Patents Assigned to Okayama University
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Publication number: 20210164004Abstract: The present invention relates to a method including culturing a C1 compound-assimilating bacterium, which is a methylotroph, and/or a yeast by using a medium comprising, for example, a C1 compound and/or glycerol as a carbon source, to thereby produce EGT.Type: ApplicationFiled: December 21, 2015Publication date: June 3, 2021Applicant: National University Corporation Okayama UniversityInventor: Akio Tani
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Publication number: 20210156797Abstract: A method is provided that allows the sulfur component concentration in gasoline to be estimated to high precision. The measuring method of the disclosure is a method of measuring the concentration of sulfur components in gasoline that contains sulfur components and aromatic components. The measuring method of the disclosure comprises: (A1) removing a portion of the gasoline by gasification to lower the proportion of the aromatic component concentration with respect to the sulfur component concentration in the gasoline, (A2) measuring values related to the refractive index of the gasoline, and (A3) measuring the sulfur component concentration in the gasoline based on the values related to the refractive index.Type: ApplicationFiled: November 9, 2020Publication date: May 27, 2021Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Okayama UniversityInventors: Akihiro HONDA, Hideki FUKANO
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Patent number: 10987372Abstract: It is an object of the present invention to provide a novel therapeutic agent for hepatoma viruses. Specifically, the present invention relates to an anti-hepatoma virus agent, containing as an active ingredient a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 is fluorine or hydrogen).Type: GrantFiled: March 10, 2017Date of Patent: April 27, 2021Assignees: KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, DAIKIN INDUSTRIES, LTD.Inventors: Masanori Ikeda, Midori Takeda, Masanori Baba, Nobuyuki Kato
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Patent number: 10940210Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.Type: GrantFiled: September 10, 2020Date of Patent: March 9, 2021Assignee: National University Corporation Okayama UniversityInventors: Hideki Matsui, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi
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Publication number: 20210054061Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.Type: ApplicationFiled: April 15, 2019Publication date: February 25, 2021Applicants: National University Corporation Okayama University, NIIGATA UNIVERSITY, National University Corporation Gunma University, Kawasaki Gakuen Educational FoundationInventors: Masakiyo SAKAGUCHI, Shinichi TOYOOKA, Shuta TOMIDA, Kazuhiko SHIEN, Hiroki SATO, Rie KINOSHITA, Junichiro FUTAMI, Kota ARAKI, Mikio OKAZAKI, Eisaku KONDO, Yusuke INOUE, Akira YAMAUCHI
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Patent number: 10894088Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.Type: GrantFiled: November 24, 2017Date of Patent: January 19, 2021Assignee: National University Corporation Okayama UniversityInventors: Hideki Matsui, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi
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Publication number: 20210005887Abstract: A positive electrode material which is used in a positive electrode of a lithium ion secondary battery disclosed here includes a positive electrode active material including a compound capable of storing and releasing lithium ions, a first coating material disposed on at least a part of the surface of the positive electrode active material, and a second coating material disposed on at least a part of the surface of the positive electrode active material. The positive electrode material is characterized in that the first coating material contains a nickel oxide having a rock salt structure, and the second coating material contains a titanium oxide.Type: ApplicationFiled: June 10, 2020Publication date: January 7, 2021Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Daisuke HORIKAWA, Yuji YAMAMOTO, Takashi TERANISHI
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Publication number: 20200397910Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.Type: ApplicationFiled: September 10, 2020Publication date: December 24, 2020Applicant: National University Corporation Okayama UniversityInventors: HIDEKI MATSUI, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi
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Patent number: 10873089Abstract: A positive electrode material for a lithium secondary battery of the present disclosure includes a positive electrode active material, a barium titanate-based dielectric, and at least one of Compound I which contains the element Ba and has the largest peak at a position with 2?=24° to 26° in an X-ray diffraction pattern obtained according to X-ray diffraction measurement using CuK? rays; and Compound II which contains the element Ti and has the largest peak at a position with 2?=26° to 28° in an X-ray diffraction pattern obtained according to X-ray diffraction measurement using CuK? rays. At least one of Compounds I and II is disposed in contact with the dielectric.Type: GrantFiled: December 10, 2018Date of Patent: December 22, 2020Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Daisuke Horikawa, Ryuta Sugiura, Takashi Teranishi
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Publication number: 20200388835Abstract: A positive electrode imparts secondary battery with low temperature output characteristics, high temperature cycle characteristics and durability against high voltage. A positive electrode of secondary battery includes positive electrode current collector and positive electrode active substance layer on positive electrode current collector. The positive electrode active substance layer contains positive electrode active substance particles and oxide particles which are dispersed in positive electrode active substance layer as separate particles from positive electrode active substance particles. The positive electrode active substance particles each include coating of titanium-containing compound at the surface. The titanium-containing compound in coating is at least one compound selected from group consisting of TiO2, TinO2n?1, wherein n is integer of 3 or more, and oxides containing Li and Ti.Type: ApplicationFiled: May 26, 2020Publication date: December 10, 2020Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Daisuke HORIKAWA, Yuji YAMAMOTO, Takashi TERANISHI
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Publication number: 20200388834Abstract: Provided is a positive electrode material which can impart a lithium secondary battery with excellent low temperature output characteristics, excellent high temperature cycle characteristics and excellent durability against high voltage. A positive electrode material of a lithium secondary battery disclosed here includes a positive electrode active substance particle, a Li-free first coating at the surface of the positive electrode active substance particle, and a Li-containing second coating at the surface of the positive electrode active substance particle. The first coating contains a titanium oxide represented by TiO2 or TinO2n-1, wherein n is an integer of 3 or more. The second coating contains a composite oxide containing Li and Ti, wherein the ratio of the number of atoms of Li relative to the number of atoms of Ti is at least 0.1 and at most 3.Type: ApplicationFiled: May 26, 2020Publication date: December 10, 2020Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Daisuke HORIKAWA, Yuji YAMAMOTO, Takashi TERANISHI
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Publication number: 20200388840Abstract: Provided is a positive electrode material which can impart a secondary battery with excellent low temperature output characteristics, excellent high temperature cycle characteristics and excellent durability against high voltage. A positive electrode material of a secondary battery disclosed here includes a positive electrode active substance particle and a coating containing a titanium-containing compound at the surface of the positive electrode active substance particle. A layer having a higher Ti concentration than the Ti concentration at a depth of 500 nm from the surface is formed in a surface portion of the positive electrode active substance particle. The titanium-containing compound in the coating is at least one compound selected from the group consisting of TiO2, TinO2n?1, wherein n is an integer of 3 or more, and oxides containing Li and Ti.Type: ApplicationFiled: June 2, 2020Publication date: December 10, 2020Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Daisuke HORIKAWA, Yuji YAMAMOTO, Takashi TERANISHI
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Publication number: 20200324001Abstract: This invention provides a DNA comprising any of the following (a) to (c): (a) a DNA comprising any of the base sequences of positions 16 to 831 of SEQ ID NO: 1, positions 16 to 822 of SEQ ID NO: 3, positions 16 to 825 of SEQ ID NO: 5, positions 16 to 819 of SEQ ID NO: 7, positions 16 to 834 of SEQ ID NO: 9, and positions 16 to 828 of SEQ ID NO: 11; (b) a DNA encoding a polypeptide comprising any of the amino acid sequences of positions 1 to 272 of SEQ ID NO: 2, positions 1 to 269 of SEQ ID NO: 4, positions 1 to 270 of SEQ ID NO: 6, positions 1 to 268 of SEQ ID NO: 8, positions 1 to 273 of SEQ ID NO: 10, and positions 1 to 271 of SEQ ID NO: 12; and (c) a complementary strand of the DNA (a) or (b).Type: ApplicationFiled: March 27, 2018Publication date: October 15, 2020Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Eiji MATSUURA, Kazuko KOBAYASHI, Fumiaki TAKENAKA
