Patents Assigned to Northwestern University
  • Patent number: 12387839
    Abstract: A system for automatically labeling massive quantities of image report data includes a memory configured to store image data and metadata corresponding to the image data. The system also includes a processor operatively coupled to the memory and configured to apply a natural language processing algorithm to identify one or more characteristics of the image report data and the metadata. The processor is also configured to label the image report data based at least in part on the one or more identified characteristics to form a labeled dataset.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: August 12, 2025
    Assignee: Northwestern University
    Inventors: Virginia Boyce Hill, Michael Alexander Iorga, Aggelos K. Katsaggelos, Todd B. Parrish
  • Patent number: 12377036
    Abstract: Included herein are methods and materials for nontoxic, biocompatible, optionally metal-free, tunable, and long-lasting coloration of human hair. More particularly, provided herein are methods, and associated formulations, for efficient formation and deposition of synthetic melanin to human hair, thereby coloration of hair, whereby the hair treatment formulation is viscous enough for treatment of hair without substantially loss of the formulation which further allows an easier application process that includes exposing the hair to the treatment formulation for an extended amount of time. For example, the hair treatment formulation, or viscous solution, can be applied and left on the hair, such as if it were a cream or gel, without requiring soaking the hair in a bath. Different colors can be achieved by tuning reaction conditions such as temperature and solution phase composition.
    Type: Grant
    Filed: June 21, 2023
    Date of Patent: August 5, 2025
    Assignee: Northwestern University
    Inventors: Nathan C. Gianneschi, Zofia Elzbieta Siwicka
  • Patent number: 12373945
    Abstract: A system to predict heating in implants includes a memory configured to store an image of a patient. The image includes a medical implant of the patient. The system also includes a processor operatively coupled to the memory and configured to determine an implant trajectory of the medical implant. The processor is also configured to determine a tangential component of an electric field that is incident upon the medical implant at a plurality of locations along the implant trajectory. The processor is further configured to determine, based on the implant trajectory and the tangential component of the electric field at each of the plurality of locations, a specific absorption rate of radiofrequency (RF) energy associated with the medical implant.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: July 29, 2025
    Assignee: Northwestern University
    Inventors: Laleh Golestani Rad, Behzad Elahi, Jasmine Christina Vu
  • Patent number: 12370267
    Abstract: The disclosed methods pertain to diagnosing whether a non-ablative, gene therapy is needed for reducing AF fibrosis in a subject, and if so, methods of reducing AF fibrosis in a subject using gene therapy with a dominant negative TGF-? R2 cDNA expression vector. Kits and computer program products are also described, wherein the kits provide materials for diagnosing and treating AF fibrosis, and the computer program products include a computer readable medium having computer readable program code for monitoring the efficacy of therapeutic ablation of fibrosis in a subject using a gene therapy method.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: July 29, 2025
    Assignee: Northwestern University
    Inventor: Rishi Arora
  • Patent number: 12372668
    Abstract: Lithium-containing thiostannate spinel compounds having the formula Li2M1+xSn3?xS8, where x is 0 or 1 and M is Mg, Fe, Mn, Ni, Ga, In, or a combination thereof; or the formula Li1.66CuSn3.33S8 are provided. Methods and devices for detecting incident neutrons and alpha-particles using the compounds are also provided. For thermal neutron detection applications, the compounds can be enriched with lithium-6 isotope (6Li) to enhance their neutron detecting capabilities.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: July 29, 2025
    Assignee: Northwestern University
    Inventors: Mercouri G. Kanatzidis, Michael Anthony Quintero
  • Patent number: 12365930
    Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
    Type: Grant
    Filed: December 14, 2022
    Date of Patent: July 22, 2025
    Assignees: Northwestern University, Cornell University
    Inventors: Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai
  • Publication number: 20250230135
    Abstract: Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
    Type: Application
    Filed: August 16, 2024
