Abstract: The present invention relates to the use of certain ?-lactamase inhibitors in conjunction with one or more ?-lactam antibiotics for the treatment of Strenotrophomonas maltophilia, tuberculosis or Pseudomonas species infections.

Abstract: The invention relates to a process for producing a crystalline A/M/X material, which crystalline A/M/X material comprises a compound of formula [A]a[M]b[X]c wherein: [A] comprises one or more A cations; [M] comprises one or more M cations which are metal or metalloid cations; [X] comprises one or more X anions; a is a number from 1 to 6; b is a number from 1 to 6; and c is a number from 1 to 18. The process is capable of producing crystalline A/M/X materials while precisely controlling their stoichiometry, leading to products with finely tunable optical properties such as peak emission wavelength. The invention also relates to process for producing a thin film comprising the crystalline A/M/X material of the invention, and to a thin film obtainable by the process of the invention. An optoelectronic device comprising the thin film is also provided.

Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orfl, E4Orf2 and E4Orf3 coding regions from AdY25.

Abstract: A process for analysing chromosome interactions relating to immunotherapy of cancer.

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.

Abstract: New breeder blanket designs and configurations for use in a nuclear fusion reactor to breed Tritium fuel are presented. The breeder blanket designs consist of steel conduits made of different sections, formed of different steels, which are used for the circulation of liquid breeder material.

Abstract: An electrolyser (F) for generating hydrogen from water, the electrolyser comprising an electrode (102), the electrode (120) comprising nanoparticles selected from Group 1 nanoparticles or alloys or composites or mixtures thereof.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: The present invention relates to a method of producing a 3D centerline of an organ vessel from a plurality of 2D x-ray images. The method comprises the steps of producing a point-cloud of 3D points which represent intersecting and non-intersecting points between projection lines from the 2D images to their respective x-ray sources; fitting a compound curve to the points in the point-cloud of 3D points; removing outliers from the point-cloud; fitting a new compound curve to the remaining points in the point-cloud of 3D points; and repeating certain steps, wherein the resultant compound curve represents the 3D centerline of the organ vessel. The method minimizes reconstruction errors and produces an optimally-reconstructed 3D vessel skeleton.

Abstract: A time-ordered series of measurements of a polymer made during translocation of the polymer through a Nanopore are analysed. The measurements are dependent on the identity of k-mers in the Nanopore, a k-mer bring k polymer units of the polymer, where k is a positive integer. The method involves deriving, from the series of measurements, a feature vector of time-ordered features representing characteristics of the measurements; and determining similarity between the derived feature vector and at least one other feature vector.

Abstract: A method of amplifying a target polynucleotide, comprising: providing a template polynucleotide comprising a 5? hairpin, a target polynucleotide and a 3? hairpin, wherein the 5? hairpin comprises one or more non-canonical nucleotides and contacting the template polynucleotide with a polymerase and canonical nucleotides, wherein the polymerase extends, using the canonical nucleotides, the target polynucleotide from its 3? end to form a first extended polynucleotide comprising the 5? hairpin at its 5? end and the complement of the 5? hairpin at its 3? end, wherein the complement of the 5? hairpin forms a 3? hairpin; and the polymerase extends the first extended polynucleotide from its 3? end to form a second extended polynucleotide comprising the 5? hairpin at its 5? end and the complement of the 5? hairpin at its 3? end, wherein the complement of the 5? hairpin forms a 3? hairpin.

Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.

Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.

Abstract: The disclosure concerns a method for producing a pool of fragments derived from a microbial protein. The disclosure also concerns a pool of fragments derived from a microbial protein, and a method for determining the presence or absence of immune cells targeting a microbe.

Abstract: The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: The present invention relates to particles, particularly virus-like particles (VLPs), comprising fusion polypeptides comprising selected repeat units derived from the repeating regions of Type I and Type II circumsporozoite proteins (CSP) of Plasmodium vivax (Pv), together with an amino acid sequence derived from the C-terminal PvCSP sequence. In some embodiments, the fusion polypeptide additionally comprises an amino acid sequence derived from the N-terminal PvCSP sequence and/or a surface antigen polypeptide derived from Hepatitis B virus (HBV-S). The invention also relates to nucleotide sequences coding for such fusion polypeptides, vectors and plasmids comprising such nucleotide sequences, and host cells comprising such vectors and plasmids. The invention additionally relates to compositions, particularly vaccine compositions, comprising the fusion polypeptides or VLPs for use as vaccines for the prevention of malaria.

Abstract: The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

Abstract: The present invention provides a computer system and method for clustering data points. The system comprises a computer server and a client device, wherein the computer server is configured to: store a dataset comprising a plurality of data points; determine a plurality of candidate clusters for the plurality of data points, where each candidate cluster corresponds to a respective set of the plurality of data points; determine, for each candidate cluster, one or more properties of that candidate cluster; and transmit, to the client device, a sample of the plurality of data points, information indicative of the plurality of candidate clusters, and information indicative of the one or more properties determined for each candidate cluster.