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Patent number: 10791622Abstract: A printed wiring board of the present disclosure that includes a power supply layer and a ground layer. A power supply layer pattern formed in the power supply layer includes a power supply layer electrode and a branch that is a direct-current power feeding path connecting adjacent electromagnetic band gap (EBG) unit cells. A capacitive coupling element including a capacitive coupling element body is disposed to oppose the power supply layer electrode with an interlayer provided therebetween.Type: GrantFiled: July 20, 2017Date of Patent: September 29, 2020Assignees: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, KYOCERA CORPORATIONInventors: Yoshitaka Toyota, Kengo Iokibe, Xingxiaoyu Lin, Toshiyuki Kaneko, Masanori Naito, Toshihisa Uehara
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Patent number: 10782296Abstract: This invention provides an anti-REIC antibody that specifically recognizes a cancer-associated protein (REIC/Dkk-3) and enables monitoring of cancer treatment effects involving the use of the REIC/Dkk-3 gene or the REIC/Dkk-3 protein as a medicine. This invention also provides a method of diagnosis involving the use of such antibody.Type: GrantFiled: September 27, 2016Date of Patent: September 22, 2020Assignees: National University Corporation Okayama University, Momotaro-Gene Inc.Inventors: Hiromi Kumon, Rie Kinoshita, Junichiro Futami
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Patent number: 10709688Abstract: This invention provides a pharmaceutical composition for treating or preventing synucleinopathy comprising a compound represented by formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 31, 2017Date of Patent: July 14, 2020Assignees: Tohoku University, National University Corporation Okayama UniversityInventors: Kohji Fukunaga, Hiroyuki Miyachi, Hiroaki Ishida, Shintaro Ban
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Patent number: 10682330Abstract: In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.Type: GrantFiled: March 22, 2013Date of Patent: June 16, 2020Assignees: ENSUIKO SUGAR REFINING CO., LTD., HIROKI HAMADA, YOSHIO SHIMIZU, NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Hiroki Hamada, Ichiro Fujiwara, Masaharu Seno, Tomonari Kasai, Tsukasa Shigehiro, Masaharu Murakami, Katsuhiko Mikuni
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Publication number: 20200179353Abstract: A method for treating an inflammatory respiratory disease, comprising administering an effective amount of an RXR agonist represented by formula (1) or (2) as an active ingredient. wherein D, R1, R2, X, Y, Z, R3, R4, X1, Y1, X2, Y2 and Z1 are defined.Type: ApplicationFiled: September 9, 2016Publication date: June 11, 2020Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITYInventors: Arihiko KANEHIRO, Utako FUJII, Daisuke MORICHIKA, Naohiro ODA, Nobuaki MIYAHARA, Akihiko TANIGUCHI, Hiroki KAKUTA
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Publication number: 20200121800Abstract: The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.Type: ApplicationFiled: November 24, 2017Publication date: April 23, 2020Applicant: National University Corporation Okayama UniversityInventors: Hideki MATSUI, Shuichi FURUYA, Hiroyuki MICHIUE, Hiroki KAKUTA, Yusuaki TAKEUCHI
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Patent number: 10542622Abstract: A printed wiring board of the present disclosure includes a power supply layer and a ground layer. A power supply layer pattern to be formed partially on the power supply layer includes a branch and a power supply layer electrode. The branch is a direct-current power feeding path for connecting adjacent electromagnetic band gap (EBG) unit cells, and the power supply layer electrode is connected through a slit provided along the branch. A capacitive coupling element disposed to oppose the power supply layer electrode with an interlayer being provided therebetween has a structure in which the EBG unit cells are disposed at regular intervals, the EBG unit cells being connected to the branch in the power supply layer pattern through a via.Type: GrantFiled: July 20, 2017Date of Patent: January 21, 2020Assignees: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, KYOCERA CORPORATIONInventors: Yoshitaka Toyota, Kengo Iokibe, Xingxiaoyu Lin, Toshiyuki Kaneko, Masanori Naito, Toshihisa Uehara