Abstract: Described herein are methods of promoting remyelination in a subject suffering from demyelination diseases by administering to the subject a combination of steroid hormones and Hedgehog signaling pathway modulators. Also described are methods of administering the combination of drugs, wherein the combination of drugs are in compositions adapted for nasal administration.

Abstract: An organic Rankine cycle system (100, 110, 120) with direct exchange and in cascade comprising a high temperature organic Rankine cycle (10) which carries out the direct heat exchange with a hot source (H) and a low temperature organic Rankine cycle (10?) in thermal communication with the high temperature cycle (10). The organic Rankine cycle system (100, 110, 120) is configured in a way that the thermal communication between the cycles (10, 10?) takes place through at least one heat exchanger (3) configured to use at least the condensation heat of the high temperature cycle to vaporize and/or preheat the working fluid of the low temperature organic Rankine cycle fluid and through a heat exchanger (4) configured to operate as working fluid sub-cooler for the high temperature organic Rankine cycle (10) and as a working fluid preheater for the low temperature organic Rankine cycle (10?).

Abstract: A pocketed spring assembly comprises parallel strings, each string joined to at least one adjacent string. At least some of the strings have springs of different gauge wire and some of the pockets of the strings having springs of different gauge wire are spliced together. At least some of the strings have springs of different geometries and some of the pockets of the strings having springs of different geometries are spliced together. At least some strings may have end sections with springs different than a middle section therebetween, the springs of the end sections being firmer than the springs of the middle section.

Abstract: Apparatuses, methods, and computer program products for quilting webs without compressing the webs. A quilting machine includes a needle bar to which needles are attached, needle thread passing through each needle, a looper shaft to which loopers are attached, a looper corresponding to each needle and from which looper thread is provided to form stitches, and a retainer bar to which spreaders are attached to facilitate stitching. A drive pulley powered by a first servo motor rotates cranks to move the needles through a cycle and rotates a belt which rotates an indexer pulley. Rotation of the indexer pulley oscillates the looper shaft and reciprocates the retainer bar. Another drive pulley powered by a second servo motor operates to move an input web through the machine between chain stitches.

Abstract: The present invention relates to an innovative system which definitively prevents the re-use of syringes with retractable needles, allowing at the same time to fill the tank by means of a mechanical system installed inside the piston. The operation that aims at preventing the re-use of the device takes place through a mechanical system that prevents the return of the piston towards the initial position of aspiration and restricts, therefore, its action in a single direction and prevents the return of the plunger to the initial position of injection and therefore restricts its action in a single direction. Moreover a rotating mechanical transition system prevents the repositioning of the piston in the previously used position. The filling of the container, instead, takes place through the use of a system via a flexible cannula placed inside the piston.

Abstract: A posturized comfort layer for a bedding or seating product has different sections of different firmness due to different mini coil springs within the sections. The springs may be individually pocketed between two sheets of non-woven polypropylene fabric joined with circular or rectangular weld seams. Regardless of the shape of the weld seams, the different firmness of the different sections of the comfort layer may be due to different mini coil springs contained in the pockets. All pockets may have the same spring, the springs may be contained in different size weld seams to create pockets of different heights.

Abstract: An apparatus for replacing a roll of material with a replacement roll of material comprises a loading station and multiple feed stations downstream of the loading station. Each station comprises two legs and a motorized drive assembly extending between the legs. The drive assembly rotates two sprockets and an endless chain surrounding the sprockets inside each of the legs at a station to raise or lower carriages. A roll support extends between the carriages at each station.

Abstract: A posturized comfort layer for a bedding or seating product has different sections of different firmness due to different pocketed mini coil springs within the sections. The springs may be individually pocketed between two sheets of non-woven polypropylene fabric joined with circular or rectangular weld seams. Regardless of the shape of the weld seams, the different firmness of the different sections of the comfort layer may be due to different mini coil springs contained in the pockets. In some embodiments, all pockets may have the same spring and the springs contained in different size weld seams to create pockets of different heights.

Abstract: A cosmetic composition comprising Janus particles, an aqueous phase and an organic phase uses Janus particles produced with a method which includes the preparation of hollow particles (1) having two non-continuous surfaces of a material with surface energy a, of which the external one (2) is accessible and the internal one (3) is inaccessible. The surface energy of the external surface (2) is thereby modified originating particles (11) with internal surface energy a and external surface energy 13. The modified particles (11) are then ground until particles are obtained constituted by small fragments (21) shaped as spherical caps with external surface (12) having modified energy and internal surface (13) having non-modified internal energy.

Abstract: A needle system for providing fluidic and/or instrument access to an internal body structure. Exemplary embodiments may include non-linear needles having anatomically appropriate lengths and curvatures. Some exemplary embodiments may include a pivotable base, which may assist in stabilizing the needle system with respect to a body structure and/or may be reconfigurable into a safety guard position. Exemplary needle systems may include expandable conduits providing fluidic and/or instrument pathways into internal body structures.

Abstract: The object of the present invention is an atmospheric gas burner (300) for cooking tops (400), in particular household cooking tops (400), where the air-gas mixture is obtained by the effect of the gas supply pressure using the principle of the tube ejector (10; 310) of Venturi that has a sufficient quantity Z?1 of ejectors (310) to supply, globally, the maximum power (Wb) provided for the same burner (300). Each of said ejectors (310) develops on a horizontal plane, has the axis of its diffuser (315) which in the first stretch (322) is substantially rectilinear and tangential to a circle with centre on the central axis (324) of said burner (300) while in the second stretch (323) gradually bends substantially as a spiral towards the same central axis (324), leads, downstream of said diffuser (315), to a converging channel (327) which gradually bends vertically upwards and which, in turn, leads to one or more diffusion chambers (328) to which one or more flame spreading caps (318) act as a cover.

Abstract: A central vacuum cleaning system includes an inlet valve mounted at various locations in a structure or RV and connected to the inlet end of a vacuum conduit. A section of hose is slidably mounted within the conduit and extends from the inlet valve for cleaning an adjacent area. The hose includes a hose plug connected with a distal end of the hose. The hose plug includes an annular channel and an orthogonally aligned slot. The hose plug may also include a first seal and a second seal.

Abstract: A locking sleeve for connection with a valve box assembly of a central vacuum system includes, a first end adapted to couple to a wall of a valve box assembly, a second end opposite the first end, a central vertical axis between the first end and the second end, a first side adapted to be adjacent to a rear wall of a valve box assembly, a second side opposite the first side, a central horizontal axis between the first side and the second side, a slidable locking mechanism moveable in a sliding manner. The slidable locking mechanism is adapted to secure a vacuum hose assembly to the valve box assembly of the central vacuum system.

Abstract: A bedding foundation comprises a connector assembly and a stabilizer assembly at each corner of the product for joining perpendicular first and second trusses. Each stabilizer assembly comprises a first bracket secured to the first truss, a second bracket secured to the second truss and a leg assembly comprising a lag and a threaded rod. One of the first and second brackets has a threaded boss and the other of the first and second brackets has an opening aligned with the threaded boss. The threaded rod extends through the aligned threaded boss and opening of the first and second brackets and the leg abuts the lower bracket to support the foundation above the ground.

Abstract: A hose cuff on a vacuum hose for connection with at least one inlet valve of a central vacuum system includes a first end, a second end opposite the first end, a longitudinal axis between the first end and the second end, a first section adjacent to the first end, and a second section adjacent to the second end. The first section is adapted to connect to a first inlet valve and the second section is adapted to connect to a different second inlet valve. The first section includes a metal portion adapted to contact pins of the first inlet valve.

Abstract: A method of constructing a building is disclosed, including selecting a standard dimension less than a wide-load trucking permit limit and designing a building on a grid defined by the selected standard dimension. The building includes a plurality of prefabricated elements, wherein each prefabricated element has a width correspond to the selected standard dimension. The plurality of prefabricated elements includes a wall panel, a roof panel, a laterally resistive frame, and a rebar cage. The method includes fabricating each of the plurality of prefabricated elements at a manufacturing plant and transporting the elements by truck to a building site. The method includes constructing intersecting grade beam footings at the building site and pouring a slab between the intersecting grade beam footings. The grade beam footings include the rebar cage and have a uniform width and depth, the grade beam footings and the slab having contiguous upper surfaces.

Abstract: An imaging system constituted of: an imager; an imager translation mechanism arranged to translate the imager along a predetermined translation axis in each of a first direction and a second direction responsive to a provided electrical power, the second direction opposing the first direction, the predetermined translation axis exhibiting an imaging angle with a floor, the first direction being toward the floor along the translation axis, the imaging angle being less than 90 degrees and greater than 0 degrees; a piston translation mechanism; and a piston power mechanism arranged to provide motive power to the piston translation mechanism, wherein the piston translation mechanism is arranged to translate the imager in the second direction responsive to the provided motive power in the absence of the provided electrical power.

Abstract: A connector for connecting a cable and a circuit board is disclosed. The connector includes an upper cover plate, a lower plate body and an auxiliary member. Through the combination of the upper cover plate and the lower plate body, the cable can be held in an accommodation space therebetween. When an external force is applied to the upper cover plate, the upper cover plate will be unlocked to form an angle between the upper cover plate and the lower plate body, and then the holding member locking the cable is deformed to release the cable.