in microbial attachment as compared to the coating absent the illumination.

Abstract: The invention relates generally to compositions and methods for the detection of zinc. Provided herein is a class of zinc-responsive probes with tunable photophysical properties that can be modified for coupling to a solid support or other chemical moieties. In particular, modifications to the 5-position of the BODIPY core allows for alteration of probe properties and functionalities.

Abstract: Systems formed by a multi-bit three-transistor (3T) memory cell (i.e., dynamic-analog RAM) are provided. The 3T memory cell includes: a read-access transistor M1 in electrical communication with a read bitline; a switch transistor M2 in electrical communication with the read-access transistor M1; a write-access transistor M3 in electrical communication with the read-access transistor M1 and a write bitline; and a memory node MEM in electrical communication between the read-access transistor M1 and the write-access transistor M3, wherein the memory node MEM is configured to store a 4-bit weight WE. An array of the 3T memory cells (i.e., dynamic-analog RAMs) may form a computing-in-memory (CIM) macro, and further form a convolutional neural network (CNN) accelerator by communicating with an application-specific integrated circuit (ASIC) which communicates with a global weight static random access memory and an activation static random access memory.

Abstract: In one aspect of the invention, a dye sensitized solar cell has a counter-electrode including carbon-titania nanocomposite thin films made by forming a carbon-based ink; forming a titania (TiO2) solution; blade-coating a mechanical mixture of the carbon-based ink and the titania solution onto a substrate; and annealing the blade-coated substrate at a first temperature for a first period of time to obtain the carbon-based titania nanocomposite thin films. In certain embodiments, the carbon-based titania nanocomposite thin films may include solvent-exfoliated graphene titania (SEG-TiO2) nanocomposite thin films, or single walled carbon nanotube titania (SWCNT-TiO2) nanocomposite thin films.

Abstract: A method for creating metadevices includes receiving, at a computing device, one or more boundary conditions for a metadevice. The method also includes processing, with an inverse-design algorithm stored in a memory of the computing device, the one or more boundary conditions to generate a metadevice structure design that satisfies the one or more boundary conditions. The method also includes converting, by a processor of the computing device, the metadevice structure design into a file that is compatible with an additive manufacturing device. The method further includes providing the file of the metadevice structure design to the additive manufacturing device.

Abstract: Composite electrocatalytic materials for catalyzing water splitting are provided. Such materials may comprise a porous, conductive support composed of a transition metal foam, the support having a surface, and a coating on the surface of the support. The coating may comprise nanorods of a first transition metal chalcogenide, each nanorod anchored on one end to the surface of the support and extending perpendicularly away from the surface of the support to a free opposing end, nanosheets of a second transition metal chalcogenide, the nanosheets coating a surface of the nanorods of the first transition metal chalcogenide, and nanosheets of a third transition metal chalcogenide, the nanosheets also coating the surface of the nanorods of the first transition metal chalcogenide.

Abstract: A composite film usable as a separator of an electrochemical device includes hBN nanosheets and at least one polymer. The hBN nanosheets are uniformly dispersed within a matrix of said least one polymer to achieve a highly porous microstructure. Said at least one polymer comprises one or more electrically insulating and electrochemically inert polymers.

Abstract: A method for characterizing atrial fibrillation includes determining, by a processor of a computing device and based on heart data, an earliest activation time of a heart being monitored. The method also includes determining, by the processor and based on the heart data, a latest activation time of the heart. The method also includes modeling, by the processor, the earliest activation time and the latest activation time within one or more activation time maps. The method further includes identifying, by the processor, an atrial fibrillation driver based at least in part on the one or more activation time maps.

Abstract: Provided herein are systems comprising multiple fluidically-coupled chamber volumes. In particular, provided herein are cell culture systems that incorporate fluid flow between multiple cell culture volumes, and method of use thereof for the culture of multiple related cell/tissue types.

Abstract: Magnetic memory devices are provided. The devices comprise a first ferromagnetic layer, a second ferromagnetic layer, and a tunnel barrier layer composed of a doped semiconductor (instead of an insulator or a dielectric) between the first and second ferromagnetic layers and forming at least one ferromagnetic-doped semiconductor interface.

Abstract: A system for making a build using directed energy deposition is provided. The system includes a primary heat source; a processing nozzle movable relative to the build for delivering a metal powder, a carrier gas for the metal powder, and a shield gas to the build; a melt pool sensor for providing information regarding a temperature of a melt pool of the build; a secondary heat source separate from the primary heat source positionable relative to the build for delivering heat to a selected area of the build; a cooling source positionable relative to the build for delivering a cooling fluid to a selected area of the build; and a control system for operating the primary heat source, the secondary heat source and the cooling source to maintain a desired temperature profile for the build. The system preferably includes a temperature sensor for providing a temperature profile of the build.

Abstract: One aspect, this invention relates to a carbide-free bainite and retained austenite steel including a composition designed and processed such that the carbide-free bainite and retained austenite steel meets property objectives comprising a yield strength in a range of about 1000-2000 MPa, a uniform ductility, a desired total elongation and hole-expansion ratio, a desired level of weldability and an austenite stability designed to have an austenite start temperature Ms? to be equal to an application temperature in range from about 50° C. to ?50° C. The property objectives are design specifications of the carbide-free bainite and retained austenite steel.

Abstract: Prosthetic liner apparatus for improving suspension and rotation control between a residual limb and a socket of a prosthesis include a liner body having a shape configured to receive the residual limb and having an outer surface that fits within the socket. The liner body may have a plurality of raised elastomeric grips located on its outer surface and a proximal end of the outer surface of the liner body includes at least an exposed smooth elastomeric region that fits within and seals with the socket. Further disclosed is a prosthetic sock having raised elastomeric grips on its inner and outer surfaces which is for use with a liner body that is smooth or textured and that may or may not include raised elastomeric grips, and that when used together with the liner body ay form a liner apparatus.

Abstract: Disclosed are substituted pyrrolidones and piperidones which may be utilized as EZH2 targeting agents. The substituted pyrrolidones and piperidones may include substituted 2-pyrrolidones and 2-piperidones. The disclosed pyrrolidones and piperidones may be used in pharmaceutical compositions and methods for treating cell proliferative disorders such as cancer.

Abstract: Provided herein are methods of preventing or reducing the incidence of primary graft dysfunction in a subject.

Abstract: Anhydrous liquid-phase exfoliation of germanium sulfide to provide few-layer germanium sulfide, as can be incorporated into electronic devices such as but not limited to batteries and cells comprising such materials.

Abstract: A system for treating atrial fibrillation includes a memory configured to store a baseline measurement of an atrial fibrillation characteristic of a patient and a post administration measurement of the atrial fibrillation characteristic of the patient. The post administration measurement is obtained subsequent to administration of a reactive oxygens species (ROS) scavenger to the patient. The system also includes a processor operatively coupled to the memory and configured to determine a change between the baseline measurement and the post administration measurement of the atrial fibrillation characteristic. The processor is further configured to identify, based on the determined change, one or more hot spots of atrial fibrillation, where the one or more hot spots comprise target areas for treatment of the atrial fibrillation.

Abstract: Provided herein are rigid macrocycles comprising a poly(peri-naphthalene) diimide (PPNDI) submit and a second diimide subunit having both high photoluminescent and electron accumulation activities. Also provided herein are methods of preparation of the rigid macrocycles and methods of using the same.