Patents Assigned to Northwestern University
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Publication number: 20250171329Abstract: A cathode for a battery includes a cathode material with the chemical formula Li1+?FexCryO2 where 0???1, and ?+x+y=2. In some variations, the cathode material has a disordered rock-salt crystal structure and the chemical formula Li1+?FexCryO2 where 0???1, and ?+x+y=2. And in at least one variations, a method of forming the cathode material includes wet ball milling solid precursors of lithium, iron, and chromium and forming a slurry, drying the slurry and forming a powder, sintering the powder, and dry ball milling the powder and forming the cathode material with the disordered rock-salt crystal structure and the chemical formula Li1+?FexCryO2 where 0???1, and ?+x+y=2.Type: ApplicationFiled: September 26, 2024Publication date: May 29, 2025Applicants: Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha, Northwestern UniversityInventors: Steven Bartholomew Joseph Torrisi, Christopher Wolverton, Yizhou Zhu, Tzu-Chen Liu, Bianca Baldassarri, Adolfo Salgado-Casanova, Muratahan Aykol, So Yubuchi, Hisatsugu Yamasaki, Jun Yoshida
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Patent number: 12313796Abstract: Inorganic perovskites doped with oxygen atoms or fluorine atoms, methods for making the doped perovskites, and hard radiation detectors incorporating the doped perovskites as photoactive layers are provided. The doped perovskites utilize lead oxide, lead fluoride, or compounds that thermally decompose into lead oxide or lead fluoride as dopant atom sources. During the crystallization of a perovskite in the presence of the dopant atom sources, oxygen or fluoride atoms from the dopant source are incorporated into the perovskite crystal lattice.Type: GrantFiled: May 5, 2021Date of Patent: May 27, 2025Assignees: Northwestern University, UChicago Argonne, LLCInventors: Wenwen Lin, Duck Young Chung, Mercouri G. Kanatzidis
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Patent number: 12311029Abstract: Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of IDO protein. The disclosed PROTACs typically include a first targeting moiety that binds to IDO (Miro). The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula MIDO-L-ME3 or ME3-L-MIDO.Type: GrantFiled: October 23, 2023Date of Patent: May 27, 2025Assignee: Northwestern UniversityInventors: Gary E. Schiltz, Derek A. Wainwright
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Patent number: 12312262Abstract: Methods for removing contaminants from aqueous media using polyelectrolyte complexes having a heterogeneous charge distribution are provided. The polyelectrolyte complexes are formed from an amphiphilic anionic random copolymer and a cationic random copolymer are provided. The polyelectrolyte complexes absorb cationic, anionic, or hydrophobic organic molecules and can be easily removed from water.Type: GrantFiled: March 1, 2021Date of Patent: May 27, 2025Assignee: Northwestern UniversityInventors: Jeremy Wang, Monica Olvera de la Cruz, John M. Torkelson
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Patent number: 12311343Abstract: Tandem catalysts for the dehydrogenation of alkanes and/or alcohols in tandem with selective hydrogen combustion are provided. Also provided are methods of making the catalysts and methods of using the catalysis for the dehydrogenation of alkanes and/or alcohols. The catalysts include a support having a surface, dehydrogenation catalysts particles dispersed on the surface of the support, and a porous selective hydrogen combustion catalyst overcoat on the dehydration catalyst particles. The catalysts couple dehydrogenation with selective hydrogen combustion in a sequence of reactions occurring in tandem to shift the equilibrium of the dehydrogenation towards higher conversion.Type: GrantFiled: July 29, 2021Date of Patent: May 27, 2025Assignee: Northwestern UniversityInventors: Justin M. Notestein, Peter C. Stair, Huan Yan
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Patent number: 12311054Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.Type: GrantFiled: July 3, 2023Date of Patent: May 27, 2025Assignee: Northwestern UniversityInventors: Evan A. Scott, Sijia Yi, David Engman, Xiaomo Li
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Publication number: 20250161048Abstract: An annuloplasty ring includes an elastic elongated core having first regions and second regions, wherein the first regions are more stretchable than the second regions and are adapted for positioning at the commissures of a target native heart valve. The first regions and the second regions may enable the annuloplasty ring to both re-establish coaptation of the leaflets of a diseased native heart valve and establish a seal around a prosthetic replacement heart to prevent paravalvular leakage after a “Valve In Ring Procedure”.Type: ApplicationFiled: November 14, 2024Publication date: May 22, 2025Applicants: Northwestern University, Cardiac Valve Innovations, LLCInventors: Patrick M. McCarthy, Hieu Cong Nguyen, Connor Wright Rowley
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Patent number: 12295971Abstract: The present disclosure relates generally to compositions and methods for improving T cell therapy. In particular, the disclosure provides polypeptides and recombinant nucleic acid constructs and/or recombinant nucleic acids encoding polypeptides having mutations capable of altering T cell signaling, cytokine production, and/or in vivo persistence in tumors of therapeutic T cells comprising the mutation. The T cell signaling can be by NFAT, NF-?B and/or AP-1 pathways. The disclosure also provides vectors and cells including the polypeptides and/or recombinant nucleic acid constructs and/or recombinant nucleic acids of the disclosure as well as methods of preparing a T cell for use in cell therapy, and methods of identifying a mutation useful for improving T cell therapy.Type: GrantFiled: April 9, 2024Date of Patent: May 13, 2025Assignees: The Regents of the University of California, Northwestern UniversityInventors: Kole Roybal, Julie Garcia, Iowis Zhu, Jaehyuk Choi, Jay Daniels
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Patent number: 12297216Abstract: Electrically conductive, metal-organic framework (MOF) materials, methods of making the materials, and chemical sensors incorporating the materials are provided. The electrically conductive MOF materials are formed from mesoporous MOF crystals having continuous strands of electrically conductive inorganic oxides within their porous structures. The inorganic strands are formed by the condensed-phase grafting of molecular metal species onto MOF nodes.Type: GrantFiled: July 18, 2019Date of Patent: May 13, 2025Assignee: Northwestern UniversityInventors: Chung-Wei Kung, Timothy Chiaan Wang, Joseph T. Hupp
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Patent number: 12290689Abstract: Systems and methods are disclosed for an electrical sensing, pacing, and ablation device comprising a bendable and stretchable balloon catheter and a bendable and stretchable first layer connected to or embedded in said balloon catheter, where the first layer has an electrode array with a plurality of electrodes. The is also a bendable and stretchable second layer connected to or embedded in the balloon catheter, and the second layer has a pressure sensor array with a plurality of pressure sensors.Type: GrantFiled: January 19, 2022Date of Patent: May 6, 2025Assignees: The George Washing University, Northwestern UniversityInventors: Igor R. Efimov, Jaclyn Ann Brennan, John A. Rogers
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Patent number: 12291533Abstract: Disclosed are new small molecules having a substituted pyrimidine or substituted fused pyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including Gaucher's disease and neurological diseases and disorders such as genetic and sporadic synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy associated with aberrant glucocerebrosidase activity. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.Type: GrantFiled: July 25, 2018Date of Patent: May 6, 2025Assignee: Northwestern UniversityInventors: Dimitri Krainc, Richard B. Silverman, Jianbin Zheng
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Publication number: 20250138027Abstract: Provided herein are methods to predict primary graft dysfunction in a subject, comprising detecting and/or quantifying complement protein in allograft biopsy tissue up to 120 minutes post-reperfusion.Type: ApplicationFiled: October 30, 2024Publication date: May 1, 2025Applicant: Northwestern UniversityInventor: Ankit BHARAT
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Patent number: 12288584Abstract: A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules. The molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.Type: GrantFiled: March 26, 2021Date of Patent: April 29, 2025Assignees: President and Fellows of Harvard College, Northwestern UniversityInventors: George M. Whitesides, Brian J. Cafferty, Alexei S. Ten, Michael J. Fink, Daniel J. Preston, Milan M. Mrksich, Amit A. Nagarkar
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Patent number: 12285909Abstract: In an aspect, a method for additive manufacture of a three-dimensional object based on a computational model comprises steps of: grayscale photohardening a precursor material to form a portion of the object; and applying a hardened meniscus coating at a feature of the object; wherein the three-dimensional object is formed via at least the combination of the steps of gray scale photohardening and applying the meniscus coating. In some embodiments, the grayscale photohardening step is a grayscale photopolymerization step. In some embodiments, the applying a hardened meniscus coating step is a meniscus equilibrium post-curing step.Type: GrantFiled: March 8, 2019Date of Patent: April 29, 2025Assignee: Northwestern UniversityInventors: Xiangfan Chen, Wenzhong Liu, Hao F. Zhang, Cheng Sun
