Patents Assigned to Northwestern University
  • Patent number: 10921212
    Abstract: An automated calibration system that includes a probe guide and a target assembly. The probe guide receives an optical probe, and the target assembly includes one or more calibration targets. The target assembly is slideable relative to the probe guide so that a first calibration target is aligned under the optical probe in a first position of the target assembly and a second calibration target is aligned under the optical probe in a second position of the target assembly.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: February 16, 2021
    Assignees: NORTHWESTERN UNIVERSITY, AMERICAN BIOOPTICS, LLC
    Inventors: Vadim Backman, Bradley Gould, Nikhil Mutyal, Frank Garrett, Jr., The Quyen Nguyen, Michael Garrett
  • Patent number: 10913100
    Abstract: A system includes a frame configured to hold a workpiece and first and second tool positioning assemblies configured to be opposed to each other on opposite sides of the workpiece. The first and second tool positioning assemblies each include a toolholder configured to secure a tool to the tool positioning assembly, a first axis assembly, a second axis assembly, and a third axis assembly. The first, second, and third axis assemblies are each configured to articulate the toolholder along a respective axis. Each axis assembly includes first and second guides extending generally parallel to the corresponding axis and disposed on opposing sides of the toolholder with respect to the corresponding axis. Each axis assembly includes first and second carriages articulable along the first and second guides of the axis assembly, respectively, in the direction of the corresponding axis.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: February 9, 2021
    Assignee: Northwestern University
    Inventors: Michael Beltran, Jian Cao, John T. Roth
  • Publication number: 20210030740
    Abstract: Disclosed are methods and compositions for treating diabetes mellitus and non-alcoholic fatty liver disease by administering a therapeutic agent that inhibits the biological activity of B cell lymphoma 6 protein (BCL6).
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Grant D. Barish, Meredith A. Sommars, Madhavi D. Senagolage
  • Publication number: 20210030850
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes (i) an affinity agent, such as a single-chain variable fragment of an antibody (scFv), which is expressed on the surface of the extracellular vesicles and (ii) a transmembrane domain, and may include additional domains. Exemplary extracellular vesicles may include but are not limited to exosomes or microvesicles.
    Type: Application
    Filed: April 10, 2019
    Publication date: February 4, 2021
    Applicant: Northwestern University
    Inventors: Joshua N. LEONARD, Devin M. STRANFORD
  • Patent number: 10908099
    Abstract: The disclosure contains a method of quantifying and/or evaluating metal ions in a dentifrice, wherein the method comprises subjecting the dentifrice to X-ray absorption spectroscopy (XAS), and wherein the XAS is used to measure and/or evaluate the metal ions in the dentifrice. Also disclosed are methods of selecting and screening for dentifrices based upon the evaluation and quantification of their metal ion content.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: February 2, 2021
    Assignees: Colgate-Palmolive Company, Northwestern University
    Inventors: Michael Fitzgerald, Iraklis Pappas, Jean-Francois Gaillard, Marco Alsina Corvalan
  • Patent number: 10906913
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: February 2, 2021
    Assignee: Northwestern University
    Inventors: M. Amin Khan, Joseph R. Moskal, Paul Wood
  • Patent number: 10906811
    Abstract: A composition includes a few-layer phosphorene nanomaterial comprising at least one of mono-, bi-, and n-layer phosphorene nanosheets, where n is an integer selected from 3 to 6; deoxygenated water; and at least one amphiphilic surface active component.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: February 2, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Mark C. Hersam, Joohoon Kang, Joshua D. Wood
  • Patent number: 10898091
    Abstract: Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine esophageal reactivity based on the area and pressure; assessing esophageal function based on the determined esophageal reactivity; and outputting an indication of esophageal function.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: January 26, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: John Erik Pandolfino, Zhiyue Lin, Peter J. Kahrilas, John O'Dea, Adrian McHugh
  • Patent number: 10902098
    Abstract: A method for encrypting logic includes generating, by a computing system, locking logic for inclusion in a logic circuit. The locking logic is generated based at least in part on an error rate and an attack complexity. The method also includes inserting, by the computing system, a one-way function into the locking logic. The method further includes applying, by the computing system, obfuscation logic to the logic circuit, where the obfuscation logic is applied on top of the locking logic.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 26, 2021
    Assignee: Northwestern University
    Inventor: Hai Zhou
  • Patent number: 10903496
    Abstract: Provided herein are systems and devices comprising rigid macrocyclic and nanoporous compositions of electronically coupled naphthalenediimide redox-active units and methods of preparation and use thereof, for example, in the field of energy generation and storage.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: January 26, 2021
    Assignees: Northwestern University, KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY
    Inventors: Dongyang Chen, Alyssa-Jennifer Avestro, Junling Sun, Zachary B. Erno, J. Fraser Stoddart
  • Publication number: 20210017305
    Abstract: Embodiments are directed to catalyst systems comprising: a procatalyst; and a co-catalyst, the co-catalyst comprising: a non-coordinating borate anion having the formula [B(C6F5)4]1? and a cation according to formula (I).
