Patents Assigned to Oxford
  • NANOPORE SENSING DEVICE
    Publication number: 20230349882
    Abstract: A nanopore sensing device comprises a planar structure provided with plural fluidic passages extending between the first and second chambers. The planar structure supports nanopores in membranes across respective passages and sensor electrodes are arranged to sense a fluidic electrical potential in respective passages between the nanopores and the second chamber. The passages comprise planar fluidic resistor portions between the sensor electrode and the second chamber, the planar fluidic resistor portions extending in a planar direction of the planar structure and being configured to form a fluidic resistor.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 2, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Ping Xie, Justin Millis, Rhodri Davies
  • CELL CLASSIFICATION ALGORITHMS, AND USE OF SUCH ALGORITHMS TO INFORM AND OPTIMISE MEDICAL TREATMENTS
    Publication number: 20230349803
    Abstract: The invention provides a method of investigating the spatial organisation of proteins in or on cells, and the use of that spatial organisation information to inform decisions about medical interventions, especially in relation to cancer treatments including CAR-T therapy. The method involves detecting one or more species of proteins on each of the plurality of cells; obtaining respective spatial coordinates of the detected proteins within the plurality of cells; detecting boundaries of the plurality of cells; and constructing a data vector based on the obtained spatial coordinates and the detected boundaries.
    Type: Application
    Filed: September 10, 2021
    Publication date: November 2, 2023
    Applicant: Oxford Nanoimaging Limited
    Inventors: Andras G. Miklosi, James H. Felce, Bo Jing, Tyler Ralston
  • Detection processes using sites of chromosome interaction
    Patent number: 11802305
    Abstract: A process for analysing epigenetically active regions of the genome.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: October 31, 2023
    Assignee: Oxford Biodynamics PLC
    Inventors: Alexandre Akoulitchev, Ewan Hunter, Aroul Ramadass
  • 2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase
    Patent number: 11802110
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(arylsulfinyl)-acetamide compounds that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-t RNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 31, 2023
    Assignee: Oxford Drug Design Limited
    Inventors: Paul William Finn, Michael Charlton, Grace Edmund, Aigars Jirgensons, Einars Loza
  • Methods and systems for optimizing sampling efficiency of dynamically sampled magnetic resonance imaging (MRI)
    Patent number: 11802926
    Abstract: The present disclosure is directed to radially-based magnetic resonance imaging. In any one or more embodiments, the present methods and systems provide that the angular increment between subsequent radial k-space spokes to be sampled to provide the imaging is performed for a predetermined or pre-defined restricted set of reconstruction window sizes (numbers of radial spokes per frame), or limited views, to maximize the uniformity of sampling within the restricted set of window sizes.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: October 31, 2023
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Sonja Sophie Schauman, Mark Chiew, Thomas Okell
  • Photovoltaic device comprising a metal halide perovskite and a passivating agent
    Patent number: 11799039
    Abstract: The present invention relates to devices comprising metal halide perovskites and organic passivating agents. In particular, the invention relates to photovoltaic and optoelectronic devices comprising passivated metal halide perovskites. The device according to the invention comprises: (a) a metal halide perovskite; and (b) a passivating agent which is an organic compound; wherein molecules of the passivating agent are chemically bonded to anions or cations in the metal halide perovskite.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: October 24, 2023
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Henry J. Snaith, Antonio Abate, Nakita K. Noel
  • Medical imaging
    Patent number: 11796619
    Abstract: Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: October 24, 2023
    Assignee: Oxford University Innovation Limited
    Inventors: Steven Chance, Rebecca McKavanagh, Mark Jenkinson, Karla Miller
  • Polymer compositions
    Patent number: 11795290
    Abstract: The invention relates to novel a high-volume swelling hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, and/or a semi-interpenetrating network and/or simple cross-linked arrangement of a plurality of one or more species of hydrophilic polymers, optionally together with one or more biocompatible polymers and optionally together with one or more plasticising agents, characterised in that at least some of the pores are at least partially collapsed and/or flattened, and further characterised in that the interpenetrating network and/or semi-interpenetrating network and/or cross-linked arrangement which defines the collapsed and/or flattened pores is substantially unbroken. The invention also relates to a process for preparing such hydrogels, and to their use as an appetite suppressant.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: October 24, 2023
    Assignee: OXFORD MEDICAL PRODUCTS LIMITED
