Patents Assigned to Parion Sciences, Inc.
  • METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS
    Publication number: 20080293740
    Abstract: The present invention provides a variety of methods of treatment of acid-sensing ion channel (ASIC) mediated pain, cough, and central nervous system disorders by ASICs inhibition with a series of pyrazinoylguanidine compounds represented by formula (I) as defined herein.
    Type: Application
    Filed: April 3, 2008
    Publication date: November 27, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Richard C. BOUCHER, Andrew J. HIRSH
  • PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS
    Publication number: 20080249109
    Abstract: The present invention relates to blocking salt taste using compounds of Formula I as defined herein.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 9, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Richard C. Boucher, Andrew J. Hirsh
  • ALAPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080200476
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: April 7, 2008
    Publication date: August 21, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael R. JOHNSON
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7410968
    Abstract: The present invention relates to compounds represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: August 12, 2008
    Assignee: PARION SCIENCES, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • SOLUBLE AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080177072
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 24, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael R. Johnson
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080176863
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 24, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • SOLUBLE AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080171879
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 17, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael R. JOHNSON
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080171880
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 17, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce Molino, Jianzhong Zhang, Bruce Sargent
  • Soluble amide & ester pyrazinoylguanidine sodium channel blockers
    Patent number: 7399766
    Abstract: The present invention provides a pyrazinoylguanidine compound represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: July 15, 2008
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080167466
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 10, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7388013
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: June 17, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Alaphatic pyrazinoylguanidine sodium channel blockers
    Patent number: 7375107
    Abstract: The present invention provides compound represented by formula (I): where the structural variables are defined herein. The compounds function as sodium channel blockers and may be used to treat a variety of respiratory conditions.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: May 20, 2008
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7368451
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Sodium channel blockers
    Patent number: 7368450
    Abstract: The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Capped pyrazinoylguanidine sodium channel blockers
    Patent number: 7368447
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • CYCLIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
    Publication number: 20080103148
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: December 20, 2007
    Publication date: May 1, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael JOHNSON
  • Cyclic Amide & Ester Pyrazinoylganidine Sodium Channel Blockers
    Publication number: 20080096896
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: August 18, 2005
    Publication date: April 24, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael R. Johnson
  • METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES
    Publication number: 20080090841
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Application
    Filed: September 7, 2007
    Publication date: April 17, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Johnson, Richard Boucher, Andrew Hirsh
  • SODIUM CHANNEL BLOCKERS
    Publication number: 20080076782
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: December 5, 2007
    Publication date: March 27, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventor: Michael JOHNSON
  • Sodium channel blockers
    Patent number: 7345044
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: March 18, 2008
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson