Patents Assigned to Okayama University
  • Patent number: 11986353
    Abstract: An ultrasonic diagnostic device according to an embodiment includes processing circuitry. The processing circuitry estimates a health state on the basis of a measurement value measured using ultrasonic image data. The processing circuitry determines an additional examination used to diagnose the health state, on the basis of the estimated health state. The processing circuitry outputs information indicative of the health state and the additional examination.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: May 21, 2024
    Assignees: National University Corporation Okayama University, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Norihisa Toh, Kousuke Namiki, Koichiro Kurita
  • Publication number: 20240124571
    Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.
    Type: Application
    Filed: November 17, 2023
    Publication date: April 18, 2024
    Applicant: National University Corporation Okayama University
    Inventors: Masakiyo SAKAGUCHI, Shinichi TOYOOKA, Shuta TOMIDA, Kazuhiko SHIEN, Hiroki SATO, Rie KINOSHITA, Junichiro FUTAMI, Kota ARAKI, Mikio OKAZAKI, Eisaku KONDO, Yusuke INOUE, Akira YAMAUCHI
  • Patent number: 11933725
    Abstract: A method is provided that allows the sulfur component concentration in gasoline to be estimated to high precision. The measuring method of the disclosure is a method of measuring the concentration of sulfur components in gasoline that contains sulfur components and aromatic components. The measuring method of the disclosure comprises: (A1) removing a portion of the gasoline by gasification to lower the proportion of the aromatic component concentration with respect to the sulfur component concentration in the gasoline, (A2) measuring values related to the refractive index of the gasoline, and (A3) measuring the sulfur component concentration in the gasoline based on the values related to the refractive index.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: March 19, 2024
    Assignees: Toyota Jidosha Kabushiki Kaisha, National University Corporation Okayama University
    Inventors: Akihiro Honda, Hideki Fukano
  • Patent number: 11858984
    Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: January 2, 2024
    Assignees: National University Corporation Okayama University, Niigata University, National University Corporation Gunma University
    Inventors: Masakiyo Sakaguchi, Shinichi Toyooka, Shuta Tomida, Kazuhiko Shien, Hiroki Sato, Rie Kinoshita, Junichiro Futami, Kota Araki, Mikio Okazaki, Eisaku Kondo, Yusuke Inoue, Akira Yamauchi
  • Patent number: 11835516
    Abstract: Provided are a determination method and a kit both for determining the possibility of the occurrence of deterioration of a renal function in the future. A method according to one aspect of the present invention involves a step of determining the level of Gal?1-3GalNAc and/or Sia?2-6Gal/GalNAc in a sample collected from a subject. A kit according to one aspect of the present invention includes a lectin capable of binding to Gal?1-3GalNAc and/or Sia?2-6Gal/GalNAc.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: December 5, 2023
    Assignees: National University Corporation Okayama University, Glycotechnica Ltd.
    Inventors: Jun Wada, Koki Mise, Masao Yamada
  • Publication number: 20230303543
    Abstract: The present invention provides a novel compound that can be used as a lactate dehydrogenase inhibitor or an active ingredient of a medicament such as an antiepileptic agent and an anti-cancer agent, and particularly, provides a novel compound excellent in metabolic stability. The novel compound according to the present invention is a compound represented by the following formula (1). In formula (1), R represents any substituent (for example, a monovalent substituent of an aromatic or non-aromatic 3 to 14-membered ring which may be unsubstituted or substituted and monocyclic or polycyclic), Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh and Ri each represent a hydrogen atom or any substituent (for example, Ra to Ri are all hydrogen atoms, or Re, Rf, Rg, Rh and Ri are hydrogen atoms and at least one of Ra, Rb, Rc and Rd is any substituent).
    Type: Application
    Filed: July 30, 2021
    Publication date: September 28, 2023
    Applicant: National University Corporation Okayama University
    Inventors: Tsuyoshi INOUE, Nagisa SADA
  • Publication number: 20230210834
    Abstract: An RNA methyltransferase inhibitor comprising sulfonamide-based compounds and/or pyrazoline-based compounds is provided
    Type: Application
    Filed: August 26, 2020
    Publication date: July 6, 2023
    Applicants: National University Corporation Okayama University, General Incorporated Association Pharma Valley Project Supporting Organization, National University Corporation Kumamoto University
    Inventors: Atsushi FUJIMURA, Kengo INOUE, Takayuki ANDO, Yoshinobu ISHIKAWA, Kazuhito TOMIZAWA
  • Publication number: 20220364129
    Abstract: The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.
    Type: Application
    Filed: July 13, 2022
    Publication date: November 17, 2022
    Applicant: National University Corporation Okayama University
    Inventor: Akio Tani
  • Publication number: 20220357217
    Abstract: An object provide a technique capable of measuring temperature on the basis of optically detected magnetic resonance with higher precision, The object is achieved by a method for measuring the temperature of an object on the basis of optically detected magnetic resonance of an inorganic fluorescent particle, including (a) irradiating the object, containing the inorganic fluorescent particle with each of multiple microwaves having different frequencies, (b) measuring the fluorescence intensities of the inorganic fluorescent particle with individual photon counters at the time of irradiation of respective microwaves, (c) correcting the fluorescence intensities on the basis of dependencies in the number of pulse measurements between the photon counters and (d) Calculating the temperature of the object on the basis of the obtained fluorescence intensity with the correction values.
    Type: Application
    Filed: June 25, 2020
    Publication date: November 10, 2022
    Applicant: National University Corporation Okayama University
    Inventor: Masazumi FUJIWARA
  • Publication number: 20220316101
    Abstract: One aspect of the present disclosure relates to a method for manufacturing a spun yarn made of carbon nanotubes. The method includes: a spun yarn precursor ? production step of producing a spun yarn precursor ? by pulling a plurality of carbon nanotubes from a carbon nanotube forest and spinning the carbon nanotubes while applying a tension of 6 mN or less per centimeter of a width of the carbon nanotube forest to the carbon nanotubes; a spun yarn precursor ? production step of producing a spun yarn precursor ? by applying a higher tension than in the spun yarn precursor ? production step to the spun yarn precursor ? to densify the spun yarn precursor ?; and a spun yarn production step of producing the spun yarn by electrically heating the spun yarn precursor ? while applying a tension to the spun yarn precursor ?.
    Type: Application
    Filed: March 31, 2022
    Publication date: October 6, 2022
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Okayama University
    Inventors: Akira KUNITOMO, Kazuhiko TAKAHASHI, Yasuhiko HAYASHI, Hirotaka INOUE, Kensuke UEHARA
  • Patent number: 11390897
    Abstract: The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 19, 2022
    Assignee: National University Corporation Okayama University
    Inventor: Akio Tani
  • Patent number: 11246948
    Abstract: An embodiment relates to a method of evaluating a lymphatic system function including: selecting one or a plurality of lymphatic routes to be evaluated from a plurality of lymphatic routes existing in four limbs; determining an injection site of a visualization agent based on information on the selected lymphatic route and injection sites of peripheries of the four limbs corresponding to the selected lymphatic route; injecting the visualization agent from the selected injection site; and visualizing the injected visualization agent and evaluating functions of the one or plurality of lymphatic routes to be evaluated.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: February 15, 2022
    Assignees: National University Corporation Okayama University, HAMAMATSU PHOTONICS K.K.
    Inventors: Akira Shinaoka, Yoshihiro Kimata, Aiji Ohtsuka, Takahiro Shikayama
  • Publication number: 20210401406
    Abstract: An ultrasonic diagnostic device according to an embodiment includes processing circuitry. The processing circuitry estimates a health state on the basis of a measurement value measured using ultrasonic image data. The processing circuitry determines an additional examination used to diagnose the health state, on the basis of the estimated health state. The processing circuitry outputs information indicative of the health state and the additional examination.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 30, 2021
    Applicants: National University Corporation Okayama University, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Norihisa TOH, Kousuke NAMIKI, Koichiro KURITA
  • Publication number: 20210164004
    Abstract: The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 3, 2021
    Applicant: National University Corporation Okayama University
    Inventor: Akio Tani
  • Publication number: 20210156797
    Abstract: A method is provided that allows the sulfur component concentration in gasoline to be estimated to high precision. The measuring method of the disclosure is a method of measuring the concentration of sulfur components in gasoline that contains sulfur components and aromatic components. The measuring method of the disclosure comprises: (A1) removing a portion of the gasoline by gasification to lower the proportion of the aromatic component concentration with respect to the sulfur component concentration in the gasoline, (A2) measuring values related to the refractive index of the gasoline, and (A3) measuring the sulfur component concentration in the gasoline based on the values related to the refractive index.
    Type: Application
    Filed: November 9, 2020
    Publication date: May 27, 2021
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Okayama University
    Inventors: Akihiro HONDA, Hideki FUKANO
  • Patent number: 10940210
    Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: March 9, 2021
    Assignee: National University Corporation Okayama University
    Inventors: Hideki Matsui, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi
  • Publication number: 20210054061
    Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.
    Type: Application
    Filed: April 15, 2019
    Publication date: February 25, 2021
    Applicants: National University Corporation Okayama University, NIIGATA UNIVERSITY, National University Corporation Gunma University, Kawasaki Gakuen Educational Foundation
    Inventors: Masakiyo SAKAGUCHI, Shinichi TOYOOKA, Shuta TOMIDA, Kazuhiko SHIEN, Hiroki SATO, Rie KINOSHITA, Junichiro FUTAMI, Kota ARAKI, Mikio OKAZAKI, Eisaku KONDO, Yusuke INOUE, Akira YAMAUCHI
  • Patent number: 10894088
    Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: January 19, 2021
    Assignee: National University Corporation Okayama University
    Inventors: Hideki Matsui, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi
  • Publication number: 20200397910
    Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 24, 2020
    Applicant: National University Corporation Okayama University
    Inventors: HIDEKI MATSUI, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi
  • Patent number: 10782296
    Abstract: This invention provides an anti-REIC antibody that specifically recognizes a cancer-associated protein (REIC/Dkk-3) and enables monitoring of cancer treatment effects involving the use of the REIC/Dkk-3 gene or the REIC/Dkk-3 protein as a medicine. This invention also provides a method of diagnosis involving the use of such antibody.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: September 22, 2020
    Assignees: National University Corporation Okayama University, Momotaro-Gene Inc.
    Inventors: Hiromi Kumon, Rie Kinoshita, Junichiro Futami