Patents Assigned to Northwestern University
  • Patent number: 11020724
    Abstract: Metal organic resins, composite materials composed of the metal organic resins, and anion exchange columns packed with the composite materials are provided. Also provided are methods of using the composite materials to remove metal anions from a sample, methods of using the metal organic resins as fluorescence sensors for detecting metal anions in a sample, and methods of making the metal organic resins and the composite materials. The metal organic resins are amine-functionalized metal organic frameworks and their associated counter anions. The composite materials are composed of metal organic resin particles coated with organic polymers, such as alginic acid polymers.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: June 1, 2021
    Assignee: Northwestern University
    Inventors: Mercouri G. Kanatzidis, Debajit Sarma, Emmanouil Manos
  • Patent number: 11016597
    Abstract: A device including a body configured to be grasped by a user's hand and a touch surface oriented on a first surface of the body, wherein the touch surface is configured to be engaged by an appendage of the user's hand when the body is grasped by the user's hand. The device also includes a friction modulator associated with the touch surface, wherein the friction modulator is configured to modulate a coefficient of friction between the user's appendage and the touch surface to provide haptic feedback.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: May 25, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: James Edward Colgate, Michael A. Peshkin, John Glassmire, Laura Winfield Alexander
  • Patent number: 11008372
    Abstract: Embodiments provided here include recombinant polypeptides, termed degradons, comprising a target binding domain and a proteasome-binding domain. Degradons of the embodiments are able to selectively target and degrade proteins bound by the target-binding domain, such as proteins associated with disease. Vectors encoding degradons and methods of treating disease with degradons and degradon expression vectors are likewise provided.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 18, 2021
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, NORTHWESTERN UNIVERSITY
    Inventor: Andreas Matouschek
  • Patent number: 11010736
    Abstract: A server in a blockchain distribution network includes a processor and a transceiver operatively coupled to the processor. The transceiver is configured to receive a transaction from a peer node. The processor is configured to assign a transaction identifier to the transaction. The transceiver is configured to propagate the transaction identifier to one or more additional peer nodes and one or more additional servers in the blockchain distribution network. The transceiver is configured to receive bytes of a blockchain that represents a plurality of transactions. The blockchain includes the transaction identifier corresponding to the transaction. The transceiver is further configured to propagate the bytes of the blockchain to the one or more additional peer nodes and to the one or more additional servers in the blockchain distribution network.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: May 18, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Uri Klarman, Aleksandar Kuzmanovic
  • Patent number: 11001618
    Abstract: Disclosed are methods and pharmaceutical compositions for treating and inhibiting conical vascularization including conical vascularization associated with viral infection, chemical injury, autoimmune conditions, and post-corneal transplantation or in subjects having a PAX6 mutation associated with conical vascularization. The methods and pharmaceutical compositions are utilized in administering treatment that results in increased concentration of FOXC1 in a subject's cornea in order to treat or inhibit corneal vascularization.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: May 11, 2021
    Assignees: Northwestern University, The Governors of the University of Alberta
    Inventors: Tsutomu Kume, Ordan Lehmann
  • Patent number: 10997232
    Abstract: A system and method for automated detection of figure element reuse. The system can receive articles or other publications from a user input or an automated input. The system then extracts images from the articles and compares them to reference images from a historical database. The comparison and detection of matches occurs via a copy-move detection algorithm implemented by a processor of the system. The processor first locates and extracts keypoints from a submission image and finds matches between those keypoints and the keypoints from a reference image using a near neighbor algorithm. The matches are clustered and the clusters are compared for keypoint matching. Matched clusters are further compared for detectable transformations. The processor may additionally implement natural language processing to filter matches based on the context of the use of the submission image in the submission and a patch detector for removing false positive features.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: May 4, 2021
    Assignees: SYRACUSE UNIVERSITY, Northwestern University, Rehabilitation Institute of Chicago
    Inventors: Daniel Ernesto Acuna, Konrad Kording
  • Patent number: 10994016
    Abstract: A method of bioactive molecule delivery includes providing a first aqueous medium comprising native graphene oxide and a second aqueous medium comprising a bioactive molecular component that includes Gd(III)-labeled molecules; mixing said first and second media to form a mixture thereof; co-incubating the mixture for a first period of time for coupling said molecular component on a surface of said native graphene oxide, to provide a co-incubation product; and contacting a cellular medium with said co-incubation product for a second period of time for cellular delivery of said bioactive molecular component.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: May 4, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Mark C. Hersam, Thomas J. Meade, Hsiang-Hua Hung
  • Patent number: 10996172
    Abstract: Surface-functionalized nano structures, arrays of the nanostructures, and method for using the arrays in surfaced-enhanced spectroscopy and dielectric sensing applications, such as surface-enhanced infrared absorption spectroscopy, are provided. The nanostructures are functionalized with specific binding moieties that are bound to the nanostructures via phosphonic acid linkers.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 4, 2021
    Assignees: NATIONAL INSTITUTE OF MATERIAL SCIENCE, Northwestern University
    Inventors: Robert P. H. Chang, Shiqiang Li, Peijun Guo, Kai Chen, Keiko Okano, Tadaaki Nagao
  • Publication number: 20210122767
    Abstract: Provided herein are rigid macrocycles comprising a poly(peri-naphthalene) diimide (PPNDI) submit and a second diimide subunit having both high photoluminescent and electron accumulation activities. Also provided herein are methods of preparation of the rigid macrocycles and methods of using the same.
    Type: Application
    Filed: January 21, 2019
    Publication date: April 29, 2021
    Applicants: Northwestern University, King Abdulaziz City for Science and Technology (KACST)
    Inventors: Siva Krishna Mohan Nalluri, James Fraser Sioddart
  • Publication number: 20210121413
    Abstract: Provided herein are immunomodulatory nanoparticles, compositions containing the same, and methods of use thereof, such as for the treatment of traumatic brain injury.
    Type: Application
    Filed: October 21, 2020
    Publication date: April 29, 2021
    Applicant: Northwestern University
    Inventors: John A. Kessler, Sripadh B. Sharma
  • Patent number: 10988767
    Abstract: Disclosed herein are pharmaceutical compositions and methods for inhibiting oxidative stress in a subject having atrial or ventricular arrhythmias, ventricular failure or heart failure. The methods include administering an effective amount of a NOX2 inhibitor agent to the subject, wherein said administering is under conditions such that a level of oxidative stress in myocardial tissue is reduced or eliminated. The pharmaceutical compositions include a NOX2 inhibitor agent.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: April 27, 2021
    Assignee: Northwestern University
    Inventor: Rishi Arora
  • Publication number: 20210113334
    Abstract: A ring sizer including a face plate that has markings usable to provide measurements of a valve. The sizer may include a clear face plate on which the markings are provided such that the valve is visible through the face plate facilitating accurate measurements of various valve dimensions and optimal ring sizing.
    Type: Application
    Filed: June 11, 2019
    Publication date: April 22, 2021
    Applicant: Northwestern University
    Inventor: Patrick M. McCarthy
  • Publication number: 20210113552
    Abstract: Disclosed are methods and compositions for enhancing cellular clearance of pathological molecules. Particularly disclosed are methods and compositions enhancing cellular clearance of pathological molecules via activating the cellular protein ykt6. The disclosed methods and compositions may be utilized in order to treat a subject having or at risk for developing a proteinopathy or other cellular storage disorder.
    Type: Application
    Filed: October 19, 2020
    Publication date: April 22, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Joseph R. Mazzulli, Leah K. Cuddy
  • Publication number: 20210116397
    Abstract: The disclosure contains a method of quantifying and/or evaluating metal ions in a dentifrice, wherein the method comprises subjecting the dentifrice to X-ray absorption spectroscopy (XAS), and wherein the XAS is used to measure and/or evaluate the metal ions in the dentifrice. Also disclosed are methods of selecting and screening for dentifrices based upon the evaluation and quantification of their metal ion content.
    Type: Application
    Filed: December 29, 2020
    Publication date: April 22, 2021
    Applicants: Colgate-Palmolive Company, Northwestern University
    Inventors: Michael FITZGERALD, Iraklis PAPPAS, Jean-Francois GAILLARD, Marco ALSINA CORVALAN
  • Publication number: 20210108005
    Abstract: Embodiments are directed to catalyst systems comprising: a procatalyst; and a co-catalyst dissolved in a non-halogenated aprotic hydrocarbon solvent, the co-catalyst comprising: a non-coordinating borate dianion having the formula: (III) and two cations, each cation being independently chosen from a cation according to formula (I) or formula (II).
    Type: Application
    Filed: March 28, 2019
    Publication date: April 15, 2021
    Applicants: Dow Global Technologies LLC, Northwestern University
    Inventors: Tobin J. Marks, Yanshan Gao, Tracy L. Lohr, Matthew D. Christianson, Jerzy Klosin, Edmund M. Carnahan, Andrew J. Young
  • Publication number: 20210106697
    Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Evan A. Scott, Guillermo A. Ameer, Jacqueline A. Burke, Helena Freire Haddad
  • Patent number: 10977628
    Abstract: A server in a blockchain distribution network includes a processor and a transceiver operatively coupled to the processor. The transceiver is configured to receive bytes of an encrypted blockchain from a peer node in a peer-to-peer network, where the server is unable to identify a source node that generated the encrypted blockchain based on the received bytes. The transceiver is also configured to propagate the bytes of the encrypted blockchain to one or more additional peer nodes and to one or more additional servers in the blockchain distribution network.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 13, 2021
    Assignee: Northwestern University
    Inventors: Uri Klarman, Aleksandar Kuzmanovic
  • Patent number: 10970690
    Abstract: A peer node in a blockchain distribution network includes a processor and a transceiver operatively coupled to the processor. The processor is configured to generate an encrypted test block. The encrypted test block is indistinguishable from an encrypted blockchain in the blockchain distribution network. The transceiver is configured to transmit the encrypted test block to a server for distribution throughout the blockchain distribution network. The transceiver is also configured to receive a message from a second peer node in the blockchain distribution network, where the message indicates that the second peer node received the encrypted test block.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 6, 2021
    Assignee: Northwestern University
    Inventors: Uri Klarman, Aleksandar Kuzmanovic
  • Patent number: 10969395
    Abstract: Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: April 6, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: John A. Rogers, Jungil Choi, Johnathan T. Reeder
  • Patent number: 10967072
    Abstract: Nanostructures for the systemic delivery of nucleic acids, such as RNA, are provided herein. The nanostructures include templated lipoprotein nanoparticles (TLPs) composed of a core decorated with proteins, a lipid bilayer and hydrophobic molecules that self-assemble with nucleic acids, such as RNA. The nanostructures are useful for research, therapeutic and diagnostic applications.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: April 6, 2021
    Assignee: Northwestern University
    Inventors: C. Shad Thaxton, Kaylin M. McMahon