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Applicants: Dow Global Technologies LLC, Northwestern University
    Inventors: Tobin J. Marks, Yanshan Gao, Tracy L. Lohr, Matthew D. Christianson, Jerzy Klosin, Edmund M. Carnahan, Andrew J. Young
  • Publication number: 20210016496
    Abstract: In an aspect, a method for additive manufacture of a three-dimensional object based on a computational model comprises steps of: grayscale photohardening a precursor material to form a portion of the object; and applying a hardened meniscus coating at a feature of the object; wherein the three-dimensional object is formed via at least the combination of the steps of gray scale photohardening and applying the meniscus coating. In some embodiments, the grayscale photohardening step is a grayscale photopolymerization step. In some embodiments, the applying a hardened meniscus coating step is a meniscus equilibrium post-curing step.
    Type: Application
    Filed: March 8, 2019
    Publication date: January 21, 2021
    Applicant: Northwestern University
    Inventors: Xiangfan CHEN, Wenzhong LIU, Hao F. ZHANG, Cheng SUN
  • Publication number: 20210009639
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 14, 2021
    Applicant: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • Publication number: 20210008246
    Abstract: Provided herein photo-reactive inks, thermal-curable materials and objects (e.g., medical implants, scaffolds, devices, etc.) made therefrom, and methods of preparation and use thereof.
    Type: Application
    Filed: September 13, 2018
    Publication date: January 14, 2021
    Applicant: Northwestern University
    Inventors: Guillermo A. AMEER, Henry Oliver Tenadooah WARE, Cheng SUN, Congwen DUAN
  • Publication number: 20210009547
    Abstract: Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.
    Type: Application
    Filed: July 8, 2020
    Publication date: January 14, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Karl A. Scheidt, Rick C. Betori, Benjamin R. McDonald
  • Publication number: 20210009603
    Abstract: Disclosed herein are tetrahydropyranoindole compounds and derivatives thereof, as well as their methods of synthesis and use. The disclosed compounds may be synthesized by methods that utilize a cooperative hydrogen bond donor/Brønsted acid system. The disclosed compounds may be useful for treating a disease, disorder, or a symptom thereof in a subject in need thereof, such as pain, swelling, and joint stiffness. The disclosed compounds also may be useful for treating cell proliferative diseases and disorders such as cancer.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 14, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Karl A. Scheidt, Mark A. Maskeri
  • Patent number: 10888332
    Abstract: An intranasal occlusion device having an inflatable balloon within a sponge that is used to prevent drainage of fluid, such as blood and other fluids into the airway during sinus and nasal minor procedures or surgeries, and methods of using the device to occlude an intranasal cavity of a patient. The device provides for suction to remove the fluid and may facilitate office-based minor procedures or surgeries.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: January 12, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: John D. Cramer, Bruce Kuang-Huay Tan
  • Patent number: 10882865
    Abstract: Disclosed are new small molecules having a pyrrolopyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may be utilized to generate activated glucocerebrosidase. The activated glucocerebrosidase thusly generated can be administered in enzyme replacement therapy and/or utilized in screening assays for new small molecules that bind to the activated glucocerebrosidase and/or modulate the activity of the activated glucocerebrosidase.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: January 5, 2021
    Assignee: Northwestern University
    Inventors: Dimitri Krainc, Richard B. Silverman, Jianbin Zheng
  • Patent number: 10881394
    Abstract: A medical device includes a surgical needle attached to an elongated mesh suture. The suture is constructed of macroporous flat wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: January 5, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Gregory Dumanian, Anandev Gurjala
  • Patent number: 10881273
    Abstract: A pre-fabricated, on-demand interface provides optical coupling between disposable and reusable portions of a fiber-optic probe. The interface uses a pre-cured, compressible optically-transmissive gel in a cavity of the disposable portion, which can be a disposable insertion tip of the fiber optic probe. The disposable portion includes an elongated housing, or sheath, and the cavity is located within and proximal of a distal end of the elongated housing. A proximal end of an optical assembly of the disposable portion is located within the cavity and contacts the gel. A first coupling, provided at a proximal end of the elongated housing, detachably couples to a mating, second coupling of the probe reusable portion. When the disposable and reusable portions are coupled together, the gel is compressed between the proximal end of the optical assembly of the disposable portion and a distal optical member of an optical assembly of the reusable portion.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: January 5, 2021
    Assignees: Northwestern University, American Biooptics LLC
    Inventors: Vadim Backman, Bradley Gould, Andrew J. Cittadine, Nikhil Mutyal