    Publication date: July 17, 2025
    Applicant: Northwestern University
    Inventors: Sangeeta Ray, Martin G. Pomper, Thomas J. Meade, Ronnie C. Mease, Ying Chen, Xing Yang, Matthew Rotz
  • Patent number: 12359279
    Abstract: Conjugated organic polymers doped with anions and methods for the use of the anion-doped conjugated organic polymers in the selective electroless extraction and recovery of gold or silver from samples containing gold anions or silver anions are provided. The anion-doped polymers have a conjugated, positively charged backbone chain that is charge-balanced with associated dopant anions.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 15, 2025
    Assignee: Northwestern University
    Inventors: Mercouri G. Kanatzidis, Shulan Ma
  • Patent number: 12357188
    Abstract: The disclosed 2-D and 3-D tomographic resistance imaging method improves tomographic resistance image resolution by adopting an orthogonal basis with the maximum number of elements N to describe the maximum resolution resistivity map ?(r), where this number of elements N is set according to the number of electrodes Q; by defining the orthogonal basis according to any known constraints in the problem, thereby enhancing the resolution where it is needed; by positioning electrodes to be sensitive to these basis functions; and by choosing current I and voltage V contact electrode pairs that maximize signal-to-noise ratio.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: July 15, 2025
    Assignee: Northwestern University
    Inventors: Matthew Allen Grayson, Chulin Wang, Claire Cecelia Onsager, Can Cenap Aygen, Charles M. Costakis, Lauren E. Lang, Andreas Tzavelis, John Ashley Rogers
  • Patent number: 12364155
    Abstract: Photocurable compositions that combine redox-active semiconducting organic polymers with photocurable organic molecules are provided. Upon exposure to radiation, the photocurable compositions form ion-permeable, electrically conductive crosslinked organic films that can be used as conducting channels in n-channel or p-channel organic electrochemical transistors, including vertical organic electrochemical transistors (vOECTs). The vOECTs can be incorporated in complementary electronic circuits.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: July 15, 2025
    Assignees: Northwestern University, Flexterra, Inc.
    Inventors: Antonio F. Facchetti, Tobin J. Marks, Wei Huang, Jianhua Chen, Yu Xia
  • Patent number: 12351944
    Abstract: Two-dimensional halide perovskites are provided. The perovskites have two-dimensional Dion-Jacobson phases and are composed of a plurality of inorganic perovskite layers separated by 3-(aminomethyl)piperidinium (3AMP) and/or 4-(aminomethyl)piperidinium (4AMP) spacer cations. The halide perovskites may have a single perovskitizer cation or mixed perovskitizer cations. Also provided are radiation-absorbing materials comprising the perovskites and photovoltaic cells comprising the radiation-absorbing materials as photoactive materials.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: July 8, 2025
    Assignee: Northwestern University
    Inventors: Lingling Mao, Weijun Ke, Konstantinos Stoumpos, Mercouri G. Kanatzidis
  • Patent number: 12354256
    Abstract: Described here are systems and method for predicting clinically relevant brain features using geometric deep learning techniques, such as may be implemented with graph convolutional neural networks or autoencoder networks that are applied to graph representations of brain surface morphology derived from medical images. As an example, graph convolutional neural networks can be applied to brain surface morphology data derived from magnetic resonance images (e.g., T1-weighted) using surface extraction techniques in order to predict brain feature data.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: July 8, 2025
    Assignee: Northwestern University
    Inventors: Pierre Alain Besson, Sarah Kathleen Bandt
  • Patent number: 12337019
    Abstract: Disclosed are methods and topical compositions for applying bacteria to skin, scalp and hair. The topical compositions include bacteria in a suitable base vehicle comprising honey for applying the bacteria to skin, scalp and hair. The base vehicle may include additional components such as, but not limited to, plant-based products, micro-nutrients, emollients and plant-sourced emulsifiers, and anti-oxidants, among other components. The topical compositions may be utilized in methods for treating and/or preventing skin, scalp, and hair conditions such as, but not limited to, dry skin, dry scalp, dandruff, psoriasis, cradle cap, seborrheic dermatitis, and/or eczema.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: June 24, 2025
    Assignees: Northwestern University, Yobee Care, Inc.
