Abstract: Provided herein are compositions and methods for the treatment of conditions such as benign prostatic hyperplasia (BPH), Lower Urinary Tract Symptoms (LUTS), chronic prostatitis (CP) and/or chronic pelvic pain syndrome (CPPS). In particular, provided herein are combination therapies comprising a mast cell inhibitor and a histamine receptor antagonist.

Abstract: A system for measuring a radiant exposure of electromagnetic radiation includes an accumulation detection module having a detector and configured to continuously monitor an electromagnetic radiation received by the detector; and an adaptive circuit configured to periodically interrogate the accumulation detection module; adjust a frequency of interrogation of the accumulation detection module based on an intensity of the electromagnetic radiation received by the detector; and autonomously transmit information related to an amount of the electromagnetic radiation received by the detector to a remote device.

Abstract: Methods for the dispersion and synthesis of multi-walled carbon nanotube-cement composites with high concentrations of multi-walled carbon nanotubes that do not require chemical dispersion aids or dispersion-enhancing chemical surface functionalization are provided. Also provided are multi-walled carbon nanotube-cement composites made using the methods. Methods for the dispersion and synthesis of carbon nanofiber-cement composites with high concentrations of carbon nanofibers that do not require chemical dispersion aids or dispersion-enhancing chemical surface functionalization are further provided. Also provided are carbon nanofiber-cement composites made using the methods.

Abstract: Thermal management composites and scaffolds for heat-generating implantable electronic devices made from the thermal management composites are provided. The composite materials are cytocompatible, porous materials that include hexagonal boron nitride particles dispersed in an elastomeric polymer binder.

Abstract: The present disclosure provides extended or sustained release compositions of a dihydropyridine calcium channel blocker, specifically isradipine, and method of using the compositions for the treatment of neurological disorders, wherein the composition provides sustained plasma levels of the dihydropyridine calcium channel blocker.

Abstract: Representative methods, apparatus and systems are disclosed for blood pressure and other vital sign monitoring using arterial applanation tonometry, including ambulatory blood pressure and other vital sign monitoring. A representative system comprises a wearable apparatus. The various embodiments measure blood pressure and other vital sign monitoring using a plurality of pressure sensors of a pressure sensor array, with one or more of the pressure sensors 140 applanating an artery, such as a radial artery. In a first embodiment, a pressure sensor signal is utilized which has the highest cross-coherence with the signals of its nearest pressure sensor neighbors of the pressure sensor array. In a second embodiment, Kalman filtering is utilized for the pressure sensor signals from the pressure sensor array.

Abstract: Provided herein are thermoresponsive polymer materials and methods of preparation and use thereof. In particular, materials are provided that cure upon exposure to physiologic conditions (e.g., human body temperature) and find use in, for example, orthopedic surgery, bone tissue engineering, and the repair of bone injuries and defects.

Abstract: Disclosed are methods and compositions for treating, inhibiting, and/or preventing heterotopic ossification in a subject in need thereof. Particularly disclosed are methods for treating, inhibiting, and/or preventing heterotopic ossification in a subject in need thereof by administering to the subject a therapeutic agent such as an immune checkpoint inhibitor and/or Fetuin-A or a variant thereof. Also disclosed are pharmaceutical compositions and pharmaceutical kits comprising an immune checkpoint inhibitor and/or Fetuin-A or a variant thereof for treating, inhibiting, and/or preventing heterotopic ossification in a subject in need thereof.

Abstract: Knitmorphs and methods of knitmophing include knitting one or more yarn materials into knitted structure having a first shape. A thermal load may then be applied to all or part of the knitted structure to deform the knitted structure into a second shape. The thermal load can be removed to return the knitted structure to the first shape or a hardening agent can be applied to lock the knitted structure in the second shape.