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Patent number: 12280580Abstract: Self-healing, hydrophobic composites and related methods are provided. A method of repelling water may comprise forming a layer of a self-healing, hydrophobic composite comprising a porous network of entangled polymer fibers and a hydrophobic phase change material infused throughout the network, on a surface of a substrate to form a treated surface; and exposing the treated surface to water, wherein the treated surface exhibits a native water droplet contact angle which is greater than that of an untreated surface without the layer of the composite.Type: GrantFiled: May 23, 2019Date of Patent: April 22, 2025Assignee: Northwestern UniversityInventors: Yuehan Yao, Nicolas Martinez Prieto, Jian Cao, Kyoo-Chul Park, Christian John Machado
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Patent number: 12281017Abstract: Methods of forming a nanocomposite of a base material and a plurality of nanoparticles are provided. In embodiments, the method comprises combining a first input stream of flowing fluid comprising a base material having nucleation sites, a second input stream of flowing fluid comprising a nanoparticle precursor material, and a third input stream of flowing fluid comprising a nanoparticle nucleation agent, to form an output stream of flowing fluid; heating or sonicating or both heating and sonicating the output stream for a period of time; and collecting a nanocomposite formed within the fluid of the output stream, the nanocomposite comprising the base material and a plurality of nanoparticles directly anchored onto a surface of the base material via the nucleation sites. The nanocomposites are also provided.Type: GrantFiled: December 20, 2019Date of Patent: April 22, 2025Assignee: Northwestern UniversityInventors: Vikas Nandwana, Vinayak P. Dravid
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Patent number: 12281310Abstract: Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular disclosed are toxic RNAi active sequences such as siRNA and shRNA for killing cancer cells. The disclosed toxic RNAi active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for cell survival and/or growth.Type: GrantFiled: January 27, 2021Date of Patent: April 22, 2025Assignee: Northwestern UniversityInventors: Marcus E. Peter, Andrea E. Murmann
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Patent number: 12282261Abstract: Methods of fabricating an object via direct laser lithography are provided. In embodiments, such a method comprises illuminating, via an optical fiber having an end facet and a metalens directly on the end facet, a location within a photosensitive composition from which an object is to be fabricated with light, thereby inducing a multiphoton process within the photosensitive composition to generate a region of the object; and repeating the illuminating step one or more additional times at one or more additional locations to generate one or more additional regions of the object.Type: GrantFiled: November 1, 2021Date of Patent: April 22, 2025Assignee: Northwestern UniversityInventors: Sridhar Krishnaswamy, Heming Wei, Wisnu Hadibrata, Koray Aydin
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Patent number: 12275605Abstract: Layering of initially mixed granular dissimilar material components deposited by surface flow is realized by varying the relative angle of the flowing layer periodically with respect to the bulk of the pile formed. Layer thickness and extent can be controlled by varying the timing and extent of the surface variations. Variation in surface flow rates may be realized by varying the feed rate from an inlet to a collection base at a fixed feed location, varying the feed location relative to the collection base, tilting the collection base that is supporting the material, and reducing the pile repose angle using vibration or fluid flow through the base.Type: GrantFiled: January 14, 2021Date of Patent: April 15, 2025Assignee: Northwestern UniversityInventors: Paul B. Umbanhowar, Richard M. Lueptow, Yi Fan
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Patent number: 12269040Abstract: Provided herein are devices and methods for the rapid processing and analysis of samples. In particular, a small-volume sample (e.g., nucleic acid sample) is exposed to (e.g., contacted with) different temperature zones within a device to process (e.g., amplify) and/or analyze (e.g., quantitate) the sample in an assay.Type: GrantFiled: May 24, 2018Date of Patent: April 8, 2025Assignee: Northwestern UniversityInventors: Sally Maureen McFall, David M. Kelso, Jennifer Lynn Reed, Tom Westberg