Patents Assigned to Parion Sciences, Inc.
  • Methods of using sodium channel blockers
    Patent number: 7332496
    Abstract: The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: February 19, 2008
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Cyclic pyrazinoylguanidine sodium channel blockers
    Patent number: 7317013
    Abstract: The present invention provides sodium channel blockers represented by formula (I): where the structural variables are defined herein. The compounds of the present invention may be used for treating a variety of conditions as described herein.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: January 8, 2008
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • METHODS OF USING SODIUM CHANNEL BLOCKERS
    Publication number: 20070265280
    Abstract: The present invention relates to use of a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels and treating a variety of conditions.
    Type: Application
    Filed: April 3, 2007
    Publication date: November 15, 2007
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7247637
    Abstract: The present invention relates to a compound represented by formula (I): where the structural variables are as defined herein. The compound is useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: July 24, 2007
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Phenolic guanidine sodium channel blockers
    Patent number: 7247636
    Abstract: The present invention relates to sodium channel blockers. The present invention also relates to a variety of methods of treatment using these sodium channel blockers.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: July 24, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Methods of using phenolic guanidine sodium channel blockers
    Patent number: 7241766
    Abstract: The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: July 10, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7192960
    Abstract: The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: March 20, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7192959
    Abstract: The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: March 20, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7192958
    Abstract: The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: March 20, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7189719
    Abstract: The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: March 13, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7186833
    Abstract: The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: March 6, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • New capped pyrazinoylguanidine sodium channel blockers
    Publication number: 20070032509
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 3, 2005
    Publication date: February 8, 2007
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Bruce Molino, Bruce Sargent, Jianzhong Zhang
  • Capped pyrazinoylguanidine sodium channel blockers
    Publication number: 20060205738
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 26, 2005
    Publication date: September 14, 2006
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Hetero substitued sodium channel blockers
    Publication number: 20060142581
    Abstract: The present invention relates to novel pyrazinoylguanidine compounds and methods of using the same.
    Type: Application
    Filed: February 18, 2004
    Publication date: June 29, 2006
    Applicant: PARION SCIENCES, INC.
    Inventor: Michael Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7064129
    Abstract: Compounds are provided which are represented by the formula: where the structural variables are defined herein. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: June 20, 2006
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Sodium channel blockers
    Patent number: 7030117
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: April 18, 2006
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7026325
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: April 11, 2006
    Assignee: Parion-Sciences, Inc.
    Inventor: Michael R. Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Publication number: 20060052394
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 9, 2006
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Publication number: 20060052395
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 9, 2006
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Soluble amide & ester pyrazinoylguanidine sodium channel blockers
    Publication number: 20060040954
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 18, 2004
    Publication date: February 23, 2006
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael Johnson