    Inventors: Anthony John Fitzpatrick, Xue Min, Jan Tadeusz Czernuszka
  • Collision avoidance for particle beam instruments
    Patent number: 11798774
    Abstract: A system for preventing collisions between components in a particle beam instrument is disclosed. The system is particularly beneficial in use with instruments wherein moveable components are used within a chamber that obscures them from being viewed from outside the chamber. The system comprises: a capacitance sensor configured to monitor the capacitance between a first component and a second component of the instrument, and a proximity module configured to: derive a capacitance parameter from the monitored capacitance between the first component and the second component; and output a proximity alert signal in accordance with a comparison between the derived capacitance parameter and a predetermined capacitance parameter threshold value.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: October 24, 2023
    Assignee: OXFORD INSTRUMENTS NANOTECHNOLOGY TOOLS LIMITED
    Inventors: Stuart Andrew Swan, Grigore Moldovan, Angus Bewick
  • Epigenetic chromosome interactions
    Patent number: 11795496
    Abstract: A method of determining responsiveness to therapy for rheumatoid arthritis.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: October 24, 2023
    Assignee: Oxford Biodynamics PLC
    Inventors: Aroul Ramadass, Ewan Hunter, Alexandre Akoulitchev
  • A DIAGNOSTIC DEVICE SUITABLE FOR DETECTION OF PATHOGENS, AND DETECTION METHODS USING SUCH A DEVICE
    Publication number: 20230333020
    Abstract: A detection system suitable for detecting pathogens present in a sample is presented. The detection system includes: a microfluidic channel configured to receive a sample solution containing a target biochemical component and configured to support a flow of the sample solution; an imaging lens; an excitation light source configured to emit an excitation light into a focal volume of the imaging lens; and a detector. The microfluidic channel comprises an observation section where the flow is aligned with respect to a central axis of the imaging lens such that the focal volume is within the observation section and the target biochemical component moves through a focal plane of the imaging lens during a movement along the observation section. The detector is configured to detect a light signal emitted by the target biochemical component on excitation with the excitation light.
    Type: Application
    Filed: May 28, 2021
    Publication date: October 19, 2023
    Applicant: Oxford Nanoimaging Limited
    Inventors: Bo Jing, Liyana Valiya Peedikakkal, Matthias Steiner
  • Determining the location of a mobile device
    Patent number: 11788843
    Abstract: A computer-implemented method of determining a location of a mobile device is provided. The method can include receiving inertial data generated at the mobile device, the inertial data including a plurality of samples taken at different times, segmenting the inertial data into pseudo-independent windows, wherein each pseudo-independent window can include a plurality of the samples and wherein one or more initial states for each pseudo-independent window are treated as unknown, estimating a change in navigation state over each pseudo-independent window using the samples of inertial data, and summing the changes in the navigation states over the pseudo-independent windows so as to determine the location of the mobile device.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: October 17, 2023
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Changhao Chen, Ronald Clark, Andrew Markham, Agathoniki Trigoni
  • Nanopore sensing device, components and method of operation
    Patent number: 11789006
    Abstract: Devices for improved nanopore sensing are described. An example device has a structure arranged to separate an analyte reservoir and an outlet chamber. An example device has a structure arranged to separate an analyte reservoir and an outlet chamber. The structure can include an array of nanopore structures, each nanopore structure comprising a passage for fluid connection through the structure between the analyte reservoir and outlet chamber. Control terminals can be arranged for applying a control signal to alter the electrical potential difference across that nanopore structure. Some embodiments include an electronic circuit configured to detect a signal from an electrical transduction element at each nanopore structure. Additional structural features and methods of operating and making the devices are described.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: October 17, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Ping Xie, Justin Millis, Ken Healy
  • Method and system for tracking sinusoidal wave parameters from a received signal that includes noise
    Patent number: 11790034
    Abstract: A system for tracking selected wave parameters from a received sinusoidal wave with noise and methods for making and using the same. The method includes performing a multi-track double integral analysis of the sinusoidal wave with noise and creating time dependent outputs. These time dependent outputs may be analyzed mathematically to determine the amplitude, frequency and/or phase of the wave with reduced noise. In one embodiment, the method may employ multiple passes through double integral analysis. The method advantageously can measure output sinusoidal wave parameters with reduced noise, measurements that are close to theoretical noise reduction limits.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: October 17, 2023
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventor: Manus Patrick Henry
  • Method of determining the presence or absence of a target analyte comprising using a reporter polynucleotide and a transmembrane pore
    Patent number: 11789014
    Abstract: The invention relates to a method of determining the presence or absence of a target analyte in a sample. The method comprises immobilising any target analyte present in the sample on a surface; contacting the surface with: (i) a first detection agent that binds specifically to the target analyte; and (ii) a reporter polynucleotide, wherein the reporter polynucleotide is bound to, or binds to, the first detection agent; and contacting a transmembrane pore with any reporter polynucleotide that has been immobilised on the surface, wherein the reporter polynucleotide is immobilised on the surface by binding of the first agent to the target analyte, and using the transmembrane pore to detect the reporter polynucleotide, thereby determining the presence or absence of the target analyte in the sample.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: October 17, 2023
    Assignee: Oxford Nanopore Technologies PLC
    Inventor: Daniel George Fordham
  • MICROFLUIDIC DEVICE
    Publication number: 20230311118
    Abstract: A microfluidic device comprises: a sensor provided in a sensing chamber; a liquid inlet and liquid outlet connecting to the sensor chamber for respectively passing liquid into and out of the sensing chamber and; a sample input port in fluid communication with the liquid inlet; a liquid collection channel downstream of the sensing chamber outlet; a flow path interruption between the liquid outlet and the liquid collection channel, preventing liquid from flowing into the liquid collection channel from upstream; a buffer liquid filling from the sample input port to the sensing chamber, and filling the sensing chamber and filing from the liquid outlet to the flow path interruption; an activation system operable to complete the flow path between the liquid outlet and the liquid collection channel such that the sensor remains unexposed to gas or a gas/liquid interface.
    Type: Application
    Filed: January 31, 2023
    Publication date: October 5, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventor: David Waterman
  • METASTATIC BIOMARKER
    Publication number: 20230305007
    Abstract: The invention relates to a method of determining whether a subject who has been diagnosed with cancer is likely to develop, or is likely to have developed, a metastasis, wherein the method comprises detecting the level of membrane-bound actin in a sample obtained from the subject. The invention also relates to methods and markers to diagnose, prognose, monitor and/or stage cancer, in particular metastatic cancer.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 28, 2023
    Applicant: OXFORD BROOKES UNIVERSITY
    Inventors: Ryan PINK, Susan BROOKS, David CARTER, Ellie BEAMAN
  • METASTATIC CANCER TREATMENT OR PREVENTION
    Publication number: 20230303672
    Abstract: The invention relates to agents which prevent or reduce the interaction between actin and one or more of its interacting partners, for use in treating or preventing metastatic cancer in a subject in need thereof. The invention also relates to a method of treating or preventing metastatic cancer, or a method of preventing or reducing epithelial cell to endothelial cell adhesion, comprising administering an agent which prevents or reduces the interaction between actin and one or more of its interacting partners.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 28, 2023
    Applicant: OXFORD BROOKES UNIVERSITY
    Inventors: Susan BROOKS, David CARTER, Ellie BEAMAN
  • A METHOD OF SELECTIVELY CHARACTERISING A POLYNUCLEOTIDE USING A DETECTOR
    Publication number: 20230295712
    Abstract: The invention provides a method of selectively characterising polynucleotides of a desired property, such as length, using a nanopore, based on the translocation of the polynucleotide through or across the nanopore. Kits and systems for use in such methods are also provided. The methods of the invention are particularly suitable for sequencing polynucleotides such as DNA.
    Type: Application
    Filed: June 18, 2021
    Publication date: September 21, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Rebecca Victoria Bowen, Clive Gavin Brown, Mark John Bruce, Daniel Ryan Garalde, James Edward Graham, Andrew John Heron, Etienne Raimondeau, James White, Christopher Peter Youd
  • CALIBRATION AND PROFILING OF A NANOPORE ARRAY DEVICE
    Publication number: 20230296582
    Abstract: A method of calibrating a nanopore array device. The nanopore array device comprising: a common electrode, an array of sensing elements each comprising a sensing electrode and a nanopore channel, and an ionic solution in contact with the common electrode and the array of sensing electrodes, the ionic solution providing electrical communication between the common electrode and each of the array of sensing electrodes via the corresponding array of nanopore channels.
    Type: Application
    Filed: March 24, 2023
    Publication date: September 21, 2023
    Applicant: Oxford Nanopore Technologies PLC
    Inventors: Graham Hall, Max Fletcher Wilson, Daniel Benjamin Trevor Ward