Abstract: This invention discloses a series of low-cost, castable, weldable, brazeable and heat-treatable aluminum alloys based on modifications of aluminum-manganese-based alloys, which turn all the non-heat treatable Mn-containing aluminum alloys into heat treatable alloys with high-strength, ductility, thermal stability, and resistance to creep, coarsening and recrystallization. These alloys inherit the excellent corrosion resistance of the Al—Mn-based alloys and can be utilized in high temperature, high stress and a variety of other applications. The modifications are made through microalloying with one or any combinations of tin, indium, antimony and bismuth at an impurity level of less than 0.02 at. %, which creates nanoscale ?-Al(Mn,TM)Si precipitates with a cubic structure (wherein TM is one or more of transition metals, and Mn is the main element) in an Al(f.c.c.)-matrix with a mean radius of about 25 nm and a relatively high volume fraction of about 2%.

Abstract: An imaging system includes a first finite conjugate objective at a frontal end of the system and a second finite conjugate objective at a distal end of the system. The system also includes a beam splitting or merging element positioned between the first finite conjugate objective and the second finite conjugate objective. The system also includes an excitation unit configured to direct an excitation beam into a sample positioned in front of the first finite conjugate objective. The excitation beam is in the form of an excitation plane. The system also includes an image sensor positioned facing the second finite conjugate objective. The image sensor lies in a conjugate plane of an excitation beam illumination plane at the frontal end of the system.

Abstract: A series of isoreticular metal-organic frameworks composed of metal nodes connected by rigid trigonal prismatic organic linkers and having a 6,12-coordinatled alb network topology are provided. Also provided are methods of synthesizing the metal-organic frameworks and methods of using the metal-organic frameworks to catalyze the hydrolysis of organic molecules, such as nerve agents, having hydrolysable bonds.

Abstract: Provided herein is a method for treating a lymphoma in a subject in need thereof, comprising administering to the subject an effective amount of at least one PD-1 pathway agonist.

Abstract: The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second fusion protein each include an affinity reagent and a reactive enzyme, and the linker includes a first and second functional groups specific for irreversibly inhibiting the first and second fusion protein reactive enzymes. The disclosure further provides a method including (a) contacting a first fusion protein including an affinity reagent and a reactive enzyme with a linker including a functional group specific for irreversibly inhibiting the first fusion protein reactive enzyme thereby coupling the first fusion protein and the linker, and (b) contacting a second fusion protein including an affinity reagent and a reactive enzyme with the linker, the linker including a functional group specific for irreversibly inhibiting the second fusion protein reactive enzyme thereby coupling the second fusion protein and the linker.

Abstract: Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer.

Abstract: Disclosed are methods, devices, kits, components, and compositions for detecting a target molecule in a test sample using a cell-free protein synthesis (CFPS) reaction. The methods, devices, kits, components, and compositions may be utilized for detecting target molecules which may include small molecules and/or metabolites of small molecules. The components and compositions used in the disclosed methods, devices, and kits may be dried or lyophilized and may be present or immobilized on a paper substrate, for example, as a paper test article.

Abstract: Provided herein is a method of detecting the presence or absence of Serine Protease Inhibitor Kazal-type 1 (SPINK1) in a subject, comprising obtaining a biological sample comprising genomic DNA from a subject having or suspected of having chronic and acute lung diseases, and detecting the presence or absence of the SPINK1 in the biological sample.

Abstract: Disclosed are systems and methods that include or utilize composable mammalian elements of transcription (COMET) including engineered recombinant proteins that regulate transcription and engineered DNA promoter sequences that are regulated by the engineered recombinant proteins. The elements may be composed to form logic gates, gene expression cascades and programs, and cell-based biosensors.

Abstract: Aspects disclosed herein include a method for treatment of a subject, the method comprising: topically administering a melanin formulation having an artificial melanin material (thereby administering artificial melanin material) to (or, to a site of) damaged skin of the subject; wherein the administered artificial melanin material comprises extracellular artificial melanin material at (or, at the site of) the damaged skin; and facilitating skin healing in the wound via at least the extracellular artificial melanin material; wherein the step of facilitating skin healing comprises at least a portion of the extracellular artificial melanin material performing a therapeutic extracellular activity.

Abstract: The present disclosure is generally directed to a system and method for monitoring and treating an emotional state. The system includes a device including an electroencephalogram, an electromyography, a sound sensor, an accelerometer, and a gyroscope. The device is communicably coupled to a converter configured to convert the data and send the data to an external device. The external device is configured to store and analyze the data. The external device in configured to send a signal to perform a medical intervention.

Abstract: Disclosed herein are receptor-substrate complexes comprising an octacationic tricyclic cyclophane and a pyrrole dye complexed therein and methods of using and making the same.

Abstract: A method of forming an ice resistant surface includes determining, based at least in part on a desired pattern of frost formation, a vertex angle for a ridge that is to be formed on a substrate. The method also includes determining, based at least in part on the desired pattern of frost formation, a vertex height for the ridge that is to be formed on the substrate. The method further includes forming a plurality of ridges on the substrate, where each ridge in the plurality of ridges has the vertex angle and the vertex height.

Abstract: An implantable bioresorbable radio frequency (RF) coil for high-resolution and high-specificity post-surgical evaluating or monitoring with magnetic resonance imaging (MRI) is disclosed. The coil includes a bioresorbable conductor configured to be resorbed within a patient while the coil is implanted in the patient. In one embodiment, the target application of this coil is the evaluation or monitoring (via MRI) of peripheral nerve regeneration following surgical repair.

Abstract: Disclosed herein are methods and compositions for administering immunotherapy to a subject in need thereof and for treating a subject in need thereof, where in the methods the subject is administered an effective amount of an inhibitor of nNOS for inducing an immunotherapeutic response in the subject and for treating the subject. The disclosed methods and composition may be utilized for treating a subject having a cell proliferative disease or disorder such as melanoma.

Abstract: A ring sizer including a face plate that has markings usable to provide measurements of a valve. The sizer may include a clear face plate on which the markings are provided such that the valve is visible through the face plate facilitating accurate measurements of various valve dimensions and optimal ring sizing.

Abstract: Diffusion-based and ion implantation-based methods are provided for fabricating planar photodetectors. The methods may be used to fabricate planar photodetectors comprising type II superlattice absorber layers but without mesa structures. The fabricated planar photodetectors exhibit high quantum efficiencies, low dark current densities, and high specific detectivities as compared to photodetectors having mesa structures.

Abstract: An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.

Abstract: Disclosed herein are rechargeable aluminum organic batteries and active materials used therein. The cathodic materials used herein comprise a macrocycle comprising a substituted or unsubstituted phenanthrenequinone unit and a graphite flake.

Abstract: Automated cell staining systems and methods are disclosed herein. In particular, the staining systems disclosed herein provide low-volume, automated bench top staining systems for staining biological samples contained on a cytological slide.