Patents Assigned to Parion Sciences, Inc.
  • SODIUM CHANNEL BLOCKERS
    Publication number: 20130012692
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: June 8, 2012
    Publication date: January 10, 2013
    Applicant: Parion Sciences, Inc.
    Inventor: MICHAEL R. JOHNSON
  • Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity
    Patent number: 8324218
    Abstract: The present application provides sodium channel blockers exemplified by the following structure: The compounds of the invention useful for treating chronic bronchitis, cystic fibrosis, sinusitis, vaginal dryness, dry eye, Sjogren's disease, distal intestinal obstruction syndrome, dry skin, esophagitis, dry mouth (xerostomia), nasal dehydration, ventilator-induced pneumonia, asthma, primary ciliary dyskinesia, otitis media, chronic obstructive pulmonary disease, emphysema, pneumonia, constipation, and chronic diverticulitis, for example.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: December 4, 2012
    Assignee: Parion Sciences, Inc.
    Inventor: Michael Ross Johnson
  • Methods of reducing risk of infection from pathogens
    Patent number: 8314105
    Abstract: Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: November 20, 2012
    Assignee: Parion Sciences, Inc.
    Inventor: Michael Ross Johnson
  • Pyrazinoylguanidine compounds for use as taste modulators
    Patent number: 8288391
    Abstract: The present invention relates to blocking salt taste using compounds of Formula I as defined herein.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: October 16, 2012
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Richard C. Boucher, Andrew J. Hirsh
  • NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20120220606
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: May 9, 2012
    Publication date: August 30, 2012
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Sodium channel blockers
    Patent number: 8227474
    Abstract: The present invention relates to pyrazinoylguanidine sodium channel blocker compounds represented by formula (I): as well as pharmaceutical compositions comprising the compounds and their use in promoting hydration of mucosal surfaces, restoring mucosal defense, and promoting mucus clearance, as well as methods of treatment for chronic bronchitis, cystic fibrosis, rhinosinusitis, nasal dehydration, asthma, ciliary dyskinesia, otitis media, chronic obstructive pulmonary disease, emphysema, and Sjögren's disease.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: July 24, 2012
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 8211895
    Abstract: The present application relates to pyrazinoyl guanidine sodium channel blockers having the structure: or a pharmaceutically acceptable salt thereof, where the structural variables are as defined herein. The present invention also relates pharmaceutical compositions comprising the sodium channel blockers and their use in methods of treatment, including the treatment of cardiovascular disease, cystic fibrosis, and chronic bronchitis and in the rehydration of mucosal surfaces and promotion of mucus clearance in a patient.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: July 3, 2012
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Methods of Reducing Risk of Infection from Pathogens
    Publication number: 20120165342
    Abstract: Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
    Type: Application
    Filed: May 21, 2010
    Publication date: June 28, 2012
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. JOHNSON, Samuel E. HOPKINS
  • Sodium channel blockers
    Patent number: 8198286
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: June 12, 2012
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • HETEROAROMATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20120116083
    Abstract: Polyaromatic sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: January 18, 2012
    Publication date: May 10, 2012
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael Ross JOHNSON
  • Phenyl substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
    Patent number: 8163758
    Abstract: Provided is class of sodium channel blockers. One example of such a compound is shown by the following formula: The compounds are useful for promoting hydration of mucosal surfaces and treating a variety of disease conditions.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: April 24, 2012
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, Andrew J. Hirsh, Richard C. Boucher, Jianzhong Zhang
  • Cyclic amide and ester pyrazinoylguanidine sodium channel blockers
    Patent number: 8143256
    Abstract: The present invention provides compounds represented by formula (I): where the structural variables are defined herein. The compound of the present invention are useful as sodium channel blockers.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: March 27, 2012
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Poly aromatic pyrazinoylguanidine sodium channel blockers
    Patent number: 8124607
    Abstract: Polyaromatic sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: February 28, 2012
    Assignee: Parion Sciences, Inc.
    Inventor: Michael Ross Johnson
  • Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
    Patent number: 8058278
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: November 15, 2011
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, Richard C. Boucher, Andrew J. Hirsh
  • Soluble amide and ester pyrazinoylguanidine sodium channel blockers
    Patent number: 8022210
    Abstract: The present invention relates to pyrazinoylguanidine compounds represented by formula (I): where X, Y and R1-R4 are as defined herein. The compounds of the present invention are useful as sodium channel blockers.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: September 20, 2011
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Soluble amide and ester pyrazinoylguanidine sodium channel blockers
    Patent number: 8008494
    Abstract: The present invention relates to pyrazinoylguanidine compounds represented by formula (I): where X, Y and R1-R4 are as defined herein. The compounds of the present invention are useful as sodium channel blockers.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: August 30, 2011
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • CYCLIC SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY
    Publication number: 20110195973
    Abstract: The present invention relates to sodium channel blockers. The present Invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: June 11, 2007
    Publication date: August 11, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael Ross Johnson
  • Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
    Patent number: 7981898
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: July 19, 2011
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, Richard C. Boucher, Andrew J. Hirsh
  • METHODS OF REDUCING RISK OF INFECTION FROM PATHOGENS
    Publication number: 20110144338
    Abstract: Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided comprising administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
    Type: Application
    Filed: August 8, 2007
    Publication date: June 16, 2011
    Applicant: Parion Sciences, Inc.
    Inventors: Michael R. JOHNSON, Samuel E. Hopkins
  • Aliphatic amide and ester pyrazinoylguanidine sodium channel blockers
    Patent number: 7956059
    Abstract: The present invention relates to pyrazinoylguanidine compounds represented by formula (I): where the structural variables are defined herein. The compounds are useful as, for example, sodium channel blockers.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: June 7, 2011
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson