Patents Assigned to Parion Sciences, Inc.
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20110046158
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: November 4, 2010
    Publication date: February 24, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Hetero substituted sodium channel blockers
    Patent number: 7875619
    Abstract: The present invention relates to group of butylphenyl-pyrazinoylguanidine compounds useful as sodium channel blockers. The compounds may be used to promote promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: January 25, 2011
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • PHENYL SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY
    Publication number: 20110008268
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: June 11, 2007
    Publication date: January 13, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Ross Johnson, Andrew J. Hirsh, Richard C. Boucher, Jianzhong Zhang
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7868010
    Abstract: The invention relates to substituted pyrazinoylguanidine compounds. These compounds are useful as sodium channel blockers, and may be effective in treating a variety of conditions including chronic bronchitis and cystic fibrosis.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: January 11, 2011
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS
    Publication number: 20110003832
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: September 7, 2010
    Publication date: January 6, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Soluble amide and ester pyrazinoylguanidine sodium channel blockers
    Patent number: 7842697
    Abstract: The present invention relates to pyrazinoylguanidine compounds represented by the formula: where the structural variables are defined herein. The compounds are useful as sodium channel blockers.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: November 30, 2010
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Sodium channel blockers
    Patent number: 7820678
    Abstract: Provided are methods of increasing hydration of mucosal surfaces by topically administering sodium channel blocking pyrazinoylguanidine compounds.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 26, 2010
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • ALIPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS WITH BETA AGONIST ACTIVITY
    Publication number: 20100267746
    Abstract: The present invention provides sodium channel blockers possessing beta-adrenergic receptor agonist activity.
    Type: Application
    Filed: June 11, 2007
    Publication date: October 21, 2010
    Applicant: PARION SCIENCES, INC.
    Inventor: Michael Ross Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7807834
    Abstract: The present invention relates to group of pyrazinoylguanidine compounds useful as sodium channel blockers. The compounds may be used to promote promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: October 5, 2010
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Bruce Sargent, Jianzhong Zhang
  • Methods of reducing risk of infection from pathogens
    Patent number: 7745442
    Abstract: Prophylactic treatment methods are provided for protection of individuals and/or populations against infection from airborne pathogens. In particular, prophylactic treatment methods are provided including administering a sodium channel blocker or pharmaceutically acceptable salts thereof to one or more members of a population at risk of exposure to or already exposed to one or more airborne pathogens, either from natural sources or from intentional release of pathogens into the environment.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: June 29, 2010
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Samuel E. Hopkins
  • SODIUM CHANNEL BLOCKERS
    Publication number: 20100144661
    Abstract: The present invention relates to sodium channel blockers. The present invention also relates to a variety of methods of treatment using the sodium channel blockers.
    Type: Application
    Filed: February 10, 2010
    Publication date: June 10, 2010
    Applicant: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • MULTIPLE NEBULIZER SYSTEMS
    Publication number: 20100074881
    Abstract: A device for administering two or more therapeutic agents simultaneously, comprising two or more nebulizers and a single connector linking the nebulizers to a nebulizer mouthpiece. Also provided is a method of administering two or more therapeutic agents simultaneously, comprising administering the therapeutic agents simultaneously with the device of the present invention to a subject in need thereof.
    Type: Application
    Filed: July 13, 2009
    Publication date: March 25, 2010
    Applicant: PARION SCIENCES, Inc.
    Inventors: Richard C. BOUCHER, Michael R. Johnson, Keith A. Johnson, William R. Thelin
  • SOLUBLE AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20090324724
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 31, 2009
    Applicant: PARION SCIENCES, INC.
    Inventor: Michael R. Johnson
  • SODIUM CHANNEL BLOCKERS
    Publication number: 20090227530
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: July 24, 2008
    Publication date: September 10, 2009
    Applicant: PARION SCIENCES, INC.
    Inventor: Michael R. JOHNSON
  • POLY AROMATIC SODIUM CHANNEL BLOCKERS
    Publication number: 20090214444
    Abstract: Polyaromatic sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: February 26, 2009
    Publication date: August 27, 2009
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael Ross Johnson
  • INHALED HYPERTONIC SALINE DELIVERED BY A HEATED NASAL CANNULA
    Publication number: 20090104272
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 23, 2009
    Applicant: PARION SCIENCES, Inc.
    Inventors: Richard C. BOUCHER, Michael Ross Johnson
  • METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES
    Publication number: 20090082287
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 26, 2009
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, Richard C. Boucher, Andrew J. Hirsh
  • SOLUBLE AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20090076273
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: March 19, 2009
    Applicant: PARION SCIENCES, INC.
    Inventor: Michael R. JOHNSON
  • METHODS OF USING SODIUM CHANNEL BLOCKERS
    Publication number: 20090062308
    Abstract: The present invention relates to use of a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are as defined herein. The compounds are useful for blocking sodium channels and treating a variety of conditions.
    Type: Application
    Filed: August 12, 2008
    Publication date: March 5, 2009
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael R. JOHNSON
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20090018144
    Abstract: The present invention relates to compounds represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
    Type: Application
    Filed: July 11, 2008
    Publication date: January 15, 2009
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. Johnson, Bruce Molino, Jianzhong Zhang, Bruce Sargent