Abstract: The present invention relates to a lipid nanoparticle system comprising a lipid component, a cationic surfactant, a non-ionic surfactant, a polysaccharide and, optionally, a positively charged peptide, useful for the release of pharmacologically active molecules, and especially for transfecting genetic material into cells and/or tissues. It also relates to methods for obtaining nanoparticles, to pharmaceutical compositions comprising it, as well as to the use thereof in gene therapy.

Abstract: Compounds derived from ?-C-phenyl-N-tert-butylnitrone, a process for the preparation thereof and use thereof for the preparation of medicaments for use in preventing or treating oxidative stress-related diseases.

Abstract: The invention relates to non-proteolysable oligopeptides that inhibit glycoprotein 41 of the AIDS virus. More specifically, the invention relates to the identification of oligopeptides, particularly hexapeptides, (D), (L) or mixed, preferably D-hexapeptides, which inhibit the binding of a retrovirus to a target cell, thereby providing novel therapies against infection from the human immunodeficiency virus (HIV). The invention also relates to the use of said D-hexapeptides in the form of single components or complex mixtures as prophylactic or therapeutic agents for retroviral infections, especially human immunodeficiency virus type 1 (HIV-1).

Abstract: This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.

Abstract: The invention relates to a process for obtaining hydrogen from natural gas which comprises (a) reacting the natural gas with a mixture of air and steam in a single reactor to obtain a gas comprising H2 and CO, (b) reacting the CO produced at a high temperature with steam to obtain a gas comprising H2 and CO2, and (c) reacting the CO which has not reacted in step (b) at a low temperature with steam to obtain a gas comprising H2 and CO2, characterized in that in step (a) the natural gas, the air and the steam are fed simultaneously and react on the same catalyst and in that the pressure used in steps (a) to (c) varies between 1 and 8 atm, as well as to a H2 production plant for carrying out the mentioned process.

Abstract: The invention relates to a method for quantifying G protein-coupled receptor (GPCR)-G protein binding by means of using a cell membrane array, which comprises (i) putting an unlabeled candidate compound in contact with a cell membrane array in the presence of labeled GTP or of a labeled, non-hydrolyzable analog thereof, in conditions allowing the interaction between said compound and said GPCR present in said cell membranes, and between said labeled GTP or analog thereof and said G protein present in said membranes; (ii) washing; and (iii) quantifying the signal obtained due to the binding of the labeled GTP (or analog) to said G protein. It is applicable in the analysis of the interaction between compounds and cell membrane receptor proteins and of the intracellular signaling mechanisms triggering this interaction mechanism mediated by said compounds.

Abstract: A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.

Abstract: The invention concerns electrically conductive composite nanoparticles having an alkyl polyacrylate core and a polyaniline coating, the dispersions comprising them and their use for preparing conductive films. The invention also concerns a method for making particles, comprising an elastomeric core and a polyaniline coating.

Abstract: The invention relates to an integral magnetic compass for obtaining deviations in real time, formed by a transparent sphere or cylinder (2), incorporating therein, in a hydrocarbon liquid (3), a polyester or silicon disk (4) to which the rose (5) and the magnet (6) are fitted, being associated with a commutation system formed by integrated software in a device or chip (7), the circuit of which has two inputs: an input (8) to the signal obtained from the magnetic compass (1) itself, obtained by means of a magnetometer (9) or optical reader (10) in association therewith, and another input (11) to the signal from the satellite compass (12) or from the gyroscopic compass (13), and said circuit having an output (14) to a display (15) for viewing and storage of the data for the corresponding deviations, thus obtaining the deviation chart for the magnetic needle in real time, said output being also applicable to the automatic pilot (16).

Abstract: A roller mounted onto a fabric winding machine to roll up fabric aims to solve the shortcomings of the conventional rollers that tend to cause fabric skewing during fabric rolling and are difficult to remove due to a lengthy structure. The roller of the invention has an outer diameter gradually enlarged towards two ends, and includes a first half roller and a second half roller that have respectively a first positioning portion and a second positioning portion at one end corresponding and fastenable to each other. The greater diameters at two ends allow the fabric to be rolled up on the roller without skewing. The two pieces design of the roller makes each piece shorter and removing from a bundle of rolled up fabric easier. The roller thus formed can facilitate fabric rolling and removal thereof.

Abstract: A fabric collection structure for a fabric cutting apparatus splits fabric and has a driving means. The fabric collection structure includes a fabric rolling rod and a fabric pressing means. The fabric pressing means has a fabric spread rod and a fabric pressing rod. During fabric collection, the driving means drives the fabric rolling rod, fabric spread rod and fabric pressing rod to rotate. The fabric split by the fabric cutting apparatus is flatly unfolded by the fabric spread rod and driven by the fabric pressing rod to be rolled on the fabric rolling rod, and is pressed by the fabric pressing rod. The fabric pressing rod is lifted by increasing thickness of the fabric rolled on the fabric rolling rod. The fabric rolling rod rolls the fabric at a fixed location. The fabric pressing means presses the fabric to control the density and a uniform fabric density is achieved.

Abstract: A tension adjustment structure for fabric winding machine includes a driving mechanism, a roller, a fabric pressing mechanism and an adjustment mechanism. The roller and the driving mechanism have corresponding transmission wheels strode by a belt. The driving mechanism drives the roller to roll up a fabric. The fabric pressing mechanism has an action arm and a fabric pressing bar located on the action arm. The fabric pressing bar has a first position without in contact with the fabric and a second position in contact with the fabric and lifted by the fabric. The adjustment mechanism is butted by the action arm when the fabric pressing bar is at the first position to butt the belt and increase initial rolling force of the roller. The action arm releases the belt while the fabric pressing bar is at the second position so that fabric rolling tightness can be controlled.

Abstract: The present invention refers to the use of glutamate transporters, glutamate and EGF to detect the presence of demyelinating diseases in a subject, to determine the status or severity of the same or to monitor the effects of a therapy administered to a subject who suffers from such diseases; to the use of the said markers for the searching, identification, development and evaluation of the efficacy of compounds for the treatment of such diseases, with a view to developing new drugs; to the use of compounds which promote the expression of the EAAT1 and EAAT2 transporters, as well as EGF for the treatment of demyelinating diseases. In a preferred embodiment, the methods and compounds of the invention are applicable to MS.

Abstract: The invention concerns a nebuliser with nanometric flow rate of a liquid effluent in a nebulising gas comprising at least arranged substantially concentric, a capillary tube for intake of the liquid effluent and a nebulising needle including a central channel fed with liquid effluent through the capillary tube, a chamber for intake of the nebulising gas feeding a nozzle for expelling the nebulising gas, the nebulising needle passing through the intake chamber and the nozzle expelling the nebulising gas, the nebulising needle including a outlet for the liquid effluent whereof the aperture diameter is less than 20 ?m, the ratio of the diameter of the outlet of the nozzle expelling the nebulising gas and the outlet of the nebulising needle being more than 10 The inventive nanometric flow rate nebuliser and nebulising installation are applicable in mass spectrometry of trace elements contained in intracellular or microbiological medium for example.

Abstract: A circular knitting machine having an integrated multiple yarn changing apparatus comprises a first yarn changing apparatus, a second yarn changing apparatus, and a driving cam set. The first and second yarn changing apparatus include respectively at least one yarn feeding means which is moved outwards through a first yarn feeding stroke and a second yarn feeding stroke to a yarn feeding position. The driving cam set includes a first driving track and a second driving track to respectively drive the yarn feeding means to proceed the first and second yarn feeding strokes. The second driving track has a driving delay zone to generate a yarn feeding time lag between the first and second yarn feeding strokes. Knitting needles located between the first and second yarn feeding means are guided to a yarn hooking position to respectively hook the yarn due to the yarn feeding time lag.

Abstract: A jacquard needle equipped with a return structure is installed in a circular knitting machine which has a computer needle selected device including plural jacquard needles and plural needle selected sheets on an upper needle dial. Each jacquard needle is driven by a cam to move a knitting needle. The needle selected sheet depresses the jacquard needle to escape from the cam. The jacquard needle includes a fulcrum, a neck, a force received section, a needle foot and a return structure. The fulcrum is connected with the knitting needle. The needle foot is located in a slide track of the cam. The return structure has a bend end at a distal end beneath the needle foot. The bend end butts an inner wall of the upper needle dial. The force received section transmits the depressing force to bend the return structure to generate a returning elasticity.

Abstract: A method and apparatus for lowering and folding fabric at the same amount knitted and unloaded by a circular knitting machine delivers a fabric continuously knitted by the circular knitting machine and temporarily holds and in a buffer transient storing apparatus which divides the fabric into three zone fabric lengths and delivers later Through the buffer transient storing apparatus the three zone fabric lengths can complement with each other mechanically so that the fabric above the reciprocal moving of the forward and reverse turning fabric folding bars can be maintained at a constant tension, and the fabric knitted continuously by the circular knitting machine can be lowered at an equal amount and folded on a fabric loading board.

Abstract: A yarn feeding plate double-sided floss blowing apparatus for circular knitting machines is installed in a circular knitting machine which includes a needle cylinder to hold a plurality of knitting needles and yarn feeding plates. The floss blowing apparatus comprises an air blowing unit. The air blowing unit includes a first air blowing duct and a second air blowing duct. The first air blowing duct has one end extended above the yarn feeding plates and bent towards a lower half portion of an outer side of the yarn feeding plates to form a first air ejection nozzle. The second air blowing duct has one end extended close to a lower half portion of an inner side of the yarn feeding plates and above the knitting needles to form a second air ejection nozzle. Thus strong airflow can blow away the floss on the yarn feeding plates at the shortest distance.

Abstract: A yarn changing set for color altering heads includes a yarn splint plate, a movable cutter plate, a yarn cutting plate and a yarn changing plate positioned in an overlapped manner. A plurality of pins are coupled between the yarn splint plate and yarn cutting plate to allow the movable cutter plate and yarn changing plate to move between them. The movable cutter plate and yarn changing plate have respectively a notch at one edge opposing each other to form a confined area to limit movement of the pins when driven by a cam. The yarn cutting plate has a plurality of notches on the edges to hold the pins. Thus an open type design is formed to expose cotton accumulating portions to facilitate clearing of accumulated cotton. Therefore, smooth operation can be maintained and life span of the machine and elements increases.

Abstract: A method for completing a transaction including receiving a credit card payment request at a card reader. The payment request can include a payment amount and a micropayment account identification identifying a pre-pay account or a post-pay account. In the event the payment request is for a pre-pay type of account and the payment amount is greater than a balance associated with the account, then a credit card account associated with the micropayment account is charged with a top off amount plus the difference between the payment amount and the remaining balance. In the event, the payment request is for a post-pay type of account and the payment amount is greater than the balance associate with the account, then a credit account associated with the micropayment account is charged with an amount equal to a credit limit plus the difference between the payment amount and the remaining credit.