Abstract: In an aspect, disclosed herein is a compound characterized by formula (FX1): A1-X1—X2-A2 (FX1); wherein: A1 is a carboxylic acid group, a carboxylate anion, or a carboxylate ester, X1 is a substituted or unsubstituted and saturated or unsaturated C1-C50 aliphatic group; X2 is a linker group selected from the group consisting of a direct bond, an organic group, -0-, —S—, —S(?O)—, —S(?O)2—, —S—S—, —N?, ?N—, —N(H)—, —N?N—N(H)—, —N(H)—N?N—, —N(OH)—, —N(?O)—, and any combination thereof; and A2 is a peptide, the peptide being terlipressin or a substituted or unsubstituted derivative, a substituted or unsubstituted natural or synthetic analogue, a substituted or unsubstituted variant, a substituted or unsubstituted isomer, or a substituted or unsubstituted fragment of terlipressin.

Abstract: The present disclosure describes systems and methods to evaluate auditory efferent function by exposing a patient to short-duration acoustic click stimuli to generate a click-evoked otoacoustic emission (CEOAE) occurring in each ear of the patient, and in response to exposing the patient to click stimuli, concurrently sampling outer hair cell activity (OHC) and medial olivocochlear reflex (MOCR; efferents) in each ear of the patient, monitoring the middle ear muscle reflex (MEMR) in each ear of the patient, and measuring a change in cochlear activity in the patient based on the CEOAE, MOCR, and MEMR of each ear of the patient.

Abstract: Disclosed are complexes and methods of using the complexes as catalysts for addition of amines to unsaturated electrophiles, as well as novel compounds produced by the disclosed complexes and methods. The disclosed methods may utilize the disclosed complexes as catalysts for adding unprotected primary amines and secondary amines to unsaturated electrophiles in an enantioselective manner to produce novel compounds which may include amino substituted succinimide compounds.

Abstract: Oxygen electrodes are provided, comprising a perovskite compound having Formula (I), Sr(Ti1-xFex-yCoy)O3-?wherein 0.90?x?0.40 and 0.02?y?0.30. Electrochemical devices comprising such oxygen electrodes are also provided, comprising a counter electrode in electrical communication with the oxygen electrode, and a solid oxide electrolyte between the oxygen electrode and the counter electrode. Methods of using such electrochemical devices are also provided, comprising exposing the oxygen electrode to a fluid comprising O2 under conditions to induce the reaction O2+4e??2O2?, or to a fluid comprising O2? under conditions to induce the reaction 2O2??O2+4e?.

Abstract: Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of IDO protein. The disclosed PROTACs typically include a first targeting moiety that binds to IDO (MIDO). The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula MIDO-L-ME3 or ME3-L-MIDO.

Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Abstract: Printable inks based on a 2D semiconductor, such as MoS2, and its applications in fully inkjet-printed optoelectronic devices are disclosed. Specifically, percolating films of MoS2 nanosheets with superlative electrical conductivity (10-2 s m?1) are achieved by tailoring the ink formulation and curing conditions. Based on an ethyl cellulose dispersant, the MoS2 nanosheet ink also offers exceptional viscosity tunability, colloidal stability, and printability on both rigid and flexible substrates. Two distinct classes of photodetectors are fabricated based on the substrate and post-print curing method. While thermal annealing of printed devices on rigid glass substrates leads to a fast photoresponse of 150 ?s, photonically annealed devices on flexible polyimide substrates possess high photoresponsivity exceeding 50 mA/W.

Abstract: Systems and/or methods can include techniques to exploit dynamic timing slack on the chip. By using a special clock generator, the clock period can be shrunk as needed at every cycle. The clock period is determined during operation by checking “critical path messengers” to indicate how much dynamic timing slack exists. Elastic pipeline timing can also be introduced to redistribute timing among pipeline stages to bring further benefits.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: Provided herein are medical devices comprising a plurality of biologically interactive devices configured for interacting with a large area biological surface. The biologically interactive devices each may comprise a sensor for measuring a physiological parameter. A wireless controller is configured to wirelessly operate the plurality of biologically interactive devices. A wireless transmitter is configured for wirelessly communicating an output from said plurality of biologically interactive devices to a remote receiver. The medical devices are particularly suited for measuring one or both of pressure and temperature, with compatibility for incorporating additional sensors of interest.