    Inventors: Ruchi Gupta, Tarun Jain
  • Patent number: 12330990
    Abstract: Methods for the dispersion and synthesis of graphene nanoplatelet-cement composites and helical carbon nanotube composites with high concentrations of graphene nanoplatelets or helical carbon nanotubes that do not require chemical dispersion aids or dispersion-enhancing chemical surface functionalization are provided. Also provided are the reinforced cement composites made using the methods.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: June 17, 2025
    Assignee: Northwestern University
    Inventor: Ange-Therese Akono
  • Patent number: 12325778
    Abstract: Disclosed herein are methods for reprocessing polyurethane compositions such as polyurethane foams. The method comprises introducing a polyurethane composition into a compounding device, heating the polyurethane composition to an effective bond-exchange temperature, and compounding the polyurethane composition for an effective bond-exchange time.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: June 10, 2025
    Assignees: Northwestern University, Cornell University, Regents of the University of Minnesota
    Inventors: David J. Fortman, William R. Dichtel, Daylan T. Sheppard, Kailong Jin, Christopher J. Ellison
  • Patent number: 12328649
    Abstract: Systems and/or methods may include an edge-computing distributed neural processor to effectively reduce the data traffic and physical wiring congestion. A local and global networking architecture may reduce traffic among multi-chips in edge computing. A mixed-signal feature extraction approach with assistance of neural network distortion recovery is also described to reduce the silicon area. High precision in signal features classification with a low bit processing circuitry may be achieved by compensating with a recursive stochastic rounding routine, and provide on-chip learning to re-classify the sensor signals.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: June 10, 2025
    Assignee: Northwestern University
    Inventor: Jie Gu
  • Patent number: 12325884
    Abstract: Disclosed are methods and systems for detecting fluoride as a target molecule in a test sample which utilize a cell-protein synthesis (CFPS) reaction and an engineered fluoride-sensing riboswitch. The components used in the disclosed methods and systems may be dried or lyophilized and may be present or immobilized on a paper substrate.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: June 10, 2025
    Assignee: Northwestern University
    Inventors: Julius B. Lucks, Walter M. Thavarajah, Adam D. Silverman, Michael C. Jewett
  • Patent number: 12326725
    Abstract: A system for determining positional information of a rotorcraft includes a central controller and a first sensor unit. The first sensor unit is mounted to a first rotating portion of the rotorcraft and is in communication with the central controller. The first sensor unit includes one or more first receivers configured to receive signals from a remote transmission source. The first sensor unit also includes a processor configured to determine a bearing of the rotorcraft relative to the remote transmission source based in part on the signals received from the remote transmission source. The first sensor unit further includes a transmitter configured to transmit the bearing of the rotorcraft to a central controller of the rotorcraft.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 10, 2025
    Assignee: Northwestern University
    Inventor: Michael S. Rubenstein
  • Patent number: 12319004
    Abstract: A system for additive manufacturing includes a multi-material vat that includes a plurality of resins. The system also includes a robotic arm that provides at least six degrees of freedom of motion, where the robotic arm moves with the six degrees of freedom to draw resin out of the multi-material vat to form an object. The system further comprises a processor operatively coupled to the robotic arm and configured to control movement of the robotic arm in the six degrees of freedom.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: June 3, 2025
    Assignee: Northwestern University
    Inventors: Jigang Huang, Cheng Sun
  • Publication number: 20250174649
    Abstract: A cathode material has the chemical formula Li4+?Mx1M?y1M?z1O8 or Li2+?Mx2M?y2M?z2O4 where 0???1, x1, y1, z1 are integers (+/?0.5) and x1+y1+z1=4, and x2, y2, z2 are integers (+/?0.05) and x2+y2+z2=2. A method for discovering a cathode material includes estimating synthesizability for a plurality of cathode material compositions, selecting a first subset of cathode material compositions from the plurality of cathode material compositions as a function of the estimated synthesizability and metal-ion diffusion availability, estimating voltage discharge, charge capacity, and oxygen stability for the first subset of cathode material compositions, and selecting a second subset of cathode material compositions from the first subset plurality of cathode material compositions as a function of the estimated voltage discharge, charge capacity, and oxygen stability.
    Type: Application
    Filed: September 26, 2024
    Publication date: May 29, 2025
    Applicants: Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha, Northwestern University
    Inventors: Steven Bartholomew Joseph Torrisi, Christopher Wolverton, Yizhou Zhu, Tzu-Chen Liu, Bianca Baldassarri, Adolfo Salgado-Casanova, Muratahan Aykol, So Yubuchi, Hisatsugu Yamasaki, Jun Yoshida